JAK3 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description Janus kinase 3|The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3718)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase JAK3 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.98
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.98
THADA thyroid adenoma associated 99.89
PM20D2 peptidase M20 domain containing 2 99.85
USP31 ubiquitin specific peptidase 31 99.72
TIGIT T cell immunoreceptor with Ig and ITIM domains 99.58
SH2D1B SH2 domain containing 1B 99.54
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.5
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 99.47
ARHGAP30 Rho GTPase activating protein 30 99.41
TRPC6 transient receptor potential cation channel, subfamily C, member 6 99.36
IRS4 insulin receptor substrate 4 99.345
DLG3 discs, large homolog 3 (Drosophila) 99.175
CBFB core-binding factor, beta subunit 99.15
SPP2 secreted phosphoprotein 2, 24kDa 98.99
KCTD12 potassium channel tetramerization domain containing 12 98.93
MAK male germ cell-associated kinase 98.91
TLK1 tousled-like kinase 1 98.86
LURAP1L leucine rich adaptor protein 1-like 98.84
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 98.73
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 98.67
PTPRA protein tyrosine phosphatase, receptor type, A 98.66
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 98.55
PDS5B PDS5 cohesin associated factor B 98.53
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 98.51
ATXN1 ataxin 1 98.49
MCC mutated in colorectal cancers 98.42
EIF1B eukaryotic translation initiation factor 1B 98.4
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 98.4
EIF1 eukaryotic translation initiation factor 1 98.4
CLDN1 claudin 1 98.34
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 98.31
MELK maternal embryonic leucine zipper kinase 98.27
DLG2 discs, large homolog 2 (Drosophila) 98.2
RCN2 reticulocalbin 2, EF-hand calcium binding domain 98.16
TGOLN2 trans-golgi network protein 2 98.12
HYAL2 hyaluronoglucosaminidase 2 98.07
ALOX5 arachidonate 5-lipoxygenase 98.01
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 97.94
PDCD5 programmed cell death 5 97.92
TLK2 tousled-like kinase 2 97.86
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 97.86
CEP43 centrosomal protein 43 97.85
MRPS27 mitochondrial ribosomal protein S27 97.68
WWC1 WW and C2 domain containing 1 97.66
CASQ2 calsequestrin 2 (cardiac muscle) 97.5
CHAF1B chromatin assembly factor 1, subunit B (p60) 97.46
PRDX1 peroxiredoxin 1 97.44
PTPN7 protein tyrosine phosphatase, non-receptor type 7 97.42
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 97.39
SHROOM1 shroom family member 1 97.33
N4BP3 NEDD4 binding protein 3 97.29
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 97.26
ERBB3 erb-b2 receptor tyrosine kinase 3 97.26
PRUNE2 prune homolog 2 (Drosophila) 97.2
FGFR2 fibroblast growth factor receptor 2 97.2
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 97.18
STK4 serine/threonine kinase 4 97.125
PDE8A phosphodiesterase 8A 97.05
SLC4A2 solute carrier family 4 (anion exchanger), member 2 97.0
DDIAS DNA damage-induced apoptosis suppressor 96.96
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 96.94
RPS29 ribosomal protein S29 96.94
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 96.85
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 96.83
PA2G4 proliferation-associated 2G4, 38kDa 96.8
CDKL5 cyclin-dependent kinase-like 5 96.7
SPRY4 sprouty homolog 4 (Drosophila) 96.61
PTPRE protein tyrosine phosphatase, receptor type, E 96.54
EML4 echinoderm microtubule associated protein like 4 96.48
MUC16 mucin 16, cell surface associated 96.41
MTDH metadherin 96.39
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 96.37
TRIOBP TRIO and F-actin binding protein 96.35
IL7R interleukin 7 receptor 96.19
MGST2 microsomal glutathione S-transferase 2 96.19
NDC80 NDC80 kinetochore complex component 96.17
CEP170B centrosomal protein 170B 96.15
NIPSNAP1 nipsnap homolog 1 (C. elegans) 96.095
TFIP11 tuftelin interacting protein 11 96.04
SLITRK6 SLIT and NTRK-like family, member 6 95.985
RUSC2 RUN and SH3 domain containing 2 95.95
SH2D3C SH2 domain containing 3C 95.86
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 95.82
LST1 leukocyte specific transcript 1 95.78
EPM2AIP1 EPM2A (laforin) interacting protein 1 95.77
SOCS6 suppressor of cytokine signaling 6 95.73
CEP68 centrosomal protein 68kDa 95.54
CNOT9 CCR4-NOT transcription complex subunit 9 95.53
SCN1B sodium channel, voltage gated, type I beta subunit 95.51
MAPK1 mitogen-activated protein kinase 1 95.45
MARVELD3 MARVEL domain containing 3 95.3
SRSF10 serine/arginine-rich splicing factor 10 95.275
TRIP11 thyroid hormone receptor interactor 11 95.23
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 95.16
TRPV2 transient receptor potential cation channel, subfamily V, member 2 95.1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 95.07
TRAF3IP2 TRAF3 interacting protein 2 95.03
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 94.86
TMC5 transmembrane channel-like 5 94.77