K562_Alendronate sodium trihydrate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Alendronate sodium trihydrate 10nM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
Similar Terms
Downloads & Tools

Genes

1000 genes differentially expressed following the K562_Alendronate sodium trihydrate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
STXBP5 syntaxin binding protein 5 (tomosyn) 0.155421
MUSK muscle, skeletal, receptor tyrosine kinase 0.109766
RPL32 ribosomal protein L32 0.0752854
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0674864
EPB41 erythrocyte membrane protein band 4.1 0.0656541
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0644536
PRRC2C proline-rich coiled-coil 2C 0.0600019
CLASP2 cytoplasmic linker associated protein 2 0.058113
XPO1 exportin 1 0.0569408
CPED1 cadherin-like and PC-esterase domain containing 1 0.0568185
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.055028
COMT catechol-O-methyltransferase 0.0540842
RAD51B RAD51 paralog B 0.0519651
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0516611
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0506941
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0494046
POTEF POTE ankyrin domain family, member F 0.0492331
SEPTIN6 septin 6 0.0484962
ENO1 enolase 1, (alpha) 0.0474658
SET SET nuclear proto-oncogene 0.0470288
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.0460537
RPL18 ribosomal protein L18 0.0458747
LOC112694756 uncharaterized LOC112694756 0.0446082
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0441285
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0433328
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.042772
PKP4 plakophilin 4 0.0426936
FNBP1 formin binding protein 1 0.0426236
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0420373
RPSA ribosomal protein SA 0.0418855
RPL13A ribosomal protein L13a 0.0414455
HMGA1 high mobility group AT-hook 1 0.0413131
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0413014
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0412756
TPI1 triosephosphate isomerase 1 0.0408766
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0406437
FAF1 Fas (TNFRSF6) associated factor 1 0.0404151
TNRC6A trinucleotide repeat containing 6A 0.0398599
GAB2 GRB2-associated binding protein 2 0.0395193
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0394707
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0394206
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.0393766
SERBP1 SERPINE1 mRNA binding protein 1 0.0393301
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0387119
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0382987
MDN1 MDN1, midasin homolog (yeast) 0.0381469
CNOT10 CCR4-NOT transcription complex, subunit 10 0.0369915
TLN1 talin 1 0.0369502
BTBD9 BTB (POZ) domain containing 9 0.0368869
STAT5B signal transducer and activator of transcription 5B 0.0366309
PARD3B par-3 family cell polarity regulator beta 0.0365749
NCOA6 nuclear receptor coactivator 6 0.0365663
JARID2 jumonji, AT rich interactive domain 2 0.0364596
NF1 neurofibromin 1 0.0361558
SRSF11 serine/arginine-rich splicing factor 11 0.0357033
SETD2 SET domain containing 2 0.0355074
FER fer (fps/fes related) tyrosine kinase 0.0354953
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0354074
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0352907
NKTR natural killer cell triggering receptor 0.0350886
BRD4 bromodomain containing 4 0.0349403
TM9SF4 transmembrane 9 superfamily protein member 4 0.0348703
RPL3 ribosomal protein L3 0.0347692
CALR calreticulin 0.0346465
ACACA acetyl-CoA carboxylase alpha 0.0343522
AIG1 androgen-induced 1 0.0342778
XKR3 XK, Kell blood group complex subunit-related family, member 3 0.0340415
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0335587
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0333006
CANX calnexin 0.0332072
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.033184
HBG1 hemoglobin, gamma A 0.0330509
LYPLA1 lysophospholipase I 0.0328976
BABAM2 BRISC and BRCA1 A complex member 2 0.0328928
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.032823
DHCR7 7-dehydrocholesterol reductase 0.0327307
CD81 CD81 molecule 0.0325301
ZZZ3 zinc finger, ZZ-type containing 3 0.032499
QSER1 glutamine and serine rich 1 0.0322719
MRPL13 mitochondrial ribosomal protein L13 0.0321902
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0321363
SAMD4B sterile alpha motif domain containing 4B 0.0320328
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0319317
GMPR guanosine monophosphate reductase 0.031867
SOS1 son of sevenless homolog 1 (Drosophila) 0.0318651
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0316832
FLNA filamin A, alpha 0.0316519
PRAME preferentially expressed antigen in melanoma 0.0315883
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0313555
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0312787
MTDH metadherin 0.0312775
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0312615
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0312058
EML4 echinoderm microtubule associated protein like 4 0.0311811
COX5A cytochrome c oxidase subunit Va 0.0311197
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0309842
INTS9 integrator complex subunit 9 0.0309199
MAU2 MAU2 sister chromatid cohesion factor 0.0306421
SFTPA2 surfactant protein A2 0.0305104
ACTG1 actin gamma 1 0.030442
DSTYK dual serine/threonine and tyrosine protein kinase 0.0303646
SND1 staphylococcal nuclease and tudor domain containing 1 0.0302758
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0301824
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0298952
RBM19 RNA binding motif protein 19 0.0295694
COP1 COP1 E3 ubiquitin ligase 0.0295466
CNST consortin, connexin sorting protein 0.0295292
VCP valosin containing protein 0.0294027
SCG3 secretogranin III 0.029317
THRAP3 thyroid hormone receptor associated protein 3 0.0293051
CHPT1 choline phosphotransferase 1 0.0292248
RPLP2 ribosomal protein, large, P2 0.0292181
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.0289362
PHF21A PHD finger protein 21A 0.0288296
VRK2 vaccinia related kinase 2 0.0288184
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0286561
ACTN4 actinin, alpha 4 0.0285656
ANKRD17 ankyrin repeat domain 17 0.0284055
NUP155 nucleoporin 155kDa 0.0283561
DCAF7 DDB1 and CUL4 associated factor 7 0.0282171
