K562_Alendronate sodium trihydrate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 100nM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_Alendronate sodium trihydrate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
XPO1 exportin 1 0.106673
FGF13 fibroblast growth factor 13 0.0897449
ZMYND8 zinc finger, MYND-type containing 8 0.0792856
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0770832
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0765693
PRKCA protein kinase C, alpha 0.0657586
RPLP1 ribosomal protein, large, P1 0.0644591
RAD51B RAD51 paralog B 0.0643171
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0618389
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0578156
ANKRD17 ankyrin repeat domain 17 0.0573928
HBG2 hemoglobin, gamma G 0.0561119
ZNF800 zinc finger protein 800 0.0515775
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0515727
ENO1 enolase 1, (alpha) 0.0510767
LOC112694756 uncharaterized LOC112694756 0.0503484
ELOVL6 ELOVL fatty acid elongase 6 0.0499053
LIMS1 LIM and senescent cell antigen-like domains 1 0.0496331
FRYL FRY-like 0.0490628
CNOT10 CCR4-NOT transcription complex, subunit 10 0.0488469
ADGRV1 adhesion G protein-coupled receptor V1 0.0484812
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0482972
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.04774
NSD2 nuclear receptor binding SET domain protein 2 0.0468057
TLK1 tousled-like kinase 1 0.0462848
RPS18 ribosomal protein S18 0.045826
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0446881
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0446109
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0440632
RICTOR RPTOR independent companion of MTOR, complex 2 0.0436973
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0436926
CANX calnexin 0.0426286
FOXO3 forkhead box O3 0.0423887
RPLP0 ribosomal protein, large, P0 0.042053
MACF1 microtubule-actin crosslinking factor 1 0.0420301
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0416861
HSPG2 heparan sulfate proteoglycan 2 0.040533
TXN2 thioredoxin 2 0.0399447
ATAD5 ATPase family, AAA domain containing 5 0.0397695
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0394663
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.0393957
IPO11 importin 11 0.0393492
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0382045
KRT8 keratin 8, type II 0.038109
FLOT2 flotillin 2 0.038076
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0379469
TNRC6A trinucleotide repeat containing 6A 0.0378618
SRP72 signal recognition particle 72kDa 0.037665
TUBA1B tubulin, alpha 1b 0.0374445
AVL9 AVL9 homolog (S. cerevisiase) 0.0371453
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.0369205
INSIG1 insulin induced gene 1 0.0362293
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0361618
ARHGAP6 Rho GTPase activating protein 6 0.0359244
DSG2 desmoglein 2 0.0356976
MKI67 marker of proliferation Ki-67 0.0355361
ESRRB estrogen-related receptor beta 0.0355299
HBE1 hemoglobin, epsilon 1 0.0352996
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0351549
C21ORF58 chromosome 21 open reading frame 58 0.0350674
HIP1 huntingtin interacting protein 1 0.0348548
PTK2B protein tyrosine kinase 2 beta 0.0348304
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0347529
EPB41 erythrocyte membrane protein band 4.1 0.0347439
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.0347358
RPL32 ribosomal protein L32 0.0346321
IGF2R insulin-like growth factor 2 receptor 0.034525
GATAD2B GATA zinc finger domain containing 2B 0.0342896
BABAM2 BRISC and BRCA1 A complex member 2 0.034
RHAG Rh-associated glycoprotein 0.0339942
CR1L complement component (3b/4b) receptor 1-like 0.03375
KLHL22 kelch-like family member 22 0.0335195
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.0334384
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0330733
PRR11 proline rich 11 0.0326883
GOLGB1 golgin B1 0.0326489
SNAP29 synaptosomal-associated protein, 29kDa 0.0326285
RPL15 ribosomal protein L15 0.0322279
RORA RAR-related orphan receptor A 0.0321263
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0320503
RTN3 reticulon 3 0.0319686
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.031944
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0318391
RPS3 ribosomal protein S3 0.0318041
PKN1 protein kinase N1 0.031726
FTH1 ferritin, heavy polypeptide 1 0.0314624
RBM25 RNA binding motif protein 25 0.0311596
BRCA2 breast cancer 2, early onset 0.0309912
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0309191
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.0308356
KHSRP KH-type splicing regulatory protein 0.0308276
RPS23 ribosomal protein S23 0.0307344
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.0306911
RPS12 ribosomal protein S12 0.0305703
MAP4 microtubule-associated protein 4 0.0305475
UBB ubiquitin B 0.0304718
MSI2 musashi RNA-binding protein 2 0.0303064
MRPL37 mitochondrial ribosomal protein L37 0.0300974
CD63 CD63 molecule 0.0300889
STEAP1B STEAP family member 1B 0.0300425
EXOC4 exocyst complex component 4 0.0299419
SFTPA2 surfactant protein A2 0.0296342
LARP1 La ribonucleoprotein domain family, member 1 0.0294121
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.0291712
BTBD7 BTB (POZ) domain containing 7 0.0291705
CSNK1D casein kinase 1, delta 0.0291671
RPL12 ribosomal protein L12 0.0291403
MLXIP MLX interacting protein 0.0291271
CAND1 cullin-associated and neddylation-dissociated 1 0.0290046
HM13 histocompatibility (minor) 13 0.0289975
RPL30 ribosomal protein L30 0.0287467
HCFC1 host cell factor C1 0.0287051
CNTNAP2 contactin associated protein-like 2 0.0286008
EZR ezrin 0.0282865
SSR1 signal sequence receptor, alpha 0.0282286
ANO10 anoctamin 10 0.0281916
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0280408
ESYT2 extended synaptotagmin-like protein 2 0.0279686
RPL18 ribosomal protein L18 0.027946
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0279142
RFWD3 ring finger and WD repeat domain 3 0.0276782
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.0276165
CENPE centromere protein E, 312kDa 0.0274631
TKT transketolase 0.0274538
RAB31 RAB31, member RAS oncogene family 0.0273574
POU6F2 POU class 6 homeobox 2 0.0273504
NUMB numb homolog (Drosophila) 0.0273238
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0272923
RAI1 retinoic acid induced 1 0.0272673
