| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/57330099 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in JW 480 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SYN2 | synapsin II | 1.35 |
| NF1 | neurofibromin 1 | 1.17 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.06 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 0.95 |
| MED22 | mediator complex subunit 22 | 0.82 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.73 |
| ZNF175 | zinc finger protein 175 | 0.61 |
| COL6A2 | collagen, type VI, alpha 2 | 0.53 |
| FAM110C | family with sequence similarity 110, member C | 0.51 |
| MSLN | mesothelin | 0.51 |
| TEP1 | telomerase-associated protein 1 | 0.51 |
| ANKRD36C | ankyrin repeat domain 36C | 0.5 |
| GAS2L1 | growth arrest-specific 2 like 1 | 0.48 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.47 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.47 |
| IL6ST | interleukin 6 signal transducer | 0.46 |
| HMBOX1 | homeobox containing 1 | 0.45 |
| IGF1R | insulin-like growth factor 1 receptor | 0.45 |
| AARS | alanyl-tRNA synthetase | 0.44 |
| PLIN2 | perilipin 2 | 0.42 |
| GPN3 | GPN-loop GTPase 3 | 0.42 |
| ZNF3 | zinc finger protein 3 | 0.41 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.41 |
| IER2 | immediate early response 2 | 0.41 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 0.4 |
| CNTLN | centlein, centrosomal protein | 0.4 |
| TMCO6 | transmembrane and coiled-coil domains 6 | 0.39 |
| FBXO41 | F-box protein 41 | 0.38 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | 0.38 |
| TRNP1 | TMF1-regulated nuclear protein 1 | 0.37 |
| TREX1 | three prime repair exonuclease 1 | 0.36 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.36 |
| AMACR | alpha-methylacyl-CoA racemase | 0.36 |
| TOR2A | torsin family 2, member A | 0.36 |
| RFXAP | regulatory factor X-associated protein | 0.36 |
| OSBPL2 | oxysterol binding protein-like 2 | 0.35 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.35 |
| KLHL2 | kelch-like family member 2 | 0.35 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.35 |
| TCTEX1D2 | Tctex1 domain containing 2 | 0.34 |
| SGMS1 | sphingomyelin synthase 1 | 0.34 |
| NOTCH3 | notch 3 | 0.34 |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.33 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.33 |
| OTC | ornithine carbamoyltransferase | 0.33 |
| AP5B1 | adaptor-related protein complex 5, beta 1 subunit | 0.32 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.32 |
| GSTO2 | glutathione S-transferase omega 2 | 0.32 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | 0.32 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.32 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.31 |
| DENND3 | DENN/MADD domain containing 3 | 0.31 |
| CEP290 | centrosomal protein 290kDa | 0.31 |
| HINFP | histone H4 transcription factor | 0.31 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.31 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | 0.31 |
| ABHD5 | abhydrolase domain containing 5 | 0.3 |
| CRY2 | cryptochrome circadian clock 2 | 0.3 |
| ZNF746 | zinc finger protein 746 | 0.3 |
| FEM1A | fem-1 homolog a (C. elegans) | 0.3 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.3 |
| IER3IP1 | immediate early response 3 interacting protein 1 | 0.29 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.29 |
| STARD5 | StAR-related lipid transfer (START) domain containing 5 | 0.29 |
| MID2 | midline 2 | 0.29 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.29 |
| RCOR2 | REST corepressor 2 | 0.28 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.28 |
| ZNF174 | zinc finger protein 174 | 0.28 |
| TMEM219 | transmembrane protein 219 | 0.28 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | 0.28 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.28 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | 0.28 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | 0.27 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.27 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.27 |
| MRPS24 | mitochondrial ribosomal protein S24 | 0.27 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.27 |
| IL17RA | interleukin 17 receptor A | 0.27 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.27 |
| XPA | xeroderma pigmentosum, complementation group A | 0.27 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.26 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | 0.26 |
| PUDP | pseudouridine 5'-phosphatase | 0.26 |
| SPRTN | SprT-like N-terminal domain | 0.26 |
| UBL3 | ubiquitin-like 3 | 0.26 |
| ZNF394 | zinc finger protein 394 | 0.26 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | 0.26 |
| MIF4GD | MIF4G domain containing | 0.26 |
| PRRX2 | paired related homeobox 2 | 0.26 |
| ABHD3 | abhydrolase domain containing 3 | 0.26 |
| RWDD3 | RWD domain containing 3 | 0.26 |
| APOE | apolipoprotein E | 0.26 |
| SUCO | SUN domain containing ossification factor | 0.26 |
| C5ORF34 | chromosome 5 open reading frame 34 | 0.25 |
| FAM126A | family with sequence similarity 126, member A | 0.25 |
| FANCM | Fanconi anemia, complementation group M | 0.25 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 0.25 |