CEP290 centrosomal protein 290kDa 0.0281645
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0280493
RRM1 ribonucleotide reductase M1 0.0278567
TMEM120B transmembrane protein 120B 0.0278369
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0276656
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.0275486
CALCOCO2 calcium binding and coiled-coil domain 2 0.0272712
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0272266
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0271868
BLTP2 bridge-like lipid transfer protein family member 2 0.0271624
SLC38A1 solute carrier family 38, member 1 0.0270867
SLTM SAFB-like, transcription modulator 0.026789
LBR lamin B receptor 0.0267491
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0266862
PGK1 phosphoglycerate kinase 1 0.026582
FASN fatty acid synthase 0.0264188
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0263229
LPIN1 lipin 1 0.0262735
RORA RAR-related orphan receptor A 0.0262446
KDM4C lysine (K)-specific demethylase 4C 0.0262331
PHACTR2 phosphatase and actin regulator 2 0.0262215
FAM117A family with sequence similarity 117, member A 0.0262083
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0261504
ANAPC1 anaphase promoting complex subunit 1 0.0261221
LYZ lysozyme 0.0261046
FAM78A family with sequence similarity 78, member A 0.02607
HBG2 hemoglobin, gamma G 0.026054
ESYT2 extended synaptotagmin-like protein 2 0.0258596
ZNF638 zinc finger protein 638 0.0258145
RPL28 ribosomal protein L28 0.0258045
CEP95 centrosomal protein 95kDa 0.0257667
CMC4 C-x(9)-C motif containing 4 0.0257608
ATM ATM serine/threonine kinase 0.0257591
CHD8 chromodomain helicase DNA binding protein 8 0.0257361
SCLT1 sodium channel and clathrin linker 1 0.0257182
YME1L1 YME1-like 1 ATPase 0.0257097
BICD1 bicaudal D homolog 1 (Drosophila) 0.0256004
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0255769
SYCP2L synaptonemal complex protein 2-like 0.0254408
RPS3 ribosomal protein S3 0.0253832
IGFBP4 insulin-like growth factor binding protein 4 0.0251861
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0250136
NCLN nicalin 0.0249284
PLD3 phospholipase D family, member 3 0.0249171
RPLP0 ribosomal protein, large, P0 0.0248676
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.0248294
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.0247842
GANAB glucosidase, alpha; neutral AB 0.0247839
DSG2 desmoglein 2 0.02477
RBMX RNA binding motif protein, X-linked 0.0247694
TMEM131L transmembrane 131 like 0.02473
PRELID2 PRELI domain containing 2 0.0246342
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0245919
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.0245507
RBL1 retinoblastoma-like 1 0.0245426
MAP4 microtubule-associated protein 4 0.02454
EHBP1 EH domain binding protein 1 0.0245197
APLP2 amyloid beta (A4) precursor-like protein 2 0.0244804
KDM4B lysine (K)-specific demethylase 4B 0.0244727
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.024428
POC5 POC5 centriolar protein 0.024406
TTC28 tetratricopeptide repeat domain 28 0.0243873
ATG7 autophagy related 7 0.0242032
OXSR1 oxidative stress responsive 1 0.0241724
LCOR ligand dependent nuclear receptor corepressor 0.0240325
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0240037
FNBP4 formin binding protein 4 0.023992
DCAF6 DDB1 and CUL4 associated factor 6 0.023868
CFDP1 craniofacial development protein 1 0.023845
TMEM131 transmembrane protein 131 0.0238274
RAB8B RAB8B, member RAS oncogene family 0.0238204
ANAPC16 anaphase promoting complex subunit 16 0.0237551
C17ORF99 chromosome 17 open reading frame 99 0.0237309
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.0237177
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0235732
PTRH2 peptidyl-tRNA hydrolase 2 0.0234956
RCOR3 REST corepressor 3 0.023469
RPS20 ribosomal protein S20 0.0234272
FTH1 ferritin, heavy polypeptide 1 0.0233774
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.0233658
RPS6 ribosomal protein S6 0.0233498
SREBF2 sterol regulatory element binding transcription factor 2 0.0233106
INTS10 integrator complex subunit 10 0.0232159
ACER3 alkaline ceramidase 3 0.0231771
PHKB phosphorylase kinase, beta 0.0231653
FERMT3 fermitin family member 3 0.0230907
TRRAP transformation/transcription domain-associated protein 0.0230009
TEX15 testis expressed 15 0.0229992
SPC25 SPC25, NDC80 kinetochore complex component 0.0229953
CIAO2A cytosolic iron-sulfur assembly component 2A 0.0229434
MED13L mediator complex subunit 13-like 0.0229263
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 0.0228049
ZC3H8 zinc finger CCCH-type containing 8 0.0227759
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.0227476
PYCR2 pyrroline-5-carboxylate reductase family, member 2 0.0227205
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0226939
CEP83 centrosomal protein 83kDa 0.0226892
ICE1 interactor of little elongation complex ELL subunit 1 0.0226508
HDGF hepatoma-derived growth factor 0.0225445
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0225295
KDM2B lysine (K)-specific demethylase 2B 0.0225173
VWDE von Willebrand factor D and EGF domains 0.022456
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0224144
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.0223834
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 0.0223245
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.022244
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0221607
USP54 ubiquitin specific peptidase 54 0.0221404
TRIP12 thyroid hormone receptor interactor 12 0.0220553
WRN Werner syndrome, RecQ helicase-like 0.0220207
DLK1 delta-like 1 homolog (Drosophila) 0.0219601
TMPO thymopoietin 0.0219558
TOP2B topoisomerase (DNA) II beta 180kDa 0.0219093
GSPT1 G1 to S phase transition 1 0.0218772
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.0218282
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.0218028
IL16 interleukin 16 0.0216764
NIPBL Nipped-B homolog (Drosophila) 0.0216296
TTC21B tetratricopeptide repeat domain 21B 0.0215252
TATDN3 TatD DNase domain containing 3 0.0215133
SIRAL2 SIR2 antiphage like 2 0.0214385
MED13 mediator complex subunit 13 0.0214381
NBAS neuroblastoma amplified sequence 0.0214175
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0213702
GTF2IRD1 GTF2I repeat domain containing 1 0.0213639
NECTIN2 nectin cell adhesion molecule 2 0.0213347
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0213313
