| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/46911863 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in JNJ-38877605 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GREB1 | growth regulation by estrogen in breast cancer 1 | 2.01 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1.19 |
| HINFP | histone H4 transcription factor | 1.1 |
| CFAP57 | cilia and flagella associated protein 57 | 1.03 |
| TBX3 | T-box 3 | 0.78 |
| METTL22 | methyltransferase like 22 | 0.78 |
| FGB | fibrinogen beta chain | 0.74 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | 0.71 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | 0.69 |
| PSEN2 | presenilin 2 | 0.67 |
| SLC16A6 | solute carrier family 16, member 6 | 0.63 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.62 |
| HAS3 | hyaluronan synthase 3 | 0.61 |
| GATA2 | GATA binding protein 2 | 0.58 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.56 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.51 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.5 |
| COMMD8 | COMM domain containing 8 | 0.49 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.48 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.48 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.47 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 0.46 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.46 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.46 |
| LYRM1 | LYR motif containing 1 | 0.46 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.44 |
| MT2A | metallothionein 2A | 0.43 |
| ATG13 | autophagy related 13 | 0.42 |
| MAGEA6 | melanoma antigen family A6 | 0.42 |
| ZNF91 | zinc finger protein 91 | 0.42 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.42 |
| ZNF302 | zinc finger protein 302 | 0.41 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.41 |
| CDON | cell adhesion associated, oncogene regulated | 0.41 |
| RPS21 | ribosomal protein S21 | 0.4 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.4 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.4 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.39 |
| RPS26 | ribosomal protein S26 | 0.39 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.39 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.39 |
| ZNF548 | zinc finger protein 548 | 0.39 |
| DST | dystonin | 0.38 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.38 |
| FAM20C | family with sequence similarity 20, member C | 0.37 |
| CD274 | CD274 molecule | 0.36 |
| MAGEE1 | melanoma antigen family E1 | 0.36 |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 0.36 |
| KLHL22 | kelch-like family member 22 | 0.36 |
| YBX3 | Y box binding protein 3 | 0.36 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | 0.36 |
| XBP1 | X-box binding protein 1 | 0.36 |
| MIDN | midnolin | 0.35 |
| RPL36AL | ribosomal protein L36a-like | 0.35 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.35 |
| CCNF | cyclin F | 0.35 |
| CCDC14 | coiled-coil domain containing 14 | 0.35 |
| NABP2 | nucleic acid binding protein 2 | 0.35 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.34 |
| CLK1 | CDC-like kinase 1 | 0.34 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | 0.34 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.33 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.33 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.33 |
| PROSER2 | proline and serine rich 2 | 0.32 |
| ZNF616 | zinc finger protein 616 | 0.32 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.32 |
| ZNF174 | zinc finger protein 174 | 0.32 |
| RPL32 | ribosomal protein L32 | 0.32 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | 0.32 |
| STX1A | syntaxin 1A (brain) | 0.32 |
| SOX7 | SRY (sex determining region Y)-box 7 | 0.31 |
| ZNF503 | zinc finger protein 503 | 0.31 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | 0.31 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.31 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.31 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.31 |
| DONSON | downstream neighbor of SON | 0.31 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.31 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.31 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.31 |
| B2M | beta-2-microglobulin | 0.31 |
| HLA-E | major histocompatibility complex, class I, E | 0.31 |
| CHMP3 | charged multivesicular body protein 3 | 0.31 |
| ZNF551 | zinc finger protein 551 | 0.31 |
| MIF4GD | MIF4G domain containing | 0.31 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.31 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.3 |
| ELOC | elongin C | 0.3 |
| KSR2 | kinase suppressor of ras 2 | 0.3 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 0.3 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | 0.3 |
| STOML1 | stomatin (EPB72)-like 1 | 0.3 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.3 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.3 |
| DENND4B | DENN/MADD domain containing 4B | 0.3 |
| ZNF268 | zinc finger protein 268 | 0.3 |
| ZFP37 | ZFP37 zinc finger protein | 0.3 |
