K562_Obatoclax Mesylate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 100nM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_Obatoclax Mesylate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MUSK muscle, skeletal, receptor tyrosine kinase 0.140042
FTL ferritin, light polypeptide 0.0818848
RPL32 ribosomal protein L32 0.0733092
LOC112694756 uncharaterized LOC112694756 0.0666542
PICALM phosphatidylinositol binding clathrin assembly protein 0.0645285
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0626324
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0583229
HBG1 hemoglobin, gamma A 0.0577223
AARS1 alanyl-tRNA synthetase 1 0.054953
USP6NL USP6 N-terminal like 0.0531644
RPS3 ribosomal protein S3 0.0527292
RPS6 ribosomal protein S6 0.0518436
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0502062
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0488059
RBM15 RNA binding motif protein 15 0.0477677
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0476396
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.046962
GOLGA2 golgin A2 0.0455596
CALR calreticulin 0.0455345
SLC38A1 solute carrier family 38, member 1 0.0454931
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.0450381
NPEPPS aminopeptidase puromycin sensitive 0.0447741
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.044179
TBL1X transducin (beta)-like 1X-linked 0.0441345
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0441219
RPLP1 ribosomal protein, large, P1 0.0437299
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.0432845
PDIA3 protein disulfide isomerase family A, member 3 0.0425639
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0422407
NEMF nuclear export mediator factor 0.0420428
LDHA lactate dehydrogenase A 0.0406146
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0400878
TLN1 talin 1 0.0400722
VIM vimentin 0.039929
TMEM131 transmembrane protein 131 0.039425
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.0392456
RERE arginine-glutamic acid dipeptide (RE) repeats 0.039163
USP34 ubiquitin specific peptidase 34 0.0386055
ZBTB20 zinc finger and BTB domain containing 20 0.0386047
TFRC transferrin receptor 0.0384733
ANAPC5 anaphase promoting complex subunit 5 0.0378987
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0378327
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.0377904
H2AC6 H2A clustered histone 6 0.037599
COP1 COP1 E3 ubiquitin ligase 0.0374537
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0372079
RNF216 ring finger protein 216 0.0372055
INSIG1 insulin induced gene 1 0.0367599
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0363904
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 0.0357793
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0355917
RPS9 ribosomal protein S9 0.0353872
SFMBT2 Scm-like with four mbt domains 2 0.0352579
COX5B cytochrome c oxidase subunit Vb 0.0350835
MAP1B microtubule-associated protein 1B 0.034942
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0345885
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.034238
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.033956
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0338668
KIAA1958 KIAA1958 0.0337172
ZZZ3 zinc finger, ZZ-type containing 3 0.0336298
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0333492
IARS1 isoleucyl-tRNA synthetase 1 0.0332693
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0331743
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.033159
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0329634
ACTG1 actin gamma 1 0.0328655
ADNP activity-dependent neuroprotector homeobox 0.0326762
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0326643
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0325881
MARCHF6 membrane associated ring-CH-type finger 6 0.0324343
RBM39 RNA binding motif protein 39 0.032216
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0322048
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0322013
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0321191
ARID1A AT rich interactive domain 1A (SWI-like) 0.0320206
AFDN afadin, adherens junction formation factor 0.0319662
TEC tec protein tyrosine kinase 0.0319123
ALG8 ALG8, alpha-1,3-glucosyltransferase 0.0318574
FLNA filamin A, alpha 0.0317748
RPL14 ribosomal protein L14 0.0317305
SCFD2 sec1 family domain containing 2 0.0317022
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0315305
ENO1 enolase 1, (alpha) 0.0312642
HIC2 hypermethylated in cancer 2 0.0312003
SOS1 son of sevenless homolog 1 (Drosophila) 0.0310587
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0310194
PHIP pleckstrin homology domain interacting protein 0.0309472
HDLBP high density lipoprotein binding protein 0.0309435
RPS2 ribosomal protein S2 0.0308881
PKM pyruvate kinase, muscle 0.0308141
WARS1 tryptophanyl-tRNA synthetase 1 0.0304195
FER fer (fps/fes related) tyrosine kinase 0.0303913
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0303003
TGFBR1 transforming growth factor, beta receptor 1 0.0301428
CALU calumenin 0.029864
LIMS1 LIM and senescent cell antigen-like domains 1 0.0298557
PRKD2 protein kinase D2 0.0297841
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0297822
RUNX1 runt-related transcription factor 1 0.0296973
UBE3C ubiquitin protein ligase E3C 0.0294688
RFX7 regulatory factor X, 7 0.0292581
SEPTIN6 septin 6 0.0291893
TXNDC11 thioredoxin domain containing 11 0.0291837
TUBA1B tubulin, alpha 1b 0.0291536
CMIP c-Maf inducing protein 0.0290743
ZNF431 zinc finger protein 431 0.0290608
NOM1 nucleolar protein with MIF4G domain 1 0.0289204
PMM2 phosphomannomutase 2 0.0289165
ZCCHC7 zinc finger, CCHC domain containing 7 0.0288417
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0287942
CBX5 chromobox homolog 5 0.0285886
DSG2 desmoglein 2 0.0284486
CD53 CD53 molecule 0.0282374
RPL31 ribosomal protein L31 0.0282298
GOLGA4 golgin A4 0.0280706
E2F3 E2F transcription factor 3 0.0279598
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0278498
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0278253
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0277708
ACYP2 acylphosphatase 2, muscle type 0.0277434
HM13 histocompatibility (minor) 13 0.0277234
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.027665
CUX1 cut-like homeobox 1 0.0275574
