K562_NVP-BSK805 2HCl_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description NVP-BSK805 2HCl 1µM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_NVP-BSK805 2HCl_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MUSK muscle, skeletal, receptor tyrosine kinase 0.117088
NCOA3 nuclear receptor coactivator 3 0.104199
GSE1 Gse1 coiled-coil protein 0.072551
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0656208
MYO1D myosin ID 0.0654893
ZNF106 zinc finger protein 106 0.0635545
KRT8 keratin 8, type II 0.0634767
PLCL1 phospholipase C-like 1 0.0630232
BCAS3 breast carcinoma amplified sequence 3 0.0613064
ANO10 anoctamin 10 0.0602646
SYTL2 synaptotagmin-like 2 0.0572077
H2AC6 H2A clustered histone 6 0.0554904
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0551783
HBG1 hemoglobin, gamma A 0.0549651
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0540542
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0537306
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0501976
BPTF bromodomain PHD finger transcription factor 0.0491629
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.048059
EPB41 erythrocyte membrane protein band 4.1 0.048047
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.046765
TLK1 tousled-like kinase 1 0.0458642
BSG basigin (Ok blood group) 0.0447899
RPLP1 ribosomal protein, large, P1 0.044112
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0421809
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0418614
RSRP1 arginine/serine-rich protein 1 0.0417522
ZNF644 zinc finger protein 644 0.0416173
CLCN3 chloride channel, voltage-sensitive 3 0.0415236
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0404351
WWOX WW domain containing oxidoreductase 0.0402806
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0401553
ABHD3 abhydrolase domain containing 3 0.0375296
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0368294
TRIM33 tripartite motif containing 33 0.0367603
TMEM116 transmembrane protein 116 0.0366245
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0365958
KRT19 keratin 19, type I 0.0363889
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.036277
WDPCP WD repeat containing planar cell polarity effector 0.0362357
ACTG1 actin gamma 1 0.0361341
TNRC18 trinucleotide repeat containing 18 0.035893
TUBB tubulin, beta class I 0.0357935
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0352853
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.0351118
UBTF upstream binding transcription factor, RNA polymerase I 0.0348716
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347174
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0347112
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0346464
MACROD2 MACRO domain containing 2 0.0346064
TMEM267 transmembrane protein 267 0.0345566
PARP1 poly (ADP-ribose) polymerase 1 0.0343596
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0342648
SEC31A SEC31 homolog A (S. cerevisiae) 0.0341212
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0340362
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0339621
PLEC plectin 0.0338814
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.0338234
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.033712
PHF3 PHD finger protein 3 0.033687
EVI5 ecotropic viral integration site 5 0.0335506
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0334578
UNC13D unc-13 homolog D (C. elegans) 0.0334475
AARS1 alanyl-tRNA synthetase 1 0.0334217
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 0.0331869
YME1L1 YME1-like 1 ATPase 0.0330733
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.0330447
NFIA nuclear factor I/A 0.0329938
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0329493
ERBIN erbb2 interacting protein 0.0328959
MBTD1 mbt domain containing 1 0.03288
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0328466
ZC3H13 zinc finger CCCH-type containing 13 0.0328241
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0326557
STK24 serine/threonine kinase 24 0.0326302
TRPS1 trichorhinophalangeal syndrome I 0.0323213
GATA3 GATA binding protein 3 0.0320438
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0318785
PHGDH phosphoglycerate dehydrogenase 0.031865
ATAD2 ATPase family, AAA domain containing 2 0.0318384
AKAP10 A kinase (PRKA) anchor protein 10 0.0317865
CYRIB CYFIP related Rac1 interactor B 0.0315926
TCF12 transcription factor 12 0.0314573
RSL1D1 ribosomal L1 domain containing 1 0.0313946
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0313472
PTBP1 polypyrimidine tract binding protein 1 0.0312657
NT5C2 5'-nucleotidase, cytosolic II 0.0308781
RPS14 ribosomal protein S14 0.0307964
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0307794
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0306707
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0305386
RPL18 ribosomal protein L18 0.0304162
UIMC1 ubiquitin interaction motif containing 1 0.0301753
RBM33 RNA binding motif protein 33 0.0298984
TRIM37 tripartite motif containing 37 0.0298946
NSD3 nuclear receptor binding SET domain protein 3 0.0298331
MAGT1 magnesium transporter 1 0.0298117
ZSWIM6 zinc finger, SWIM-type containing 6 0.029726
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0295838
KIF5B kinesin family member 5B 0.0294821
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0294219
GCC2 GRIP and coiled-coil domain containing 2 0.0293437
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0290385
ZNF655 zinc finger protein 655 0.0290255
CST3 cystatin C 0.0289995
LMNA lamin A/C 0.0289081
GANAB glucosidase, alpha; neutral AB 0.0287891
ADGRV1 adhesion G protein-coupled receptor V1 0.0287468
RPS3 ribosomal protein S3 0.0287257
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0286346
SPOP speckle-type POZ protein 0.0283883
GDI2 GDP dissociation inhibitor 2 0.0282438
CSDE1 cold shock domain containing E1, RNA-binding 0.0282411
PARD6B par-6 family cell polarity regulator beta 0.0281542
SNX25 sorting nexin 25 0.0280491
MFGE8 milk fat globule-EGF factor 8 protein 0.0279864
FLNB filamin B, beta 0.0279767
STX8 syntaxin 8 0.0279759
MTDH metadherin 0.0279549
RANBP9 RAN binding protein 9 0.0278704
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0278012
NAV1 neuron navigator 1 0.0277954
PRR11 proline rich 11 0.0277199
IGF1R insulin-like growth factor 1 receptor 0.0275472
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0275183
