JNK_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/JNK_DN.V1_UP
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Genes

379 genes differentially expressed following the JNK_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACADL acyl-CoA dehydrogenase, long chain
ACKR3 atypical chemokine receptor 3
ADAM12 ADAM metallopeptidase domain 12
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
AGRP agouti related neuropeptide
AGTPBP1 ATP/GTP binding protein 1
AGXT alanine-glyoxylate aminotransferase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALOX12B arachidonate 12-lipoxygenase, 12R type
ANXA13 annexin A13
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARL4A ADP-ribosylation factor-like 4A
ARMC8 armadillo repeat containing 8
ARSF arylsulfatase F
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
BAG2 BCL2-associated athanogene 2
BEAN1 brain expressed, associated with NEDD4, 1
BIRC3 baculoviral IAP repeat containing 3
BMP7 bone morphogenetic protein 7
BMX BMX non-receptor tyrosine kinase
C1S complement component 1, s subcomponent
C8G complement component 8, gamma polypeptide
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CBX4 chromobox homolog 4
CCL1 chemokine (C-C motif) ligand 1
CCL15 chemokine (C-C motif) ligand 15
CCL22 chemokine (C-C motif) ligand 22
CCL4 chemokine (C-C motif) ligand 4
CD37 CD37 molecule
CD83 CD83 molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CGA glycoprotein hormones, alpha polypeptide
CLCN4 chloride channel, voltage-sensitive 4
CLDN18 claudin 18
CLIP3 CAP-GLY domain containing linker protein 3
CRMP1 collapsin response mediator protein 1
CTSZ cathepsin Z
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DGKQ diacylglycerol kinase, theta 110kDa
DIAPH2-AS1 DIAPH2 antisense RNA 1
DRD1 dopamine receptor D1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFHD1 EF-hand domain family, member D1
ELN elastin
EPHA3 EPH receptor A3
EPHA4 EPH receptor A4
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERVK-6 endogenous retrovirus group K, member 6
EYA2 EYA transcriptional coactivator and phosphatase 2
F11 coagulation factor XI
FAM161A family with sequence similarity 161, member A
FAM65B family with sequence similarity 65, member B
FOXA2 forkhead box A2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GCH1 GTP cyclohydrolase 1
GHRH growth hormone releasing hormone
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR31 G protein-coupled receptor 31
GPR37L1 G protein-coupled receptor 37 like 1
GPR45 G protein-coupled receptor 45
GPX7 glutathione peroxidase 7
HIST1H1E histone cluster 1, H1e
HIST1H2AK histone cluster 1, H2ak
HIST1H2AM histone cluster 1, H2am
HIST1H2BN histone cluster 1, H2bn
HNF1B HNF1 homeobox B
HOXA2 homeobox A2
HOXA4 homeobox A4
HOXC4 homeobox C4
HR hair growth associated
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSPA12A heat shock 70kDa protein 12A
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IFNA2 interferon, alpha 2
IGFBP3 insulin-like growth factor binding protein 3
IGLV6-57 immunoglobulin lambda variable 6-57
IL10RA interleukin 10 receptor, alpha
IL12RB1 interleukin 12 receptor, beta 1
IL13RA2 interleukin 13 receptor, alpha 2
INPP5J inositol polyphosphate-5-phosphatase J
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0368 KIAA0368
KIAA1211L KIAA1211-like
KLK7 kallikrein-related peptidase 7
KRT34 keratin 34, type I
KRT37 keratin 37, type I
KRT9 keratin 9, type I
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP7 microtubule-associated protein 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED13 mediator complex subunit 13
MICU2 mitochondrial calcium uptake 2
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MPL MPL proto-oncogene, thrombopoietin receptor
MRAS muscle RAS oncogene homolog
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MVD mevalonate (diphospho) decarboxylase
MYOM1 myomesin 1
N4BP2L2 NEDD4 binding protein 2-like 2
NID2 nidogen 2 (osteonidogen)
NLE1 notchless homolog 1 (Drosophila)
NOX1 NADPH oxidase 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR2J2 olfactory receptor, family 2, subfamily J, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PLAA phospholipase A2-activating protein
