K562_Obatoclax Mesylate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description Obatoclax Mesylate 10nM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_Obatoclax Mesylate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MARCHF3 membrane associated ring-CH-type finger 3 0.0973235
LOC112694756 uncharaterized LOC112694756 0.0942096
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0857651
ESYT2 extended synaptotagmin-like protein 2 0.0744012
LDLR low density lipoprotein receptor 0.0722396
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0716841
ENO1 enolase 1, (alpha) 0.0673681
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.059979
OGA O-GlcNAcase 0.0592991
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0587685
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0569038
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0568742
KDM6A lysine (K)-specific demethylase 6A 0.0537869
FTL ferritin, light polypeptide 0.0537768
SQLE squalene epoxidase 0.0534115
HBG1 hemoglobin, gamma A 0.0525342
HMGA1 high mobility group AT-hook 1 0.0517853
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0516721
ZMYND8 zinc finger, MYND-type containing 8 0.0514742
YARS1 tyrosyl-tRNA synthetase 1 0.0506392
NIBAN1 niban apoptosis regulator 1 0.0504005
RTN4 reticulon 4 0.0495403
SETD5 SET domain containing 5 0.049512
RHAG Rh-associated glycoprotein 0.0469825
ASXL1 additional sex combs like transcriptional regulator 1 0.0465338
MUSK muscle, skeletal, receptor tyrosine kinase 0.0462639
PDLIM5 PDZ and LIM domain 5 0.0449504
HBG2 hemoglobin, gamma G 0.0446426
RPS8 ribosomal protein S8 0.044559
EPB41 erythrocyte membrane protein band 4.1 0.0444483
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0442747
FBXO11 F-box protein 11 0.0441545
TOP1 topoisomerase (DNA) I 0.0435546
ADAM17 ADAM metallopeptidase domain 17 0.0434927
HIP1 huntingtin interacting protein 1 0.0433343
KRT8 keratin 8, type II 0.0431417
XRN1 5'-3' exoribonuclease 1 0.0424142
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0420948
SACK1A scaffolding CK1 anchoring protein A 0.0418773
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.0413174
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0409706
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.040847
RIOK3 RIO kinase 3 0.0406345
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0405612
PKM pyruvate kinase, muscle 0.0402631
PRKCB protein kinase C, beta 0.0400651
STK40 serine/threonine kinase 40 0.039817
MICU1 mitochondrial calcium uptake 1 0.0396332
CEP350 centrosomal protein 350kDa 0.039415
FBXO42 F-box protein 42 0.0388855
MSMO1 methylsterol monooxygenase 1 0.0383927
BHLHE40 basic helix-loop-helix family, member e40 0.0376354
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.0376316
RPL5 ribosomal protein L5 0.037217
LIMS1 LIM and senescent cell antigen-like domains 1 0.03715
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0371105
NKTR natural killer cell triggering receptor 0.0370085
RSF1 remodeling and spacing factor 1 0.0370056
FAM13A family with sequence similarity 13, member A 0.0366684
RCOR1 REST corepressor 1 0.036329
USP9X ubiquitin specific peptidase 9, X-linked 0.0362765
TLN1 talin 1 0.0361835
VCL vinculin 0.036084
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0359389
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.03592
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0357728
MCAM melanoma cell adhesion molecule 0.0354831
SRGN serglycin 0.0353992
UBE3C ubiquitin protein ligase E3C 0.0353841
YME1L1 YME1-like 1 ATPase 0.0352526
EZR ezrin 0.0350544
OAZ1 ornithine decarboxylase antizyme 1 0.034963
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0346829
PDIA6 protein disulfide isomerase family A, member 6 0.0343852
AFF4 AF4/FMR2 family, member 4 0.0343553
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0340294
KIF2A kinesin heavy chain member 2A 0.0340144
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0333154
SEC31A SEC31 homolog A (S. cerevisiae) 0.0332699
HBE1 hemoglobin, epsilon 1 0.033145
H2BC15 H2B clustered histone 15 0.0329346
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0327382
KPNB1 karyopherin (importin) beta 1 0.0324848
RPS6 ribosomal protein S6 0.0322564
ASXL2 additional sex combs like transcriptional regulator 2 0.0322192
OSBPL8 oxysterol binding protein-like 8 0.0320205
INSIG1 insulin induced gene 1 0.0319612
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0319058
CDCP1 CUB domain containing protein 1 0.0318969
RPLP0 ribosomal protein, large, P0 0.0318866
CLIC4 chloride intracellular channel 4 0.0317606
RBM26 RNA binding motif protein 26 0.0316597
ZNF431 zinc finger protein 431 0.0313553
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0312688
MON2 MON2 homolog (S. cerevisiae) 0.0311225
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0308749
ZCCHC7 zinc finger, CCHC domain containing 7 0.0301765
SERINC1 serine incorporator 1 0.0300545
KMT2E lysine (K)-specific methyltransferase 2E 0.0299912
COPE coatomer protein complex, subunit epsilon 0.0299803
RPL15 ribosomal protein L15 0.0299102
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0298125
PICALM phosphatidylinositol binding clathrin assembly protein 0.0297922
ADAM10 ADAM metallopeptidase domain 10 0.029645
LRRC8B leucine rich repeat containing 8 family, member B 0.0294971
