JAK2 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description Janus kinase 2|This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3717)
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100 substrates of the kinase JAK2 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
PLPPR4 phospholipid phosphatase related 4 99.98
PM20D2 peptidase M20 domain containing 2 99.96
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 99.91
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 99.87
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 99.83
EIF3I eukaryotic translation initiation factor 3, subunit I 99.76
EIF1B eukaryotic translation initiation factor 1B 99.71
EIF1 eukaryotic translation initiation factor 1 99.71
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 99.67
SIPA1L1 signal-induced proliferation-associated 1 like 1 99.59
CHAF1B chromatin assembly factor 1, subunit B (p60) 99.5
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 99.47
EML4 echinoderm microtubule associated protein like 4 99.41
TNRC6B trinucleotide repeat containing 6B 99.3
MKNK1 MAP kinase interacting serine/threonine kinase 1 99.26
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 99.12
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.01
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.01
RHOG ras homolog family member G 98.97
N4BP3 NEDD4 binding protein 3 98.95
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 98.915
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 98.91
FKBP5 FK506 binding protein 5 98.9
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 98.82
FCHO1 FCH domain only 1 98.77
CHRM2 cholinergic receptor, muscarinic 2 98.67
TIGIT T cell immunoreceptor with Ig and ITIM domains 98.62
USP31 ubiquitin specific peptidase 31 98.56
ZNF143 zinc finger protein 143 98.545
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 98.51
MAK male germ cell-associated kinase 98.47
ITSN1 intersectin 1 (SH3 domain protein) 98.45
HCST hematopoietic cell signal transducer 98.45
FKBP10 FK506 binding protein 10, 65 kDa 98.38
ESYT2 extended synaptotagmin-like protein 2 98.32
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 98.29
ARRDC3 arrestin domain containing 3 98.25
C12ORF75 chromosome 12 open reading frame 75 98.14
SYNPO2 synaptopodin 2 98.1
DLG3 discs, large homolog 3 (Drosophila) 97.92
SH2D3C SH2 domain containing 3C 97.85
CUEDC2 CUE domain containing 2 97.83
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 97.7
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 97.59
HDAC6 histone deacetylase 6 97.59
THRB thyroid hormone receptor, beta 97.55
SHROOM1 shroom family member 1 97.53
ARHGAP30 Rho GTPase activating protein 30 97.5
NUMA1 nuclear mitotic apparatus protein 1 97.48
CMKLR1 chemerin chemokine-like receptor 1 97.37
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 97.37
PRKCE protein kinase C, epsilon 97.29
TFRC transferrin receptor 97.29
BAG4 BCL2-associated athanogene 4 97.22
MOK MOK protein kinase 97.16
BAG3 BCL2-associated athanogene 3 97.02
CKS1B CDC28 protein kinase regulatory subunit 1B 96.98
NKX3-1 NK3 homeobox 1 96.96
ALOX5 arachidonate 5-lipoxygenase 96.94
PPP1R18 protein phosphatase 1, regulatory subunit 18 96.81
TRPC6 transient receptor potential cation channel, subfamily C, member 6 96.74
NOLC1 nucleolar and coiled-body phosphoprotein 1 96.69
RTN4 reticulon 4 96.67
TBL3 transducin (beta)-like 3 96.67
CBARP CACN subunit beta associated regulatory protein 96.655
MRPS27 mitochondrial ribosomal protein S27 96.56
MALL mal, T-cell differentiation protein-like 96.54
TXNIP thioredoxin interacting protein 96.48
WBP2 WW domain binding protein 2 96.425
ZCCHC3 zinc finger, CCHC domain containing 3 96.39
IL7R interleukin 7 receptor 96.39
WDR62 WD repeat domain 62 96.35
GRAMD4 GRAM domain containing 4 96.17
JUNB jun B proto-oncogene 96.13
C8A complement component 8, alpha polypeptide 96.08
SIN3A SIN3 transcription regulator family member A 96.08
DLG2 discs, large homolog 2 (Drosophila) 96.04
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 96.02
SNX2 sorting nexin 2 96.0
DDIAS DNA damage-induced apoptosis suppressor 95.99
RANBP1 RAN binding protein 1 95.89
LURAP1L leucine rich adaptor protein 1-like 95.82
IRS4 insulin receptor substrate 4 95.79
CRYZ crystallin, zeta (quinone reductase) 95.71
STAT1 signal transducer and activator of transcription 1, 91kDa 95.67
UMPS uridine monophosphate synthetase 95.53
LATS2 large tumor suppressor kinase 2 95.49
MAP4 microtubule-associated protein 4 95.45
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 95.43
MYL11 myosin light chain 11 95.34
TRIM58 tripartite motif containing 58 95.34
FPR2 formyl peptide receptor 2 95.32
LAPTM4A lysosomal protein transmembrane 4 alpha 95.32
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 95.23
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 95.19
PPA2 pyrophosphatase (inorganic) 2 95.18
PTPN7 protein tyrosine phosphatase, non-receptor type 7 95.1
PRKCA protein kinase C, alpha 95.045
SCN1B sodium channel, voltage gated, type I beta subunit 95.03
ATG3 autophagy related 3 94.92