RAB6A RAB6A, member RAS oncogene family 0.0274825
ASXL2 additional sex combs like transcriptional regulator 2 0.0273638
ACSL3 acyl-CoA synthetase long-chain family member 3 0.027351
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.027335
EP300 E1A binding protein p300 0.0272507
TPM3 tropomyosin 3 0.0272342
CCNY cyclin Y 0.0271276
CHD4 chromodomain helicase DNA binding protein 4 0.0271273
ZNF800 zinc finger protein 800 0.0270932
HBG2 hemoglobin, gamma G 0.0269446
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0268816
LRP12 low density lipoprotein receptor-related protein 12 0.0268499
DSPP dentin sialophosphoprotein 0.0268249
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0267755
DMWD dystrophia myotonica, WD repeat containing 0.0265666
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0265282
KRT18 keratin 18, type I 0.0264575
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0262791
TRAK1 trafficking protein, kinesin binding 1 0.0262668
LDHB lactate dehydrogenase B 0.0262454
SMAP2 small ArfGAP2 0.0261893
ANAPC1 anaphase promoting complex subunit 1 0.0261436
SKAP2 src kinase associated phosphoprotein 2 0.02606
KLHL22 kelch-like family member 22 0.0260518
RPS13 ribosomal protein S13 0.0260067
MARCHF3 membrane associated ring-CH-type finger 3 0.0260005
DSTN destrin (actin depolymerizing factor) 0.0259884
PA2G4 proliferation-associated 2G4, 38kDa 0.0259185
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0258279
RNF216 ring finger protein 216 0.0257785
THOC2 THO complex 2 0.0257253
HOMER1 homer scaffolding protein 1 0.0256271
CDC73 cell division cycle 73 0.0255625
NQO1 NAD(P)H dehydrogenase, quinone 1 0.025456
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0254033
DARS1 aspartyl-tRNA synthetase 1 0.0253893
TOR1AIP2 torsin A interacting protein 2 0.025356
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0253327
RSF1 remodeling and spacing factor 1 0.0252381
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0252211
SPPL3 signal peptide peptidase like 3 0.0250798
ZNF721 zinc finger protein 721 0.0249655
FRYL FRY-like 0.0249635
PDZD8 PDZ domain containing 8 0.0248966
NIPBL Nipped-B homolog (Drosophila) 0.0247855
GMDS GDP-mannose 4,6-dehydratase 0.024785
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0247647
FAM193B family with sequence similarity 193, member B 0.0247518
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0246851
LARP1 La ribonucleoprotein domain family, member 1 0.0246115
CCDC6 coiled-coil domain containing 6 0.0245262
RPN2 ribophorin II 0.0245223
COMMD10 COMM domain containing 10 0.0244678
PDS5A PDS5 cohesin associated factor A 0.0244574
TTC3 tetratricopeptide repeat domain 3 0.02445
SULF2 sulfatase 2 0.0244208
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0244177
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.02435
NSD1 nuclear receptor binding SET domain protein 1 0.024342
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0242968
FAM89A family with sequence similarity 89, member A 0.024187
IRF3 interferon regulatory factor 3 0.0241816
ENO1 enolase 1, (alpha) 0.0241764
CXXC5 CXXC finger protein 5 0.0241657
ARL15 ADP-ribosylation factor-like 15 0.0239792
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0239665
RESF1 retroelement silencing factor 1 0.0239556
SOD1 superoxide dismutase 1, soluble 0.0239106
WDR70 WD repeat domain 70 0.0237992
NCOA1 nuclear receptor coactivator 1 0.0237871
ZBTB20 zinc finger and BTB domain containing 20 0.0236146
POLH polymerase (DNA directed), eta 0.0235774
RPS8 ribosomal protein S8 0.0235634
IGBP1 immunoglobulin (CD79A) binding protein 1 0.0235503
AFF1 AF4/FMR2 family, member 1 0.0235488
RPS6 ribosomal protein S6 0.0235443
JARID2 jumonji, AT rich interactive domain 2 0.0235394
FIG4 FIG4 phosphoinositide 5-phosphatase 0.0234992
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0234776
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0233957
PKM pyruvate kinase, muscle 0.0233673
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0232554
FBXL20 F-box and leucine-rich repeat protein 20 0.0230388
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 0.0230316
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0229117
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 0.0229027
ZC3H6 zinc finger CCCH-type containing 6 0.0228887
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0228714
TNRC6B trinucleotide repeat containing 6B 0.0228681
AVL9 AVL9 homolog (S. cerevisiase) 0.0228488
ADARB1 adenosine deaminase, RNA-specific, B1 0.0228443
HDGFL3 HDGF like 3 0.0227746
HIP1 huntingtin interacting protein 1 0.0226796
ZZZ3 zinc finger, ZZ-type containing 3 0.0226694
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0226272
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.0226263
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0224997
CEP290 centrosomal protein 290kDa 0.0224696
DRC8 dynein regulatory complex subunit 8 0.0223352
STAT5B signal transducer and activator of transcription 5B 0.0223103
SEPTIN6 septin 6 0.0222273
RPS10 ribosomal protein S10 0.0221833
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0221484
UBAP2 ubiquitin associated protein 2 0.0221442
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0221224
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0220659
SFTPA2 surfactant protein A2 0.0220647
DTNA dystrobrevin, alpha 0.022038
CAMTA1 calmodulin binding transcription activator 1 0.0220195
ARHGAP6 Rho GTPase activating protein 6 0.0220164
CLSPN claspin 0.022002
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0219937
RSU1 Ras suppressor protein 1 0.0219655
MPHOSPH8 M-phase phosphoprotein 8 0.0218311
DPY19L4 dpy-19-like 4 (C. elegans) 0.0218261
KIAA2026 KIAA2026 0.0217665
SLC38A10 solute carrier family 38, member 10 0.0217505
CCSER2 coiled-coil serine-rich protein 2 0.0217163
SLC39A11 solute carrier family 39, member 11 0.0217083
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0216904
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0216821
GTF2IRD1 GTF2I repeat domain containing 1 0.0216699
COPS4 COP9 signalosome subunit 4 0.0216083
POU6F2 POU class 6 homeobox 2 0.0215813
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0215753
EGF epidermal growth factor 0.0215614
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.0215331
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.0215263
