JAK3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Janus kinase 3|The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3718)
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Genes

314 genes differentially expressed following the JAK3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM212 transmembrane protein 212 3.05473
TRIM15 tripartite motif containing 15 3.05473
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 3.05473
EPPIN epididymal peptidase inhibitor 3.05473
UNC13C unc-13 homolog C (C. elegans) 3.05473
LRRC14B leucine rich repeat containing 14B 3.05473
ADTRP androgen-dependent TFPI-regulating protein 3.05473
SH2D6 SH2 domain containing 6 3.05473
PROB1 proline-rich basic protein 1 3.05473
WT1 Wilms tumor 1 3.05473
LRRC53 leucine rich repeat containing 53 3.05473
BTC betacellulin 3.05473
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.05473
CST11 cystatin 11 3.05473
ZNF285 zinc finger protein 285 3.05473
ZACN zinc activated ligand-gated ion channel 3.05473
LRRD1 leucine-rich repeats and death domain containing 1 3.05473
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.05473
CARD14 caspase recruitment domain family, member 14 3.05473
FGD2 FYVE, RhoGEF and PH domain containing 2 3.05473
USP26 ubiquitin specific peptidase 26 3.05473
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.05473
NPPC natriuretic peptide C 3.05473
FAM90A1 family with sequence similarity 90, member A1 3.05473
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.05473
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.05473
PRDM12 PR domain containing 12 3.05473
LGALS9 lectin, galactoside-binding, soluble, 9 3.05473
CPLX1 complexin 1 3.05473
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.05473
TMC3 transmembrane channel-like 3 3.05473
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.05473
MYL2 myosin, light chain 2, regulatory, cardiac, slow 3.05473
LOC105378220 macrophage receptor MARCO-like 3.05473
HES2 hes family bHLH transcription factor 2 3.05473
EPHB3 EPH receptor B3 3.05473
MPO myeloperoxidase 3.05473
VSX1 visual system homeobox 1 3.05473
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.05473
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.05473
ARSF arylsulfatase F 3.05473
RFPL3 ret finger protein-like 3 3.05473
CXCL2 chemokine (C-X-C motif) ligand 2 3.05473
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.05473
ADAT3 adenosine deaminase, tRNA-specific 3 3.05473
S100A1 S100 calcium binding protein A1 3.05473
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.05473
BHMT2 betaine--homocysteine S-methyltransferase 2 3.05473
PANO1 proapoptotic nucleolar protein 1 3.05473
GPR75 G protein-coupled receptor 75 3.05473
SPMAP1 sperm microtubule associated protein 1 3.05473
CBLIF cobalamin binding intrinsic factor 3.05473
GK3 glycerol kinase 3 3.05473
FAM237B family with sequence similarity 237 member B 3.05473
GON7 GON7 subunit of KEOPS complex 3.05473
PNMA8B PNMA family member 8B 3.05473
SQOR sulfide quinone oxidoreductase 3.05473
PHF24 PHD finger protein 24 3.05473
SEPTIN14 septin 14 3.05473
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.05473
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.05473
DNAAF8 dynein axonemal assembly factor 8 3.05473
AJM1 apical junction component 1 homolog 3.05473
SPMIP10 sperm microtubule inner protein 10 3.05473
TEKTL1 tektin like 1 3.05473
GNG14 G protein subunit gamma 14 3.05473
C1ORF232 chromosome 1 open reading frame 230 3.05473
ACP7 acid phosphatase 7, tartrate resistant (putative) 3.05473
SMIM31 small integral membrane protein 31 3.05473
LY6L lymphocyte antigen 6 family member L 3.05473
FNDC11 fibronectin type III domain containing 11 3.05473
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.05473
SPACDR sperm acrosome developmental regulator 3.05473
PNLIPRP3 pancreatic lipase-related protein 3 3.05473