USP9X ubiquitin specific peptidase 9, X-linked 0.0272162
U2SURP U2 snRNP-associated SURP domain containing 0.0271657
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0271611
TPM4 tropomyosin 4 0.0270982
PDIA3 protein disulfide isomerase family A, member 3 0.026922
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0269172
LRP5 low density lipoprotein receptor-related protein 5 0.026821
PCDH9 protocadherin 9 0.0267301
NECTIN2 nectin cell adhesion molecule 2 0.0267257
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 0.0266895
SPIDR scaffolding protein involved in DNA repair 0.0266846
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0266069
AIG1 androgen-induced 1 0.0265989
ZGRF1 zinc finger, GRF-type containing 1 0.0261394
ZYG11B zyg-11 family member B, cell cycle regulator 0.0261032
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0260077
FBXO42 F-box protein 42 0.0259046
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0258863
TTF1 transcription termination factor, RNA polymerase I 0.0258652
MYO1F myosin IF 0.0258595
SRBD1 S1 RNA binding domain 1 0.02573
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0256544
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0256425
ABHD12 abhydrolase domain containing 12 0.0256333
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0256091
PHIP pleckstrin homology domain interacting protein 0.0255642
H1-10 H1.10 linker histone 0.025431
SACK1A scaffolding CK1 anchoring protein A 0.0254039
PHF14 PHD finger protein 14 0.0253864
TTLL10 tubulin tyrosine ligase-like family member 10 0.0253556
BAIAP2L1 BAI1-associated protein 2-like 1 0.0253334
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0252924
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.0252039
HDAC1 histone deacetylase 1 0.0251835
PRRC2C proline-rich coiled-coil 2C 0.0251401
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0249974
BRD4 bromodomain containing 4 0.0249659
BRCA1 breast cancer 1, early onset 0.0249269
TMEM232 transmembrane protein 232 0.0247605
ERGIC3 ERGIC and golgi 3 0.0247105
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0247025
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.024689
SFMBT2 Scm-like with four mbt domains 2 0.0246635
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.024627
AHI1 Abelson helper integration site 1 0.0244904
MSN moesin 0.0244359
FANCA Fanconi anemia, complementation group A 0.0243976
CBFB core-binding factor, beta subunit 0.0243893
DCAKD dephospho-CoA kinase domain containing 0.0243738
PPHLN1 periphilin 1 0.0243076
OXSR1 oxidative stress responsive 1 0.024268
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0242491
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0242069
PHKB phosphorylase kinase, beta 0.0241694
NUP153 nucleoporin 153kDa 0.0241424
DCAF16 DDB1 and CUL4 associated factor 16 0.0241155
RPLP2 ribosomal protein, large, P2 0.0240927
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.0240011
MFGE8 milk fat globule-EGF factor 8 protein 0.023958
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0239307
POTEF POTE ankyrin domain family, member F 0.0238995
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0237772
H1-2 H1.2 linker histone, cluster member 0.0237712
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0237422
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0236945
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0236184
DYM dymeclin 0.0236137
OGA O-GlcNAcase 0.0236117
KLHL20 kelch-like family member 20 0.0235716
CUL1 cullin 1 0.0234527
FNDC3B fibronectin type III domain containing 3B 0.0234349
CTSC cathepsin C 0.0233978
MYO18A myosin XVIIIA 0.0233075
ACIN1 apoptotic chromatin condensation inducer 1 0.0232881
PHF12 PHD finger protein 12 0.0232767
UBE2K ubiquitin-conjugating enzyme E2K 0.0232623
SEPTIN6 septin 6 0.0232557
AQR aquarius intron-binding spliceosomal factor 0.0232102
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0231698
VDAC2 voltage-dependent anion channel 2 0.0231447
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0230278
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.023025
ANKRD10 ankyrin repeat domain 10 0.0230231
DMD dystrophin 0.022978
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.0229606
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0228608
PICALM phosphatidylinositol binding clathrin assembly protein 0.0228387
HBG1 hemoglobin, gamma A 0.0227775
FOXJ3 forkhead box J3 0.022772
KIF13B kinesin family member 13B 0.0227286
TMEM135 transmembrane protein 135 0.0227255
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0227076
RSBN1 round spermatid basic protein 1 0.0227022
RBL1 retinoblastoma-like 1 0.0225929
CLIC1 chloride intracellular channel 1 0.0225276
MRE11 MRE11 homolog, double strand break repair nuclease 0.0224746
SERF2 small EDRK-rich factor 2 0.0224678
RNF24 ring finger protein 24 0.0224645
BMAL2 basic helix-loop-helix ARNT like 2 0.0224318
AKAP10 A kinase (PRKA) anchor protein 10 0.022429
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0223589
CCDC47 coiled-coil domain containing 47 0.0223195
NCAPG non-SMC condensin I complex, subunit G 0.0223019
SPNS1 spinster homolog 1 (Drosophila) 0.0222924
STIM1 stromal interaction molecule 1 0.0222533
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0222061
SP3 Sp3 transcription factor 0.0221533
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0221408
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0221201
BTNL9 butyrophilin-like 9 0.0220607
CCDC138 coiled-coil domain containing 138 0.0220545
CDC42SE2 CDC42 small effector 2 0.0220052
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0219095
MRPL13 mitochondrial ribosomal protein L13 0.0218584
METTL15 methyltransferase like 15 0.0218522
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0218345
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0218299
GDE1 glycerophosphodiester phosphodiesterase 1 0.0217719
MAN2B1 mannosidase, alpha, class 2B, member 1 0.0217672
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.0217671
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0217506
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.0216753
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0216606
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0216432
MMS22L MMS22-like, DNA repair protein 0.0216062
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.0216038
