K562_Alendronate sodium trihydrate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 1µM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
Similar Terms
Downloads & Tools

Genes

1000 genes differentially expressed following the K562_Alendronate sodium trihydrate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0780393
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0775318
TBC1D5 TBC1 domain family, member 5 0.0621709
XPO1 exportin 1 0.0615337
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.0609357
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0550139
CNST consortin, connexin sorting protein 0.054908
ZEB2 zinc finger E-box binding homeobox 2 0.054234
ATG5 autophagy related 5 0.053177
SIK3 SIK family kinase 3 0.0525367
TAOK3 TAO kinase 3 0.0524823
HP1BP3 heterochromatin protein 1, binding protein 3 0.0521423
UBE3C ubiquitin protein ligase E3C 0.0513234
CALU calumenin 0.051213
ZFAND3 zinc finger, AN1-type domain 3 0.050557
MUSK muscle, skeletal, receptor tyrosine kinase 0.0501674
NMU neuromedin U 0.0499613
SMIM44 small integral membrane protein 44 0.0499463
SRPK1 SRSF protein kinase 1 0.0487401
SRRM2 serine/arginine repetitive matrix 2 0.048186
HBG2 hemoglobin, gamma G 0.0479749
EEF2 eukaryotic translation elongation factor 2 0.0476163
NLRP1 NLR family, pyrin domain containing 1 0.047127
MBNL1 muscleblind-like splicing regulator 1 0.0462013
MTDH metadherin 0.0448543
TUBA1B tubulin, alpha 1b 0.0444822
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0437677
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0437401
RPS3 ribosomal protein S3 0.0433903
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0433288
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0433006
GRB2 growth factor receptor-bound protein 2 0.0430342
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0430149
NUCB1 nucleobindin 1 0.0429945
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0428178
MAML2 mastermind-like 2 (Drosophila) 0.0420329
HBG1 hemoglobin, gamma A 0.0418556
OSBP oxysterol binding protein 0.0414681
CHD4 chromodomain helicase DNA binding protein 4 0.0412737
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0408714
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.040146
MPHOSPH9 M-phase phosphoprotein 9 0.0399057
PRAME preferentially expressed antigen in melanoma 0.0387823
TFRC transferrin receptor 0.0384968
ZNF106 zinc finger protein 106 0.038478
PDIA6 protein disulfide isomerase family A, member 6 0.0376944
IQGAP1 IQ motif containing GTPase activating protein 1 0.0372839
SFSWAP splicing factor, suppressor of white-apricot family 0.037118
SCFD2 sec1 family domain containing 2 0.0370594
GMDS GDP-mannose 4,6-dehydratase 0.0367475
PKP4 plakophilin 4 0.0366312
TNPO3 transportin 3 0.0365228
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.0364497
ANAPC5 anaphase promoting complex subunit 5 0.0363502
GTF2IRD1 GTF2I repeat domain containing 1 0.0363214
PRDX5 peroxiredoxin 5 0.0361962
SON SON DNA binding protein 0.036182
ATP5F1B ATP synthase F1 subunit beta 0.0360005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0359459
DIDO1 death inducer-obliterator 1 0.035824
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.0356316
FLNA filamin A, alpha 0.0353291
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0353177
PHGDH phosphoglycerate dehydrogenase 0.0351366
MYO3B myosin IIIB 0.0351332
RANBP2 RAN binding protein 2 0.0346462
KAT6B K(lysine) acetyltransferase 6B 0.0345751
CPED1 cadherin-like and PC-esterase domain containing 1 0.0341057
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0340453
STAU2 staufen double-stranded RNA binding protein 2 0.0338595
USP15 ubiquitin specific peptidase 15 0.0337204
GPHN gephyrin 0.0337156
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0335893
ATP5MC3 ATP synthase membrane subunit c locus 3 0.0335418
UBAP2 ubiquitin associated protein 2 0.0333697
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0333635
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0333118
AQR aquarius intron-binding spliceosomal factor 0.0332165
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.0329386
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.0329352
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0327439
PHIP pleckstrin homology domain interacting protein 0.0326569
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0325647
ESRRB estrogen-related receptor beta 0.03242
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 0.0323435
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0323166
NUP214 nucleoporin 214kDa 0.0319468
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0318343
NUP155 nucleoporin 155kDa 0.0317569
MSH3 mutS homolog 3 0.0316514
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0316142
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0315353
KRT18 keratin 18, type I 0.0314952
NCAPG2 non-SMC condensin II complex, subunit G2 0.031021
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0307002
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0306857
SEC31A SEC31 homolog A (S. cerevisiae) 0.0303275
FAM193A family with sequence similarity 193, member A 0.0301546
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0301102
ANKRD11 ankyrin repeat domain 11 0.0298809
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0298551
RHOBTB3 Rho-related BTB domain containing 3 0.0298328
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.0297093
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0297056
TULP4 tubby like protein 4 0.0294849
KIF5B kinesin family member 5B 0.0294336
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0293799
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0293502
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.0293187
PHTF2 putative homeodomain transcription factor 2 0.0291737
IPO9 importin 9 0.0290841
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0290665
WDR70 WD repeat domain 70 0.0286952
SERBP1 SERPINE1 mRNA binding protein 1 0.0286753
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.0286624
ACTN4 actinin, alpha 4 0.0286413
PEAK1 pseudopodium-enriched atypical kinase 1 0.0285606
NOL8 nucleolar protein 8 0.0285407
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0284035
NSD1 nuclear receptor binding SET domain protein 1 0.0283967
NONO non-POU domain containing, octamer-binding 0.0283899