RPS18 ribosomal protein S18 0.0215058
SSBP2 single-stranded DNA binding protein 2 0.0214733
PAPOLA poly(A) polymerase alpha 0.021356
BCR breakpoint cluster region 0.0213046
PRNP prion protein 0.0212123
ZNF429 zinc finger protein 429 0.0211806
TBC1D14 TBC1 domain family, member 14 0.0211756
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0211374
WDR33 WD repeat domain 33 0.0211339
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.0211214
ARHGAP21 Rho GTPase activating protein 21 0.0210723
GNAS GNAS complex locus 0.0210479
MARK4 MAP/microtubule affinity-regulating kinase 4 0.0210373
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0209823
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.0209317
EIF1AX eukaryotic translation initiation factor 1A, X-linked 0.0208582
SPC24 SPC24, NDC80 kinetochore complex component 0.0208437
SMIM44 small integral membrane protein 44 0.0208048
NQO2 NAD(P)H dehydrogenase, quinone 2 0.0207772
UBA2 ubiquitin-like modifier activating enzyme 2 0.0207397
RTN3 reticulon 3 0.0207317
RPL34 ribosomal protein L34 0.0207288
NRIP1 nuclear receptor interacting protein 1 0.0206958
MEF2C myocyte enhancer factor 2C 0.0206218
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.0205733
ANKRD23 ankyrin repeat domain 23 0.0205429
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0205345
SRPK2 SRSF protein kinase 2 0.020508
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0204897
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0204808
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0204228
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.0204087
GRAMD1A GRAM domain containing 1A 0.0204078
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0203284
NUP107 nucleoporin 107kDa 0.0202902
AFDN afadin, adherens junction formation factor 0.020268
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.0201845
METAP2 methionyl aminopeptidase 2 0.0201785
NAP1L1 nucleosome assembly protein 1-like 1 0.0201565
COXFA4 cytochrome c oxidase associated subunit FA4 0.0201094
SESN1 sestrin 1 0.0200865
RPS2 ribosomal protein S2 0.0200207
KIAA1328 KIAA1328 0.0200043
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.0199512
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0199458
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.0199025
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0198926
ANAPC7 anaphase promoting complex subunit 7 0.0198753
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0198748
SUSD1 sushi domain containing 1 0.0198466
RIOK3 RIO kinase 3 0.019798
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0197322
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0197062
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.019637
RAD21 RAD21 homolog (S. pombe) 0.0195609
NEBL nebulette 0.0194317
FNBP1 formin binding protein 1 0.0194034
RAB23 RAB23, member RAS oncogene family 0.0193841
N4BP2 NEDD4 binding protein 2 0.0192486
COL21A1 collagen, type XXI, alpha 1 0.0192364
VCP valosin containing protein 0.019234
CLTCL1 clathrin, heavy chain-like 1 0.0192152
MAP2K4 mitogen-activated protein kinase kinase 4 0.0191928
ARHGAP17 Rho GTPase activating protein 17 0.0191903
ATP5F1A ATP synthase F1 subunit alpha 0.0191902
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.0191793
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0191042
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0190848
RSL24D1 ribosomal L24 domain containing 1 0.0190694
CERT1 ceramide transporter 1 0.0189792
RBM25 RNA binding motif protein 25 0.0189619
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0189416
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0189193
TAC4 tachykinin 4 (hemokinin) 0.0188944
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.0188839
RHBDD1 rhomboid domain containing 1 0.0188426
INTS7 integrator complex subunit 7 0.0188005
WASHC3 WASH complex subunit 3 0.0188003
GMEB1 glucocorticoid modulatory element binding protein 1 0.0187643
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.0187602
LARP1B La ribonucleoprotein domain family, member 1B 0.018756
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.0187207
CIRSR corepressor of RBPJ and splicing regulator 0.0186958
CFDP1 craniofacial development protein 1 0.0186956
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.0186467
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.018643
RAB27B RAB27B, member RAS oncogene family 0.018611
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.0186012
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.0185929
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.0185857
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 0.0185461
ACER3 alkaline ceramidase 3 0.0185452
FAM78A family with sequence similarity 78, member A 0.0185176
HMGN1 high mobility group nucleosome binding domain 1 0.0184971
STRBP spermatid perinuclear RNA binding protein 0.01842
RACK1 receptor for activated C kinase 1 0.0184136
MPV17 MpV17 mitochondrial inner membrane protein 0.0184128
HDAC8 histone deacetylase 8 0.018364
SPPL2A signal peptide peptidase like 2A 0.0183434
HSPA4 heat shock 70kDa protein 4 0.0183303
NELFCD negative elongation factor complex member C/D 0.0182833
ZDHHC20 zinc finger, DHHC-type containing 20 0.0182786
MOB1A MOB kinase activator 1A 0.0182523
ELAVL1 ELAV like RNA binding protein 1 0.0182345
SIN3A SIN3 transcription regulator family member A 0.0182299
TNPO3 transportin 3 0.0182133
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.0181437
MINK1 misshapen-like kinase 1 0.0181397
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.0181145
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0180746
DNA2 DNA replication helicase/nuclease 2 0.0180476
ZNF217 zinc finger protein 217 0.0180033
ANK1 ankyrin 1, erythrocytic 0.0179834
GOLGB1 golgin B1 0.0179598
CCNC cyclin C 0.0179503
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.0179159
KIF13B kinesin family member 13B 0.0178952
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0178606
PCCB propionyl CoA carboxylase, beta polypeptide 0.0178179
ZFPM2 zinc finger protein, FOG family member 2 0.0177628
BRWD1 bromodomain and WD repeat domain containing 1 0.017752
SKA2 spindle and kinetochore associated complex subunit 2 0.0176975
VMP1 vacuole membrane protein 1 0.0176946
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0176761
C21ORF58 chromosome 21 open reading frame 58 0.0176716
