| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25021165 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in JZL 184 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 2.48 |
| RAB26 | RAB26, member RAS oncogene family | 0.79 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.75 |
| ZNF33A | zinc finger protein 33A | 0.74 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | 0.63 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.6 |
| ZNF576 | zinc finger protein 576 | 0.59 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.59 |
| STYX | serine/threonine/tyrosine interacting protein | 0.57 |
| ZG16B | zymogen granule protein 16B | 0.49 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.48 |
| RBM48 | RNA binding motif protein 48 | 0.44 |
| ULK1 | unc-51 like autophagy activating kinase 1 | 0.42 |
| C11ORF98 | chromosome 11 open reading frame 98 | 0.42 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.4 |
| ABHD2 | abhydrolase domain containing 2 | 0.39 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.39 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.39 |
| SPPL3 | signal peptide peptidase like 3 | 0.38 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.38 |
| DDN | dendrin | 0.36 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.36 |
| ERMARD | ER membrane-associated RNA degradation | 0.36 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.35 |
| RUBCN | rubicon autophagy regulator | 0.33 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.32 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.32 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.32 |
| C15ORF41 | chromosome 15 open reading frame 41 | 0.31 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.31 |
| CNTRL | centriolin | 0.31 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.3 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | 0.3 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.3 |
| DTWD2 | DTW domain containing 2 | 0.3 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.3 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.3 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.29 |
| SH2B2 | SH2B adaptor protein 2 | 0.29 |
| PRMT2IP | PRMT2 interacting protein | 0.29 |
| CCDC66 | coiled-coil domain containing 66 | 0.29 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.28 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.28 |
| TMEM242 | transmembrane protein 242 | 0.28 |
| ECM1 | extracellular matrix protein 1 | 0.28 |
| NAGA | N-acetylgalactosaminidase, alpha- | 0.28 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 0.27 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | 0.27 |
| CCSER2 | coiled-coil serine-rich protein 2 | 0.27 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.26 |
| ISL2 | ISL LIM homeobox 2 | 0.26 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | 0.26 |
| KLHL17 | kelch-like family member 17 | 0.26 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.26 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.26 |
| SGMS2 | sphingomyelin synthase 2 | 0.26 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.25 |
| TMEM231 | transmembrane protein 231 | 0.25 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.25 |
| ZNF136 | zinc finger protein 136 | 0.25 |
| NHP2 | NHP2 ribonucleoprotein | 0.25 |
| HYLS1 | hydrolethalus syndrome 1 | 0.25 |
| ZNF100 | zinc finger protein 100 | 0.25 |
| PROS1 | protein S (alpha) | 0.25 |
| MRAS | muscle RAS oncogene homolog | 0.24 |
| DIPK1A | divergent protein kinase domain 1A | 0.24 |
| TTC30B | tetratricopeptide repeat domain 30B | 0.24 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.24 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.24 |
| KMT5B | lysine methyltransferase 5B | 0.24 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.24 |
| ZNF169 | zinc finger protein 169 | 0.24 |
| ZNF624 | zinc finger protein 624 | 0.23 |
| ZNF197 | zinc finger protein 197 | 0.23 |
| EAF2 | ELL associated factor 2 | 0.23 |
| FBXW5 | F-box and WD repeat domain containing 5 | 0.23 |
| TYSND1 | trypsin domain containing 1 | 0.22 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.22 |
| PRR36 | proline rich 36 | 0.22 |
| RAB30 | RAB30, member RAS oncogene family | 0.22 |
| RELT | RELT tumor necrosis factor receptor | 0.22 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | 0.22 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.22 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.22 |
| PLCB4 | phospholipase C, beta 4 | 0.22 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.22 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | 0.22 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 0.22 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | 0.22 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | 0.22 |
| RBM20 | RNA binding motif protein 20 | 0.22 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.21 |
| TATDN2 | TatD DNase domain containing 2 | 0.21 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.21 |
| CCDC84 | coiled-coil domain containing 84 | 0.21 |
| S100A2 | S100 calcium binding protein A2 | 0.21 |
| E2F8 | E2F transcription factor 8 | 0.21 |
| DEDD | death effector domain containing | 0.21 |
| ATXN7L1 | ataxin 7-like 1 | 0.21 |