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.028305
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 0.0282474
AHCTF1 AT hook containing transcription factor 1 0.0281976
SRP72 signal recognition particle 72kDa 0.028142
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.028023
SPOP speckle-type POZ protein 0.0278128
BCOR BCL6 corepressor 0.0278077
RLF rearranged L-myc fusion 0.0277503
FARSB phenylalanyl-tRNA synthetase, beta subunit 0.0276588
FOXK2 forkhead box K2 0.0276173
LIMD1 LIM domains containing 1 0.0276074
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.027607
AKAP10 A kinase (PRKA) anchor protein 10 0.0274899
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0274235
TMEM267 transmembrane protein 267 0.0273559
RHAG Rh-associated glycoprotein 0.0273017
UNC13D unc-13 homolog D (C. elegans) 0.0272518
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0271259
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0270231
MACO1 macoilin 1 0.0268769
ATAD3A ATPase family, AAA domain containing 3A 0.0268562
BCCIP BRCA2 and CDKN1A interacting protein 0.0266505
AFDN afadin, adherens junction formation factor 0.0265587
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0265419
OSBPL8 oxysterol binding protein-like 8 0.0263739
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0262752
CHML choroideremia-like (Rab escort protein 2) 0.0261297
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0260956
RPS5 ribosomal protein S5 0.0260409
ATG10 autophagy related 10 0.0260204
THRB thyroid hormone receptor, beta 0.0259951
INTS8 integrator complex subunit 8 0.0259271
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 0.0258869
MARCHF8 membrane associated ring-CH-type finger 8 0.0258841
SAP130 Sin3A-associated protein, 130kDa 0.0258762
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.025828
MTREX Mtr4 exosome RNA helicase 0.0256347
TMEM41A transmembrane protein 41A 0.0255703
EXOC6 exocyst complex component 6 0.0255334
PTBP2 polypyrimidine tract binding protein 2 0.0255191
FAM222B family with sequence similarity 222, member B 0.0254251
RPL14 ribosomal protein L14 0.0253763
BLM Bloom syndrome, RecQ helicase-like 0.0253572
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0253462
ENOSF1 enolase superfamily member 1 0.025346
CALR calreticulin 0.0252769
JUND jun D proto-oncogene 0.0252703
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0252569
MLXIP MLX interacting protein 0.0252517
MRPL4 mitochondrial ribosomal protein L4 0.0252081
RPL15 ribosomal protein L15 0.0251993
DKC1 dyskeratosis congenita 1, dyskerin 0.025194
ANTXR2 anthrax toxin receptor 2 0.025031
CBFB core-binding factor, beta subunit 0.0250243
POTEF POTE ankyrin domain family, member F 0.0250199
WTAP Wilms tumor 1 associated protein 0.0249919
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0249779
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0247764
AKIRIN1 akirin 1 0.024512
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0245075
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.0243633
LDLR low density lipoprotein receptor 0.0243116
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0243037
INSIG1 insulin induced gene 1 0.024236
NCOA4 nuclear receptor coactivator 4 0.0242218
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0241833
CRLF3 cytokine receptor-like factor 3 0.0239433
EIF4E eukaryotic translation initiation factor 4E 0.023939
DAZAP1 DAZ associated protein 1 0.0239256
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0238721
ACTG1 actin gamma 1 0.0238596
SMC5 structural maintenance of chromosomes 5 0.0238501
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0238283
GPATCH2L G patch domain containing 2-like 0.0238196
TRRAP transformation/transcription domain-associated protein 0.0238136
ATL3 atlastin GTPase 3 0.0237285
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.0237135
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.0236181
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.0235819
EIF5B eukaryotic translation initiation factor 5B 0.0235226
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0234302
PHKB phosphorylase kinase, beta 0.0233399
NUP153 nucleoporin 153kDa 0.0232804
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.023253
ADGRB3 adhesion G protein-coupled receptor B3 0.0232322
EHD2 EH-domain containing 2 0.0232307
FASN fatty acid synthase 0.023157
ARHGAP24 Rho GTPase activating protein 24 0.0230929
RAB7A RAB7A, member RAS oncogene family 0.023069
WDR43 WD repeat domain 43 0.0229113
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 0.022896
NFE2 nuclear factor, erythroid 2 0.0228559
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.0226962
ZNF398 zinc finger protein 398 0.0226915
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 0.0226482
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.022644
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0226403
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0226191
OLA1 Obg-like ATPase 1 0.0225886
ELOVL6 ELOVL fatty acid elongase 6 0.0225741
RPS21 ribosomal protein S21 0.0225681
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0225303
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.02252
ZFC3H1 zinc finger, C3H1-type containing 0.0225037
RHEB Ras homolog enriched in brain 0.0224667
SRFBP1 serum response factor binding protein 1 0.0224648
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.022449
H1-10 H1.10 linker histone 0.0223844
ETNK1 ethanolamine kinase 1 0.0223265
SMC4 structural maintenance of chromosomes 4 0.0223174
RNF114 ring finger protein 114 0.0222883
UBE4A ubiquitination factor E4A 0.022195
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.0220425
DEK DEK proto-oncogene 0.0220307
WDR37 WD repeat domain 37 0.022014
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.0219993
ARHGAP35 Rho GTPase activating protein 35 0.0219436
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0218865
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0218747
SELENOI selenoprotein I 0.0218546
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0218324
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0217086
TMEM168 transmembrane protein 168 0.0216916
ACACA acetyl-CoA carboxylase alpha 0.0216419
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 0.0215892
HIPK2 homeodomain interacting protein kinase 2 0.0215566
