JAK3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description Janus kinase 3|The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3718)
External Link http://www.ncbi.nlm.nih.gov/gene/3718
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185 interacting proteins for JAK3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ADAP1 ArfGAP with dual PH domains 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARF6 ADP-ribosylation factor 6
ARHGAP9 Rho GTPase activating protein 9
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BTK Bruton agammaglobulinemia tyrosine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD81 CD81 molecule
CDK1 cyclin-dependent kinase 1
CDK13 cyclin-dependent kinase 13
CENPF centromere protein F, 350/400kDa
CISH cytokine inducible SH2-containing protein
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DGKZ diacylglycerol kinase, zeta
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
EIF4B eukaryotic translation initiation factor 4B
ELAVL1 ELAV like RNA binding protein 1
EPHA1 EPH receptor A1
EPHB3 EPH receptor B3
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FES FES proto-oncogene, tyrosine kinase
FN3K fructosamine 3 kinase
GAB1 GRB2-associated binding protein 1
GAK cyclin G associated kinase
GSN gelsolin
GTF2B general transcription factor IIB
HRAS Harvey rat sarcoma viral oncogene homolog
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1A interleukin 1, alpha
IL2 interleukin 2
IL20RA interleukin 20 receptor, alpha
IL21 interleukin 21
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9 interleukin 9
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INSL6 insulin-like 6
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT74 keratin 74, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LEPR leptin receptor
LMNB1 lamin B1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MARK1 MAP/microtubule affinity-regulating kinase 1
MEP1B meprin A, beta
MTIF2 mitochondrial translational initiation factor 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYLK myosin light chain kinase
NCKAP1 NCK-associated protein 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM5 PDZ and LIM domain 5
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKM pyruvate kinase, muscle
PLCB2 phospholipase C, beta 2
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PRMT5 protein arginine methyltransferase 5
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRK protein tyrosine phosphatase, receptor type, K
RAB35 RAB35, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD17 RAD17 homolog (S. pombe)
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
SGK1 serum/glucocorticoid regulated kinase 1
SGMS1 sphingomyelin synthase 1
SH2B2 SH2B adaptor protein 2
SH3GL3 SH3-domain GRB2-like 3
SHB Src homology 2 domain containing adaptor protein B
SIGLEC10 sialic acid binding Ig-like lectin 10
SMC6 structural maintenance of chromosomes 6
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOCS5 suppressor of cytokine signaling 5
SOS1 son of sevenless homolog 1 (Drosophila)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TIAF1 TGFB1-induced anti-apoptotic factor 1
TYK2 tyrosine kinase 2
UBASH3A ubiquitin associated and SH3 domain containing A
UBC ubiquitin C
UGCG UDP-glucose ceramide glucosyltransferase
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
VAV2 vav 2 guanine nucleotide exchange factor
VIL1 villin 1
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2