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0275507
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0274093
TMEM165 transmembrane protein 165 0.0273357
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.0273319
LNPEP leucyl/cystinyl aminopeptidase 0.0272069
DENND5A DENN/MADD domain containing 5A 0.0271828
RESF1 retroelement silencing factor 1 0.0271132
CDC45 cell division cycle 45 0.0270718
RRM1 ribonucleotide reductase M1 0.0270288
VDAC2 voltage-dependent anion channel 2 0.0269534
PRELID2 PRELI domain containing 2 0.0269355
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.0269105
TMEM192 transmembrane protein 192 0.0268979
SMG5 SMG5 nonsense mediated mRNA decay factor 0.0267805
SCAF11 SR-related CTD-associated factor 11 0.0267518
SFTPA2 surfactant protein A2 0.026659
EXOC4 exocyst complex component 4 0.0266396
STRBP spermatid perinuclear RNA binding protein 0.0264302
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.0263749
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0263742
SNX29 sorting nexin 29 0.0263643
HEPH hephaestin 0.0263628
TAGLN2 transgelin 2 0.0263165
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.0262355
RPL8 ribosomal protein L8 0.0261283
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0260754
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.0260645
RPL23A ribosomal protein L23a 0.0259704
FNDC3B fibronectin type III domain containing 3B 0.0259541
ZNF207 zinc finger protein 207 0.0259273
PHF20 PHD finger protein 20 0.0259155
RPS8 ribosomal protein S8 0.0259102
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0258762
ASCC1 activating signal cointegrator 1 complex subunit 1 0.0258106
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0257586
IRF3 interferon regulatory factor 3 0.025696
KIF13B kinesin family member 13B 0.0255807
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0255263
HEATR1 HEAT repeat containing 1 0.0254865
PTBP3 polypyrimidine tract binding protein 3 0.0254638
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0254619
COX7C cytochrome c oxidase subunit VIIc 0.0254072
SUSD1 sushi domain containing 1 0.0253109
MED13 mediator complex subunit 13 0.0252878
CLIC4 chloride intracellular channel 4 0.0252831
FBXO34 F-box protein 34 0.0251506
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0251257
TMEM267 transmembrane protein 267 0.025054
ATL3 atlastin GTPase 3 0.025053
H3-3B H3.3 histone B 0.0250357
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0250315
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0250165
KMT2E lysine (K)-specific methyltransferase 2E 0.0249188
CHD4 chromodomain helicase DNA binding protein 4 0.0249124
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0247588
ADCY8 adenylate cyclase 8 (brain) 0.0247443
FBXL20 F-box and leucine-rich repeat protein 20 0.0246782
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0246597
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.0246482
FNIP2 folliculin interacting protein 2 0.0246283
USP49 ubiquitin specific peptidase 49 0.0245366
PACS1 phosphofurin acidic cluster sorting protein 1 0.0244881
PCM1 pericentriolar material 1 0.0244333
MACC1 metastasis associated in colon cancer 1 0.0243791
RPS23 ribosomal protein S23 0.0243457
CADM2 cell adhesion molecule 2 0.024287
OSBPL8 oxysterol binding protein-like 8 0.0242594
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0242469
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0241298
RELN reelin 0.0240932
RAB27A RAB27A, member RAS oncogene family 0.0240198
SQLE squalene epoxidase 0.0239687
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.023965
RPL15 ribosomal protein L15 0.0239442
RPS5 ribosomal protein S5 0.0239198
ZNF146 zinc finger protein 146 0.023861
EPHB4 EPH receptor B4 0.0238102
XPO1 exportin 1 0.0237858
PTK2 protein tyrosine kinase 2 0.0237783
ANTXR2 anthrax toxin receptor 2 0.0237721
NUP62 nucleoporin 62kDa 0.0237674
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0237164
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.02355
GRID1 glutamate receptor, ionotropic, delta 1 0.0234787
POU2F1 POU class 2 homeobox 1 0.023414
LMNA lamin A/C 0.0234054
LONP2 lon peptidase 2, peroxisomal 0.0233898
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.0233508
YDJC YdjC homolog (bacterial) 0.0233224
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0232614
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 0.0232564
CST3 cystatin C 0.023245
PKP4 plakophilin 4 0.0232277
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0231532
NCAM2 neural cell adhesion molecule 2 0.0231187
SPATS2 spermatogenesis associated, serine-rich 2 0.0231014
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0230804
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0230381
TAOK1 TAO kinase 1 0.0230311
LEPROT leptin receptor overlapping transcript 0.0230117
UBC ubiquitin C 0.0229674
RPS16 ribosomal protein S16 0.0228498
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.022813
LYPLA1 lysophospholipase I 0.0227151
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0226977
RAB10 RAB10, member RAS oncogene family 0.0226964
EZR ezrin 0.0226363
ZNF562 zinc finger protein 562 0.0225619
RB1CC1 RB1-inducible coiled-coil 1 0.0225328
MYH9 myosin, heavy chain 9, non-muscle 0.0224397
RPL19 ribosomal protein L19 0.0224331
NCAPD3 non-SMC condensin II complex, subunit D3 0.0224316
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 0.0224284
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0224178
SERTAD2 SERTA domain containing 2 0.0224052
TET3 tet methylcytosine dioxygenase 3 0.0222877
EMP3 epithelial membrane protein 3 0.0221118
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0219974
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0219886
PRRC2C proline-rich coiled-coil 2C 0.0219289
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0219226
RPN1 ribophorin I 0.021922
MEGF8 multiple EGF-like-domains 8 0.021869
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.0218625
RPL10A ribosomal protein L10a 0.0218419
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0218271
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.0218144
RPL3 ribosomal protein L3 0.0217691
SPPL2A signal peptide peptidase like 2A 0.0217419
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0217256
GOLM2 golgi membrane protein 2 0.0216637