PRKCB protein kinase C, beta 0.021602
AGGF1 angiogenic factor with G patch and FHA domains 1 0.0214206
ARHGAP25 Rho GTPase activating protein 25 0.0213981
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0213623
H3-3B H3.3 histone B 0.0213467
KMT2A lysine (K)-specific methyltransferase 2A 0.0213138
POU2F1 POU class 2 homeobox 1 0.0212993
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.0212929
SNW1 SNW domain containing 1 0.0212658
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 0.021263
BRI3BP BRI3 binding protein 0.0212348
TRIM37 tripartite motif containing 37 0.0211231
RPL10A ribosomal protein L10a 0.0211186
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0210868
EIF4B eukaryotic translation initiation factor 4B 0.0210236
GPATCH2L G patch domain containing 2-like 0.0210012
F11R F11 receptor 0.020968
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.020943
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0209006
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0208971
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0208947
ZMIZ1 zinc finger, MIZ-type containing 1 0.020873
ANKRD28 ankyrin repeat domain 28 0.0208705
FBXL13 F-box and leucine-rich repeat protein 13 0.0208504
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0207977
GPR137 G protein-coupled receptor 137 0.0207621
CDC45 cell division cycle 45 0.0207211
C1RL complement component 1, r subcomponent-like 0.0207065
PUS7 pseudouridylate synthase 7 (putative) 0.020706
SLC38A5 solute carrier family 38, member 5 0.0206721
LMBR1 limb development membrane protein 1 0.0206684
ADGRE5 adhesion G protein-coupled receptor E5 0.020565
FDPS farnesyl diphosphate synthase 0.0205622
TMEM192 transmembrane protein 192 0.0205207
SPTBN2 spectrin, beta, non-erythrocytic 2 0.0204829
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.02046
CLYBL citrate lyase beta like 0.0204557
CLCN3 chloride channel, voltage-sensitive 3 0.0203565
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 0.0202805
RAB14 RAB14, member RAS oncogene family 0.0202521
INTS7 integrator complex subunit 7 0.0202485
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.0202423
RNF38 ring finger protein 38 0.0202011
WDR43 WD repeat domain 43 0.0201884
ZNF251 zinc finger protein 251 0.0201671
STON2 stonin 2 0.020164
RPL28 ribosomal protein L28 0.02014
IREB2 iron-responsive element binding protein 2 0.0200987
SLC35E1 solute carrier family 35, member E1 0.0200983
RAD21 RAD21 homolog (S. pombe) 0.0200644
DENND5A DENN/MADD domain containing 5A 0.0200248
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0200188
FAM78A family with sequence similarity 78, member A 0.0199622
SLC35A4 solute carrier family 35, member A4 0.0198855
LRRC8B leucine rich repeat containing 8 family, member B 0.0198416
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0196928
DCAF7 DDB1 and CUL4 associated factor 7 0.0196839
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.0196593
SMC4 structural maintenance of chromosomes 4 0.019611
COTL1 coactosin-like F-actin binding protein 1 0.0195933
REPS1 RALBP1 associated Eps domain containing 1 0.019547
IFNGR1 interferon gamma receptor 1 0.0194875
FAM222B family with sequence similarity 222, member B 0.0194588
MOB1B MOB kinase activator 1B 0.01939
CD44 CD44 molecule (Indian blood group) 0.0193881
ZNF33A zinc finger protein 33A 0.019372
ATP5MC3 ATP synthase membrane subunit c locus 3 0.0193568
SRRM1 serine/arginine repetitive matrix 1 0.0193305
EVI5 ecotropic viral integration site 5 0.019316
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0192727
BCLAF1 BCL2-associated transcription factor 1 0.0192435
PHF21A PHD finger protein 21A 0.0192392
KIAA1328 KIAA1328 0.019239
IST1 increased sodium tolerance 1 homolog (yeast) 0.0192129
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.0191236
STK26 serine/threonine protein kinase 26 0.0191189
CORO1C coronin, actin binding protein, 1C 0.0190997
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0190823
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0190822
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0190635
SLC30A9 solute carrier family 30 (zinc transporter), member 9 0.0190567
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0190239
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.01895
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0189454
ATF6 activating transcription factor 6 0.0189288
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0188748
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0188669
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0188663
CEP104 centrosomal protein 104kDa 0.0188256
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0187759
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0187708
SDF4 stromal cell derived factor 4 0.0187442
LDB2 LIM domain binding 2 0.0187117
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0186989
ZNF623 zinc finger protein 623 0.0186721
CST3 cystatin C 0.0186534
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0186484
TACC1 transforming, acidic coiled-coil containing protein 1 0.0185863
ICMT isoprenylcysteine carboxyl methyltransferase 0.0185743
PRELID2 PRELI domain containing 2 0.0185535
RCOR1 REST corepressor 1 0.0185235
IL10RB interleukin 10 receptor, beta 0.0184978
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.018495
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 0.0184831
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0184639
PA2G4 proliferation-associated 2G4, 38kDa 0.0184433
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.018428
ZNF100 zinc finger protein 100 0.0183862
RNFT2 ring finger protein, transmembrane 2 0.0183828
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.018365
NUP155 nucleoporin 155kDa 0.0183318
USP45 ubiquitin specific peptidase 45 0.0183121
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0183075
RPL4 ribosomal protein L4 0.0182762
RPS11 ribosomal protein S11 0.018269
DUT deoxyuridine triphosphatase 0.0182649
ACVR2B activin A receptor, type IIB 0.0182615
NCKIPSD NCK interacting protein with SH3 domain 0.0182593
EDC3 enhancer of mRNA decapping 3 0.0182168
TMOD1 tropomodulin 1 0.0180798
RPS21 ribosomal protein S21 0.0180778
BLM Bloom syndrome, RecQ helicase-like 0.0180327
FER fer (fps/fes related) tyrosine kinase 0.0180325
PUM1 pumilio RNA-binding family member 1 0.0180099