PCED1B PC-esterase domain containing 1B 0.0215065
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0214735
ULK4 unc-51 like kinase 4 0.0214472
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.0214266
ZNF655 zinc finger protein 655 0.0214084
ANKRD12 ankyrin repeat domain 12 0.021389
MPV17 MpV17 mitochondrial inner membrane protein 0.0213663
GSPT1 G1 to S phase transition 1 0.0213598
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0213528
TSLIG1 tRNA splicing ligase complex subunit 1 0.0213424
RAD54L RAD54-like (S. cerevisiae) 0.0213156
MINDY3 MINDY lysine 48 deubiquitinase 3 0.0212898
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0212576
STIP1 stress-induced phosphoprotein 1 0.0212348
DIAPH1 diaphanous-related formin 1 0.021143
CLYBL citrate lyase beta like 0.0211208
RPLP2 ribosomal protein, large, P2 0.0210872
CLIC1 chloride intracellular channel 1 0.0210804
TUSC3 tumor suppressor candidate 3 0.021028
CDC123 cell division cycle 123 0.0210208
DCAKD dephospho-CoA kinase domain containing 0.021001
TCF12 transcription factor 12 0.0209907
NUP107 nucleoporin 107kDa 0.0209684
DGCR2 DiGeorge syndrome critical region gene 2 0.0209558
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0209373
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0209166
ABI2 abl-interactor 2 0.0208976
LARP1B La ribonucleoprotein domain family, member 1B 0.0208867
ZNF346 zinc finger protein 346 0.0208836
BSG basigin (Ok blood group) 0.0208767
ST7L suppression of tumorigenicity 7 like 0.0208667
DENND4A DENN/MADD domain containing 4A 0.0207844
RIOK3 RIO kinase 3 0.0207635
NUP160 nucleoporin 160kDa 0.0207352
EXOC4 exocyst complex component 4 0.0207029
PAAF1 proteasomal ATPase-associated factor 1 0.0207021
DSG2 desmoglein 2 0.0206866
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.0206547
PRMT3 protein arginine methyltransferase 3 0.0206373
USP9X ubiquitin specific peptidase 9, X-linked 0.0206107
NAP1L1 nucleosome assembly protein 1-like 1 0.0205893
RICTOR RPTOR independent companion of MTOR, complex 2 0.020589
ETV1 ets variant 1 0.0205422
CCNK cyclin K 0.0205409
RBBP6 retinoblastoma binding protein 6 0.0204838
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0204795
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0204369
INO80 INO80 complex subunit 0.0204278
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0204266
NCOA6 nuclear receptor coactivator 6 0.0203379
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0203205
CDK17 cyclin-dependent kinase 17 0.020311
PRRC2B proline-rich coiled-coil 2B 0.0203
VIM vimentin 0.0202738
H3-3B H3.3 histone B 0.0202717
TRIM25 tripartite motif containing 25 0.0202331
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.0201884
GMEB1 glucocorticoid modulatory element binding protein 1 0.020163
NCAPD3 non-SMC condensin II complex, subunit D3 0.0201475
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.0201353
SFXN1 sideroflexin 1 0.0201114
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 0.0200955
TCF3 transcription factor 3 0.0200698
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.020029
NUP62 nucleoporin 62kDa 0.0200071
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0199957
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.0199674
UBA6 ubiquitin-like modifier activating enzyme 6 0.0199481
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0199388
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.0198618
PRPF4B pre-mRNA processing factor 4B 0.0198375
SRPK2 SRSF protein kinase 2 0.0197916
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.0197615
TTL tubulin tyrosine ligase 0.019758
RSF1 remodeling and spacing factor 1 0.0197332
AK3 adenylate kinase 3 0.0196726
TAPT1 transmembrane anterior posterior transformation 1 0.0196531
ALKBH5 AlkB family member 5, RNA demethylase 0.0196378
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0196267
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0196143
PPA2 pyrophosphatase (inorganic) 2 0.0196078
PTBP1 polypyrimidine tract binding protein 1 0.0195958
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0195915
TSC22D2 TSC22 domain family, member 2 0.0195841
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0195671
WDR73 WD repeat domain 73 0.0195297
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0194362
SPIRE1 spire-type actin nucleation factor 1 0.0194178
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0194142
PTEN phosphatase and tensin homolog 0.0194074
ZNF445 zinc finger protein 445 0.0193442
RPLP0 ribosomal protein, large, P0 0.0193267
RNF2 ring finger protein 2 0.0193249
LOC112694756 uncharaterized LOC112694756 0.0193218
RPL6 ribosomal protein L6 0.0193027
THOC2 THO complex 2 0.0192838
CEP57 centrosomal protein 57kDa 0.0192707
COMMD1 copper metabolism (Murr1) domain containing 1 0.0192576
TBCD tubulin folding cofactor D 0.0192497
TRIM65 tripartite motif containing 65 0.0192357
H1-2 H1.2 linker histone, cluster member 0.0192013
CTSC cathepsin C 0.0191894
CEPT1 choline/ethanolamine phosphotransferase 1 0.0191757
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.0191626
EIF4B eukaryotic translation initiation factor 4B 0.0191298
SMYD3 SET and MYND domain containing 3 0.0191107
ARFIP1 ADP-ribosylation factor interacting protein 1 0.0191001
SCAND3 SCAN domain containing 3 0.0190842
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.0190777
RPL23 ribosomal protein L23 0.0190732
TGFBR3 transforming growth factor, beta receptor III 0.0190685
KIF21A kinesin family member 21A 0.0190616
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0189862
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 0.01898
KATNBL1 katanin p80 subunit B-like 1 0.0189694
LSR lipolysis stimulated lipoprotein receptor 0.0189641
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0189596
SERINC1 serine incorporator 1 0.0189484
GALK2 galactokinase 2 0.0189438
CALN1 calneuron 1 0.0189069
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.0188601
RNFT2 ring finger protein, transmembrane 2 0.0188496
TMOD3 tropomodulin 3 (ubiquitous) 0.0188365
HMGB1 high mobility group box 1 0.0187999
ZMYM4 zinc finger, MYM-type 4 0.0187877
LASP1 LIM and SH3 protein 1 0.0187475
PDCD11 programmed cell death 11 0.0187027
SFXN2 sideroflexin 2 0.0187011
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0186895
ATAD2B ATPase family, AAA domain containing 2B 0.0186685