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0213305
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.0213203
USP1 ubiquitin specific peptidase 1 0.0212745
POLK polymerase (DNA directed) kappa 0.0212675
GTSF1 gametocyte specific factor 1 0.0212652
CCDC88A coiled-coil domain containing 88A 0.0212524
USP49 ubiquitin specific peptidase 49 0.0212256
PUM2 pumilio RNA-binding family member 2 0.0212191
CTSC cathepsin C 0.0212103
GEMIN5 gem (nuclear organelle) associated protein 5 0.0211578
PTBP1 polypyrimidine tract binding protein 1 0.0211468
ELAVL1 ELAV like RNA binding protein 1 0.0210496
SDC3 syndecan 3 0.0210128
KDM3B lysine (K)-specific demethylase 3B 0.0209053
HMGB1 high mobility group box 1 0.0208518
ZFPM2 zinc finger protein, FOG family member 2 0.0208463
FAM13B family with sequence similarity 13, member B 0.0208435
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0207613
TARS1 threonyl-tRNA synthetase 1 0.0207154
RPL7A ribosomal protein L7a 0.0207131
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0206711
B2M beta-2-microglobulin 0.0206647
XPO6 exportin 6 0.0206585
ATP5F1B ATP synthase F1 subunit beta 0.0206207
PRPF4B pre-mRNA processing factor 4B 0.0206101
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0205653
ATL2 atlastin GTPase 2 0.0205414
SRPK1 SRSF protein kinase 1 0.0205162
PFN1 profilin 1 0.0204672
MIDEAS mitotic deacetylase associated SANT domain protein 0.0204325
ARRB1 arrestin, beta 1 0.0204096
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0203387
QPRT quinolinate phosphoribosyltransferase 0.0203102
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.0202856
PUM3 pumilio RNA binding family member 3 0.0202819
SRPRA SRP receptor subunit alpha 0.0202533
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0202266
SFMBT2 Scm-like with four mbt domains 2 0.0201827
NLRP1 NLR family, pyrin domain containing 1 0.0201187
PMM2 phosphomannomutase 2 0.0200661
KIF13A kinesin family member 13A 0.0200448
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0200349
MTG2 mitochondrial ribosome-associated GTPase 2 0.0200341
RHAG Rh-associated glycoprotein 0.019987
CEP295 centrosomal protein 295kDa 0.0199279
FLOT2 flotillin 2 0.0199177
ARTN artemin 0.0199067
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.0198813
RPL11 ribosomal protein L11 0.0198643
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.0198581
AK1 adenylate kinase 1 0.0196999
RNF213 ring finger protein 213 0.0196678
SMIM8 small integral membrane protein 8 0.019629
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0195917
ZNF813 zinc finger protein 813 0.0195633
NUP62 nucleoporin 62kDa 0.0195596
NONO non-POU domain containing, octamer-binding 0.0195086
ADGRE5 adhesion G protein-coupled receptor E5 0.0194531
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0194421
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.019416
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.0194049
TOR1AIP1 torsin A interacting protein 1 0.0193984
KMT2A lysine (K)-specific methyltransferase 2A 0.0193586
MECR mitochondrial trans-2-enoyl-CoA reductase 0.0193276
ITSN2 intersectin 2 0.0193229
MIPOL1 mirror-image polydactyly 1 0.0192918
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.0192472
ANGPT1 angiopoietin 1 0.0192416
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0192402
ANKRD28 ankyrin repeat domain 28 0.0192061
DENND4C DENN/MADD domain containing 4C 0.0192043
RANBP3 RAN binding protein 3 0.0191786
ZC3H6 zinc finger CCCH-type containing 6 0.0190843
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0190324
METTL15 methyltransferase like 15 0.019021
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.018936
TGOLN2 trans-golgi network protein 2 0.0189245
CHD4 chromodomain helicase DNA binding protein 4 0.0189163
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.0188804
CDC5L cell division cycle 5-like 0.0188476
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.0188455
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0188188
BRWD3 bromodomain and WD repeat domain containing 3 0.0187478
BRI3BP BRI3 binding protein 0.018746
SNW1 SNW domain containing 1 0.0186598
COCH cochlin 0.0186119
TOM1L2 target of myb1-like 2 (chicken) 0.0185817
DYNC2I1 dynein 2 intermediate chain 1 0.0185709
RPL37A ribosomal protein L37a 0.0185429
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.018483
MYO18A myosin XVIIIA 0.0184721
ATP5F1E ATP synthase F1 subunit epsilon 0.0184411
RPL35A ribosomal protein L35a 0.0184406
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0184225
BLM Bloom syndrome, RecQ helicase-like 0.0184225
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 0.0183688
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0183051
ARID1A AT rich interactive domain 1A (SWI-like) 0.0182994
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.018222
EEIG2 EEIG family member 2 0.0181245
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 0.0181056
PITPNB phosphatidylinositol transfer protein, beta 0.0180488
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.0179875
MTRFR mitochondrial translation release factor in rescue 0.0179036
CLTCL1 clathrin, heavy chain-like 1 0.0178189
COQ9 coenzyme Q9 0.0178049
CLIP1 CAP-GLY domain containing linker protein 1 0.0177967
DYM dymeclin 0.0177771
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.0177289
KAZN kazrin, periplakin interacting protein 0.0177149
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0176963
AQR aquarius intron-binding spliceosomal factor 0.0176919
DNAH14 dynein, axonemal, heavy chain 14 0.0176778
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0176704
TTC1 tetratricopeptide repeat domain 1 0.0176508
ZNF395 zinc finger protein 395 0.0176361
ZNF146 zinc finger protein 146 0.0176349
HSPA8 heat shock 70kDa protein 8 0.0176324
ANXA2 annexin A2 0.0176321
NFE2L1 nuclear factor, erythroid 2-like 1 0.017619
HIC2 hypermethylated in cancer 2 0.0176189
RBBP8 retinoblastoma binding protein 8 0.017599
SPOP speckle-type POZ protein 0.0175876
ANKRD23 ankyrin repeat domain 23 0.0175829
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.0175481
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.01753
RBM17 RNA binding motif protein 17 0.0175157
HIPK2 homeodomain interacting protein kinase 2 0.0175131
ATP5F1A ATP synthase F1 subunit alpha 0.0175097
FXYD5 FXYD domain containing ion transport regulator 5 0.0175089
