| Dataset | LINCS L1000 CMAP Chemical Perturbation Consensus Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a (Chemical Entities of Biological Interest Ontology, CHEBI_43616) |
| Similar Terms | |
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80 genes differentially expressed following the K-252A small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 5.34106 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | 5.28347 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.77748 |
| SESN1 | sestrin 1 | 4.22081 |
| LDB1 | LIM domain binding 1 | 3.92728 |
| CAMLG | calcium modulating ligand | 3.84983 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 3.825 |
| TP53I3 | tumor protein p53 inducible protein 3 | 3.62781 |
| GOLGA5 | golgin A5 | 3.57108 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 3.56638 |
| HPS6 | Hermansky-Pudlak syndrome 6 | 3.55901 |
| TP53TG1 | TP53 target 1 (non-protein coding) | 3.55367 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3.55263 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | 3.5028 |
| RPS27L | ribosomal protein S27-like | 3.50173 |
| TMEM94 | transmembrane protein 94 | 3.50173 |
| RDH14 | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | 3.47535 |
| ZNF623 | zinc finger protein 623 | 3.45164 |
| MST1 | macrophage stimulating 1 | 3.44691 |
| GSPT2 | G1 to S phase transition 2 | 3.44528 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 | 3.44382 |
| PNPLA4 | patatin-like phospholipase domain containing 4 | 3.44167 |
| CCNG2 | cyclin G2 | 3.43653 |
| TRIM22 | tripartite motif containing 22 | 3.43344 |
| UBE2Q1 | ubiquitin-conjugating enzyme E2Q family member 1 | 3.43032 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 | 3.38845 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 3.37556 |
| TTLL3 | tubulin tyrosine ligase-like family member 3 | 3.32336 |
| ZNF189 | zinc finger protein 189 | 3.31832 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 3.2461 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 3.17391 |
| AAR2 | AAR2 splicing factor homolog (S. cerevisiae) | 3.1396 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 | 3.13232 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 3.10939 |
| FAS | Fas cell surface death receptor | 3.10624 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 3.08711 |
| ARHGAP29 | Rho GTPase activating protein 29 | 3.07396 |
| SEC31B | SEC31 homolog B (S. cerevisiae) | 3.06193 |
| ACTMAP | actin maturation protease | 3.03342 |
| WBP1L | WW domain binding protein 1-like | 3.01903 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 3.014 |
| MAP3K7CL | MAP3K7 C-terminal like | 3.01032 |
| SLFN12 | schlafen family member 12 | 3.0054 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NUP205 | nucleoporin 205kDa | -4.35838 |
| RHOA | ras homolog family member A | -4.05759 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -3.77329 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | -3.74988 |
| MCM3 | minichromosome maintenance complex component 3 | -3.63663 |
| WDR77 | WD repeat domain 77 | -3.62752 |
| CIT | citron rho-interacting serine/threonine kinase | -3.60852 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -3.58261 |
| GUF1 | GUF1 GTPase homolog (S. cerevisiae) | -3.55854 |
| NUP188 | nucleoporin 188kDa | -3.54511 |
| SLIT2 | slit homolog 2 (Drosophila) | -3.52313 |
| GATAD2A | GATA zinc finger domain containing 2A | -3.49277 |
| PHGDH | phosphoglycerate dehydrogenase | -3.45461 |
| FOSL1 | FOS-like antigen 1 | -3.45461 |
| POLR1F | RNA polymerase I subunit F | -3.41915 |
| IMPDH1 | IMP (inosine 5'-monophosphate) dehydrogenase 1 | -3.32657 |
| SAE1 | SUMO1 activating enzyme subunit 1 | -3.30429 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | -3.25614 |
| STEAP1B | STEAP family member 1B | -3.23942 |
| IPO8 | importin 8 | -3.23438 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -3.22752 |
| TPX2 | TPX2, microtubule-associated | -3.20853 |
| DNM1 | dynamin 1 | -3.16858 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | -3.16585 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -3.13672 |
| DAZAP1 | DAZ associated protein 1 | -3.13215 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -3.12152 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -3.10086 |
| KRT1 | keratin 1, type II | -3.0998 |
| CDC6 | cell division cycle 6 | -3.08806 |
| LAD1 | ladinin 1 | -3.07749 |
| BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor | -3.06529 |
| TRIM25 | tripartite motif containing 25 | -3.0638 |
| CDCA3 | cell division cycle associated 3 | -3.06075 |
| GNB1L | guanine nucleotide binding protein (G protein), beta polypeptide 1-like | -3.05653 |
| RANBP1 | RAN binding protein 1 | -3.04526 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -3.01166 |