TMEM164 transmembrane protein 164 0.0176464
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0176177
ECD ecdysoneless homolog (Drosophila) 0.017578
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0174932
EEA1 early endosome antigen 1 0.0174924
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0174707
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0174612
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.0174471
STON2 stonin 2 0.017444
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0174433
CNTN5 contactin 5 0.0174244
APLP2 amyloid beta (A4) precursor-like protein 2 0.0174112
SP3 Sp3 transcription factor 0.0173934
CLCN4 chloride channel, voltage-sensitive 4 0.0173903
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0173893
PUDP pseudouridine 5'-phosphatase 0.017382
KMT5B lysine methyltransferase 5B 0.0173655
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.017364
VEZT vezatin, adherens junctions transmembrane protein 0.0173346
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.0173109
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0172871
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 0.0172708
UBE2H ubiquitin-conjugating enzyme E2H 0.0172614
HELQ helicase, POLQ-like 0.0172448
SOCS4 suppressor of cytokine signaling 4 0.0172222
DPP9 dipeptidyl-peptidase 9 0.0171972
SERTAD2 SERTA domain containing 2 0.0171754
TRAK2 trafficking protein, kinesin binding 2 0.0171732
NDRG1 N-myc downstream regulated 1 0.0171408
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0170989
HDGF hepatoma-derived growth factor 0.0170873
PHF14 PHD finger protein 14 0.0170873
SPTA1 spectrin, alpha, erythrocytic 1 0.0170798
COG4 component of oligomeric golgi complex 4 0.017074
SH3BGRL SH3 domain binding glutamate-rich protein like 0.017007
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0170001
IREB2 iron-responsive element binding protein 2 0.016952
SET SET nuclear proto-oncogene 0.0169337
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.0169142
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.016882
EDF1 endothelial differentiation-related factor 1 0.0168434
HSPA1A heat shock 70kDa protein 1A 0.0168307
ATP5MC3 ATP synthase membrane subunit c locus 3 0.0168287
WASF2 WAS protein family, member 2 0.0168173
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.0167881
NEU3 sialidase 3 (membrane sialidase) 0.0167574
THOC5 THO complex 5 0.0167537
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 0.0167034
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 0.0166916
HSDL2 hydroxysteroid dehydrogenase like 2 0.016687
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.0166362
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0165964
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0165904
FBXL17 F-box and leucine-rich repeat protein 17 0.0165873
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0165817
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0165519
CDC42 cell division cycle 42 0.0165503
FAM120B family with sequence similarity 120B 0.0165293
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0165186
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0165126
EZR ezrin 0.0164961
MARCHF6 membrane associated ring-CH-type finger 6 0.0164772
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.0164601
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.016455
SLC38A9 solute carrier family 38, member 9 0.0164404
MIER1 mesoderm induction early response 1, transcriptional regulator 0.016439
CARS1 cysteinyl-tRNA synthetase 1 0.0164244
MAML3 mastermind-like 3 (Drosophila) 0.0164071
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0163979
CLSTN1 calsyntenin 1 0.0163903
LAMP2 lysosomal-associated membrane protein 2 0.0163546
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0163043
TKT transketolase 0.0162948
TMEM41A transmembrane protein 41A 0.0162897
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 0.0162754
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.016233
PBX1 pre-B-cell leukemia homeobox 1 0.0162322
PPA1 pyrophosphatase (inorganic) 1 0.0162052
SPC25 SPC25, NDC80 kinetochore complex component 0.0161908
H1-10 H1.10 linker histone 0.0161741
TEX9 testis expressed 9 0.0161688
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.0161621
ASCC1 activating signal cointegrator 1 complex subunit 1 0.0161529
RPSA ribosomal protein SA 0.016131
KIF15 kinesin family member 15 0.0161088
HSPH1 heat shock 105kDa/110kDa protein 1 0.0161021
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 0.0160902
BCAP31 B-cell receptor-associated protein 31 0.0160765
PTPRK protein tyrosine phosphatase, receptor type, K 0.0160719
RNF38 ring finger protein 38 0.0160165
OAZ1 ornithine decarboxylase antizyme 1 0.0160152
RNF24 ring finger protein 24 0.0160052
TMEM43 transmembrane protein 43 0.015967
LMAN1 lectin, mannose-binding, 1 0.0159645
PITX1 paired-like homeodomain 1 0.0159557
PACS1 phosphofurin acidic cluster sorting protein 1 0.0159553
SLC30A9 solute carrier family 30 (zinc transporter), member 9 0.0159322
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.015897
COG8 component of oligomeric golgi complex 8 0.0158944
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.0158706
XRRA1 X-ray radiation resistance associated 1 0.0158704
DMD dystrophin 0.0158685
LASP1 LIM and SH3 protein 1 0.0158526
RDX radixin 0.0158253
BBX bobby sox homolog (Drosophila) 0.0158202
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.0158039
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0158018
ATOSA atos homolog A 0.0158017
RPAP3 RNA polymerase II associated protein 3 0.0157283
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0157049
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.0157022
UBE2B ubiquitin-conjugating enzyme E2B 0.0156771
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.0156764
ESYT1 extended synaptotagmin-like protein 1 0.0156634
KLF3 Kruppel-like factor 3 (basic) 0.0156365
CAMKMT calmodulin-lysine N-methyltransferase 0.0156075
ATP11B ATPase, class VI, type 11B 0.0156042
CEBPZOS CEBPZ opposite strand 0.0155973
ANXA2 annexin A2 0.0155785
DLG1 discs, large homolog 1 (Drosophila) 0.0155738
ATP9B ATPase, class II, type 9B 0.0155619
IPP intracisternal A particle-promoted polypeptide 0.0155562

decreased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) -0.0885698
ACTN4 actinin, alpha 4 -0.0795172