LARS1 leucyl-tRNA synthetase 1 0.0175064
EIF6 eukaryotic translation initiation factor 6 0.0174783
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0174439
MAPK14 mitogen-activated protein kinase 14 0.0174437
TMEM164 transmembrane protein 164 0.0174168
CCM2 cerebral cavernous malformation 2 0.0174166
DOCK9 dedicator of cytokinesis 9 0.0174125
RBM15 RNA binding motif protein 15 0.0173844
TRIM56 tripartite motif containing 56 0.017371
RPS28 ribosomal protein S28 0.0173159
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0173151
ARHGAP6 Rho GTPase activating protein 6 0.0173001
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0172828
YY1 YY1 transcription factor 0.0172502
EXOC6 exocyst complex component 6 0.0172246
MACF1 microtubule-actin crosslinking factor 1 0.0172229
MPZ myelin protein zero 0.0172191
COPG2 coatomer protein complex, subunit gamma 2 0.0172024
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.0171895
CLSPN claspin 0.0171815
ADIPOR2 adiponectin receptor 2 0.0171641
KDM1B lysine (K)-specific demethylase 1B 0.0171624
ANXA11 annexin A11 0.0171614
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0171577
FTL ferritin, light polypeptide 0.0171562
DBF4 DBF4 zinc finger 0.0171135
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.0171118
RNF111 ring finger protein 111 0.0171087
UBB ubiquitin B 0.0170825
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0170817
RPN2 ribophorin II 0.0170794
PHIP pleckstrin homology domain interacting protein 0.0170487
EFCAB14 EF-hand calcium binding domain 14 0.017048
CALU calumenin 0.0170035
TMEM117 transmembrane protein 117 0.0169982
SRRM2 serine/arginine repetitive matrix 2 0.0169963
SORBS1 sorbin and SH3 domain containing 1 0.0169951
NAP1L4 nucleosome assembly protein 1-like 4 0.016983
TCF20 transcription factor 20 (AR1) 0.0169776
RCSD1 RCSD domain containing 1 0.0169703
SWI5 SWI5 recombination repair homolog (yeast) 0.0169585
AFMID arylformamidase 0.0169493
MOK MOK protein kinase 0.0169392
CD63 CD63 molecule 0.0169293
TMED9 transmembrane emp24 protein transport domain containing 9 0.0169254
ZNF521 zinc finger protein 521 0.0169047
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.0169036
TSEN54 TSEN54 tRNA splicing endonuclease subunit 0.0168546
PTBP3 polypyrimidine tract binding protein 3 0.0167996
PLA2G12A phospholipase A2, group XIIA 0.016729
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.0167275
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0167235
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 0.0167172
RRBP1 ribosome binding protein 1 0.0166698
PARD3 par-3 family cell polarity regulator 0.0166667
AFG2A AFG2 AAA ATPase homolog A 0.0166547
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0166403
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.0166255
ACD adrenocortical dysplasia homolog (mouse) 0.0165793
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.0165782
STK24 serine/threonine kinase 24 0.0165704
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 0.0165292
HSPG2 heparan sulfate proteoglycan 2 0.0165285
GMPS guanine monphosphate synthase 0.0165254
IGF2R insulin-like growth factor 2 receptor 0.016516
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.0164983
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0164971
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.0164861
EEF2K eukaryotic elongation factor 2 kinase 0.0164483
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0164438
HEBP2 heme binding protein 2 0.0164247
MSH2 mutS homolog 2 0.0163375
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0163245
CLEC2D C-type lectin domain family 2, member D 0.0163184
APRT adenine phosphoribosyltransferase 0.0162623
JPT1 Jupiter microtubule associated homolog 1 0.0162315
CYBA cytochrome b-245, alpha polypeptide 0.0162249
SNX9 sorting nexin 9 0.0162153
RNF149 ring finger protein 149 0.0162047
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0161894
SSH2 slingshot protein phosphatase 2 0.0161725
ZHX3 zinc fingers and homeoboxes 3 0.0161676
KLHL22 kelch-like family member 22 0.0161509
PCSK7 proprotein convertase subtilisin/kexin type 7 0.0161483
VPS26C VPS26 endosomal protein sorting factor C 0.0161348
RMDN3 regulator of microtubule dynamics 3 0.0161085
RAN RAN, member RAS oncogene family 0.0161051
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0160696
LMBR1 limb development membrane protein 1 0.0160554
KIF20B kinesin family member 20B 0.0160454
RBBP5 retinoblastoma binding protein 5 0.0160163
HAUS6 HAUS augmin-like complex, subunit 6 0.0160097
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0159966
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0159842
TBCE tubulin folding cofactor E 0.0159757
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0159297
COPS5 COP9 signalosome subunit 5 0.0159262
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 0.0159164
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0159157
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.0158831
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.0158822
PARPBP PARP1 binding protein 0.0158606
NCAPG non-SMC condensin I complex, subunit G 0.0158596
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.0158534
FBXO7 F-box protein 7 0.0158431
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0158127
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.0158059
METTL8 methyltransferase like 8 0.0157989
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0157852
CELF2 CUGBP, Elav-like family member 2 0.0157814
CORO1C coronin, actin binding protein, 1C 0.015768
DSCAM Down syndrome cell adhesion molecule 0.0157379
WRNIP1 Werner helicase interacting protein 1 0.0157293
CFAP161 cilia and flagella associated protein 161 0.0156938
POC1B POC1 centriolar protein B 0.01569
ACBD6 acyl-CoA binding domain containing 6 0.0156847
UNK unkempt family zinc finger 0.015663
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0156302
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0156266
ZFYVE28 zinc finger, FYVE domain containing 28 0.0156154
SKAP2 src kinase associated phosphoprotein 2 0.0156111
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.015586
ATP5PD ATP synthase peripheral stalk subunit d 0.0155598

decreased expression

Symbol Name Standardized Value
PRKCA protein kinase C, alpha -0.128704
SMYD3 SET and MYND domain containing 3 -0.123778