| CCDC85B | coiled-coil domain containing 85B | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL7A1 | collagen, type VII, alpha 1 | -2.18 |
| SBSN | suprabasin | -1.64 |
| IFI30 | interferon, gamma-inducible protein 30 | -1.35 |
| MGLL | monoglyceride lipase | -1.13 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -0.78 |
| BCO2 | beta-carotene oxygenase 2 | -0.61 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.59 |
| TTN | titin | -0.55 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | -0.44 |
| RBL2 | retinoblastoma-like 2 | -0.42 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.42 |
| KLHL15 | kelch-like family member 15 | -0.41 |
| FTL | ferritin, light polypeptide | -0.41 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.4 |
| ABHD14A | abhydrolase domain containing 14A | -0.4 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | -0.4 |
| RNF19B | ring finger protein 19B | -0.4 |
| XIRP2 | xin actin binding repeat containing 2 | -0.39 |
| ZNF3 | zinc finger protein 3 | -0.39 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | -0.38 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.38 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | -0.37 |
| ADCK1 | aarF domain containing kinase 1 | -0.35 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -0.34 |
| KIF21B | kinesin family member 21B | -0.33 |
| CCDC57 | coiled-coil domain containing 57 | -0.33 |
| FAM135A | family with sequence similarity 135, member A | -0.32 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -0.31 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.31 |
| GLMP | glycosylated lysosomal membrane protein | -0.31 |
| TMOD2 | tropomodulin 2 (neuronal) | -0.31 |
| MRPL55 | mitochondrial ribosomal protein L55 | -0.31 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | -0.3 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.3 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.3 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.3 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.29 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | -0.29 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.29 |
| CFAP410 | cilia and flagella associated protein 410 | -0.28 |
| GRAMD2B | GRAM domain containing 2B | -0.28 |
| SLC25A46 | solute carrier family 25, member 46 | -0.28 |
| MAGEA2 | melanoma antigen family A2 | -0.28 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | -0.28 |
| CHN1 | chimerin 1 | -0.27 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.27 |
| H3C1 | H3 clustered histone 1 | -0.26 |
| TMEM64 | transmembrane protein 64 | -0.26 |
| PIP | prolactin-induced protein | -0.26 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.25 |
| UBTD1 | ubiquitin domain containing 1 | -0.25 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.25 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.25 |
| PRKD3 | protein kinase D3 | -0.25 |
| SF1 | splicing factor 1 | -0.25 |
| FAM117A | family with sequence similarity 117, member A | -0.25 |
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) | -0.24 |
| TSPYL4 | TSPY-like 4 | -0.24 |
| INO80D | INO80 complex subunit D | -0.24 |
| DTNA | dystrobrevin, alpha | -0.24 |
| TEN1 | TEN1 CST complex subunit | -0.24 |
| TRIM29 | tripartite motif containing 29 | -0.24 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -0.23 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.23 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.23 |
| SON | SON DNA binding protein | -0.23 |
| UBL7 | ubiquitin-like 7 | -0.23 |
| TUBAL3 | tubulin, alpha-like 3 | -0.23 |
| SPIDR | scaffolding protein involved in DNA repair | -0.23 |
| MICB | MHC class I polypeptide-related sequence B | -0.22 |
| UBAP1 | ubiquitin associated protein 1 | -0.22 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.22 |
| BAG4 | BCL2-associated athanogene 4 | -0.22 |
| TMEM189 | transmembrane protein 189 | -0.22 |
| TRIM39 | tripartite motif containing 39 | -0.22 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) | -0.22 |
| POF1B | premature ovarian failure, 1B | -0.22 |
| ANK2 | ankyrin 2, neuronal | -0.22 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | -0.22 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -0.21 |
| PDIK1L | PDLIM1 interacting kinase 1 like | -0.21 |
| SMIM26 | small integral membrane protein 26 | -0.21 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.21 |
| HBA1 | hemoglobin, alpha 1 | -0.21 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.21 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.21 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -0.21 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -0.21 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | -0.21 |
| PTGES | prostaglandin E synthase | -0.2 |
| ZNF888 | zinc finger protein 888 | -0.2 |
| FAM210B | family with sequence similarity 210, member B | -0.2 |
| SLC9A7 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 | -0.2 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.2 |
| CA8 | carbonic anhydrase VIII | -0.2 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.2 |
| DISP1 | dispatched homolog 1 (Drosophila) | -0.2 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.2 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | -0.2 |
| DALRD3 | DALR anticodon binding domain containing 3 | -0.19 |
