JNK cascade Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. (Gene Ontology, GO_0007254)
External Link http://amigo.geneontology.org/amigo/term/GO:0007254
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Genes

35 genes participating in the JNK cascade biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DAXX death-domain associated protein
DUSP9 dual specificity phosphatase 9
FGF12 fibroblast growth factor 12
FGF14 fibroblast growth factor 14
GPS1 G protein pathway suppressor 1
GPS2 G protein pathway suppressor 2
LRRK2 leucine-rich repeat kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP3K15 mitogen-activated protein kinase kinase kinase 15
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK9 mitogen-activated protein kinase 9
MINK1 misshapen-like kinase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RIPK2 receptor-interacting serine-threonine kinase 2
SH2D3A SH2 domain containing 3A
SH2D3C SH2 domain containing 3C
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TRIB1 tribbles pseudokinase 1