ARL15 ADP-ribosylation factor-like 15 -0.0927156
ZFAND3 zinc finger, AN1-type domain 3 -0.0820284
FBXL13 F-box and leucine-rich repeat protein 13 -0.0776256
VCL vinculin -0.0616895
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0613252
FDPS farnesyl diphosphate synthase -0.0590606
USP32 ubiquitin specific peptidase 32 -0.0567328
ZMYND8 zinc finger, MYND-type containing 8 -0.0559699
GSE1 Gse1 coiled-coil protein -0.0517022
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0500103
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -0.0481305
SLC39A11 solute carrier family 39, member 11 -0.0474958
PRKCB protein kinase C, beta -0.0474941
ANK1 ankyrin 1, erythrocytic -0.0471128
ERBIN erbb2 interacting protein -0.0464347
AAK1 AP2 associated kinase 1 -0.0430789
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0428378
SOX6 SRY (sex determining region Y)-box 6 -0.0418523
NUMB numb homolog (Drosophila) -0.0417983
MARCHF3 membrane associated ring-CH-type finger 3 -0.040319
AGO3 argonaute RISC catalytic component 3 -0.0397869
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0396302
MAST2 microtubule associated serine/threonine kinase 2 -0.0386083
KNL1 kinetochore scaffold 1 -0.0385251
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0384797
BIRC6 baculoviral IAP repeat containing 6 -0.0384683
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0384493
CDC14A cell division cycle 14A -0.0382602
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0381326
RNASE3 ribonuclease, RNase A family, 3 -0.0377844
TNPO3 transportin 3 -0.0372944
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0372858
SRSF4 serine/arginine-rich splicing factor 4 -0.0369873
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0369468
KDM6A lysine (K)-specific demethylase 6A -0.0364711
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.036056
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0359822
CALN1 calneuron 1 -0.0353749
FBXL20 F-box and leucine-rich repeat protein 20 -0.0351558
EXOC4 exocyst complex component 4 -0.0350181
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0349987
MBD5 methyl-CpG binding domain protein 5 -0.0347415
UBE2K ubiquitin-conjugating enzyme E2K -0.0344924
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0344417
SATB2 SATB homeobox 2 -0.0343525
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0342561
UBE4B ubiquitination factor E4B -0.0342291
LTBP1 latent transforming growth factor beta binding protein 1 -0.0338484
PHF3 PHD finger protein 3 -0.0337233
HOMER1 homer scaffolding protein 1 -0.0333613
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0333445
PICALM phosphatidylinositol binding clathrin assembly protein -0.0333323
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.0330476
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0327037
NCOA3 nuclear receptor coactivator 3 -0.0326675
RELN reelin -0.032562
RTN4 reticulon 4 -0.032547
PTK2B protein tyrosine kinase 2 beta -0.0325427
CCDC57 coiled-coil domain containing 57 -0.0325116
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0324953
LMNA lamin A/C -0.0324288
GDI2 GDP dissociation inhibitor 2 -0.0323609
UBXN7 UBX domain protein 7 -0.0321902
MACC1 metastasis associated in colon cancer 1 -0.0321347
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.0319746
ANTXR2 anthrax toxin receptor 2 -0.0318081
GGNBP2 gametogenetin binding protein 2 -0.0317985
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0316121
ANO10 anoctamin 10 -0.0316004
ZEB2 zinc finger E-box binding homeobox 2 -0.0315935
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0314427
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0310722
TNIK TRAF2 and NCK interacting kinase -0.0310468
DENND4A DENN/MADD domain containing 4A -0.0308588
USP34 ubiquitin specific peptidase 34 -0.0305402
RANBP10 RAN binding protein 10 -0.030322
NBEAL1 neurobeachin-like 1 -0.0302233
ERI1 exoribonuclease 1 -0.0301327
SELENOI selenoprotein I -0.0300788
TXNRD1 thioredoxin reductase 1 -0.0299712
KCMF1 potassium channel modulatory factor 1 -0.029718
SPPL2A signal peptide peptidase like 2A -0.0296538
PARVB parvin, beta -0.0293216
CDC25C cell division cycle 25C -0.0292219
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0289151
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0288554
KPNB1 karyopherin (importin) beta 1 -0.0288462
SUSD1 sushi domain containing 1 -0.0287156
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0287143
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0286524
CEP128 centrosomal protein 128kDa -0.0285552
TPX2 TPX2, microtubule-associated -0.0285495
MMS22L MMS22-like, DNA repair protein -0.0285455
PRDX1 peroxiredoxin 1 -0.0285365
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0284109
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0282381
OLA1 Obg-like ATPase 1 -0.0281822
MYO9B myosin IXB -0.0279901
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.0279166
MACO1 macoilin 1 -0.0279134
TNPO2 transportin 2 -0.0278645
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0278138
COPA coatomer protein complex, subunit alpha -0.0277625
TNRC6B trinucleotide repeat containing 6B -0.0275387
LATS1 large tumor suppressor kinase 1 -0.0274869
IARS1 isoleucyl-tRNA synthetase 1 -0.0274628
ASPH aspartate beta-hydroxylase -0.0273982
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0272427
DARS1 aspartyl-tRNA synthetase 1 -0.0272035
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0269513
MOB1B MOB kinase activator 1B -0.0268449
CLIC4 chloride intracellular channel 4 -0.0267237
CEP192 centrosomal protein 192kDa -0.0266962
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -0.0266496
LTBP4 latent transforming growth factor beta binding protein 4 -0.026433
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0262261
FOXP1 forkhead box P1 -0.0260059
ZBTB38 zinc finger and BTB domain containing 38 -0.0259738
RBM14-RBM4 RBM14-RBM4 readthrough -0.0258566
SRPK2 SRSF protein kinase 2 -0.0254873
TACC3 transforming, acidic coiled-coil containing protein 3 -0.0254088
PPP6C protein phosphatase 6, catalytic subunit -0.0253441
PPARD peroxisome proliferator-activated receptor delta -0.0253131
ZNF609 zinc finger protein 609 -0.0252369
GATAD2A GATA zinc finger domain containing 2A -0.0252122
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0251563
AFF1 AF4/FMR2 family, member 1 -0.0250973
DHCR24 24-dehydrocholesterol reductase -0.0249947