PMCH pro-melanin-concentrating hormone
PMEL premelanosome protein
PNOC prepronociceptin
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP1R8 protein phosphatase 1, regulatory subunit 8
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRR3 proline rich 3
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB35 RAB35, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RRAD Ras-related associated with diabetes
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
S1PR1 sphingosine-1-phosphate receptor 1
SCN2B sodium channel, voltage gated, type II beta subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SKAP1 src kinase associated phosphoprotein 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC26A10 solute carrier family 26, member 10
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNAI2 snail family zinc finger 2
SPICE1 spindle and centriole associated protein 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STC2 stanniocalcin 2
SYNE1 spectrin repeat containing, nuclear envelope 1
SZRD1 SUZ RNA binding domain containing 1
TACR1 tachykinin receptor 1
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TEK TEK tyrosine kinase, endothelial
TET3 tet methylcytosine dioxygenase 3
TFEC transcription factor EC
TGM1 transglutaminase 1
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNC1 troponin C type 1 (slow)
TNNT2 troponin T type 2 (cardiac)
TRIM24 tripartite motif containing 24
TRIM31 tripartite motif containing 31
TSN translin
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UNG uracil-DNA glycosylase
YAP1 Yes-associated protein 1
ZFHX2 zinc finger homeobox 2
ZNF204P zinc finger protein 204, pseudogene
ZNF280B zinc finger protein 280B
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABHD2 abhydrolase domain containing 2
ACVRL1 activin A receptor type II-like 1
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
AGO2 argonaute RISC catalytic component 2
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APLP1 amyloid beta (A4) precursor-like protein 1
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
AR androgen receptor
ARHGAP4 Rho GTPase activating protein 4
ARR3 arrestin 3, retinal (X-arrestin)
ASGR1 asialoglycoprotein receptor 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL9 B-cell CLL/lymphoma 9
BLM Bloom syndrome, RecQ helicase-like
BTK Bruton agammaglobulinemia tyrosine kinase
C10ORF10 chromosome 10 open reading frame 10
CA5BP1 carbonic anhydrase VB pseudogene 1
CABP1 calcium binding protein 1
CAPN11 calpain 11
CCL11 chemokine (C-C motif) ligand 11
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDC45 cell division cycle 45
CDKN3 cyclin-dependent kinase inhibitor 3
CHD1L chromodomain helicase DNA binding protein 1-like
COL13A1 collagen, type XIII, alpha 1
CRX cone-rod homeobox
CRYBA1 crystallin, beta A1
CRYM crystallin, mu
CTRC chymotrypsin C (caldecrin)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DEFA3 defensin, alpha 3, neutrophil-specific
DENND5A DENN/MADD domain containing 5A
DSCR4 Down syndrome critical region 4
DUSP4 dual specificity phosphatase 4
DUSP8 dual specificity phosphatase 8
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA5 ephrin-A5
EPHB1 EPH receptor B1
ERVW-1 endogenous retrovirus group W, member 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP6 fatty acid binding protein 6, ileal
FAM110B family with sequence similarity 110, member B
FAM131B family with sequence similarity 131, member B
FAM182B family with sequence similarity 182, member B
FASLG Fas ligand (TNF superfamily, member 6)
FBP2 fructose-1,6-bisphosphatase 2
FER fer (fps/fes related) tyrosine kinase
FLRT1 fibronectin leucine rich transmembrane protein 1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GCGR glucagon receptor
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GGCX gamma-glutamyl carboxylase
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA4 gap junction protein, alpha 4, 37kDa
GPR12 G protein-coupled receptor 12
GPR171 G protein-coupled receptor 171
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
HMGB3P30 high mobility group box 3 pseudogene 30
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IDUA iduronidase, alpha-L-