LYPLA1 lysophospholipase I 0.0179603
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0179373
TMOD3 tropomodulin 3 (ubiquitous) 0.0179211
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0179162
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0178902
MARCHF7 membrane associated ring-CH-type finger 7 0.0178676
RCSD1 RCSD domain containing 1 0.0178222
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.017814
TXNIP thioredoxin interacting protein 0.0177617
IGF1 insulin-like growth factor 1 (somatomedin C) 0.0177581
ZNF638 zinc finger protein 638 0.0177512
TTF2 transcription termination factor, RNA polymerase II 0.0177504
AURKB aurora kinase B 0.0177417
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.017725
ZNF518B zinc finger protein 518B 0.0177059
EXOC6 exocyst complex component 6 0.0176905
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.017687
NSD3 nuclear receptor binding SET domain protein 3 0.0176274
AK1 adenylate kinase 1 0.0175251
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0175018
EXO1 exonuclease 1 0.0174851
ELP2 elongator acetyltransferase complex subunit 2 0.0174332
SFXN1 sideroflexin 1 0.0173724
AXIN1 axin 1 0.0173691
EDARADD EDAR-associated death domain 0.0173651
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0173408
SOCS4 suppressor of cytokine signaling 4 0.017337
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0173347
RNF145 ring finger protein 145 0.017305
CALR calreticulin 0.0172995
PTH2R parathyroid hormone 2 receptor 0.0172667
GSTP1 glutathione S-transferase pi 1 0.0172112
MAST2 microtubule associated serine/threonine kinase 2 0.0171269
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0171174
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0171148
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.0170965
GTF2A2 general transcription factor IIA, 2, 12kDa 0.0170961
COG4 component of oligomeric golgi complex 4 0.017096
NUP98 nucleoporin 98kDa 0.0170735
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.0170694
SRSF10 serine/arginine-rich splicing factor 10 0.0170553
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0170545
HSDL2 hydroxysteroid dehydrogenase like 2 0.017047
URM1 ubiquitin related modifier 1 0.0170459
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.0170412
HMBOX1 homeobox containing 1 0.0170333
LAPTM4B lysosomal protein transmembrane 4 beta 0.0170244
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0170189
MUC1 mucin 1, cell surface associated 0.0170062
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0169972
SNAP23 synaptosomal-associated protein, 23kDa 0.0169845
CKAP2 cytoskeleton associated protein 2 0.0169592
CADM2 cell adhesion molecule 2 0.0169337
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.0169035
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.016882
ERBIN erbb2 interacting protein 0.0168263
WDFY3 WD repeat and FYVE domain containing 3 0.0168012
ARRDC3 arrestin domain containing 3 0.0167927
HMGN1 high mobility group nucleosome binding domain 1 0.0167894
STMN3 stathmin-like 3 0.0167005
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0166937
HDLBP high density lipoprotein binding protein 0.0166923
CENPF centromere protein F, 350/400kDa 0.0166787
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.016671
HOOK2 hook microtubule-tethering protein 2 0.0166494
C19ORF12 chromosome 19 open reading frame 12 0.0166397
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0166344
PAIP2 poly(A) binding protein interacting protein 2 0.0166008
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.0165738
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0165463
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0165276
LETMD1 LETM1 domain containing 1 0.016518
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 0.0164775
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0164576
TPGS2 tubulin polyglutamylase complex subunit 2 0.0164496
ATXN7L1 ataxin 7-like 1 0.0164409
DENND1A DENN/MADD domain containing 1A 0.0164391
MTX2 metaxin 2 0.0164081
FERMT3 fermitin family member 3 0.0163847
FAM120B family with sequence similarity 120B 0.016373
ZNF282 zinc finger protein 282 0.0163698
SCLT1 sodium channel and clathrin linker 1 0.0163617
CREM cAMP responsive element modulator 0.0163599
MRPS27 mitochondrial ribosomal protein S27 0.0163301
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.0162979
TNIP1 TNFAIP3 interacting protein 1 0.0162829
TOR1AIP2 torsin A interacting protein 2 0.0162611
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 0.0162572
DHRS7B dehydrogenase/reductase (SDR family) member 7B 0.0162511
SPATA5L1 spermatogenesis associated 5-like 1 0.016225
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.0162058
EIF3K eukaryotic translation initiation factor 3, subunit K 0.0162037
UFD1 ubiquitin recognition factor in ER associated degradation 1 0.016182
MEGF9 multiple EGF-like-domains 9 0.0161553
RBMX RNA binding motif protein, X-linked 0.0161232
MTMR9 myotubularin related protein 9 0.0161209
LRRC28 leucine rich repeat containing 28 0.016082
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0160676
EMP3 epithelial membrane protein 3 0.0160234
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0160164
ZC3H7A zinc finger CCCH-type containing 7A 0.0159991
PIH1D1 PIH1 domain containing 1 0.0159764
CREB1 cAMP responsive element binding protein 1 0.0159736
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0159655
SETX senataxin 0.0159645
TAPBP TAP binding protein (tapasin) 0.0159487
WDR82 WD repeat domain 82 0.0159429
RPS28 ribosomal protein S28 0.0159352
SLC35F2 solute carrier family 35, member F2 0.0158944
LBR lamin B receptor 0.0158644
ARTN artemin 0.0158485
RAB4A RAB4A, member RAS oncogene family 0.0158163
CSDE1 cold shock domain containing E1, RNA-binding 0.0157958
CEP152 centrosomal protein 152kDa 0.0157518
CCDC9 coiled-coil domain containing 9 0.0157501
USP37 ubiquitin specific peptidase 37 0.0157237
USP47 ubiquitin specific peptidase 47 0.0157036
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0156897
GGNBP2 gametogenetin binding protein 2 0.0156706
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.0156677
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.0156483

decreased expression

Symbol Name Standardized Value
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0987604