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -0.0248304
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0246718
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0246554
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0246016
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0245413
SUGP2 SURP and G patch domain containing 2 -0.024512
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0245019
FBH1 F-box DNA helicase 1 -0.0244832
SCAI suppressor of cancer cell invasion -0.0244726
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0244477
YARS1 tyrosyl-tRNA synthetase 1 -0.0243893
MYO18B myosin XVIIIB -0.0243703
ZC3H3 zinc finger CCCH-type containing 3 -0.0243175
ZC3H4 zinc finger CCCH-type containing 4 -0.0243065
PRR16 proline rich 16 -0.0242926
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0242799
MOB3B MOB kinase activator 3B -0.0240863
TRIM33 tripartite motif containing 33 -0.0240501
NFYC nuclear transcription factor Y, gamma -0.0239724
TOP1 topoisomerase (DNA) I -0.023923
CDC27 cell division cycle 27 -0.0238589
TTC7A tetratricopeptide repeat domain 7A -0.023561
DST dystonin -0.0235593
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0234965
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0234542
GPC5 glypican 5 -0.0233817
TSLIG1 tRNA splicing ligase complex subunit 1 -0.023339
CEP85 centrosomal protein 85kDa -0.0233129
DENR density-regulated protein -0.0231435
LASP1 LIM and SH3 protein 1 -0.0230145
ITCH itchy E3 ubiquitin protein ligase -0.0229828
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0228587
FOXO3 forkhead box O3 -0.0228401
SENP5 SUMO1/sentrin specific peptidase 5 -0.022815
DTNBP1 dystrobrevin binding protein 1 -0.0228018
ANAPC10 anaphase promoting complex subunit 10 -0.0225495
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.0224838
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0224576
ARL8B ADP-ribosylation factor-like 8B -0.0223989
FGF13 fibroblast growth factor 13 -0.0223959
CD44 CD44 molecule (Indian blood group) -0.0223951
UBE3D ubiquitin protein ligase E3D -0.0222925
FOXK2 forkhead box K2 -0.0221992
PDLIM5 PDZ and LIM domain 5 -0.0221735
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0220336
PRR14L proline rich 14-like -0.0219482
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0217599
ADAM10 ADAM metallopeptidase domain 10 -0.0216786
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0216672
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.021662
PCDH9 protocadherin 9 -0.0216498
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.021414
USP3 ubiquitin specific peptidase 3 -0.0214059
UBE2H ubiquitin-conjugating enzyme E2H -0.0213936
NDC1 NDC1 transmembrane nucleoporin -0.0213463
TRAPPC12 trafficking protein particle complex 12 -0.0213116
TLK1 tousled-like kinase 1 -0.0213061
AKAP8L A kinase (PRKA) anchor protein 8-like -0.0212774
LIN9 lin-9 DREAM MuvB core complex component -0.0211624
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0211377
ARHGAP11B Rho GTPase activating protein 11B -0.0211262
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0210431
TRIM27 tripartite motif containing 27 -0.020968
TULP4 tubby like protein 4 -0.0209303
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0209144
WDR44 WD repeat domain 44 -0.0209009
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0208535
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0208157
TPM3 tropomyosin 3 -0.0208088
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0207828
MVD mevalonate (diphospho) decarboxylase -0.0207276
TPGS2 tubulin polyglutamylase complex subunit 2 -0.0206569
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0206232
OXR1 oxidation resistance 1 -0.0205627
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0204777
SENP7 SUMO1/sentrin specific peptidase 7 -0.0204585
RHOA ras homolog family member A -0.0204443
LIN28B lin-28 homolog B (C. elegans) -0.0204139
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -0.0203527
LCORL ligand dependent nuclear receptor corepressor-like -0.0203256
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.0203119
SFPQ splicing factor proline/glutamine-rich -0.0202961
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0202692
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0202276
ANXA7 annexin A7 -0.0202185
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0201792
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0201338
CCNY cyclin Y -0.0201229
SLC38A2 solute carrier family 38, member 2 -0.0201115
BCLAF1 BCL2-associated transcription factor 1 -0.0201114
NOSIP nitric oxide synthase interacting protein -0.0200648
R3HDM2 R3H domain containing 2 -0.0199066
SLC71A2 solute carrier family 71 member 2 -0.0198875
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -0.0198838
RUNX1 runt-related transcription factor 1 -0.0198157
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0198085
DNASE1 deoxyribonuclease I -0.0197945
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0197817
CENPE centromere protein E, 312kDa -0.0197427
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0197069
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0196386
CDK17 cyclin-dependent kinase 17 -0.0196357
CELF1 CUGBP, Elav-like family member 1 -0.0195876
ORAI2 ORAI calcium release-activated calcium modulator 2 -0.0195284
NCOR1 nuclear receptor corepressor 1 -0.019515
ECD ecdysoneless homolog (Drosophila) -0.0194842
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.019456
PARD6B par-6 family cell polarity regulator beta -0.0194519
GRB10 growth factor receptor-bound protein 10 -0.0194428
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0192913
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.0192541
RPL37 ribosomal protein L37 -0.0192371
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0192019
BCOR BCL6 corepressor -0.0190069
WDR70 WD repeat domain 70 -0.0189779
UFD1 ubiquitin recognition factor in ER associated degradation 1 -0.0189733
ZBTB44 zinc finger and BTB domain containing 44 -0.0189591
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0189454
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 -0.0189176
ETF1 eukaryotic translation termination factor 1 -0.0188961
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.018896
SPATS2 spermatogenesis associated, serine-rich 2 -0.0188682