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0186636
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0186629
HYOU1 hypoxia up-regulated 1 0.0186605
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.0185564
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0185403
TNRC6A trinucleotide repeat containing 6A 0.0185304
HMGA1 high mobility group AT-hook 1 0.0185142
MDN1 MDN1, midasin homolog (yeast) 0.0184679
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0184424
CTSD cathepsin D 0.0184365
WT1 Wilms tumor 1 0.0183823
RSRC1 arginine/serine-rich coiled-coil 1 0.0183658
TTC27 tetratricopeptide repeat domain 27 0.0182308
IP6K1 inositol hexakisphosphate kinase 1 0.0182262
PDLIM1 PDZ and LIM domain 1 0.0181909
KEAP1 kelch-like ECH-associated protein 1 0.018122
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.0181142
HOMER1 homer scaffolding protein 1 0.0180593
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0180536
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 0.0180471
SMAD3 SMAD family member 3 0.0180356
DOCK8 dedicator of cytokinesis 8 0.0180216
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.018002
GMPS guanine monphosphate synthase 0.017993
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0179699
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0179691
DNAH8 dynein, axonemal, heavy chain 8 0.0179398
DCAF10 DDB1 and CUL4 associated factor 10 0.0179252
FAM120A family with sequence similarity 120A 0.0179229
RSL1D1 ribosomal L1 domain containing 1 0.0178639
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 0.0178391
INTS4 integrator complex subunit 4 0.0178351
KIAA1958 KIAA1958 0.0178268
RABL6 RAB, member RAS oncogene family-like 6 0.0178164
CTPS2 CTP synthase 2 0.0177995
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0177986
TRIM44 tripartite motif containing 44 0.0177539
SASH1 SAM and SH3 domain containing 1 0.0177429
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.017683
SPPL2A signal peptide peptidase like 2A 0.0176811
DCAF7 DDB1 and CUL4 associated factor 7 0.0176479
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0176285
TRIB3 tribbles pseudokinase 3 0.0176144
CAVIN1 caveolae associated protein 1 0.0176014
ARPC5L actin related protein 2/3 complex, subunit 5-like 0.0175751
MCAM melanoma cell adhesion molecule 0.0175471
CLSTN1 calsyntenin 1 0.0175394
TRIM28 tripartite motif containing 28 0.0175141
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.0175073
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 0.0175033
ESYT2 extended synaptotagmin-like protein 2 0.0174841
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0174836
MED24 mediator complex subunit 24 0.0174617
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0174589
PLEKHJ1 pleckstrin homology domain containing, family J member 1 0.0174562
WDR59 WD repeat domain 59 0.0174536
MACC1 metastasis associated in colon cancer 1 0.017442
COPS3 COP9 signalosome subunit 3 0.0173796
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0173603
RTN3 reticulon 3 0.0173063
PARD3 par-3 family cell polarity regulator 0.0173028
FNBP1 formin binding protein 1 0.0173002
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0172925
C6ORF89 chromosome 6 open reading frame 89 0.0172832
MKRN2 makorin ring finger protein 2 0.0172643
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.0171979
SERTAD2 SERTA domain containing 2 0.0171819
RTN4 reticulon 4 0.0171735
FAM120B family with sequence similarity 120B 0.017169
NUP88 nucleoporin 88kDa 0.0171027
GOLM2 golgi membrane protein 2 0.0170963
DARS1 aspartyl-tRNA synthetase 1 0.0170861
CERT1 ceramide transporter 1 0.0170695
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0170659
ADCY8 adenylate cyclase 8 (brain) 0.0170648
RPL37 ribosomal protein L37 0.0170551
ASXL1 additional sex combs like transcriptional regulator 1 0.0170229
IQSEC1 IQ motif and Sec7 domain 1 0.0170201
HPS5 Hermansky-Pudlak syndrome 5 0.0170189
ITM2B integral membrane protein 2B 0.0169643
KIF13B kinesin family member 13B 0.0169547
RAB8B RAB8B, member RAS oncogene family 0.0169438
R3HDM1 R3H domain containing 1 0.0169411
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0169345
RUFY2 RUN and FYVE domain containing 2 0.0169214
YIPF5 Yip1 domain family, member 5 0.0169061
SMC6 structural maintenance of chromosomes 6 0.0168614
FAM20B family with sequence similarity 20, member B 0.0168537
KYAT1 kynurenine aminotransferase 1 0.0168529
RPSA ribosomal protein SA 0.0168421
C5ORF22 chromosome 5 open reading frame 22 0.0168094
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0168014
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0167865
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.0167559
PTDSS1 phosphatidylserine synthase 1 0.0167465
DROSHA drosha, ribonuclease type III 0.016707
ZNF589 zinc finger protein 589 0.0166588
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0166467
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.0166157
H2AC6 H2A clustered histone 6 0.0165893
PARK7 parkinson protein 7 0.0165367
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0165082
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.0165038
ZNF37A zinc finger protein 37A 0.0164669
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0164653
LMTK2 lemur tyrosine kinase 2 0.0164491
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0164409
SEPTIN7 septin 7 0.0164272
ARLN allregulin 0.0163804
WDR12 WD repeat domain 12 0.0163632
RBM28 RNA binding motif protein 28 0.0163532
CNOT10 CCR4-NOT transcription complex, subunit 10 0.0163427
CCDC125 coiled-coil domain containing 125 0.0163348
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0163337
PURA purine-rich element binding protein A 0.0163244
STIL SCL/TAL1 interrupting locus 0.0162971
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 0.0162894
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0162677
SKIC3 SKI3 subunit of superkiller complex 0.0162447
PHACTR2 phosphatase and actin regulator 2 0.0161624
RACK1 receptor for activated C kinase 1 0.0161551
NBAS neuroblastoma amplified sequence 0.0161476
EIF4A3 eukaryotic translation initiation factor 4A3 0.0161448

decreased expression

Symbol Name Standardized Value
PRKCA protein kinase C, alpha -0.126464
ZFPM2 zinc finger protein, FOG family member 2 -0.081171
MACF1 microtubule-actin crosslinking factor 1 -0.0774016