ARL15 ADP-ribosylation factor-like 15 -0.0927374
SMYD3 SET and MYND domain containing 3 -0.0699838
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0675636
SEC31A SEC31 homolog A (S. cerevisiae) -0.0646781
FHIT fragile histidine triad -0.0603812
RABGAP1L RAB GTPase activating protein 1-like -0.0587945
KMT2C lysine (K)-specific methyltransferase 2C -0.0575839
ANTXR2 anthrax toxin receptor 2 -0.0569614
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0562964
LTBP1 latent transforming growth factor beta binding protein 1 -0.0518922
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0504509
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0500752
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.049977
MED13L mediator complex subunit 13-like -0.0499291
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0498404
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0471752
TOP1 topoisomerase (DNA) I -0.0470163
TUT4 terminal uridylyl transferase 4 -0.0466844
SRPK2 SRSF protein kinase 2 -0.0466345
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0441305
TPX2 TPX2, microtubule-associated -0.0441016
MBNL2 muscleblind-like splicing regulator 2 -0.0435867
CCNY cyclin Y -0.0434972
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0433319
NUP205 nucleoporin 205kDa -0.0430241
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0418566
COG5 component of oligomeric golgi complex 5 -0.0412573
TRIM24 tripartite motif containing 24 -0.0411701
CUX1 cut-like homeobox 1 -0.0410581
MEIS2 Meis homeobox 2 -0.0407564
MCU mitochondrial calcium uniporter -0.040715
MAPK1 mitogen-activated protein kinase 1 -0.0405059
ZFAND3 zinc finger, AN1-type domain 3 -0.0401896
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0399541
SETD2 SET domain containing 2 -0.0396294
FAM171A1 family with sequence similarity 171, member A1 -0.0395231
ACACA acetyl-CoA carboxylase alpha -0.0392384
JARID2 jumonji, AT rich interactive domain 2 -0.0382179
GSK3B glycogen synthase kinase 3 beta -0.0380673
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0379475
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0378176
CEP85L centrosomal protein 85kDa-like -0.0377406
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0369832
ELOVL5 ELOVL fatty acid elongase 5 -0.036812
TBC1D5 TBC1 domain family, member 5 -0.0364983
ASPH aspartate beta-hydroxylase -0.0362684
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0360066
DLG1 discs, large homolog 1 (Drosophila) -0.0358373
TNPO2 transportin 2 -0.0353416
SGMS1 sphingomyelin synthase 1 -0.0352628
AP2A1 adaptor-related protein complex 2, alpha 1 subunit -0.0347227
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0342673
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0342031
TTC27 tetratricopeptide repeat domain 27 -0.0341687
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.0341165
DSTYK dual serine/threonine and tyrosine protein kinase -0.0340665
SREBF2 sterol regulatory element binding transcription factor 2 -0.0340316
ERI3 ERI1 exoribonuclease family member 3 -0.033982
GAB2 GRB2-associated binding protein 2 -0.0338064
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0337992
SF3A3 splicing factor 3a, subunit 3, 60kDa -0.0337319
ARID1B AT rich interactive domain 1B (SWI1-like) -0.033616
KDM2A lysine (K)-specific demethylase 2A -0.0334736
KCTD20 potassium channel tetramerization domain containing 20 -0.03344
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0332904
RAB7A RAB7A, member RAS oncogene family -0.0331262
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0330879
CYRIB CYFIP related Rac1 interactor B -0.0330672
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0330569
PHACTR4 phosphatase and actin regulator 4 -0.0327262
GMDS GDP-mannose 4,6-dehydratase -0.0326623
GTF2I general transcription factor IIi -0.0324896
RAB10 RAB10, member RAS oncogene family -0.032393
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0323573
UBE2H ubiquitin-conjugating enzyme E2H -0.0320991
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0320404
TPST2 tyrosylprotein sulfotransferase 2 -0.0319296
RHEB Ras homolog enriched in brain -0.0317705
CNKSR3 CNKSR family member 3 -0.0317674
ARRB1 arrestin, beta 1 -0.0317502
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0316948
PDE3B phosphodiesterase 3B, cGMP-inhibited -0.0316895
WAC WW domain containing adaptor with coiled-coil -0.0314504
CAB39 calcium binding protein 39 -0.0313951
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0312613
GATAD2A GATA zinc finger domain containing 2A -0.0308493
R3HDM2 R3H domain containing 2 -0.0306122
CEP350 centrosomal protein 350kDa -0.0305672
AHCTF1 AT hook containing transcription factor 1 -0.0299756
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0298654
USP15 ubiquitin specific peptidase 15 -0.0298225
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0298223
KMT2E lysine (K)-specific methyltransferase 2E -0.0297383
SOS1 son of sevenless homolog 1 (Drosophila) -0.0296833
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0294657
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.02937
UBE3D ubiquitin protein ligase E3D -0.0293032
DHDDS dehydrodolichyl diphosphate synthase -0.0292367
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0290531
UBE4B ubiquitination factor E4B -0.0288981
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0287257
SLC38A1 solute carrier family 38, member 1 -0.0284748
PLCL1 phospholipase C-like 1 -0.028287
STAG2 stromal antigen 2 -0.0282136
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0279763
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0277191
RPAP2 RNA polymerase II associated protein 2 -0.0275496
MYO1D myosin ID -0.027502
NPTN neuroplastin -0.0270591
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.027041
EEA1 early endosome antigen 1 -0.0268811
CSNK1A1 casein kinase 1, alpha 1 -0.0268066
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.026782
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0266774
BCAS3 breast carcinoma amplified sequence 3 -0.0266572
DENND4C DENN/MADD domain containing 4C -0.0264929
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0264053
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.026336
GLUL glutamate-ammonia ligase -0.0262881
KDM6A lysine (K)-specific demethylase 6A -0.0262807
PUM3 pumilio RNA binding family member 3 -0.0261828