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -0.0188172
GALK2 galactokinase 2 -0.0187663
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0187456
MEIS2 Meis homeobox 2 -0.0187363
AHNAK AHNAK nucleoprotein -0.0187237
TUBB tubulin, beta class I -0.0186913
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0186746
RNF8 ring finger protein 8, E3 ubiquitin protein ligase -0.0186723
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0186585
ARF4 ADP-ribosylation factor 4 -0.0185884
SNX14 sorting nexin 14 -0.0185722
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0185547
KMT2E lysine (K)-specific methyltransferase 2E -0.018423
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0184051
TCEA1 transcription elongation factor A (SII), 1 -0.0183974
ADAM17 ADAM metallopeptidase domain 17 -0.0183933
ANKRD13C ankyrin repeat domain 13C -0.0183908
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0183389
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0183197
CENPK centromere protein K -0.0183154
AHCYL2 adenosylhomocysteinase-like 2 -0.0183122
RPL30 ribosomal protein L30 -0.0182603
ARHGAP17 Rho GTPase activating protein 17 -0.0182487
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0182197
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0182078
MRTFB myocardin related transcription factor B -0.0181468
SPIRE1 spire-type actin nucleation factor 1 -0.0181468
MAPK8 mitogen-activated protein kinase 8 -0.0180562
SRSF2 serine/arginine-rich splicing factor 2 -0.0180548
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.018036
RAB6A RAB6A, member RAS oncogene family -0.0180269
SLC25A42 solute carrier family 25, member 42 -0.0180169
KRIT1 KRIT1, ankyrin repeat containing -0.0180162
ASXL1 additional sex combs like transcriptional regulator 1 -0.0179967
CTR9 CTR9, Paf1/RNA polymerase II complex component -0.0179938
FANCA Fanconi anemia, complementation group A -0.0179731
RFWD3 ring finger and WD repeat domain 3 -0.0179552
HCFC1 host cell factor C1 -0.0179474
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -0.0179163
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.0178421
LUZP1 leucine zipper protein 1 -0.0178409
CACUL1 CDK2-associated, cullin domain 1 -0.0178368
ORC3 origin recognition complex, subunit 3 -0.0177595
XXYLT1 xyloside xylosyltransferase 1 -0.0177557
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0177346
QRICH1 glutamine-rich 1 -0.017611
STK38 serine/threonine kinase 38 -0.0175584
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.0175481
RIOK3 RIO kinase 3 -0.0174291
RPF2 ribosome production factor 2 homolog (S. cerevisiae) -0.0174097
GDNF glial cell derived neurotrophic factor -0.0174059
FAM193A family with sequence similarity 193, member A -0.0173608
ENSA endosulfine alpha -0.0173306
H4C8 H4 clustered histone 8 -0.0173296
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0173141
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) -0.0173031
GGT7 gamma-glutamyltransferase 7 -0.017298
TGFBR3 transforming growth factor, beta receptor III -0.0172919
FRMD8 FERM domain containing 8 -0.0172512
SLC38A6 solute carrier family 38, member 6 -0.017207
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0171394
ZNF217 zinc finger protein 217 -0.0171279
RUFY2 RUN and FYVE domain containing 2 -0.0171217
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0170864
NCKAP1 NCK-associated protein 1 -0.0170381
ECPAS Ecm29 proteasome adaptor and scaffold -0.0170344
VRK1 vaccinia related kinase 1 -0.0170325
RHOT1 ras homolog family member T1 -0.0170219
NT5DC3 5'-nucleotidase domain containing 3 -0.0170095
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0169831
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0169491
PHTF1 putative homeodomain transcription factor 1 -0.0169318
DLAT dihydrolipoamide S-acetyltransferase -0.0169275
MYB v-myb avian myeloblastosis viral oncogene homolog -0.0169036
STK26 serine/threonine protein kinase 26 -0.0168807
TCERG1 transcription elongation regulator 1 -0.0168362
CLSTN1 calsyntenin 1 -0.0168106
PPA2 pyrophosphatase (inorganic) 2 -0.0168095
EVL Enah/Vasp-like -0.0168076
PRMT7 protein arginine methyltransferase 7 -0.0168033
CDK6 cyclin-dependent kinase 6 -0.0167958
GATAD2B GATA zinc finger domain containing 2B -0.0167897
ZNF326 zinc finger protein 326 -0.0167868
GATA3 GATA binding protein 3 -0.0167835
TFRC transferrin receptor -0.0167643
STK40 serine/threonine kinase 40 -0.0167044
MAPK6 mitogen-activated protein kinase 6 -0.0166294
CARD11 caspase recruitment domain family, member 11 -0.0165772
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -0.0165355
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -0.016453
SPTB spectrin, beta, erythrocytic -0.0164485
HDLBP high density lipoprotein binding protein -0.0164151
KAT6A K(lysine) acetyltransferase 6A -0.0164084
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0164026
ELL elongation factor RNA polymerase II -0.0163056
YBX3 Y box binding protein 3 -0.016224
NUP133 nucleoporin 133kDa -0.0162156
RBL2 retinoblastoma-like 2 -0.0162156
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0162143
INTS6 integrator complex subunit 6 -0.0162104
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -0.0162077
RBM41 RNA binding motif protein 41 -0.0161979
CAPRIN1 cell cycle associated protein 1 -0.0161554
AGPS alkylglycerone phosphate synthase -0.0161272
PANK3 pantothenate kinase 3 -0.0161246
BPTF bromodomain PHD finger transcription factor -0.0160888
RABGAP1L RAB GTPase activating protein 1-like -0.0160631
SDHAF3 succinate dehydrogenase complex assembly factor 3 -0.0160613
DPP9 dipeptidyl-peptidase 9 -0.0160537
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0160108
HLTF helicase-like transcription factor -0.0160077
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0160006
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0159655
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0159632
PRKCSH protein kinase C substrate 80K-H -0.0159578
HBE1 hemoglobin, epsilon 1 -0.0159572
NALF1 NALCN channel auxiliary factor 1 -0.0159128
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.0158827
H2AZ2 H2A.Z variant histone 2 -0.0158555
MBTD1 mbt domain containing 1 -0.0158493
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -0.0158277
HBZ hemoglobin, zeta -0.0158257
VASP vasodilator-stimulated phosphoprotein -0.0157924
E2F3 E2F transcription factor 3 -0.0157791