PRKCB protein kinase C, beta -0.074917
FBXL13 F-box and leucine-rich repeat protein 13 -0.0682863
JMJD1C jumonji domain containing 1C -0.0641177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0602391
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0584353
MARCHF3 membrane associated ring-CH-type finger 3 -0.0582815
MKI67 marker of proliferation Ki-67 -0.0573818
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0560256
FBXL20 F-box and leucine-rich repeat protein 20 -0.055811
RABGAP1L RAB GTPase activating protein 1-like -0.0532108
EPB41 erythrocyte membrane protein band 4.1 -0.0509811
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0506516
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0505762
MYO1D myosin ID -0.0504742
MAST2 microtubule associated serine/threonine kinase 2 -0.0496171
SCAI suppressor of cancer cell invasion -0.0492057
FAF1 Fas (TNFRSF6) associated factor 1 -0.0485891
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0456119
JARID2 jumonji, AT rich interactive domain 2 -0.0449147
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0434416
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0427736
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0407651
BBX bobby sox homolog (Drosophila) -0.0405738
ELOVL5 ELOVL fatty acid elongase 5 -0.0403232
UBTF upstream binding transcription factor, RNA polymerase I -0.0392909
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0384134
METTL15 methyltransferase like 15 -0.0381364
KDM5B lysine (K)-specific demethylase 5B -0.0376646
FDPS farnesyl diphosphate synthase -0.0375539
RELN reelin -0.0375481
MED13L mediator complex subunit 13-like -0.037418
USP6NL USP6 N-terminal like -0.0373908
ELP4 elongator acetyltransferase complex subunit 4 -0.037189
CENPF centromere protein F, 350/400kDa -0.037102
CCDC91 coiled-coil domain containing 91 -0.0365298
BMP2K BMP2 inducible kinase -0.0364779
ARHGAP11B Rho GTPase activating protein 11B -0.0363074
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0358106
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.0357207
ANK1 ankyrin 1, erythrocytic -0.0356436
PHF20 PHD finger protein 20 -0.0356374
FANCI Fanconi anemia, complementation group I -0.0350179
TRIM24 tripartite motif containing 24 -0.0350005
UCK2 uridine-cytidine kinase 2 -0.0345245
SYNJ2 synaptojanin 2 -0.0343163
CCDC88A coiled-coil domain containing 88A -0.034306
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0342156
MYO18B myosin XVIIIB -0.034101
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -0.0339394
CCNY cyclin Y -0.0339341
USP32 ubiquitin specific peptidase 32 -0.0338562
RPL37A ribosomal protein L37a -0.033328
FYCO1 FYVE and coiled-coil domain containing 1 -0.0331538
DOCK11 dedicator of cytokinesis 11 -0.0326641
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.0324658
PHACTR4 phosphatase and actin regulator 4 -0.0324186
GAB2 GRB2-associated binding protein 2 -0.0320913
COMMD10 COMM domain containing 10 -0.0320275
TRAPPC9 trafficking protein particle complex 9 -0.0318449
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0316227
UBN2 ubinuclein 2 -0.0315855
WDR26 WD repeat domain 26 -0.0312085
ERBIN erbb2 interacting protein -0.0310681
FOXP1 forkhead box P1 -0.0309814
ZMYND8 zinc finger, MYND-type containing 8 -0.0309225
LMBR1 limb development membrane protein 1 -0.0307039
CUX1 cut-like homeobox 1 -0.0302983
RBM14-RBM4 RBM14-RBM4 readthrough -0.0302742
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0302616
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.030176
RBM15 RNA binding motif protein 15 -0.0301381
CDC14A cell division cycle 14A -0.0300129
MARCHF6 membrane associated ring-CH-type finger 6 -0.0299698
CFH complement factor H -0.0299689
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0298717
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0298289
ZNF292 zinc finger protein 292 -0.0298258
CTBP2 C-terminal binding protein 2 -0.0297865
LTBP1 latent transforming growth factor beta binding protein 1 -0.0297197
DIAPH3 diaphanous-related formin 3 -0.0296564
CDK13 cyclin-dependent kinase 13 -0.0294345
CNTNAP2 contactin associated protein-like 2 -0.0293232
ARB2A ARB2 cotranscriptional regulator A -0.0292669
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0292186
EPS15 epidermal growth factor receptor pathway substrate 15 -0.029113
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0290109
TMEM245 transmembrane protein 245 -0.0289549
SSBP2 single-stranded DNA binding protein 2 -0.0287852
WNK1 WNK lysine deficient protein kinase 1 -0.028694
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0286756
SLC38A2 solute carrier family 38, member 2 -0.0285807
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0285043
KDM2A lysine (K)-specific demethylase 2A -0.0284951
RPL30 ribosomal protein L30 -0.0283456
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.028209
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0281793
RPS14 ribosomal protein S14 -0.0278825
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0278115
PKM pyruvate kinase, muscle -0.0278008
RORA RAR-related orphan receptor A -0.0277667
TET3 tet methylcytosine dioxygenase 3 -0.0276791
NAP1L4 nucleosome assembly protein 1-like 4 -0.027639
ANO10 anoctamin 10 -0.0275675
FN1 fibronectin 1 -0.0274184
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0269887
COPB1 coatomer protein complex, subunit beta 1 -0.026961
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0269451
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0269381
RIPOR3 RIPOR family member 3 -0.0268877
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0267265
PICALM phosphatidylinositol binding clathrin assembly protein -0.0266092
MICU1 mitochondrial calcium uptake 1 -0.026259
ARHGAP21 Rho GTPase activating protein 21 -0.0262115
TBC1D22A TBC1 domain family, member 22A -0.025953
SSR1 signal sequence receptor, alpha -0.0258701
KMT2A lysine (K)-specific methyltransferase 2A -0.0258288
RUSC2 RUN and SH3 domain containing 2 -0.0257956
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0256677
MAP7 microtubule-associated protein 7 -0.0256132
PLEC plectin -0.0256109
FASTKD1 FAST kinase domains 1 -0.0255961
LRP10 low density lipoprotein receptor-related protein 10 -0.0255669
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0255652
IARS1 isoleucyl-tRNA synthetase 1 -0.0255297