FHIT fragile histidine triad -0.07888
MACF1 microtubule-actin crosslinking factor 1 -0.0686308
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0639149
DIAPH1 diaphanous-related formin 1 -0.0590252
JMJD1C jumonji domain containing 1C -0.0587487
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0576344
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -0.0566837
LMBR1 limb development membrane protein 1 -0.0549984
TTC28 tetratricopeptide repeat domain 28 -0.0532681
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0531546
PICALM phosphatidylinositol binding clathrin assembly protein -0.0527988
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0526782
ANKRD28 ankyrin repeat domain 28 -0.0497078
PRKCA protein kinase C, alpha -0.0489994
SRRM2 serine/arginine repetitive matrix 2 -0.0486754
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0477126
CALR calreticulin -0.0473287
ATXN2 ataxin 2 -0.046905
CDK13 cyclin-dependent kinase 13 -0.046531
NUP214 nucleoporin 214kDa -0.0462613
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.0461255
LYRM4 LYR motif containing 4 -0.0453541
NUP98 nucleoporin 98kDa -0.0447228
NGLY1 N-glycanase 1 -0.0443559
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0441665
CCDC91 coiled-coil domain containing 91 -0.0441636
ZMYND8 zinc finger, MYND-type containing 8 -0.0438903
GOLGA4 golgin A4 -0.0432868
SETD5 SET domain containing 5 -0.0427103
ARHGAP11B Rho GTPase activating protein 11B -0.0418219
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0415243
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0415204
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.041492
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -0.0414383
CCDC57 coiled-coil domain containing 57 -0.041242
MKI67 marker of proliferation Ki-67 -0.0408289
CD2AP CD2-associated protein -0.0404259
FKBP5 FK506 binding protein 5 -0.0396859
KIF13A kinesin family member 13A -0.0389943
CEP295 centrosomal protein 295kDa -0.038773
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.0387529
MEIS2 Meis homeobox 2 -0.0386779
KIF2A kinesin heavy chain member 2A -0.0385734
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0385277
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0380499
DNM2 dynamin 2 -0.0380195
DIAPH3 diaphanous-related formin 3 -0.0378049
RHOBTB3 Rho-related BTB domain containing 3 -0.0377879
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.0374484
COG5 component of oligomeric golgi complex 5 -0.0372008
ESYT2 extended synaptotagmin-like protein 2 -0.036701
AIG1 androgen-induced 1 -0.0366301
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -0.03663
ASPH aspartate beta-hydroxylase -0.0365204
USP34 ubiquitin specific peptidase 34 -0.0359803
CALU calumenin -0.0356552
KIF18B kinesin family member 18B -0.0355886
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0352226
RBM6 RNA binding motif protein 6 -0.0350398
FGF13 fibroblast growth factor 13 -0.0349378
GATAD2B GATA zinc finger domain containing 2B -0.0348225
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0348064
CTBP2 C-terminal binding protein 2 -0.0344948
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0344119
USP32 ubiquitin specific peptidase 32 -0.0343895
SF3A3 splicing factor 3a, subunit 3, 60kDa -0.034005
AK1 adenylate kinase 1 -0.0339435
CDC14A cell division cycle 14A -0.0337461
ZNF609 zinc finger protein 609 -0.0337285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0337162
MAP4 microtubule-associated protein 4 -0.0329884
AGO2 argonaute RISC catalytic component 2 -0.0328991
SLC38A1 solute carrier family 38, member 1 -0.0327072
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.032561
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.032293
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0321993
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0321577
BABAM2 BRISC and BRCA1 A complex member 2 -0.0318036
SMYD3 SET and MYND domain containing 3 -0.031495
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0314524
TFRC transferrin receptor -0.0314014
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0312806
TUT4 terminal uridylyl transferase 4 -0.031256
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0308572
OGA O-GlcNAcase -0.0308137
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0307789
TASOR2 transcription activation suppressor family member 2 -0.0302987
AKAP9 A kinase (PRKA) anchor protein 9 -0.030172
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0300821
ZFYVE9 zinc finger, FYVE domain containing 9 -0.0300599
RHOT1 ras homolog family member T1 -0.0299505
GMPS guanine monphosphate synthase -0.0298958
CENPC centromere protein C -0.0298257
MED13L mediator complex subunit 13-like -0.0298076
PKP4 plakophilin 4 -0.0297784
VAC14 Vac14 homolog (S. cerevisiae) -0.0296625
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0296164
KMT2C lysine (K)-specific methyltransferase 2C -0.0295824
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0295739
LYPLA1 lysophospholipase I -0.029484
BMP2K BMP2 inducible kinase -0.0294613
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0293799
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -0.0290163
CDK6 cyclin-dependent kinase 6 -0.0286534
PHACTR4 phosphatase and actin regulator 4 -0.0284778
CDK19 cyclin-dependent kinase 19 -0.0282029
UBE3D ubiquitin protein ligase E3D -0.0279531
CENPE centromere protein E, 312kDa -0.027935
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0279226
POTEF POTE ankyrin domain family, member F -0.0278625
TGOLN2 trans-golgi network protein 2 -0.0277709
TMOD1 tropomodulin 1 -0.0277351
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.027709
BRCA1 breast cancer 1, early onset -0.027702
SLC35D4 solute carrier family 35 member D4 -0.0276898
LRRC61 leucine rich repeat containing 61 -0.0276052
CDCA2 cell division cycle associated 2 -0.0274716
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.027277
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -0.0272751
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0269666
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0268105
CTCF CCCTC-binding factor (zinc finger protein) -0.0267236
TAPBP TAP binding protein (tapasin) -0.026574
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0264967
HEATR1 HEAT repeat containing 1 -0.0264803
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0263863