| CBR3 | carbonyl reductase 3 | 0.25 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | -1.31 |
| ANKRD22 | ankyrin repeat domain 22 | -0.99 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.95 |
| RGS19 | regulator of G-protein signaling 19 | -0.79 |
| ABHD17A | abhydrolase domain containing 17A | -0.74 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.73 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | -0.67 |
| INO80D | INO80 complex subunit D | -0.61 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.56 |
| KLHDC2 | kelch domain containing 2 | -0.55 |
| HLA-E | major histocompatibility complex, class I, E | -0.53 |
| FAM171B | family with sequence similarity 171, member B | -0.53 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.52 |
| MAX | MYC associated factor X | -0.52 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.5 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.49 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.48 |
| DIPK1B | divergent protein kinase domain 1B | -0.48 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.47 |
| MANEAL | mannosidase, endo-alpha-like | -0.46 |
| B9D1 | B9 protein domain 1 | -0.46 |
| OGG1 | 8-oxoguanine DNA glycosylase | -0.46 |
| NUDT7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | -0.45 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.45 |
| MT1F | metallothionein 1F | -0.45 |
| USP31 | ubiquitin specific peptidase 31 | -0.44 |
| TRIM8 | tripartite motif containing 8 | -0.44 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.44 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.44 |
| CCDC57 | coiled-coil domain containing 57 | -0.44 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | -0.43 |
| DENND4B | DENN/MADD domain containing 4B | -0.43 |
| LRFN4 | leucine rich repeat and fibronectin type III domain containing 4 | -0.43 |
| RCAN1 | regulator of calcineurin 1 | -0.43 |
| RGN | regucalcin | -0.43 |
| PUM2 | pumilio RNA-binding family member 2 | -0.42 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | -0.41 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.41 |
| USP19 | ubiquitin specific peptidase 19 | -0.41 |
| ZNF460 | zinc finger protein 460 | -0.4 |
| SNX24 | sorting nexin 24 | -0.4 |
| TMEM39A | transmembrane protein 39A | -0.39 |
| TDRKH | tudor and KH domain containing | -0.39 |
| GOLGA7 | golgin A7 | -0.39 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | -0.39 |
| MIPOL1 | mirror-image polydactyly 1 | -0.38 |
| SPHK2 | sphingosine kinase 2 | -0.38 |
| M1AP | meiosis 1 associated protein | -0.37 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.36 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.36 |
| TMEM94 | transmembrane protein 94 | -0.35 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -0.35 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.35 |
| LAP3 | leucine aminopeptidase 3 | -0.35 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.35 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.35 |
| CALU | calumenin | -0.34 |
| MCOLN1 | mucolipin 1 | -0.34 |
| CCDC115 | coiled-coil domain containing 115 | -0.34 |
| TULP3 | tubby like protein 3 | -0.34 |
| PTOV1 | prostate tumor overexpressed 1 | -0.34 |
| TMEM104 | transmembrane protein 104 | -0.34 |
| MYADM | myeloid-associated differentiation marker | -0.34 |
| ZNF664 | zinc finger protein 664 | -0.33 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.33 |
| NKAP | NFKB activating protein | -0.33 |
| C12ORF60 | chromosome 12 open reading frame 60 | -0.32 |
| UBL4A | ubiquitin-like 4A | -0.32 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | -0.32 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | -0.31 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -0.31 |
| TNNC2 | troponin C type 2 (fast) | -0.31 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | -0.31 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.31 |
| ANKRD12 | ankyrin repeat domain 12 | -0.3 |
| TPM1 | tropomyosin 1 (alpha) | -0.3 |
| PARD6B | par-6 family cell polarity regulator beta | -0.3 |
| B2M | beta-2-microglobulin | -0.3 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.3 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.3 |
| ABHD13 | abhydrolase domain containing 13 | -0.29 |
| ENO1 | enolase 1, (alpha) | -0.29 |
| ZFP1 | ZFP1 zinc finger protein | -0.29 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.29 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.29 |
| KIAA1191 | KIAA1191 | -0.28 |
| CEP68 | centrosomal protein 68kDa | -0.28 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.28 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | -0.28 |
| FOSL1 | FOS-like antigen 1 | -0.28 |
| MCL1 | myeloid cell leukemia 1 | -0.28 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.27 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | -0.27 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.27 |
| CCDC34 | coiled-coil domain containing 34 | -0.27 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.27 |
| MT1E | metallothionein 1E | -0.27 |
| ISY1 | ISY1 splicing factor homolog (S. cerevisiae) | -0.27 |
| NTN1 | netrin 1 | -0.27 |