FIMP1 fertilization-influencing membrane protein 1 3.05473
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.05473
MYH15 myosin, heavy chain 15 3.05473
TMEM235 transmembrane protein 235 3.05473
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.05473
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 3.05473
C3ORF80 chromosome 3 open reading frame 80 3.05473
CD48 CD48 molecule 3.05473
MTNR1B melatonin receptor 1B 3.05473
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.05473
ISM2 isthmin 2 3.05473
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.05473
LECT2 leukocyte cell-derived chemotaxin 2 3.05473
CCR3 chemokine (C-C motif) receptor 3 3.05473
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.05473
BLM Bloom syndrome, RecQ helicase-like 3.05473
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.05473
C15ORF62 chromosome 15 open reading frame 62 3.05473
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.05473
SOAT2 sterol O-acyltransferase 2 3.05473
LRRC73 leucine rich repeat containing 73 3.05473
VCX3A variable charge, X-linked 3A 3.05473
C7ORF57 chromosome 7 open reading frame 57 3.05473
UTS2 urotensin 2 3.05473
CFHR4 complement factor H-related 4 3.05473
STAB1 stabilin 1 3.05473
S100Z S100 calcium binding protein Z 3.05473
CYSLTR1 cysteinyl leukotriene receptor 1 3.05473
GLOD5 glyoxalase domain containing 5 3.05473
CDHR5 cadherin-related family member 5 3.05473
EMX2 empty spiracles homeobox 2 3.05473
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.05473
SPO11 SPO11 meiotic protein covalently bound to DSB 3.05473
CCDC27 coiled-coil domain containing 27 3.05473
TBXA2R thromboxane A2 receptor 3.05473
MAT2A methionine adenosyltransferase II, alpha 3.05473
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.05473
ZNF541 zinc finger protein 541 3.05473
FBXO39 F-box protein 39 3.05473
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.05473
CCDC154 coiled-coil domain containing 154 3.05473
GLYATL3 glycine-N-acyltransferase-like 3 3.05473
NIM1K NIM1 serine/threonine protein kinase 3.05473
CLIC3 chloride intracellular channel 3 3.05473
F10 coagulation factor X 3.05473
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.05473
OPRK1 opioid receptor, kappa 1 3.05473
C2CD4D C2 calcium-dependent domain containing 4D 3.05473
CCDC179 coiled-coil domain containing 179 3.05473
RRH retinal pigment epithelium-derived rhodopsin homolog 3.05473
CD27 CD27 molecule 3.05473
CDH22 cadherin 22, type 2 3.05473
ADAP1 ArfGAP with dual PH domains 1 3.05473
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 3.05473
CNGB1 cyclic nucleotide gated channel beta 1 3.05473
STRC stereocilin 3.05473
GOLGA8J golgin A8 family, member J 3.05473
CFP complement factor properdin 3.05473
ART1 ADP-ribosyltransferase 1 3.05473
IBSP integrin-binding sialoprotein 3.05473
CA5A carbonic anhydrase VA, mitochondrial 3.05473
CTSS cathepsin S 3.05473
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.05473
FBXO40 F-box protein 40 3.05473
SST somatostatin 3.05473
SPATA9 spermatogenesis associated 9 3.05473
TBX1 T-box 1 3.05473
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.05473
SMIM17 small integral membrane protein 17 3.05473
CLEC9A C-type lectin domain family 9, member A 3.05473
FCRLB Fc receptor-like B 3.05473
ITGAD integrin, alpha D 3.05473
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.05473
VTCN1 V-set domain containing T cell activation inhibitor 1 3.05473
APOL3 apolipoprotein L, 3 3.05473
IFNK interferon, kappa 3.05473
TMEM86B transmembrane protein 86B 3.05473
CHAT choline O-acetyltransferase 3.05473
IRX1 iroquois homeobox 1 3.05473
TUBAL3 tubulin, alpha-like 3 3.05473
PGM5 phosphoglucomutase 5 3.05473
BCL2L15 BCL2-like 15 3.05473
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.05473
CLNK cytokine-dependent hematopoietic cell linker 3.05473
STOML3 stomatin (EPB72)-like 3 3.05473