COG5 component of oligomeric golgi complex 5 -0.0254865
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.0254303
TMOD1 tropomodulin 1 -0.0254097
ARID1A AT rich interactive domain 1A (SWI-like) -0.0253184
BRCA2 breast cancer 2, early onset -0.0253029
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0251589
KDM4B lysine (K)-specific demethylase 4B -0.0250126
TRPS1 trichorhinophalangeal syndrome I -0.0249565
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0249145
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0248407
GDNF glial cell derived neurotrophic factor -0.024727
MED12 mediator complex subunit 12 -0.024675
TNRC18 trinucleotide repeat containing 18 -0.0246235
TNIK TRAF2 and NCK interacting kinase -0.0246129
CKAP5 cytoskeleton associated protein 5 -0.024597
HDAC8 histone deacetylase 8 -0.02448
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0244728
MIER1 mesoderm induction early response 1, transcriptional regulator -0.02438
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0243652
CEP295 centrosomal protein 295kDa -0.0243614
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0243001
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0241559
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.024137
RC3H2 ring finger and CCCH-type domains 2 -0.024003
KNTC1 kinetochore associated 1 -0.0239798
PEX14 peroxisomal biogenesis factor 14 -0.0239596
BLVRB biliverdin reductase B -0.0238692
MAPK8 mitogen-activated protein kinase 8 -0.0237796
BMPR1A bone morphogenetic protein receptor, type IA -0.0236913
NIBAN1 niban apoptosis regulator 1 -0.0236645
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0236633
SNX6 sorting nexin 6 -0.0234398
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0234384
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0233005
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0232301
CD2AP CD2-associated protein -0.0232245
EGFL7 EGF-like-domain, multiple 7 -0.0231565
ARHGAP15 Rho GTPase activating protein 15 -0.0230734
PLCL1 phospholipase C-like 1 -0.0230451
NUP210 nucleoporin 210kDa -0.0230388
EFCAB14 EF-hand calcium binding domain 14 -0.0229747
NOL4L nucleolar protein 4-like -0.0229304
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0229222
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0229048
FTH1 ferritin, heavy polypeptide 1 -0.0228487
INTS7 integrator complex subunit 7 -0.0225827
EZR ezrin -0.0224814
CDC27 cell division cycle 27 -0.0224337
CR1L complement component (3b/4b) receptor 1-like -0.0224222
FNDC3A fibronectin type III domain containing 3A -0.0223899
PLAGL1 pleiomorphic adenoma gene-like 1 -0.0223835
HCFC1 host cell factor C1 -0.0223386
RHD Rh blood group, D antigen -0.022318
TNRC6B trinucleotide repeat containing 6B -0.022294
SQLE squalene epoxidase -0.022285
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0222557
BIN3 bridging integrator 3 -0.0222431
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0222378
TMC6 transmembrane channel-like 6 -0.0222308
STAU1 staufen double-stranded RNA binding protein 1 -0.0221456
SMC1A structural maintenance of chromosomes 1A -0.0221298
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0220755
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0220727
FGF13 fibroblast growth factor 13 -0.0220326
CLASP1 cytoplasmic linker associated protein 1 -0.0219888
NFIA nuclear factor I/A -0.0219297
RPAP2 RNA polymerase II associated protein 2 -0.0219226
PRELID2 PRELI domain containing 2 -0.0219223
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0218747
ABHD5 abhydrolase domain containing 5 -0.0218633
PDE4D phosphodiesterase 4D, cAMP-specific -0.0218052
FUBP3 far upstream element (FUSE) binding protein 3 -0.0217676
KMT2C lysine (K)-specific methyltransferase 2C -0.0216055
HPRT1 hypoxanthine phosphoribosyltransferase 1 -0.0215871
SAMD4A sterile alpha motif domain containing 4A -0.0215763
C17ORF99 chromosome 17 open reading frame 99 -0.0214493
TET2 tet methylcytosine dioxygenase 2 -0.0214231
NOL10 nucleolar protein 10 -0.0214159
MMS22L MMS22-like, DNA repair protein -0.0213383
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0213339
HDAC2 histone deacetylase 2 -0.0211479
RFC2 replication factor C (activator 1) 2, 40kDa -0.0211045
DCAF6 DDB1 and CUL4 associated factor 6 -0.0210935
C1ORF159 chromosome 1 open reading frame 159 -0.0210165
TM9SF3 transmembrane 9 superfamily member 3 -0.0210156
PRPF38B pre-mRNA processing factor 38B -0.020984
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.0209635
AK1 adenylate kinase 1 -0.0209113
AGFG1 ArfGAP with FG repeats 1 -0.0208805
LRP12 low density lipoprotein receptor-related protein 12 -0.0208517
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -0.0207581
GPC5 glypican 5 -0.0206767
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0206303
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0206052
PTBP3 polypyrimidine tract binding protein 3 -0.020604
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0205984
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -0.0205759
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -0.0203775
SFPQ splicing factor proline/glutamine-rich -0.0203774
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0202407
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B -0.0201723
SRSF4 serine/arginine-rich splicing factor 4 -0.020123
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.0200895
USP49 ubiquitin specific peptidase 49 -0.0200612
SOX6 SRY (sex determining region Y)-box 6 -0.0200342
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.0200066
HBE1 hemoglobin, epsilon 1 -0.0199503
VMP1 vacuole membrane protein 1 -0.0198305
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0197421
SOS2 son of sevenless homolog 2 (Drosophila) -0.0197255
PDE8A phosphodiesterase 8A -0.0197182
TGOLN2 trans-golgi network protein 2 -0.0197156
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0196705
LNPK lunapark, ER junction formation factor -0.019621
AAK1 AP2 associated kinase 1 -0.0195882
RNF217 ring finger protein 217 -0.0195683
KIF13A kinesin family member 13A -0.0195141
CCDC6 coiled-coil domain containing 6 -0.0194819
ARL5A ADP-ribosylation factor-like 5A -0.0194259
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0193959
UQCRC2 ubiquinol-cytochrome c reductase core protein II -0.0192844
QTMAN queuosine-tRNA mannosyltransferase -0.0192409