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0262982
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0262735
ADD3 adducin 3 (gamma) -0.0262189
FAM13B family with sequence similarity 13, member B -0.0260988
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0260893
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -0.0259805
MCU mitochondrial calcium uniporter -0.025826
KIF4A kinesin family member 4A -0.0256947
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0255506
WRN Werner syndrome, RecQ helicase-like -0.0254839
WDR26 WD repeat domain 26 -0.0254329
TBCK TBC1 domain containing kinase -0.0253394
RICTOR RPTOR independent companion of MTOR, complex 2 -0.025306
PTK2 protein tyrosine kinase 2 -0.0249983
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0245402
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0242584
NUP153 nucleoporin 153kDa -0.0242439
SCARB1 scavenger receptor class B, member 1 -0.0241353
DNM1 dynamin 1 -0.0241261
GPC5 glypican 5 -0.0241198
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 -0.0240896
TCERG1 transcription elongation regulator 1 -0.023947
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.0238087
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0235794
NEK7 NIMA-related kinase 7 -0.0235268
SUCO SUN domain containing ossification factor -0.0235148
ARHGAP24 Rho GTPase activating protein 24 -0.0234115
OSBPL3 oxysterol binding protein-like 3 -0.0233558
MSI2 musashi RNA-binding protein 2 -0.0233039
STX5 syntaxin 5 -0.023287
PHKB phosphorylase kinase, beta -0.0232155
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0231864
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0229594
RYBP RING1 and YY1 binding protein -0.0228213
EXOC4 exocyst complex component 4 -0.0227797
WDR36 WD repeat domain 36 -0.0226316
FBXO28 F-box protein 28 -0.0224751
AGO3 argonaute RISC catalytic component 3 -0.0223903
AKIRIN1 akirin 1 -0.0223499
CLIP1 CAP-GLY domain containing linker protein 1 -0.0223435
SRSF4 serine/arginine-rich splicing factor 4 -0.021961
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.0219079
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0218412
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0218242
RLF rearranged L-myc fusion -0.0217627
DCTN4 dynactin 4 (p62) -0.0217579
TTC33 tetratricopeptide repeat domain 33 -0.0216876
NCAM2 neural cell adhesion molecule 2 -0.0216428
SINHCAF SIN3-HDAC complex associated factor -0.0215463
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.021523
RHEB Ras homolog enriched in brain -0.0215214
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0215166
ZEB2 zinc finger E-box binding homeobox 2 -0.0214326
NARS1 asparaginyl-tRNA synthetase 1 -0.0213978
EMP2 epithelial membrane protein 2 -0.021397
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0213794
CAPN1 calpain 1, (mu/I) large subunit -0.0212768
CFAP161 cilia and flagella associated protein 161 -0.0212751
MBD5 methyl-CpG binding domain protein 5 -0.0212284
SH2B3 SH2B adaptor protein 3 -0.0211301
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.020958
KDM4B lysine (K)-specific demethylase 4B -0.0209142
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0208735
REPS1 RALBP1 associated Eps domain containing 1 -0.0208434
KRIT1 KRIT1, ankyrin repeat containing -0.0208296
MOB3B MOB kinase activator 3B -0.0205983
CCDC88A coiled-coil domain containing 88A -0.0205905
PPA2 pyrophosphatase (inorganic) 2 -0.0205828
TMEM245 transmembrane protein 245 -0.020577
TCAF1 TRPM8 channel-associated factor 1 -0.0205725
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0205067
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.0204979
SEPTIN11 septin 11 -0.0204785
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -0.0204755
GDNF glial cell derived neurotrophic factor -0.0204671
CLCN7 chloride channel, voltage-sensitive 7 -0.0204574
ZYG11B zyg-11 family member B, cell cycle regulator -0.0204428
PDIA6 protein disulfide isomerase family A, member 6 -0.020404
SDCCAG8 serologically defined colon cancer antigen 8 -0.0203846
FOXJ3 forkhead box J3 -0.0203578
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0203405
RIOK1 RIO kinase 1 -0.0203396
USP48 ubiquitin specific peptidase 48 -0.0203331
RNF149 ring finger protein 149 -0.0202697
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0202611
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) -0.0202053
UBE4B ubiquitination factor E4B -0.0201944
PIF1 PIF1 5'-to-3' DNA helicase -0.0201934
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0201475
SFMBT2 Scm-like with four mbt domains 2 -0.0201385
ARHGAP15 Rho GTPase activating protein 15 -0.0201218
DNAAF9 dynein axonemal assembly factor 9 -0.0200999
RPLP0 ribosomal protein, large, P0 -0.0200791
PHF21A PHD finger protein 21A -0.0200499
ASF1B anti-silencing function 1B histone chaperone -0.0200461
MED15 mediator complex subunit 15 -0.0200423
CUL4A cullin 4A -0.0199905
TANGO2 transport and golgi organization 2 homolog (Drosophila) -0.0199459
RFWD3 ring finger and WD repeat domain 3 -0.0199437
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0198784
STIL SCL/TAL1 interrupting locus -0.0198774
EML2 echinoderm microtubule associated protein like 2 -0.0198635
GRAP2 GRB2-related adaptor protein 2 -0.0198634
FAM120A family with sequence similarity 120A -0.0198613
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0198508
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0198339
RBBP6 retinoblastoma binding protein 6 -0.0197414
UBXN7 UBX domain protein 7 -0.0197362
CEP350 centrosomal protein 350kDa -0.0197263
SORCS1 sortilin-related VPS10 domain containing receptor 1 -0.0196629
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0196528
DCAF10 DDB1 and CUL4 associated factor 10 -0.0196479
SECISBP2L SECIS binding protein 2-like -0.0196369
TTC7B tetratricopeptide repeat domain 7B -0.0196137
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.0195772
SLMAP sarcolemma associated protein -0.0195584
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0195476
KYAT1 kynurenine aminotransferase 1 -0.0195366
MSH3 mutS homolog 3 -0.0195319
ACBD6 acyl-CoA binding domain containing 6 -0.0195169
SUGP2 SURP and G patch domain containing 2 -0.0194915
NCALD neurocalcin delta -0.0194798
NOP58 NOP58 ribonucleoprotein -0.0194367
GSTK1 glutathione S-transferase kappa 1 -0.0194032
MACROH2A1 macroH2A.1 histone -0.0194025