RBP4 retinol binding protein 4, plasma 3.05473
NPR3 natriuretic peptide receptor 3 3.05473
FAM81B family with sequence similarity 81, member B 3.05473
PCDHGA11 protocadherin gamma subfamily A, 11 3.05473
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.05473
TBC1D28 TBC1 domain family, member 28 3.05473
PRSS57 protease, serine, 57 3.05473
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.05473
PMP2 peripheral myelin protein 2 3.05473
BATF2 basic leucine zipper transcription factor, ATF-like 2 3.05473
HSF4 heat shock transcription factor 4 3.05473
KRT17 keratin 17, type I 3.05473
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 3.05473
DYTN dystrotelin 3.05473
SPRN shadow of prion protein homolog (zebrafish) 3.05473
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.05473
MAGEB17 melanoma antigen family B17 3.05473
DCDC1 doublecortin domain containing 1 3.02385
MYRIP myosin VIIA and Rab interacting protein 2.99237
LRRC56 leucine rich repeat containing 56 2.97396
CSNK2B casein kinase 2, beta polypeptide 2.94137
HSPA4L heat shock 70kDa protein 4-like 2.90014
TUBGCP5 tubulin, gamma complex associated protein 5 2.84777
OXNAD1 oxidoreductase NAD-binding domain containing 1 2.7987
SNX14 sorting nexin 14 2.75482
ZNF431 zinc finger protein 431 2.73567
CALN1 calneuron 1 2.72809
TMEM143 transmembrane protein 143 2.66632
MTUS2 microtubule associated tumor suppressor candidate 2 2.63041
WDR27 WD repeat domain 27 2.61674
CHD8 chromodomain helicase DNA binding protein 8 2.595
TCTA T-cell leukemia translocation altered 2.44351
ZBED8 zinc finger, BED-type containing 8 2.43213
KCNK17 potassium channel, two pore domain subfamily K, member 17 2.40671
C11ORF86 chromosome 11 open reading frame 86 2.3913
TMEM45B transmembrane protein 45B 2.3364
PLCD1 phospholipase C, delta 1 2.32545
ADCY2 adenylate cyclase 2 (brain) 2.32429
SENP1 SUMO1/sentrin specific peptidase 1 2.25112
INSM1 insulinoma-associated 1 2.25011
JRK Jrk homolog (mouse) 2.24747
RBMS2 RNA binding motif, single stranded interacting protein 2 2.24103
ZNF121 zinc finger protein 121 2.23756
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.20668
NOP14 NOP14 nucleolar protein 2.20668
CIPC CLOCK-interacting pacemaker 2.1377
CREB3L2 cAMP responsive element binding protein 3-like 2 2.10473
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.10473
GPR75-ASB3 GPR75-ASB3 readthrough 2.10303
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 2.09343
ZNF283 zinc finger protein 283 2.06685
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.06685
SSBP3 single stranded DNA binding protein 3 2.04418
CCDC33 coiled-coil domain containing 33 2.04418
MEN1 multiple endocrine neoplasia I 2.0256
MOB3A MOB kinase activator 3A 2.0256

decreased expression

Symbol Name Standardized Value
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -3.05473
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.05473
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -3.05473
CCL25 chemokine (C-C motif) ligand 25 -3.05473
LOX lysyl oxidase -3.05473
ACOX2 acyl-CoA oxidase 2, branched chain -3.05473
THPO thrombopoietin -3.05473
CIMAP2 ciliary microtubule associated protein 2 -3.05473
TNRC18 trinucleotide repeat containing 18 -3.05473
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -3.05473
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -3.05473
PGLYRP1 peptidoglycan recognition protein 1 -3.05473
LAMP5 lysosomal-associated membrane protein family, member 5 -3.05473
NPIPB8 nuclear pore complex interacting protein family, member B8 -3.05473
ANXA9 annexin A9 -3.05473
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -3.05473
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -3.05473
SLC49A3 solute carrier family 49 member 3 -3.05473
ZNF491 zinc finger protein 491 -3.05473
BCL2L10 BCL2-like 10 (apoptosis facilitator) -3.05473