| TLR9 | toll-like receptor 9 | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -2.39 |
| ANKRD24 | ankyrin repeat domain 24 | -1.61 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -1.08 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.76 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.71 |
| ITGB8 | integrin, beta 8 | -0.66 |
| MSMO1 | methylsterol monooxygenase 1 | -0.64 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.61 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.61 |
| SBSN | suprabasin | -0.61 |
| CLDN3 | claudin 3 | -0.6 |
| C14ORF93 | chromosome 14 open reading frame 93 | -0.59 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.58 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.57 |
| RNF115 | ring finger protein 115 | -0.56 |
| NOTCH3 | notch 3 | -0.55 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -0.54 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.54 |
| S100A6 | S100 calcium binding protein A6 | -0.54 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.54 |
| MEST | mesoderm specific transcript | -0.53 |
| DNAJC14 | DnaJ (Hsp40) homolog, subfamily C, member 14 | -0.51 |
| RPLP1 | ribosomal protein, large, P1 | -0.51 |
| GPC4 | glypican 4 | -0.51 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.5 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.49 |
| DUSP6 | dual specificity phosphatase 6 | -0.48 |
| CCDC57 | coiled-coil domain containing 57 | -0.48 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.48 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.48 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.48 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.47 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.46 |
| IRF9 | interferon regulatory factor 9 | -0.46 |
| RPLP2 | ribosomal protein, large, P2 | -0.44 |
| BID | BH3 interacting domain death agonist | -0.44 |
| TRAK1 | trafficking protein, kinesin binding 1 | -0.44 |
| SLC38A2 | solute carrier family 38, member 2 | -0.43 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) | -0.42 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.42 |
| IFRD1 | interferon-related developmental regulator 1 | -0.42 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.42 |
| ACTBL2 | actin, beta-like 2 | -0.42 |
| DES | desmin | -0.42 |
| TP53 | tumor protein p53 | -0.42 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.4 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.4 |
| CLTB | clathrin, light chain B | -0.4 |
| RNF4 | ring finger protein 4 | -0.4 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.4 |
| TMEM173 | transmembrane protein 173 | -0.4 |
| GLRX5 | glutaredoxin 5 | -0.4 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.4 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.39 |
| H4C1 | H4 clustered histone 1 | -0.39 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.39 |
| DOCK11 | dedicator of cytokinesis 11 | -0.39 |
| CCDC158 | coiled-coil domain containing 158 | -0.38 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.38 |
| SMO | smoothened, frizzled class receptor | -0.38 |
| APOE | apolipoprotein E | -0.38 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | -0.38 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.38 |
| EMP3 | epithelial membrane protein 3 | -0.36 |
| TIPE1 | TNF alpha induced protein 8 like 1 | -0.36 |
| ARFGEF3 | ARFGEF family member 3 | -0.36 |
| PRSS23 | protease, serine, 23 | -0.36 |
| CSNK2B | casein kinase 2, beta polypeptide | -0.35 |
| DPYD | dihydropyrimidine dehydrogenase | -0.35 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.35 |
| CLTA | clathrin, light chain A | -0.35 |
| FBXO17 | F-box protein 17 | -0.35 |
| CCDC102A | coiled-coil domain containing 102A | -0.35 |
| RPL34 | ribosomal protein L34 | -0.35 |
| LIME1 | Lck interacting transmembrane adaptor 1 | -0.34 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.34 |
| LPIN1 | lipin 1 | -0.34 |
| DUSP5 | dual specificity phosphatase 5 | -0.34 |
| AHR | aryl hydrocarbon receptor | -0.34 |
| ZNF652 | zinc finger protein 652 | -0.33 |
| SQLE | squalene epoxidase | -0.33 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.33 |
| MTFR1L | mitochondrial fission regulator 1-like | -0.33 |
| MIEN1 | migration and invasion enhancer 1 | -0.32 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.32 |
| MXRA7 | matrix-remodelling associated 7 | -0.32 |
| KLHL5 | kelch-like family member 5 | -0.31 |
| SLC35F3 | solute carrier family 35, member F3 | -0.31 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.31 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.31 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -0.31 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -0.31 |
| RHOQ | ras homolog family member Q | -0.31 |
| PARD6A | par-6 family cell polarity regulator alpha | -0.31 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.31 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | -0.31 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.3 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.3 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.3 |