KIAA0513 KIAA0513 0.0216361
C9ORF78 chromosome 9 open reading frame 78 0.0216185
RNF24 ring finger protein 24 0.0215641
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0215514
SNX14 sorting nexin 14 0.0215098
IER2 immediate early response 2 0.0214934
RPL36A ribosomal protein L36a 0.0214845
WIPF3 WAS/WASL interacting protein family, member 3 0.0214249
KLHDC10 kelch domain containing 10 0.021377
CANX calnexin 0.0213624
TTC27 tetratricopeptide repeat domain 27 0.0213402
ASXL2 additional sex combs like transcriptional regulator 2 0.0213243
CDK6 cyclin-dependent kinase 6 0.0213166
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0212709
LRP12 low density lipoprotein receptor-related protein 12 0.0212655
CEP128 centrosomal protein 128kDa 0.0212286
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0212273
CD320 CD320 molecule 0.0212043
HAUS2 HAUS augmin-like complex, subunit 2 0.0211883
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.0211459
SORBS1 sorbin and SH3 domain containing 1 0.0211356
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.0211176
TAOK3 TAO kinase 3 0.021109
NECTIN2 nectin cell adhesion molecule 2 0.0210838
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0209858
TMCO1 transmembrane and coiled-coil domains 1 0.0209501
EPHB6 EPH receptor B6 0.0208944
STK40 serine/threonine kinase 40 0.0208851
AGO2 argonaute RISC catalytic component 2 0.0208116
RPL5 ribosomal protein L5 0.0208076
DESI2 desumoylating isopeptidase 2 0.0207966
MICALL2 MICAL-like 2 0.0207722
ZMYM2 zinc finger, MYM-type 2 0.0207529
NT5DC3 5'-nucleotidase domain containing 3 0.0207323
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0207289
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.0206393
SLK STE20-like kinase 0.0206276
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.0205792
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.0205278
UBN2 ubinuclein 2 0.0205025
MINK1 misshapen-like kinase 1 0.0204745
GMPR guanosine monophosphate reductase 0.0204722
MBTD1 mbt domain containing 1 0.0204003
ORAI2 ORAI calcium release-activated calcium modulator 2 0.0203237
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0202883
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0201903
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0201877
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0201234
AFMID arylformamidase 0.0200616
QSER1 glutamine and serine rich 1 0.0200579
DMD dystrophin 0.0200539
SNF8 SNF8, ESCRT-II complex subunit 0.0200262
ARHGAP18 Rho GTPase activating protein 18 0.020025
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0199454
SYPL1 synaptophysin-like 1 0.0199158
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 0.0198444
CTSB cathepsin B 0.0197983
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0197815
FUBP3 far upstream element (FUSE) binding protein 3 0.0197788
SSH2 slingshot protein phosphatase 2 0.0197687
SRRM1 serine/arginine repetitive matrix 1 0.0197444
APTX aprataxin 0.0197272
EIF4E eukaryotic translation initiation factor 4E 0.0197102
SIK2 salt-inducible kinase 2 0.0196751
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.0196606
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0196486
PFN1 profilin 1 0.0196182
BLTP2 bridge-like lipid transfer protein family member 2 0.0195606
FBH1 F-box DNA helicase 1 0.0195403
ARHGAP6 Rho GTPase activating protein 6 0.0195221
MEF2A myocyte enhancer factor 2A 0.0195186
CREB5 cAMP responsive element binding protein 5 0.0194909
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0194675
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.0194609
MSI2 musashi RNA-binding protein 2 0.0194384
XRRA1 X-ray radiation resistance associated 1 0.0193472
TACC1 transforming, acidic coiled-coil containing protein 1 0.0193301
ATAD2 ATPase family, AAA domain containing 2 0.0193294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0193266
RBBP6 retinoblastoma binding protein 6 0.0193034
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 0.0192893
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.0192782
KDM4C lysine (K)-specific demethylase 4C 0.0192345
MYO1E myosin IE 0.0192073
CPQ carboxypeptidase Q 0.0191205
RPL13A ribosomal protein L13a 0.019118
RBM26 RNA binding motif protein 26 0.019114
FLOT1 flotillin 1 0.0191085
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0190663
WAPL WAPL cohesin release factor 0.0190333
RBM10 RNA binding motif protein 10 0.0189243
STX8 syntaxin 8 0.018913
MOB1B MOB kinase activator 1B 0.0188685
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0188552
RINT1 RAD50 interactor 1 0.0188219
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0188009
SPPL3 signal peptide peptidase like 3 0.0187845
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.0187799
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0187548
LONP1 lon peptidase 1, mitochondrial 0.0187414
MEGF9 multiple EGF-like-domains 9 0.0187347
CNTN5 contactin 5 0.018701
FADS2 fatty acid desaturase 2 0.0186992
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.0186978
HDAC7 histone deacetylase 7 0.0186756
CD47 CD47 molecule 0.0186703
PLIN4 perilipin 4 0.0186668
TFR2 transferrin receptor 2 0.0186334
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0186273
NUP188 nucleoporin 188kDa 0.018511
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0184933
N4BP2L2 NEDD4 binding protein 2-like 2 0.0184902
ACD adrenocortical dysplasia homolog (mouse) 0.0184698
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0184242
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0183867
EXOC3L2 exocyst complex component 3-like 2 0.018367
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0183197
RSRP1 arginine/serine-rich protein 1 0.0183079
SENP5 SUMO1/sentrin specific peptidase 5 0.0182864
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0182785
ACSBG1 acyl-CoA synthetase bubblegum family member 1 0.018271
ZNF623 zinc finger protein 623 0.0182361
ARRDC3 arrestin domain containing 3 0.018236
STEAP1B STEAP family member 1B 0.0182177
KDM1A lysine (K)-specific demethylase 1A 0.0181841
COPG2 coatomer protein complex, subunit gamma 2 0.018129
GSPT1 G1 to S phase transition 1 0.0181164
RBM28 RNA binding motif protein 28 0.0180852
RPN2 ribophorin II 0.0180608
COQ8B coenzyme Q8B 0.0179763
LSR lipolysis stimulated lipoprotein receptor 0.0179246