TUBB1 tubulin, beta 1 class VI -3.05473
ANKRD42-DT ANKRD42 divergent transcript -3.05473
CCNI2 cyclin I family, member 2 -3.05473
RXFP2 relaxin/insulin-like family peptide receptor 2 -3.05473
SPATA31H1 SPATA31 subfamily H member 1 -3.05473
TMEM255A transmembrane protein 255A -3.05473
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.05473
BHLHA15 basic helix-loop-helix family, member a15 -3.05473
XCL1 chemokine (C motif) ligand 1 -3.05473
MEI1 meiosis inhibitor 1 -3.05473
ISL1 ISL LIM homeobox 1 -3.05473
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -3.05473
TUBB8 tubulin, beta 8 class VIII -3.05473
DUSP12 dual specificity phosphatase 12 -3.03337
VIL1 villin 1 -3.02385
MRPL48 mitochondrial ribosomal protein L48 -3.01338
DRC3 dynein regulatory complex subunit 3 -2.9371
MTF2 metal response element binding transcription factor 2 -2.86166
TSN translin -2.85065
GET1 guided entry of tail-anchored proteins factor 1 -2.75637
ANGPT4 angiopoietin 4 -2.69393
CCHCR1 coiled-coil alpha-helical rod protein 1 -2.6849
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.67622
KLHL21 kelch-like family member 21 -2.64768
TFDP1 transcription factor Dp-1 -2.63707
IFRD1 interferon-related developmental regulator 1 -2.56924
LYPLA1 lysophospholipase I -2.56775
CD164 CD164 molecule, sialomucin -2.5628
CENPW centromere protein W -2.54082
POU3F4 POU class 3 homeobox 4 -2.508
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.46209
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -2.44041
ANAPC4 anaphase promoting complex subunit 4 -2.42549
CHIC1 cysteine-rich hydrophobic domain 1 -2.42479
MT1G metallothionein 1G -2.40996
SUCLG1 succinate-CoA ligase, alpha subunit -2.39507
ACY1 aminoacylase 1 -2.3846
CRIPT cysteine-rich PDZ-binding protein -2.38192
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -2.34333
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.32545
SOX21 SRY (sex determining region Y)-box 21 -2.32545
TOR4A torsin family 4, member A -2.29891
ZCCHC10 zinc finger, CCHC domain containing 10 -2.29104
HDAC1 histone deacetylase 1 -2.24747
CCDC134 coiled-coil domain containing 134 -2.24397
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.24103
FOXH1 forkhead box H1 -2.20668
ZNF547 zinc finger protein 547 -2.19779
FAM133B family with sequence similarity 133, member B -2.1744
RND3 Rho family GTPase 3 -2.1744
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.15925
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.15589
AP3M1 adaptor-related protein complex 3, mu 1 subunit -2.15433
ZNF22 zinc finger protein 22 -2.1531
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -2.14651
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -2.1444
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 -2.14291
TRAF5 TNF receptor-associated factor 5 -2.13596
SGK1 serum/glucocorticoid regulated kinase 1 -2.13449
TCEAL5 transcription elongation factor A (SII)-like 5 -2.11859
ZNF69 zinc finger protein 69 -2.10593
GOLM1 golgi membrane protein 1 -2.10433
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) -2.09187
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.07098
ANKH ANKH inorganic pyrophosphate transport regulator -2.05738
RPL38 ribosomal protein L38 -2.05379
H3C7 H3 clustered histone 7 -2.04418
UXT ubiquitously-expressed, prefoldin-like chaperone -2.04295
ALPL alkaline phosphatase, liver/bone/kidney -2.04295
SMIM14 small integral membrane protein 14 -2.02326
SOX5 SRY (sex determining region Y)-box 5 -2.02283
NUP37 nucleoporin 37kDa -2.02052
RAB3IP RAB3A interacting protein -2.02024
FSTL1 follistatin-like 1 -2.01357
METTL6 methyltransferase like 6 -2.00951
RNFT1 ring finger protein, transmembrane 1 -2.00189
C1ORF167 chromosome 1 open reading frame 167 -2.00189
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.00189
KCTD16 potassium channel tetramerization domain containing 16 -2.00189