TTC21B tetratricopeptide repeat domain 21B -0.0193922
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0193717
PTPRA protein tyrosine phosphatase, receptor type, A -0.019307
FBXL13 F-box and leucine-rich repeat protein 13 -0.0193047
ATXN10 ataxin 10 -0.0192343
RHBDD2 rhomboid domain containing 2 -0.0192247
ACO1 aconitase 1, soluble -0.0191932
TRAPPC9 trafficking protein particle complex 9 -0.0191545
YEATS2 YEATS domain containing 2 -0.0190608
ATAD2B ATPase family, AAA domain containing 2B -0.0190575
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0190196
PDE3B phosphodiesterase 3B, cGMP-inhibited -0.0190083
FBH1 F-box DNA helicase 1 -0.0189936
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0189637
CARD11 caspase recruitment domain family, member 11 -0.0189448
KIDINS220 kinase D-interacting substrate, 220kDa -0.0189333
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0188915
INO80 INO80 complex subunit -0.0188877
ANGPT1 angiopoietin 1 -0.0188771
AHCTF1 AT hook containing transcription factor 1 -0.0188338
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0188293
GALK2 galactokinase 2 -0.0187234
KAT6A K(lysine) acetyltransferase 6A -0.0187009
UBE3A ubiquitin protein ligase E3A -0.0186564
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0186284
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0185833
PIAS2 protein inhibitor of activated STAT, 2 -0.0185493
SLC35F2 solute carrier family 35, member F2 -0.0184881
NDC1 NDC1 transmembrane nucleoporin -0.0184872
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0184375
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0184303
RUFY2 RUN and FYVE domain containing 2 -0.0184257
NBAS neuroblastoma amplified sequence -0.0184203
HMBOX1 homeobox containing 1 -0.0183865
RPS19 ribosomal protein S19 -0.0183809
FBXO17 F-box protein 17 -0.0183681
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0183093
PAIP2 poly(A) binding protein interacting protein 2 -0.0182691
LARP4 La ribonucleoprotein domain family, member 4 -0.0182588
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0182418
SUN1 Sad1 and UNC84 domain containing 1 -0.0182101
ACBD3 acyl-CoA binding domain containing 3 -0.0182033
EPHB6 EPH receptor B6 -0.0182021
SENP5 SUMO1/sentrin specific peptidase 5 -0.0181789
SMC6 structural maintenance of chromosomes 6 -0.0181587
CUL5 cullin 5 -0.0181465
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -0.018136
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -0.0181256
CDCP1 CUB domain containing protein 1 -0.0181204
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -0.0181187
COMT catechol-O-methyltransferase -0.0181175
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0180373
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0179632
BMPR1A bone morphogenetic protein receptor, type IA -0.0179622
IPO11 importin 11 -0.017947
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0178265
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.0177822
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 -0.0177705
CHD1L chromodomain helicase DNA binding protein 1-like -0.0177444
NFYC nuclear transcription factor Y, gamma -0.0176867
CHD3 chromodomain helicase DNA binding protein 3 -0.0176838
NUDCD3 NudC domain containing 3 -0.0176675
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.017648
LONP2 lon peptidase 2, peroxisomal -0.0175879
TK1 thymidine kinase 1, soluble -0.0175727
TOP3B topoisomerase (DNA) III beta -0.0175706
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0175668
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0175611
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0175088
SAFB2 scaffold attachment factor B2 -0.0174911
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0174837
NUP210 nucleoporin 210kDa -0.0174738
STRN3 striatin, calmodulin binding protein 3 -0.0174294
USP37 ubiquitin specific peptidase 37 -0.0174271
FAM117A family with sequence similarity 117, member A -0.0174033
MON2 MON2 homolog (S. cerevisiae) -0.0173812
FAF1 Fas (TNFRSF6) associated factor 1 -0.0173687
WDR45B WD repeat domain 45B -0.0173498
PRELID2 PRELI domain containing 2 -0.0173395
RCOR3 REST corepressor 3 -0.017338
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0173202
MTFR1 mitochondrial fission regulator 1 -0.0172879
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -0.0172747
CBX5 chromobox homolog 5 -0.0172627
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0172609
ECPAS Ecm29 proteasome adaptor and scaffold -0.0172513
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0172299
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0171769
NADK NAD kinase -0.0171665
ATP13A3 ATPase type 13A3 -0.0171294
GPR107 G protein-coupled receptor 107 -0.017126
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0170488
S100PBP S100P binding protein -0.0170125
RANBP1 RAN binding protein 1 -0.0169803
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0169648
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -0.0169442
MRTFB myocardin related transcription factor B -0.016937
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0168873
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0168452
CASS4 Cas scaffolding protein family member 4 -0.0168339
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -0.0167996
HSPA13 heat shock protein 70kDa family, member 13 -0.0167912
PHTF2 putative homeodomain transcription factor 2 -0.0167776
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0167681
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0167589
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0167418
TRAPPC11 trafficking protein particle complex 11 -0.0167181
DOCK2 dedicator of cytokinesis 2 -0.0167181
UBN1 ubinuclein 1 -0.0167103
RNMT RNA (guanine-7-) methyltransferase -0.0167046
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0167039
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -0.0166737
ZNF804A zinc finger protein 804A -0.0166285
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0166207
RIPOR3 RIPOR family member 3 -0.0166148
LIN28B lin-28 homolog B (C. elegans) -0.016605
SACK1A scaffolding CK1 anchoring protein A -0.0166007
PRPF4B pre-mRNA processing factor 4B -0.0165709
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -0.0165645
TMEM50B transmembrane protein 50B -0.0165204
C16ORF95 chromosome 16 open reading frame 95 -0.0165149
PDE8A phosphodiesterase 8A -0.0164864