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0178937
ADGRL1 adhesion G protein-coupled receptor L1 0.0177924
CREB1 cAMP responsive element binding protein 1 0.0177801
OCIAD1 OCIA domain containing 1 0.0177692
MEIS1 Meis homeobox 1 0.0177115
TUBB4B tubulin, beta 4B class IVb 0.017706
TMEM181 transmembrane protein 181 0.0176978
CPED1 cadherin-like and PC-esterase domain containing 1 0.0176628
AGFG1 ArfGAP with FG repeats 1 0.0176604
ATL2 atlastin GTPase 2 0.0176574
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0176201
RPL11 ribosomal protein L11 0.0175807
RABL6 RAB, member RAS oncogene family-like 6 0.0175771
RTN3 reticulon 3 0.0175608
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 0.0175189
FAM178B family with sequence similarity 178, member B 0.0174878
U2SURP U2 snRNP-associated SURP domain containing 0.0174648
LTAP1 lipid transport auxiliary protein 1 0.0174317
OGA O-GlcNAcase 0.0174249
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0174013
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0173766
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0173666
TMX1 thioredoxin-related transmembrane protein 1 0.0173633
GATAD1 GATA zinc finger domain containing 1 0.0173563
DYM dymeclin 0.0173277
OAZ1 ornithine decarboxylase antizyme 1 0.0173048
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0173047
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0173042
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.0172644
BAIAP2L1 BAI1-associated protein 2-like 1 0.0172613
NCK1 NCK adaptor protein 1 0.0172517
BSG basigin (Ok blood group) 0.0172497
H1-10 H1.10 linker histone 0.0172415
MCM4 minichromosome maintenance complex component 4 0.0172289
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0172195
RTTN rotatin 0.0172018
H2AZ2 H2A.Z variant histone 2 0.0171966
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.017147
MTREX Mtr4 exosome RNA helicase 0.0171042
TMEM59 transmembrane protein 59 0.0170994
ADD2 adducin 2 (beta) 0.017099
UBXN11 UBX domain protein 11 0.017076
CDCP1 CUB domain containing protein 1 0.0170684
CD81 CD81 molecule 0.0170057
BRCA1 breast cancer 1, early onset 0.0170003
SUMO2 small ubiquitin-like modifier 2 0.0169979
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.0169965
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0169853
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.0169787
RNF213 ring finger protein 213 0.0169311
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0168799
NVL nuclear VCP-like 0.0168695
RAI14 retinoic acid induced 14 0.0168632
EDF1 endothelial differentiation-related factor 1 0.0168497
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.01684
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 0.0168374
TXNIP thioredoxin interacting protein 0.0168325
MACROD1 MACRO domain containing 1 0.0168128
LYRM7 LYR motif containing 7 0.0167889
CR1L complement component (3b/4b) receptor 1-like 0.0167867
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 0.0167431
DDRGK1 DDRGK domain containing 1 0.0167203
YIPF5 Yip1 domain family, member 5 0.0167159
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0167151
BLVRB biliverdin reductase B 0.0167065
WDFY2 WD repeat and FYVE domain containing 2 0.0167058
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.016681
BTBD1 BTB (POZ) domain containing 1 0.0166591
NF1 neurofibromin 1 0.0166264
TSC22D4 TSC22 domain family, member 4 0.0166259
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0166185
DHCR24 24-dehydrocholesterol reductase 0.0166028
PTMS parathymosin 0.0165953
KIDINS220 kinase D-interacting substrate, 220kDa 0.0165823
NUP210 nucleoporin 210kDa 0.0165762
ETF1 eukaryotic translation termination factor 1 0.016562
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.0165334
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0165306
LDLRAP1 low density lipoprotein receptor adaptor protein 1 0.0165168
SKA2 spindle and kinetochore associated complex subunit 2 0.0164758
GPC5 glypican 5 0.0164741
BTN3A3 butyrophilin, subfamily 3, member A3 0.0164615
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.0164302
ERICH1 glutamate-rich 1 0.0163762
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0163724
NAE1 NEDD8 activating enzyme E1 subunit 1 0.0163619
AGTPBP1 ATP/GTP binding protein 1 0.0163335
CEP162 centrosomal protein 162kDa 0.0163315
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.016325
AKAP9 A kinase (PRKA) anchor protein 9 0.0163136
GPR158 G protein-coupled receptor 158 0.0163071
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0163005
SNX6 sorting nexin 6 0.0162823
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.0162818
ERAP1 endoplasmic reticulum aminopeptidase 1 0.0162666
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0162549
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.016245
RPS21 ribosomal protein S21 0.0162389
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0161928
GBA2 glucosidase, beta (bile acid) 2 0.0161782
CCNI cyclin I 0.016169
NFE2L1 nuclear factor, erythroid 2-like 1 0.0161629
NUP214 nucleoporin 214kDa 0.0161595
SQSTM1 sequestosome 1 0.0161494
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0160992
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0160668
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.0159896
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0159438
FAM241A family with sequence similarity 241 member A 0.0159285
SNRPA small nuclear ribonucleoprotein polypeptide A 0.0158908
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.0158903
BLZF1 basic leucine zipper nuclear factor 1 0.015869
ATG5 autophagy related 5 0.0158466
DCTD dCMP deaminase 0.0158383

decreased expression

Symbol Name Standardized Value
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0789864
JMJD1C jumonji domain containing 1C -0.071466
FBXL13 F-box and leucine-rich repeat protein 13 -0.0689652
PCDH9 protocadherin 9 -0.0643463
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0603476
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0576517
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0565934
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0560447
GSE1 Gse1 coiled-coil protein -0.0543752
NFIA nuclear factor I/A -0.0541734
ARL15 ADP-ribosylation factor-like 15 -0.0536885
HIP1 huntingtin interacting protein 1 -0.0530097