SQLE squalene epoxidase -0.0261468
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -0.0260112
CHD6 chromodomain helicase DNA binding protein 6 -0.0258599
DNAAF9 dynein axonemal assembly factor 9 -0.0258186
COP1 COP1 E3 ubiquitin ligase -0.0256882
MAP1B microtubule-associated protein 1B -0.0254556
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0254115
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0253154
DST dystonin -0.0252934
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -0.0252576
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.0251984
ADGRB3 adhesion G protein-coupled receptor B3 -0.0250174
SSBP3 single stranded DNA binding protein 3 -0.025016
ANKRD11 ankyrin repeat domain 11 -0.0250153
CDC14A cell division cycle 14A -0.0249658
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0249112
TAOK3 TAO kinase 3 -0.0248655
IMMT inner membrane protein, mitochondrial -0.024833
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0247921
AMBRA1 autophagy/beclin-1 regulator 1 -0.0246936
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0246638
USP24 ubiquitin specific peptidase 24 -0.0246352
NCALD neurocalcin delta -0.0246178
PIAS1 protein inhibitor of activated STAT, 1 -0.024576
TMCC1 transmembrane and coiled-coil domain family 1 -0.024548
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0245119
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0243587
RBM15 RNA binding motif protein 15 -0.0241564
RTN4 reticulon 4 -0.0240866
ZBTB38 zinc finger and BTB domain containing 38 -0.0240614
CENPP centromere protein P -0.0240335
GTF2IRD1 GTF2I repeat domain containing 1 -0.0239982
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.023924
TMEM131 transmembrane protein 131 -0.0238391
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0236699
FAR1 fatty acyl CoA reductase 1 -0.0236105
RPL22 ribosomal protein L22 -0.0236095
ARHGAP18 Rho GTPase activating protein 18 -0.0235761
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0234669
CEP192 centrosomal protein 192kDa -0.023434
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -0.023375
TNRC6B trinucleotide repeat containing 6B -0.0233534
TEX2 testis expressed 2 -0.023335
VWDE von Willebrand factor D and EGF domains -0.0232436
REEP3 receptor accessory protein 3 -0.0232116
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0231949
DGKH diacylglycerol kinase, eta -0.0231562
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0231224
TMEM120B transmembrane protein 120B -0.0230979
BICRAL BICRA like chromatin remodeling complex associated protein -0.02299
CEP170 centrosomal protein 170kDa -0.0229669
RHBDD2 rhomboid domain containing 2 -0.0229555
PRKX protein kinase, X-linked -0.0228782
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.022844
MYO16 myosin XVI -0.0228211
AAGAB alpha- and gamma-adaptin binding protein -0.0227259
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0226768
PRR16 proline rich 16 -0.0225665
MTDH metadherin -0.0224092
SATB2 SATB homeobox 2 -0.0223713
TTC28 tetratricopeptide repeat domain 28 -0.0223234
CPEB1 cytoplasmic polyadenylation element binding protein 1 -0.0222832
CFH complement factor H -0.0222577
METAP1 methionyl aminopeptidase 1 -0.0222057
MYO19 myosin XIX -0.0221769
XPO5 exportin 5 -0.0219517
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0219254
FOXP1 forkhead box P1 -0.0219104
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -0.0218381
ZC3HC1 zinc finger, C3HC-type containing 1 -0.0218362
FLNA filamin A, alpha -0.0218212
RELN reelin -0.0217984
RNASE12 ribonuclease, RNase A family, 12 (non-active) -0.021782
GSPT1 G1 to S phase transition 1 -0.0217085
NRF1 nuclear respiratory factor 1 -0.0217047
DOCK11 dedicator of cytokinesis 11 -0.0217015
SENP7 SUMO1/sentrin specific peptidase 7 -0.0216594
AOPEP aminopeptidase O (putative) -0.0216154
CCND3 cyclin D3 -0.0215949
RFX7 regulatory factor X, 7 -0.0215283
IARS1 isoleucyl-tRNA synthetase 1 -0.0215239
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0215028
MYO3B myosin IIIB -0.0214619
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.021373
SOS2 son of sevenless homolog 2 (Drosophila) -0.02136
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0212823
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0212456
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.020983
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0208983
RNF169 ring finger protein 169 -0.0208498
SFXN5 sideroflexin 5 -0.0208115
SARS2 seryl-tRNA synthetase 2, mitochondrial -0.020785
DNM2 dynamin 2 -0.0207027
NT5DC1 5'-nucleotidase domain containing 1 -0.0206657
TMEM44 transmembrane protein 44 -0.0205413
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -0.020469
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0204493
FLAD1 flavin adenine dinucleotide synthetase 1 -0.0203924
WASHC4 WASH complex subunit 4 -0.0203768
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0203646
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.0203345
RPL3 ribosomal protein L3 -0.0203104
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0202179
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0201017
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.0200273
CHD4 chromodomain helicase DNA binding protein 4 -0.020015
DIAPH3 diaphanous-related formin 3 -0.0199281
PDE4A phosphodiesterase 4A, cAMP-specific -0.0198694
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0198643
ACSM3 acyl-CoA synthetase medium-chain family member 3 -0.0198385
PTK2 protein tyrosine kinase 2 -0.0197904
MCM9 minichromosome maintenance complex component 9 -0.0197797
PLCD1 phospholipase C, delta 1 -0.0197792
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0196889
YY1AP1 YY1 associated protein 1 -0.0196784
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0196452
ZNF804A zinc finger protein 804A -0.0196349
ENOSF1 enolase superfamily member 1 -0.0195897
CERS6 ceramide synthase 6 -0.0195875
CCDC137 coiled-coil domain containing 137 -0.0195733
ZFPM2 zinc finger protein, FOG family member 2 -0.0195693
UCK2 uridine-cytidine kinase 2 -0.0195039
AFF1 AF4/FMR2 family, member 1 -0.0194632
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0194542
ABHD3 abhydrolase domain containing 3 -0.019448
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0194131
AARS1 alanyl-tRNA synthetase 1 -0.0193973