LIN9 lin-9 DREAM MuvB core complex component -0.0164741
EMSY EMSY transcriptional repressor, BRCA2 interacting -0.0164528
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.0164414
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.0164289
TMSB10 thymosin beta 10 -0.0164148
NDFIP1 Nedd4 family interacting protein 1 -0.0163956
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.0163841
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0163707
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0163514
TCP1 t-complex 1 -0.0163472
RNF169 ring finger protein 169 -0.0163266
DIDO1 death inducer-obliterator 1 -0.0162653
LDAH lipid droplet associated hydrolase -0.0162414
NUMB numb homolog (Drosophila) -0.0162089
ANAPC10 anaphase promoting complex subunit 10 -0.0162037
PRC1 protein regulator of cytokinesis 1 -0.0161805
HSPB1 heat shock 27kDa protein 1 -0.01618
NLRP1 NLR family, pyrin domain containing 1 -0.0161496
TACC3 transforming, acidic coiled-coil containing protein 3 -0.0161193
SAFB scaffold attachment factor B -0.0160895
PRKX protein kinase, X-linked -0.0160758
WWC2 WW and C2 domain containing 2 -0.016013
AAK1 AP2 associated kinase 1 -0.0159803
C11ORF58 chromosome 11 open reading frame 58 -0.0159731
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0159382
MYO1F myosin IF -0.0159104
ACVR1 activin A receptor, type I -0.0158895
SOS2 son of sevenless homolog 2 (Drosophila) -0.0158724
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0158365
TMEM41B transmembrane protein 41B -0.0158222
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0158186
DNPEP aspartyl aminopeptidase -0.0157851
CEP128 centrosomal protein 128kDa -0.0157509
RC3H1 ring finger and CCCH-type domains 1 -0.015734
CAB39 calcium binding protein 39 -0.0157332
HDLBP high density lipoprotein binding protein -0.0157051
USP25 ubiquitin specific peptidase 25 -0.015693
RINT1 RAD50 interactor 1 -0.0156753
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -0.0156372
ATG14 autophagy related 14 -0.0156349
UTRN utrophin -0.0156342
ZFAND3 zinc finger, AN1-type domain 3 -0.0156264
ZDHHC5 zinc finger, DHHC-type containing 5 -0.0155853
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0155597
PITPNA phosphatidylinositol transfer protein, alpha -0.0155519
WNK1 WNK lysine deficient protein kinase 1 -0.0155472
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0155459
CCDC138 coiled-coil domain containing 138 -0.0155313
RHOA ras homolog family member A -0.0154936
GATD1 glutamine amidotransferase class 1 domain containing 1 -0.0154864
NSD2 nuclear receptor binding SET domain protein 2 -0.015419
PUM3 pumilio RNA binding family member 3 -0.0154172
RHOH ras homolog family member H -0.0154099
FUBP3 far upstream element (FUSE) binding protein 3 -0.0154075
GPHRA golgi pH regulator A -0.0153897
MACC1 metastasis associated in colon cancer 1 -0.0153805
EML4 echinoderm microtubule associated protein like 4 -0.0153236
CENPF centromere protein F, 350/400kDa -0.015302
NECTIN2 nectin cell adhesion molecule 2 -0.0153008
CCP110 centriolar coiled coil protein 110kDa -0.0152461
TMEM33 transmembrane protein 33 -0.0152382
KIF11 kinesin family member 11 -0.0152252
THEM4 thioesterase superfamily member 4 -0.0152077
RAB22A RAB22A, member RAS oncogene family -0.0152014
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.015173
RPS11 ribosomal protein S11 -0.0151629
TPP2 tripeptidyl peptidase II -0.0151602
XXYLT1 xyloside xylosyltransferase 1 -0.0151265
IKBIP IKBKB interacting protein -0.0151143
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.0150216
STK11 serine/threonine kinase 11 -0.0150207
KIAA0319L KIAA0319-like -0.0150145
MYO18A myosin XVIIIA -0.0150135
CD58 CD58 molecule -0.014956
NUMA1 nuclear mitotic apparatus protein 1 -0.0149519
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -0.0149511
UBE4A ubiquitination factor E4A -0.014936
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0149341
AOPEP aminopeptidase O (putative) -0.0149272
CSPP1 centrosome and spindle pole associated protein 1 -0.0148947
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.0148919
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.014862
NCOR2 nuclear receptor corepressor 2 -0.0148589
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -0.0148575
C6ORF89 chromosome 6 open reading frame 89 -0.0148525
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -0.0148339
MTMR9 myotubularin related protein 9 -0.0148331
TRIM27 tripartite motif containing 27 -0.0148317
MACO1 macoilin 1 -0.0148288
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -0.0148269
CYB561A3 cytochrome b561 family, member A3 -0.0148099
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0148077
MAP2K1 mitogen-activated protein kinase kinase 1 -0.014799
ELOVL5 ELOVL fatty acid elongase 5 -0.014798
CUL3 cullin 3 -0.0147926
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -0.0147834
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.014751
WDR45 WD repeat domain 45 -0.0147184
VASP vasodilator-stimulated phosphoprotein -0.0147092
SPATS2 spermatogenesis associated, serine-rich 2 -0.0146986
GGT7 gamma-glutamyltransferase 7 -0.014698
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0146485
DHCR7 7-dehydrocholesterol reductase -0.0146264
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0146115
CHEK2 checkpoint kinase 2 -0.0145973
NCAPG2 non-SMC condensin II complex, subunit G2 -0.014592
TMEM63B transmembrane protein 63B -0.0145614
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0145596
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0145491
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0145435
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -0.0145015
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0144805
ZNF562 zinc finger protein 562 -0.0144141
TEX2 testis expressed 2 -0.0144094
MFSD11 major facilitator superfamily domain containing 11 -0.0144064
CISD1 CDGSH iron sulfur domain 1 -0.0143998
TRA2A transformer 2 alpha homolog (Drosophila) -0.0143946
EXOC6 exocyst complex component 6 -0.0143913
CD44 CD44 molecule (Indian blood group) -0.014383
RPL36 ribosomal protein L36 -0.0143802
DSCAM Down syndrome cell adhesion molecule -0.0143536
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0143485
RPL11 ribosomal protein L11 -0.0143485
SUMF2 sulfatase modifying factor 2 -0.0143372
CLIP2 CAP-GLY domain containing linker protein 2 -0.0143329