SETD2 SET domain containing 2 -0.0527784
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0524783
SETD5 SET domain containing 5 -0.0504815
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0494899
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0476408
SRPK2 SRSF protein kinase 2 -0.0475558
KDM2A lysine (K)-specific demethylase 2A -0.046491
AGO3 argonaute RISC catalytic component 3 -0.0442709
GATAD2B GATA zinc finger domain containing 2B -0.0437999
ZFPM2 zinc finger protein, FOG family member 2 -0.0434748
MEIS2 Meis homeobox 2 -0.0427925
CNKSR3 CNKSR family member 3 -0.0427251
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.042217
NSD1 nuclear receptor binding SET domain protein 1 -0.041803
MAP4 microtubule-associated protein 4 -0.0416765
ANKRD17 ankyrin repeat domain 17 -0.0415081
RNASE3 ribonuclease, RNase A family, 3 -0.0412615
TNIK TRAF2 and NCK interacting kinase -0.0412147
TSC22D2 TSC22 domain family, member 2 -0.0408444
RTN4 reticulon 4 -0.0405092
TNRC6B trinucleotide repeat containing 6B -0.0402095
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0399936
NMU neuromedin U -0.0394918
NUMB numb homolog (Drosophila) -0.0391257
RPL30 ribosomal protein L30 -0.0388959
KIF2C kinesin family member 2C -0.0385184
VCL vinculin -0.0382686
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0375283
NUP153 nucleoporin 153kDa -0.0366563
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.036644
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0364181
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0363075
CCDC88A coiled-coil domain containing 88A -0.0360661
AHCTF1 AT hook containing transcription factor 1 -0.0356799
PHACTR4 phosphatase and actin regulator 4 -0.0356106
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0355365
MBD5 methyl-CpG binding domain protein 5 -0.0352986
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0350688
DNM2 dynamin 2 -0.0343632
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0341862
KIF14 kinesin family member 14 -0.0340809
KLHL22 kelch-like family member 22 -0.0340082
USP15 ubiquitin specific peptidase 15 -0.0338664
RPL28 ribosomal protein L28 -0.0337597
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0337375
DCAF10 DDB1 and CUL4 associated factor 10 -0.033716
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0334444
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0331367
GDNF glial cell derived neurotrophic factor -0.0330872
MYO9B myosin IXB -0.0328388
SRBD1 S1 RNA binding domain 1 -0.0325867
LYRM4 LYR motif containing 4 -0.0325217
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0324643
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0323658
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0323645
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0323408
POLK polymerase (DNA directed) kappa -0.0321203
TRIM33 tripartite motif containing 33 -0.0320407
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0318358
SRSF4 serine/arginine-rich splicing factor 4 -0.0318277
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0316736
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0316728
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0316136
TPST2 tyrosylprotein sulfotransferase 2 -0.031445
RHEB Ras homolog enriched in brain -0.0312988
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.031267
UBTF upstream binding transcription factor, RNA polymerase I -0.0310726
CERS6 ceramide synthase 6 -0.0309138
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0309031
ZNF609 zinc finger protein 609 -0.0308931
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0305781
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0303048
CAB39 calcium binding protein 39 -0.0300517
TRRAP transformation/transcription domain-associated protein -0.0297812
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0297473
STAG2 stromal antigen 2 -0.0297021
GPBP1 GC-rich promoter binding protein 1 -0.0296748
CREBBP CREB binding protein -0.0296727
CENPF centromere protein F, 350/400kDa -0.029588
KIF2A kinesin heavy chain member 2A -0.0294661
ANLN anillin, actin binding protein -0.0292126
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.029153
DSCAM Down syndrome cell adhesion molecule -0.0291433
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.02912
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0290391
KDM5B lysine (K)-specific demethylase 5B -0.0290272
PLEC plectin -0.0290238
RHBDD2 rhomboid domain containing 2 -0.0289999
HELZ helicase with zinc finger -0.0289691
ELOVL6 ELOVL fatty acid elongase 6 -0.0289461
AK1 adenylate kinase 1 -0.0289017
KDM3B lysine (K)-specific demethylase 3B -0.0288544
TRA2A transformer 2 alpha homolog (Drosophila) -0.0287662
RNF217 ring finger protein 217 -0.0287348
JARID2 jumonji, AT rich interactive domain 2 -0.0285446
TRIM24 tripartite motif containing 24 -0.0284456
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0283497
ZNF326 zinc finger protein 326 -0.0282881
NUP98 nucleoporin 98kDa -0.0279967
ELP4 elongator acetyltransferase complex subunit 4 -0.0278509
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0277708
MARCHF3 membrane associated ring-CH-type finger 3 -0.0277279
PUM2 pumilio RNA-binding family member 2 -0.0276497
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0274428
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0270672
PPARD peroxisome proliferator-activated receptor delta -0.0270303
TTC28 tetratricopeptide repeat domain 28 -0.0268413
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0268403
SSBP3 single stranded DNA binding protein 3 -0.0268322
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0268045
MRPS27 mitochondrial ribosomal protein S27 -0.0266569
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0266102
CD2AP CD2-associated protein -0.0265415
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.0265135
CDC14A cell division cycle 14A -0.0264183
POLR1B polymerase (RNA) I polypeptide B, 128kDa -0.0262975
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0262648
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0261434
KIF20B kinesin family member 20B -0.026114
RAB21 RAB21, member RAS oncogene family -0.0260641
NCOR1 nuclear receptor corepressor 1 -0.0258959
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0257711
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -0.0256234