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -0.0191762
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0191275
FOXM1 forkhead box M1 -0.019101
KEL Kell blood group, metallo-endopeptidase -0.0190867
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0190811
HBA2 hemoglobin, alpha 2 -0.019066
STX12 syntaxin 12 -0.0190418
MSN moesin -0.0190291
CD58 CD58 molecule -0.0189948
NCAM2 neural cell adhesion molecule 2 -0.0189554
RTF2 replication termination factor 2 -0.0189295
LRRC8B leucine rich repeat containing 8 family, member B -0.0188914
ATP11A ATPase, class VI, type 11A -0.0188207
FLNB filamin B, beta -0.0188059
LAPTM4B lysosomal protein transmembrane 4 beta -0.0187958
CENPC centromere protein C -0.0187726
FANCC Fanconi anemia, complementation group C -0.0187615
AOPEP aminopeptidase O (putative) -0.0187555
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0186818
MEF2C myocyte enhancer factor 2C -0.0186505
MED27 mediator complex subunit 27 -0.018619
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0185611
SMAP2 small ArfGAP2 -0.0185581
ZFYVE28 zinc finger, FYVE domain containing 28 -0.0184439
NFYC nuclear transcription factor Y, gamma -0.018434
RUFY1 RUN and FYVE domain containing 1 -0.0184005
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -0.0183974
SGMS1 sphingomyelin synthase 1 -0.0183881
KRIT1 KRIT1, ankyrin repeat containing -0.018382
RNF24 ring finger protein 24 -0.0183746
MRPS18B mitochondrial ribosomal protein S18B -0.0183596
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -0.0183468
SERINC5 serine incorporator 5 -0.0183101
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0182857
CERS6 ceramide synthase 6 -0.0182608
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0182359
REPS1 RALBP1 associated Eps domain containing 1 -0.0181957
SULF2 sulfatase 2 -0.0181822
CACUL1 CDK2-associated, cullin domain 1 -0.0181077
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0180703
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.0180394
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0180385
XRN1 5'-3' exoribonuclease 1 -0.0179732
RPS15 ribosomal protein S15 -0.0179622
RAD21 RAD21 homolog (S. pombe) -0.0179523
PGPEP1 pyroglutamyl-peptidase I -0.017867
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -0.0178282
RNF149 ring finger protein 149 -0.017822
ZC3H4 zinc finger CCCH-type containing 4 -0.0177787
DMD dystrophin -0.0177784
FRYL FRY-like -0.017761
ARMH3 armadillo like helical domain containing 3 -0.0177521
RPS18 ribosomal protein S18 -0.0177372
ATXN2 ataxin 2 -0.0176847
ELP6 elongator acetyltransferase complex subunit 6 -0.0176514
TMEM165 transmembrane protein 165 -0.0176339
SLC25A42 solute carrier family 25, member 42 -0.0175782
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0175284
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0175146
MAP4 microtubule-associated protein 4 -0.017511
RHBDD2 rhomboid domain containing 2 -0.0174314
HPS1 Hermansky-Pudlak syndrome 1 -0.017362
CSNK1D casein kinase 1, delta -0.0173576
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0173505
MZT2A mitotic spindle organizing protein 2A -0.0173399
ADAM10 ADAM metallopeptidase domain 10 -0.0173391
TSEN15 TSEN15 tRNA splicing endonuclease subunit -0.0172985
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0172879
KANTR KDM5C adjacent non-coding transcript -0.0172514
ASPH aspartate beta-hydroxylase -0.0172485
AVL9 AVL9 homolog (S. cerevisiase) -0.0172314
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0172242
GRID1 glutamate receptor, ionotropic, delta 1 -0.0171964
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0171716
AHNAK AHNAK nucleoprotein -0.0171645
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0171457
TRIM37 tripartite motif containing 37 -0.0171436
DMXL2 Dmx-like 2 -0.017135
GDA guanine deaminase -0.0171096
UBE2O ubiquitin-conjugating enzyme E2O -0.0170908
WDR20 WD repeat domain 20 -0.0170816
SDCCAG8 serologically defined colon cancer antigen 8 -0.0170736
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0170671
AKAP11 A kinase (PRKA) anchor protein 11 -0.0170552
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -0.0170521
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.017025
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0170089
F8 coagulation factor VIII, procoagulant component -0.0169914
SORCS1 sortilin-related VPS10 domain containing receptor 1 -0.0168517
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0168336
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.0167798
BLTP3B bridge-like lipid transfer protein family member 3B -0.0167705
PTK2B protein tyrosine kinase 2 beta -0.0167653
COXFA4 cytochrome c oxidase associated subunit FA4 -0.0167433
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0167093
DSCAM Down syndrome cell adhesion molecule -0.0166966
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0166922
PLCD1 phospholipase C, delta 1 -0.0166826
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -0.0166295
FOXO3 forkhead box O3 -0.0166158
TSC22D4 TSC22 domain family, member 4 -0.016587
SLC12A9 solute carrier family 12, member 9 -0.0165791
WWC2 WW and C2 domain containing 2 -0.0165537
MIPOL1 mirror-image polydactyly 1 -0.0164945
TTF2 transcription termination factor, RNA polymerase II -0.0164804
NFX1 nuclear transcription factor, X-box binding 1 -0.0164384
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0164359
CEP85L centrosomal protein 85kDa-like -0.016429
SETX senataxin -0.0164274
NIPSNAP2 nipsnap homolog 2 -0.0164244
CARD8 caspase recruitment domain family, member 8 -0.016416
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.0164115
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.016411
ATP9B ATPase, class II, type 9B -0.0163729
CLCN7 chloride channel, voltage-sensitive 7 -0.0163715
FAM178B family with sequence similarity 178, member B -0.0163442
METAP1 methionyl aminopeptidase 1 -0.016319
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0162925
TBL1X transducin (beta)-like 1X-linked -0.0162783
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -0.0161661
UBE3A ubiquitin protein ligase E3A -0.0161115
FAM78A family with sequence similarity 78, member A -0.016097
EXOC6B exocyst complex component 6B -0.0160955
RPS17 ribosomal protein S17 -0.0160293
WDR7 WD repeat domain 7 -0.0159404
PGK1 phosphoglycerate kinase 1 -0.0158928