SCAP SREBF chaperone -0.0193501
BLTP3A bridge-like lipid transfer protein family member 3A -0.0193285
SNX2 sorting nexin 2 -0.0192889
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0192888
YLPM1 YLP motif containing 1 -0.0190832
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0190705
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.019067
NVL nuclear VCP-like -0.0190558
RETREG3 reticulophagy regulator family member 3 -0.0190359
HSPA4 heat shock 70kDa protein 4 -0.0190345
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0189751
ANK1 ankyrin 1, erythrocytic -0.0189655
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 -0.0189647
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0189105
CDCP1 CUB domain containing protein 1 -0.0188484
ACTN4 actinin, alpha 4 -0.0188292
SNX9 sorting nexin 9 -0.0188216
TNIK TRAF2 and NCK interacting kinase -0.0188173
NEBL nebulette -0.0187628
GYPC glycophorin C (Gerbich blood group) -0.0187508
CLASP1 cytoplasmic linker associated protein 1 -0.0187041
MAP7 microtubule-associated protein 7 -0.0186696
FAF2 Fas associated factor family member 2 -0.018628
PTPRC protein tyrosine phosphatase, receptor type, C -0.0186183
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0186173
CUTA cutA divalent cation tolerance homolog (E. coli) -0.0186003
NFIA nuclear factor I/A -0.0185856
TESK2 testis-specific kinase 2 -0.0185697
GANAB glucosidase, alpha; neutral AB -0.0185369
LYRM4 LYR motif containing 4 -0.0185175
SZRD1 SUZ RNA binding domain containing 1 -0.0184846
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0184609
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0184495
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0184072
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0183837
PDIA4 protein disulfide isomerase family A, member 4 -0.018368
SUSD6 sushi domain containing 6 -0.0182575
STAT5B signal transducer and activator of transcription 5B -0.0182314
ZC3H7B zinc finger CCCH-type containing 7B -0.018217
FOXN2 forkhead box N2 -0.018182
NF1 neurofibromin 1 -0.018128
CARD8 caspase recruitment domain family, member 8 -0.0181212
MED12 mediator complex subunit 12 -0.0180417
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -0.0179867
TMEM181 transmembrane protein 181 -0.0179483
DOCK8 dedicator of cytokinesis 8 -0.0179467
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0179455
RIOK3 RIO kinase 3 -0.0179284
NALF1 NALCN channel auxiliary factor 1 -0.0179154
NUP214 nucleoporin 214kDa -0.0179008
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -0.0178611
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0178231
FLNB filamin B, beta -0.0178063
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0177841
SASH1 SAM and SH3 domain containing 1 -0.0177821
TMEM184B transmembrane protein 184B -0.0177699
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.017735
TEC tec protein tyrosine kinase -0.0177231
UBA2 ubiquitin-like modifier activating enzyme 2 -0.017694
EP400 E1A binding protein p400 -0.017692
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0176384
TCF3 transcription factor 3 -0.0176161
TUG1 taurine up-regulated 1 (non-protein coding) -0.0176027
CHD9 chromodomain helicase DNA binding protein 9 -0.0175966
LIN9 lin-9 DREAM MuvB core complex component -0.017567
BMP2K BMP2 inducible kinase -0.0175532
PTPRA protein tyrosine phosphatase, receptor type, A -0.0175106
HBS1L HBS1-like translational GTPase -0.0174962
DGLUCY D-glutamate cyclase -0.017486
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0174331
RUSF1 RUS family member 1 -0.0173491
NCAM2 neural cell adhesion molecule 2 -0.0173295
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0173072
DENND4A DENN/MADD domain containing 4A -0.0172958
TYK2 tyrosine kinase 2 -0.0172854
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0172824
FNDC3A fibronectin type III domain containing 3A -0.0172692
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0172646
NOL10 nucleolar protein 10 -0.0172464
MGA MGA, MAX dimerization protein -0.0172464
GEN1 GEN1 Holliday junction 5' flap endonuclease -0.0172177
IFRD1 interferon-related developmental regulator 1 -0.0171899
SLMAP sarcolemma associated protein -0.0171709
IFT74 intraflagellar transport 74 -0.0170763
STRIP2 striatin interacting protein 2 -0.0170693
KLHL23 kelch-like family member 23 -0.0170504
TBL1X transducin (beta)-like 1X-linked -0.0170493
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.0170223
NCOA3 nuclear receptor coactivator 3 -0.0170167
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -0.0170001
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0169963
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0169351
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0169339
ZYG11A zyg-11 family member A, cell cycle regulator -0.016902
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0168831
CTBP2 C-terminal binding protein 2 -0.0168615
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -0.0168136
ZNF146 zinc finger protein 146 -0.0167968
XRN2 5'-3' exoribonuclease 2 -0.0167733
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0167664
NBEAL1 neurobeachin-like 1 -0.0167423
PITPNA phosphatidylinositol transfer protein, alpha -0.0167387
SDAD1 SDA1 domain containing 1 -0.0167078
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0166847
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -0.0166246
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.0166097
ZNF644 zinc finger protein 644 -0.016588
PRRC2B proline-rich coiled-coil 2B -0.0165694
NFYC nuclear transcription factor Y, gamma -0.0165467
LUZP1 leucine zipper protein 1 -0.0165213
URI1 URI1, prefoldin-like chaperone -0.0165213
ZNF398 zinc finger protein 398 -0.0165141
METTL2B methyltransferase like 2B -0.0165084
TMEM168 transmembrane protein 168 -0.0164969
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0164701
MCPH1 microcephalin 1 -0.0164697
UBAC1 UBA domain containing 1 -0.0164675
SAFB scaffold attachment factor B -0.016453
SNX25 sorting nexin 25 -0.0164416
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.016436
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0164359
CLIP1 CAP-GLY domain containing linker protein 1 -0.0164289
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -0.0164288
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -0.0163945