ECPAS Ecm29 proteasome adaptor and scaffold -0.0255994
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -0.0255897
FLNB filamin B, beta -0.0255807
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0254111
TRAPPC10 trafficking protein particle complex 10 -0.0254018
SLTM SAFB-like, transcription modulator -0.0253757
XXYLT1 xyloside xylosyltransferase 1 -0.0252709
MCM9 minichromosome maintenance complex component 9 -0.0252078
LMBR1 limb development membrane protein 1 -0.0251275
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.025042
USP9X ubiquitin specific peptidase 9, X-linked -0.0249749
L2HGDH L-2-hydroxyglutarate dehydrogenase -0.0249442
SON SON DNA binding protein -0.0246336
TCF12 transcription factor 12 -0.0245184
ADCY7 adenylate cyclase 7 -0.0244937
ATP5F1B ATP synthase F1 subunit beta -0.0244829
NLN neurolysin (metallopeptidase M3 family) -0.0244199
CCAR1 cell division cycle and apoptosis regulator 1 -0.0243858
ASXL1 additional sex combs like transcriptional regulator 1 -0.0243603
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -0.0243049
NRDC nardilysin convertase -0.0242212
PLCD1 phospholipase C, delta 1 -0.0240711
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0239818
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -0.0238292
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0238066
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0237509
FRYL FRY-like -0.0237391
PCSK7 proprotein convertase subtilisin/kexin type 7 -0.023706
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0235532
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.0235291
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -0.0235095
MYO3B myosin IIIB -0.0235083
SERGEF secretion regulating guanine nucleotide exchange factor -0.0234622
ATG10 autophagy related 10 -0.0234117
MFSD11 major facilitator superfamily domain containing 11 -0.0233556
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0233128
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0232787
CENPK centromere protein K -0.0232673
HMBOX1 homeobox containing 1 -0.0231951
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta -0.0231407
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.023053
TENT2 terminal nucleotidyltransferase 2 -0.0229879
MCM7 minichromosome maintenance complex component 7 -0.0228338
TRAK1 trafficking protein, kinesin binding 1 -0.0228095
MAP7 microtubule-associated protein 7 -0.0227764
KIF4A kinesin family member 4A -0.0227569
GPHN gephyrin -0.0227562
CENPE centromere protein E, 312kDa -0.0226081
TRIM56 tripartite motif containing 56 -0.0224952
CDC73 cell division cycle 73 -0.0224193
MCPH1 microcephalin 1 -0.0224055
INO80 INO80 complex subunit -0.0223118
ZYG11A zyg-11 family member A, cell cycle regulator -0.0222124
MAST2 microtubule associated serine/threonine kinase 2 -0.0222098
MTPN myotrophin -0.0221544
ARHGAP24 Rho GTPase activating protein 24 -0.0221432
KAT6B K(lysine) acetyltransferase 6B -0.0221374
CDK8 cyclin-dependent kinase 8 -0.0221234
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0220669
KATNBL1 katanin p80 subunit B-like 1 -0.0220114
ACTN1 actinin, alpha 1 -0.0219938
SYNJ2 synaptojanin 2 -0.0219332
PKD1 polycystic kidney disease 1 (autosomal dominant) -0.0219
CFDP1 craniofacial development protein 1 -0.0218964
RCOR1 REST corepressor 1 -0.0218572
MTCH2 mitochondrial carrier 2 -0.0218211
MORF4L2 mortality factor 4 like 2 -0.0217972
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0217561
SOGA1 suppressor of glucose, autophagy associated 1 -0.0216417
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0216297
RABGAP1L RAB GTPase activating protein 1-like -0.0215864
ADD3 adducin 3 (gamma) -0.0215631
SLC39A11 solute carrier family 39, member 11 -0.0214977
PKN2 protein kinase N2 -0.0214388
TBCE tubulin folding cofactor E -0.0214167
MCU mitochondrial calcium uniporter -0.0213387
JAK2 Janus kinase 2 -0.0213104
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0212925
VAC14 Vac14 homolog (S. cerevisiae) -0.021225
WDR70 WD repeat domain 70 -0.0211734
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0210977
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0210945
UBXN7 UBX domain protein 7 -0.02103
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0210225
ECD ecdysoneless homolog (Drosophila) -0.0210185
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.021017
MTMR3 myotubularin related protein 3 -0.0209509
TMEM50A transmembrane protein 50A -0.0208554
SMYD3 SET and MYND domain containing 3 -0.0207669
AURKA aurora kinase A -0.0207194
DMTF1 cyclin D binding myb-like transcription factor 1 -0.0206948
SFXN1 sideroflexin 1 -0.0206918
TRPS1 trichorhinophalangeal syndrome I -0.0206753
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0206713
CABIN1 calcineurin binding protein 1 -0.0206475
SKIC3 SKI3 subunit of superkiller complex -0.0205747
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0205652
SEPTIN9 septin 9 -0.0205481
SNX8 sorting nexin 8 -0.020491
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -0.0204857
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0204649
SARS2 seryl-tRNA synthetase 2, mitochondrial -0.0204342
PLD3 phospholipase D family, member 3 -0.0204228
CEP350 centrosomal protein 350kDa -0.0203765
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.020373
SDHAF3 succinate dehydrogenase complex assembly factor 3 -0.0203424
UBE3D ubiquitin protein ligase E3D -0.0203292
GON4L gon-4-like (C. elegans) -0.0202583
POM121C POM121 transmembrane nucleoporin C -0.0202406
MDN1 MDN1, midasin homolog (yeast) -0.0202213
PUS7 pseudouridylate synthase 7 (putative) -0.0201616
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0201387
RC3H1 ring finger and CCCH-type domains 1 -0.0201352
SREBF2 sterol regulatory element binding transcription factor 2 -0.0200892
SP3 Sp3 transcription factor -0.0200526
CPEB3 cytoplasmic polyadenylation element binding protein 3 -0.0198807
GRB2 growth factor receptor-bound protein 2 -0.0198515
EIF3J eukaryotic translation initiation factor 3, subunit J -0.0198064
GGT7 gamma-glutamyltransferase 7 -0.0198005
USP32 ubiquitin specific peptidase 32 -0.0197928
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0197875
WDR33 WD repeat domain 33 -0.0197081
PHTF2 putative homeodomain transcription factor 2 -0.0196776
FAM13B family with sequence similarity 13, member B -0.0196729