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0158797
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0158603
ERCC3 excision repair cross-complementation group 3 -0.0158586
SCAF4 SR-related CTD-associated factor 4 -0.015825
LRP5 low density lipoprotein receptor-related protein 5 -0.0158153
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0158021
PRC1 protein regulator of cytokinesis 1 -0.0157847
TBL2 transducin (beta)-like 2 -0.0157767
CDK19 cyclin-dependent kinase 19 -0.0157554
CHD9 chromodomain helicase DNA binding protein 9 -0.0157423
EML4 echinoderm microtubule associated protein like 4 -0.0157083
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -0.0156967
SEC24A SEC24 family member A -0.0156854
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0156578
KYNU kynureninase -0.0156411
LONP1 lon peptidase 1, mitochondrial -0.0156189
EVL Enah/Vasp-like -0.0156085
KIAA2026 KIAA2026 -0.01557
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) -0.0155169
DPP7 dipeptidyl-peptidase 7 -0.0155078
PARG poly (ADP-ribose) glycohydrolase -0.0154433
SEC11A SEC11 homolog A (S. cerevisiae) -0.0154233
NT5C2 5'-nucleotidase, cytosolic II -0.0154105
ZNF721 zinc finger protein 721 -0.0153708
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -0.0153233
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0153014
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.0152926
SOGA1 suppressor of glucose, autophagy associated 1 -0.0152843
TMEM50A transmembrane protein 50A -0.0152786
FAR1 fatty acyl CoA reductase 1 -0.0152306
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0152262
TBCA tubulin folding cofactor A -0.0152166
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -0.0151871
CHPT1 choline phosphotransferase 1 -0.0151789
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -0.0151558
PTPRB protein tyrosine phosphatase, receptor type, B -0.0151503
COX5B cytochrome c oxidase subunit Vb -0.015146
KIF14 kinesin family member 14 -0.0151029
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0150843
EFR3A EFR3 homolog A (S. cerevisiae) -0.0150741
RARS2 arginyl-tRNA synthetase 2, mitochondrial -0.015027
CENPN centromere protein N -0.0150228
CPOX coproporphyrinogen oxidase -0.0150109
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0150072
AHCYL2 adenosylhomocysteinase-like 2 -0.0150034
SELENOO selenoprotein O -0.0150011
SQSTM1 sequestosome 1 -0.0149994
COPA coatomer protein complex, subunit alpha -0.0149975
SSH1 slingshot protein phosphatase 1 -0.0149931
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0149872
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -0.014985
NFIB nuclear factor I/B -0.0149568
NCOA7 nuclear receptor coactivator 7 -0.0149459
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -0.0149203
SLC19A1 solute carrier family 19 (folate transporter), member 1 -0.0149078
SF3A2 splicing factor 3a, subunit 2, 66kDa -0.0148822
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0148752
CMC4 C-x(9)-C motif containing 4 -0.0148561
ZCCHC17 zinc finger, CCHC domain containing 17 -0.0148468
SS18 synovial sarcoma translocation, chromosome 18 -0.0148078
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0147559
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0147293
NUMB numb homolog (Drosophila) -0.0147045
ZNF407 zinc finger protein 407 -0.0147039
TOM1L1 target of myb1 (chicken)-like 1 -0.0146611
DENND1A DENN/MADD domain containing 1A -0.0146549
FBXL2 F-box and leucine-rich repeat protein 2 -0.01461
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0145875
TRAF3 TNF receptor-associated factor 3 -0.0145593
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0145588
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.0145536
WDR62 WD repeat domain 62 -0.0145206
PTER phosphotriesterase related -0.0145105
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0144631
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0144324
SRGN serglycin -0.0144312
NELFB negative elongation factor complex member B -0.0144184
GGT7 gamma-glutamyltransferase 7 -0.0143722
PCDHB16 protocadherin beta 16 -0.0143539
FRMD8 FERM domain containing 8 -0.0143393
STIM1 stromal interaction molecule 1 -0.0143249
ERCC8 excision repair cross-complementation group 8 -0.014303
MCM4 minichromosome maintenance complex component 4 -0.0142632
TOP1 topoisomerase (DNA) I -0.0142564
PBRM1 polybromo 1 -0.0142322
RIC8B RIC8 guanine nucleotide exchange factor B -0.0141973
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0141746
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0141701
GARRE1 granule associated Rac and RHOG effector 1 -0.0141617
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0141142
DSTYK dual serine/threonine and tyrosine protein kinase -0.0141016
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -0.014092
HIP1 huntingtin interacting protein 1 -0.0140622
BRIX1 BRX1, biogenesis of ribosomes -0.0140515
VKORC1 vitamin K epoxide reductase complex, subunit 1 -0.014029
DLG1 discs, large homolog 1 (Drosophila) -0.013982
DPH5 diphthamide biosynthesis 5 -0.0139785
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0139485
ESR1 estrogen receptor 1 -0.0139462
TBCE tubulin folding cofactor E -0.0139283
ECE1 endothelin converting enzyme 1 -0.0138934
ZNF175 zinc finger protein 175 -0.0138501
MYO6 myosin VI -0.0138277
UGDH UDP-glucose 6-dehydrogenase -0.0138258
SIRT2 sirtuin 2 -0.0137998
AFF4 AF4/FMR2 family, member 4 -0.0137978
CDC25C cell division cycle 25C -0.013787
CFAP161 cilia and flagella associated protein 161 -0.0137731
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -0.0137665
MECP2 methyl CpG binding protein 2 -0.0137534
FAF2 Fas associated factor family member 2 -0.0137528
TXNRD2 thioredoxin reductase 2 -0.0137453
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -0.0137314
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0137176
TENT2 terminal nucleotidyltransferase 2 -0.013716
YEATS2 YEATS domain containing 2 -0.0137093
PUM3 pumilio RNA binding family member 3 -0.0137044
RNF144A ring finger protein 144A -0.0136885
SBF2 SET binding factor 2 -0.0136814
MYO16 myosin XVI -0.0136429
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0136028
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0135884
TATDN1 TatD DNase domain containing 1 -0.0135779
ADNP activity-dependent neuroprotector homeobox -0.0135727
USP37 ubiquitin specific peptidase 37 -0.013537