IL2RB interleukin 2 receptor, beta
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF8 interferon regulatory factor 8
IRGC immunity-related GTPase family, cinema
ITGA10 integrin, alpha 10
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JPH3 junctophilin 3
KAT5 K(lysine) acetyltransferase 5
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2
KIF22 kinesin family member 22
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KLHL35 kelch-like family member 35
KMT2A lysine (K)-specific methyltransferase 2A
KNTC1 kinetochore associated 1
KPNA3 karyopherin alpha 3 (importin alpha 4)
KRT75 keratin 75, type II
LINC00342 long intergenic non-protein coding RNA 342
LINC00588 long intergenic non-protein coding RNA 588
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY86 lymphocyte antigen 86
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAP1B microtubule-associated protein 1B
MAT1A methionine adenosyltransferase I, alpha
MBNL2 muscleblind-like splicing regulator 2
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MFSD7 major facilitator superfamily domain containing 7
MIA melanoma inhibitory activity
MMP2 matrix metallopeptidase 2
MYL9 myosin, light chain 9, regulatory
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NDRG2 NDRG family member 2
NELL2 NEL-like 2 (chicken)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMB neuromedin B
NOVA1 neuro-oncological ventral antigen 1
NPR1 natriuretic peptide receptor 1
NPY1R neuropeptide Y receptor Y1
NR2E1 nuclear receptor subfamily 2, group E, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRP2 neuropilin 2
OPRK1 opioid receptor, kappa 1
OR7A5 olfactory receptor, family 7, subfamily A, member 5
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
PACRG PARK2 co-regulated
PAQR4 progestin and adipoQ receptor family member IV
PCDH9 protocadherin 9
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDGFB platelet-derived growth factor beta polypeptide
PFAS phosphoribosylformylglycinamidine synthase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP prolactin-induced protein
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCD1 phospholipase C, delta 1
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB40A RAB40A, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RARA retinoic acid receptor, alpha
RCAN2 regulator of calcineurin 2
RGS14 regulator of G-protein signaling 14
RGS16 regulator of G-protein signaling 16
RIMS1 regulating synaptic membrane exocytosis 1
RND1 Rho family GTPase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SHB Src homology 2 domain containing adaptor protein B
SIPA1 signal-induced proliferation-associated 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SMAD9 SMAD family member 9
SMAP1 small ArfGAP 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMYD2 SET and MYND domain containing 2
SOGA1 suppressor of glucose, autophagy associated 1
SOX10 SRY (sex determining region Y)-box 10
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX3 synovial sarcoma, X breakpoint 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK35 serine/threonine kinase 35
STON1 stonin 1
SV2B synaptic vesicle glycoprotein 2B
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYT17 synaptotagmin XVII
TBKBP1 TBK1 binding protein 1
THY1 Thy-1 cell surface antigen
TM4SF4 transmembrane 4 L six family member 4
TNIK TRAF2 and NCK interacting kinase
TNS2 tensin 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM10 tripartite motif containing 10
TRO trophinin
TSPAN2 tetraspanin 2
TTLL3 tubulin tyrosine ligase-like family member 3
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
TULP1 tubby like protein 1
TYMP thymidine phosphorylase
UBE2C ubiquitin-conjugating enzyme E2C
UBL4A ubiquitin-like 4A
VASP vasodilator-stimulated phosphoprotein
VEGFC vascular endothelial growth factor C
WIPF1 WAS/WASL interacting protein family, member 1
XIST X inactive specific transcript (non-protein coding)
YPEL1 yippee-like 1 (Drosophila)
ZC2HC1A zinc finger, C2HC-type containing 1A
ZCCHC14 zinc finger, CCHC domain containing 14
ZIC2 Zic family member 2
ZNF549 zinc finger protein 549
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1