NEB nebulin -0.0196417
PHF19 PHD finger protein 19 -0.0196034
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -0.0195579
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0195297
ANKRD28 ankyrin repeat domain 28 -0.0195139
LRRC41 leucine rich repeat containing 41 -0.0195041
MYO6 myosin VI -0.0194215
ACO2 aconitase 2, mitochondrial -0.0191005
KPNB1 karyopherin (importin) beta 1 -0.0190908
RDX radixin -0.0190839
CEP85L centrosomal protein 85kDa-like -0.0190677
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0190489
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -0.0189987
MTMR12 myotubularin related protein 12 -0.0189851
STRIP2 striatin interacting protein 2 -0.0189754
LARP1 La ribonucleoprotein domain family, member 1 -0.0189658
AFF1 AF4/FMR2 family, member 1 -0.0189481
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -0.0189385
RBBP4 retinoblastoma binding protein 4 -0.0189069
TRAPPC8 trafficking protein particle complex 8 -0.0188605
EMP2 epithelial membrane protein 2 -0.0188476
ESRRB estrogen-related receptor beta -0.0187729
CPEB1 cytoplasmic polyadenylation element binding protein 1 -0.0187371
DPP8 dipeptidyl-peptidase 8 -0.0185751
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0185665
EARS2 glutamyl-tRNA synthetase 2, mitochondrial -0.0185578
TENM1 teneurin transmembrane protein 1 -0.0185573
RPS20 ribosomal protein S20 -0.018523
ERBIN erbb2 interacting protein -0.018489
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0184818
CFAP97 cilia and flagella associated protein 97 -0.0184789
COPA coatomer protein complex, subunit alpha -0.0184631
C17ORF99 chromosome 17 open reading frame 99 -0.0184532
RSF1 remodeling and spacing factor 1 -0.018389
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0183025
CDIN1 CDAN1 interacting nuclease 1 -0.0182801
SRSF7 serine/arginine-rich splicing factor 7 -0.0182447
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0182417
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.018211
PCDHB16 protocadherin beta 16 -0.018156
CHLSN cholesin -0.018125
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0180804
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0179686
TASOR2 transcription activation suppressor family member 2 -0.0178935
STAMBP STAM binding protein -0.0178673
DENND4A DENN/MADD domain containing 4A -0.0178522
PUM3 pumilio RNA binding family member 3 -0.0178059
HSDL2 hydroxysteroid dehydrogenase like 2 -0.0177838
SS18 synovial sarcoma translocation, chromosome 18 -0.017774
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0177222
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.0177174
SSB Sjogren syndrome antigen B (autoantigen La) -0.0177171
GYS1 glycogen synthase 1 (muscle) -0.0177058
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -0.0176688
IQGAP1 IQ motif containing GTPase activating protein 1 -0.017661
ZNF148 zinc finger protein 148 -0.0176496
PHF12 PHD finger protein 12 -0.017644
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0176301
NCBP1 nuclear cap binding protein subunit 1, 80kDa -0.0175993
PLA2G12A phospholipase A2, group XIIA -0.0174672
DNASE1 deoxyribonuclease I -0.0174403
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0174304
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0174124
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0173712
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0172821
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -0.0172596
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0172483
PCDHB11 protocadherin beta 11 -0.0172253
GALK2 galactokinase 2 -0.0172012
AK3 adenylate kinase 3 -0.0171982
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0171525
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0170903
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0170747
HOMER1 homer scaffolding protein 1 -0.0170672
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0170569
RIC1 RAB6A GEF complex partner 1 -0.0170197
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.017012
SLC25A42 solute carrier family 25, member 42 -0.0170055
COPS2 COP9 signalosome subunit 2 -0.0169909
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0169802
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0169349
ARMH3 armadillo like helical domain containing 3 -0.0169311
PHACTR1 phosphatase and actin regulator 1 -0.0169157
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0169144
SEC24B SEC24 family member B -0.0169087
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.016904
RNF169 ring finger protein 169 -0.0168454
CHD9 chromodomain helicase DNA binding protein 9 -0.0168407
PRC1 protein regulator of cytokinesis 1 -0.0168212
SORT1 sortilin 1 -0.0168173
SRPK1 SRSF protein kinase 1 -0.0167987
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0167702
NFX1 nuclear transcription factor, X-box binding 1 -0.0167519
SDCCAG8 serologically defined colon cancer antigen 8 -0.0167381
ATXN7L1 ataxin 7-like 1 -0.0167335
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.016731
TYK2 tyrosine kinase 2 -0.0167223
ACBD3 acyl-CoA binding domain containing 3 -0.0166952
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0166895
ARHGAP17 Rho GTPase activating protein 17 -0.0166713
PBRM1 polybromo 1 -0.0166284
ACTN4 actinin, alpha 4 -0.0165908
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -0.0165854
CUL2 cullin 2 -0.0165785
R3HDM2 R3H domain containing 2 -0.0165463
ERI3 ERI1 exoribonuclease family member 3 -0.0165314
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -0.0164757
SRRM2 serine/arginine repetitive matrix 2 -0.0164592
CDCA8 cell division cycle associated 8 -0.0164223
TTL tubulin tyrosine ligase -0.0164013
SCAF4 SR-related CTD-associated factor 4 -0.016387
WAC WW domain containing adaptor with coiled-coil -0.0163787
CDK12 cyclin-dependent kinase 12 -0.0163517
KIAA0232 KIAA0232 -0.0163457
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.016328
LATS1 large tumor suppressor kinase 1 -0.0163183
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.0162844
PDCD10 programmed cell death 10 -0.0162576
CDCA2 cell division cycle associated 2 -0.0162122
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0162078
ESR1 estrogen receptor 1 -0.01616
UTRN utrophin -0.0161298
SLX4IP SLX4 interacting protein -0.0161266
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -0.0161231