GFOD2 glucose-fructose oxidoreductase domain containing 2 -0.0163077
FBXO34 F-box protein 34 -0.0162967
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -0.0162694
PHF20 PHD finger protein 20 -0.016197
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0161856
C18ORF25 chromosome 18 open reading frame 25 -0.0161825
RPS15 ribosomal protein S15 -0.0161745
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -0.0161285
SLC10A7 solute carrier family 10, member 7 -0.0160533
BLTP2 bridge-like lipid transfer protein family member 2 -0.0160384
SLC39A11 solute carrier family 39, member 11 -0.0160313
METTL8 methyltransferase like 8 -0.0160275
MPC1 mitochondrial pyruvate carrier 1 -0.0159972
NAT10 N-acetyltransferase 10 (GCN5-related) -0.0159652
ATG12 autophagy related 12 -0.0159161
USP3 ubiquitin specific peptidase 3 -0.015896
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -0.0158904
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.015882
SH2B3 SH2B adaptor protein 3 -0.015878
C2ORF42 chromosome 2 open reading frame 42 -0.0158644
ADD3 adducin 3 (gamma) -0.0158458
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0158405
ANKRD13C ankyrin repeat domain 13C -0.0158383
SCARB2 scavenger receptor class B, member 2 -0.0158186
PARD3B par-3 family cell polarity regulator beta -0.0158003
ZNF207 zinc finger protein 207 -0.0157965
GPATCH4 G patch domain containing 4 -0.0157695
BLTP1 bridge-like lipid transfer protein family member 1 -0.0157671
JMJD1C jumonji domain containing 1C -0.0157572
CEP85 centrosomal protein 85kDa -0.0157461
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0157443
ENOX2 ecto-NOX disulfide-thiol exchanger 2 -0.0157161
CSNK1G1 casein kinase 1, gamma 1 -0.0157157
ABI1 abl-interactor 1 -0.0156984
PDLIM5 PDZ and LIM domain 5 -0.0156829
SIK3 SIK family kinase 3 -0.0156772
UIMC1 ubiquitin interaction motif containing 1 -0.0156712
KRIT1 KRIT1, ankyrin repeat containing -0.0156707
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0156694
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0156647
FOXK1 forkhead box K1 -0.0156627
ZNF175 zinc finger protein 175 -0.0156465
AFG2A AFG2 AAA ATPase homolog A -0.0156411
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0156291
APLF aprataxin and PNKP like factor -0.015623
FBXO11 F-box protein 11 -0.015619
MYEOV myeloma overexpressed -0.015607
DBF4B DBF4 zinc finger B -0.0156061
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0156035
AFTPH aftiphilin -0.0155872
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -0.015555
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -0.0155173
TFCP2 transcription factor CP2 -0.0154889
PCNP PEST proteolytic signal containing nuclear protein -0.0154711
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0154109
COQ4 coenzyme Q4 -0.0154015
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0153983
DGKZ diacylglycerol kinase, zeta -0.0153855
GNL1 guanine nucleotide binding protein-like 1 -0.0153419
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0153367
MTOR mechanistic target of rapamycin (serine/threonine kinase) -0.015315
CCDC12 coiled-coil domain containing 12 -0.0153117
RUSC2 RUN and SH3 domain containing 2 -0.0153018
RC3H1 ring finger and CCCH-type domains 1 -0.0152899
TRIM56 tripartite motif containing 56 -0.0152822
NCOR1 nuclear receptor corepressor 1 -0.0152798
SNX6 sorting nexin 6 -0.0152714
SCG3 secretogranin III -0.0152212
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -0.0152093
ASXL2 additional sex combs like transcriptional regulator 2 -0.0152003
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0151774
TET3 tet methylcytosine dioxygenase 3 -0.015173
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0151652
CAPRIN1 cell cycle associated protein 1 -0.0151296
MRPL20 mitochondrial ribosomal protein L20 -0.0151183
UBE2I ubiquitin-conjugating enzyme E2I -0.0151127
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0151059
FAM178B family with sequence similarity 178, member B -0.015105
VCP valosin containing protein -0.0150909
ZNF395 zinc finger protein 395 -0.0150461
PWWP2A PWWP domain containing 2A -0.0150205
RB1CC1 RB1-inducible coiled-coil 1 -0.0150178
MIPOL1 mirror-image polydactyly 1 -0.015001
XPOT exportin, tRNA -0.0149927
CEP57 centrosomal protein 57kDa -0.0149844
FBXO17 F-box protein 17 -0.014945
NCOA7 nuclear receptor coactivator 7 -0.0149437
CELF2 CUGBP, Elav-like family member 2 -0.0149057
TPI1 triosephosphate isomerase 1 -0.0149045
ACBD6 acyl-CoA binding domain containing 6 -0.0148896
TMEM131L transmembrane 131 like -0.014856
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0148546
NDC80 NDC80 kinetochore complex component -0.014838
AP3D1 adaptor-related protein complex 3, delta 1 subunit -0.0148281
RAD23A RAD23 homolog A (S. cerevisiae) -0.0148139
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0148096
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.014807
ZNF106 zinc finger protein 106 -0.0147873
ZNF611 zinc finger protein 611 -0.0147862
WARS1 tryptophanyl-tRNA synthetase 1 -0.0147133
VEGFB vascular endothelial growth factor B -0.0147027
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0146906
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0146689
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0146349
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0146214
ENSA endosulfine alpha -0.0146174
ATXN10 ataxin 10 -0.0145994
ZNF281 zinc finger protein 281 -0.0145884
SINHCAF SIN3-HDAC complex associated factor -0.0145764
NUDCD3 NudC domain containing 3 -0.0145621
ZNF148 zinc finger protein 148 -0.0145174
AGO1 argonaute RISC catalytic component 1 -0.0145123
TMEM43 transmembrane protein 43 -0.0145097
USP32 ubiquitin specific peptidase 32 -0.0144992
PKP4 plakophilin 4 -0.0144734
ANXA7 annexin A7 -0.0144495
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing -0.0144292
CCSER1 coiled-coil serine-rich protein 1 -0.0144012
AKAP8 A kinase (PRKA) anchor protein 8 -0.0143844
KIFC1 kinesin family member C1 -0.0143818
PDS5A PDS5 cohesin associated factor A -0.0143764
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0143596
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -0.0143202
CHD7 chromodomain helicase DNA binding protein 7 -0.0143132
FAM193A family with sequence similarity 193, member A -0.014282
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -0.0142499
PGLS 6-phosphogluconolactonase -0.0142477