RAB11A RAB11A, member RAS oncogene family -0.0157709
FASTKD1 FAST kinase domains 1 -0.0157557
CUX1 cut-like homeobox 1 -0.015729
SNX19 sorting nexin 19 -0.0157236
MBNL1 muscleblind-like splicing regulator 1 -0.0157116
RUSC2 RUN and SH3 domain containing 2 -0.015643
TBC1D22A TBC1 domain family, member 22A -0.01562
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0156182
RAD23B RAD23 homolog B (S. cerevisiae) -0.0155899
ZNF804B zinc finger protein 804B -0.0155645
GLS2 glutaminase 2 (liver, mitochondrial) -0.0155366
RTN3 reticulon 3 -0.0155244
RAP1A RAP1A, member of RAS oncogene family -0.0155204
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0155202
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.015465
RPS17 ribosomal protein S17 -0.0154649
CCDC14 coiled-coil domain containing 14 -0.015429
RAB10 RAB10, member RAS oncogene family -0.0154232
TMEM59 transmembrane protein 59 -0.0154046
MYLIP myosin regulatory light chain interacting protein -0.0153679
LSG1 large 60S subunit nuclear export GTPase 1 -0.0153625
DIAPH3 diaphanous-related formin 3 -0.0153504
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0153334
FUBP1 far upstream element (FUSE) binding protein 1 -0.015332
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -0.015319
ARHGAP18 Rho GTPase activating protein 18 -0.0153065
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.015289
TOR1AIP2 torsin A interacting protein 2 -0.015285
EIF1 eukaryotic translation initiation factor 1 -0.0152842
ZC3H13 zinc finger CCCH-type containing 13 -0.0152737
BLTP3B bridge-like lipid transfer protein family member 3B -0.0152727
LARS2 leucyl-tRNA synthetase 2, mitochondrial -0.0152704
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.015253
APOE apolipoprotein E -0.0152063
POLH polymerase (DNA directed), eta -0.0151953
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0151791
DEPDC1B DEP domain containing 1B -0.0151605
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0151216
TTC7B tetratricopeptide repeat domain 7B -0.0151126
ZDHHC13 zinc finger, DHHC-type containing 13 -0.0151113
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.0150945
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.015039
MAML2 mastermind-like 2 (Drosophila) -0.0150305
ANKRD52 ankyrin repeat domain 52 -0.0150283
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0150046
PRNP prion protein -0.0149936
PREPL prolyl endopeptidase-like -0.0149907
ZFX zinc finger protein, X-linked -0.0149671
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0149518
GPHN gephyrin -0.0149316
TET1 tet methylcytosine dioxygenase 1 -0.0149305
F2RL3 coagulation factor II (thrombin) receptor-like 3 -0.0149266
GATD1 glutamine amidotransferase class 1 domain containing 1 -0.014922
NVL nuclear VCP-like -0.0148838
ADNP2 ADNP homeobox 2 -0.014874
PXDN peroxidasin -0.0148714
PARP6 poly (ADP-ribose) polymerase family, member 6 -0.0148494
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0148493
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0148328
SSBP2 single-stranded DNA binding protein 2 -0.0148268
NOP58 NOP58 ribonucleoprotein -0.0148218
GPHRA golgi pH regulator A -0.0147907
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0147303
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.014721
MED12 mediator complex subunit 12 -0.0147158
STIL SCL/TAL1 interrupting locus -0.0146794
GCLM glutamate-cysteine ligase, modifier subunit -0.014678
NCAM2 neural cell adhesion molecule 2 -0.0146731
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0146683
RPL22 ribosomal protein L22 -0.0146523
SFI1 Sfi1 homolog, spindle assembly associated (yeast) -0.0146374
GNAS GNAS complex locus -0.0146354
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0146295
NUP214 nucleoporin 214kDa -0.0146194
TBC1D15 TBC1 domain family, member 15 -0.0146054
SQLE squalene epoxidase -0.0145881
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0145796
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0145575
SCAF4 SR-related CTD-associated factor 4 -0.0145518
NCBP1 nuclear cap binding protein subunit 1, 80kDa -0.0145344
FBXL17 F-box and leucine-rich repeat protein 17 -0.0145229
GCDH glutaryl-CoA dehydrogenase -0.0144963
ZNF407 zinc finger protein 407 -0.0144762
BZW2 basic leucine zipper and W2 domains 2 -0.0144396
TMEM64 transmembrane protein 64 -0.0144383
RHBDD2 rhomboid domain containing 2 -0.0144364
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0144319
SQSTM1 sequestosome 1 -0.0144252
MCPH1 microcephalin 1 -0.0144223
BICD2 bicaudal D homolog 2 (Drosophila) -0.014395
SCAF11 SR-related CTD-associated factor 11 -0.0143688
MEF2A myocyte enhancer factor 2A -0.0143578
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0143528
VTA1 vesicle (multivesicular body) trafficking 1 -0.0143478
RLF rearranged L-myc fusion -0.0143452
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0143448
DBF4B DBF4 zinc finger B -0.014343
TBC1D4 TBC1 domain family, member 4 -0.014331
HBP1 HMG-box transcription factor 1 -0.0143283
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0143154
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0143102
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.014295
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0142865
CCDC47 coiled-coil domain containing 47 -0.014279
UCK2 uridine-cytidine kinase 2 -0.0142782
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0142259
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -0.0142126
KDM4A lysine (K)-specific demethylase 4A -0.0142117
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -0.0142047
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0141976
AHDC1 AT hook, DNA binding motif, containing 1 -0.0141937
MARCHF6 membrane associated ring-CH-type finger 6 -0.0141933
CEP57 centrosomal protein 57kDa -0.0141927
EIF4A2 eukaryotic translation initiation factor 4A2 -0.014146
ASCC2 activating signal cointegrator 1 complex subunit 2 -0.0141363
DCHS2 dachsous cadherin-related 2 -0.014135
ATP5F1D ATP synthase F1 subunit delta -0.0141337
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0140936
ADCY8 adenylate cyclase 8 (brain) -0.0140871
FAM168B family with sequence similarity 168, member B -0.0140736
LRRC59 leucine rich repeat containing 59 -0.014049
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0140148
PRRC2A proline-rich coiled-coil 2A -0.0139583
STMP1 short transmembrane mitochondrial protein 1 -0.0139554