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0161152
DHDDS dehydrodolichyl diphosphate synthase -0.0161146
TENT4B terminal nucleotidyltransferase 4B -0.0160934
SDAD1 SDA1 domain containing 1 -0.0160903
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -0.0160767
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0160716
SPC25 SPC25, NDC80 kinetochore complex component -0.0160589
PIAS2 protein inhibitor of activated STAT, 2 -0.0160301
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.01602
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -0.016009
DNAH14 dynein, axonemal, heavy chain 14 -0.0159407
TET1 tet methylcytosine dioxygenase 1 -0.0158539
SFPQ splicing factor proline/glutamine-rich -0.0158506
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.0158478
P3H1 prolyl 3-hydroxylase 1 -0.0158475
FXN frataxin -0.0158344
KIF11 kinesin family member 11 -0.0158303
TUFM Tu translation elongation factor, mitochondrial -0.0158068
POT1 protection of telomeres 1 -0.0157893
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -0.0157853
AMPD3 adenosine monophosphate deaminase 3 -0.0157706
LCOR ligand dependent nuclear receptor corepressor -0.0157681
RAB27B RAB27B, member RAS oncogene family -0.0157589
ANAPC16 anaphase promoting complex subunit 16 -0.0157582
FANCI Fanconi anemia, complementation group I -0.015751
ABHD2 abhydrolase domain containing 2 -0.0157343
RPL22 ribosomal protein L22 -0.0157282
ATAD5 ATPase family, AAA domain containing 5 -0.0156541
AKAP11 A kinase (PRKA) anchor protein 11 -0.0156289
PTDSS2 phosphatidylserine synthase 2 -0.0156038
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -0.0155972
SHARPIN SHANK-associated RH domain interactor -0.0155707
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0155308
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0155274
ARHGAP11B Rho GTPase activating protein 11B -0.0154928
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 -0.0154791
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0154581
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -0.0154531
SAE1 SUMO1 activating enzyme subunit 1 -0.0154293
COG8 component of oligomeric golgi complex 8 -0.0154261
SCYL2 SCY1-like 2 (S. cerevisiae) -0.0154154
ZCCHC14 zinc finger, CCHC domain containing 14 -0.0154097
FCHO2 FCH domain only 2 -0.0153646
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0153471
USP25 ubiquitin specific peptidase 25 -0.0153461
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.015326
ORC4 origin recognition complex, subunit 4 -0.0153231
SP100 SP100 nuclear antigen -0.015309
GSTCD glutathione S-transferase, C-terminal domain containing -0.0153084
TMEM50B transmembrane protein 50B -0.0153077
HBS1L HBS1-like translational GTPase -0.0152695
TMEM167A transmembrane protein 167A -0.0152624
CORO2A coronin, actin binding protein, 2A -0.0152419
LARP4B La ribonucleoprotein domain family, member 4B -0.0152065
KRT19 keratin 19, type I -0.0151758
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -0.0151396
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0151271
SH2B3 SH2B adaptor protein 3 -0.0151097
SPIRE1 spire-type actin nucleation factor 1 -0.0151086
FANCL Fanconi anemia, complementation group L -0.0150961
KDM6A lysine (K)-specific demethylase 6A -0.0150921
BZW2 basic leucine zipper and W2 domains 2 -0.0150805
GSR glutathione reductase -0.0150701
CLASRP CLK4-associating serine/arginine rich protein -0.0150653
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0150647
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0150565
SAMD4B sterile alpha motif domain containing 4B -0.015043
JAK1 Janus kinase 1 -0.0150317
NGLY1 N-glycanase 1 -0.0149881
SLC35D4 solute carrier family 35 member D4 -0.0149784
CELF1 CUGBP, Elav-like family member 1 -0.0149727
EIF1AX eukaryotic translation initiation factor 1A, X-linked -0.0149553
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0149551
ARHGAP11A Rho GTPase activating protein 11A -0.0148952
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0148934
GPSM2 G-protein signaling modulator 2 -0.0148892
CHD8 chromodomain helicase DNA binding protein 8 -0.0148678
TTC19 tetratricopeptide repeat domain 19 -0.0148653
PSEN1 presenilin 1 -0.0148575
SLC44A5 solute carrier family 44, member 5 -0.0148379
FAM117B family with sequence similarity 117, member B -0.0148369
TXNRD1 thioredoxin reductase 1 -0.0148251
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0148179
RBM20 RNA binding motif protein 20 -0.0147745
FBXO11 F-box protein 11 -0.0147684
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0147683
TTC7A tetratricopeptide repeat domain 7A -0.0147541
UROD uroporphyrinogen decarboxylase -0.0147419
ZCCHC17 zinc finger, CCHC domain containing 17 -0.0147373
UNKL unkempt family zinc finger-like -0.0147255
GRAMD1A GRAM domain containing 1A -0.0147236
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0147061
FAM222B family with sequence similarity 222, member B -0.0146917
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0146886
TFAM transcription factor A, mitochondrial -0.0146556
SEC31A SEC31 homolog A (S. cerevisiae) -0.0146366
KATNA1 katanin p60 (ATPase containing) subunit A 1 -0.0146187
FAM13A family with sequence similarity 13, member A -0.0146172
DLG1 discs, large homolog 1 (Drosophila) -0.014616
RSRC1 arginine/serine-rich coiled-coil 1 -0.0146115
IL6ST interleukin 6 signal transducer -0.0146039
FBXW11 F-box and WD repeat domain containing 11 -0.0145855
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.014537
MAPRE2 microtubule-associated protein, RP/EB family, member 2 -0.0145328
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -0.0145233
RSBN1L round spermatid basic protein 1-like -0.0145181
MINDY3 MINDY lysine 48 deubiquitinase 3 -0.0144425
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -0.0144084
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0144057
SAFB scaffold attachment factor B -0.0143992
ZMYND8 zinc finger, MYND-type containing 8 -0.0143523
LDAH lipid droplet associated hydrolase -0.0143507
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 -0.0143344
CCSER2 coiled-coil serine-rich protein 2 -0.0143058
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.0143006
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -0.0142965
SERF2 small EDRK-rich factor 2 -0.0142918