STX8 syntaxin 8 0.0294936
PDIA3 protein disulfide isomerase family A, member 3 0.0294667
RBBP6 retinoblastoma binding protein 6 0.0292651
C6ORF89 chromosome 6 open reading frame 89 0.0292036
CMIP c-Maf inducing protein 0.0291131
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.029061
TANK TRAF family member-associated NFKB activator 0.029016
PPP6C protein phosphatase 6, catalytic subunit 0.0289878
MBNL2 muscleblind-like splicing regulator 2 0.0289382
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0286993
TGOLN2 trans-golgi network protein 2 0.0285038
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.0284354
H1-10 H1.10 linker histone 0.028161
USP48 ubiquitin specific peptidase 48 0.0280539
RSRP1 arginine/serine-rich protein 1 0.0278948
SLC38A2 solute carrier family 38, member 2 0.0277655
TBC1D5 TBC1 domain family, member 5 0.0276685
MCM4 minichromosome maintenance complex component 4 0.0276671
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0275595
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.027517
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0273353
KHSRP KH-type splicing regulatory protein 0.0272971
MBNL1 muscleblind-like splicing regulator 1 0.0271939
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0271253
MED15 mediator complex subunit 15 0.0270055
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.026995
SPAG9 sperm associated antigen 9 0.0268483
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0268032
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.026803
HMBOX1 homeobox containing 1 0.0265734
PLCL1 phospholipase C-like 1 0.0265319
CAVIN1 caveolae associated protein 1 0.0265239
CD63 CD63 molecule 0.0265086
ZNF800 zinc finger protein 800 0.0263967
AKAP11 A kinase (PRKA) anchor protein 11 0.0263298
VEPH1 ventricular zone expressed PH domain-containing 1 0.0263267
GAB2 GRB2-associated binding protein 2 0.026218
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0261894
PGK1 phosphoglycerate kinase 1 0.0261674
MYO18B myosin XVIIIB 0.0261274
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0260943
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.0260866
LRRC41 leucine rich repeat containing 41 0.0259986
RPLP1 ribosomal protein, large, P1 0.0259649
NPC1 Niemann-Pick disease, type C1 0.0259028
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0258601
PTGES2 prostaglandin E synthase 2 0.0258547
OTUD5 OTU deubiquitinase 5 0.0258
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0257862
VWDE von Willebrand factor D and EGF domains 0.0257724
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0257468
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0257313
PARD3B par-3 family cell polarity regulator beta 0.0257097
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0256589
RPS2 ribosomal protein S2 0.0256053
SEC24A SEC24 family member A 0.0255982
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0254246
ZNF106 zinc finger protein 106 0.0253965
COPB1 coatomer protein complex, subunit beta 1 0.0253885
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0251766
PLAGL1 pleiomorphic adenoma gene-like 1 0.0251013
NFX1 nuclear transcription factor, X-box binding 1 0.0250668
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0249889
KREMEN1 kringle containing transmembrane protein 1 0.0249856
SESN2 sestrin 2 0.0249518
SELENOI selenoprotein I 0.024915
RPS12 ribosomal protein S12 0.0248696
ATP5F1B ATP synthase F1 subunit beta 0.0248295
DCAF7 DDB1 and CUL4 associated factor 7 0.024608
FLNA filamin A, alpha 0.0245898
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0245819
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0245413
IARS1 isoleucyl-tRNA synthetase 1 0.0245059
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.0244999
CCNY cyclin Y 0.0243704
RAB2A RAB2A, member RAS oncogene family 0.0242834
BCL6 B-cell CLL/lymphoma 6 0.0242592
ARHGAP12 Rho GTPase activating protein 12 0.0242294
POFUT4 protein O-fucosyltransferase 4 0.0241905
GKAP1 G kinase anchoring protein 1 0.0241891
OXNAD1 oxidoreductase NAD-binding domain containing 1 0.0241257
ADARB1 adenosine deaminase, RNA-specific, B1 0.0241141
SLC35F2 solute carrier family 35, member F2 0.024108
QKI QKI, KH domain containing, RNA binding 0.0240708
POM121 POM121 transmembrane nucleoporin 0.0239588
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0239061
ODR4 odr-4 GPCR localization factor homolog 0.0238967
TALDO1 transaldolase 1 0.0238654
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0237387
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.0237281
SEC24D SEC24 family member D 0.0237182
RB1CC1 RB1-inducible coiled-coil 1 0.0236934
RICTOR RPTOR independent companion of MTOR, complex 2 0.0236572
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 0.0236281
CASS4 Cas scaffolding protein family member 4 0.0236027
GDNF glial cell derived neurotrophic factor 0.0235839
COPA coatomer protein complex, subunit alpha 0.0235024
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0234225
ASCC1 activating signal cointegrator 1 complex subunit 1 0.0234208
DSCAM Down syndrome cell adhesion molecule 0.0234141
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0233489
LTBP1 latent transforming growth factor beta binding protein 1 0.0233106
NUP214 nucleoporin 214kDa 0.023293
KMT2A lysine (K)-specific methyltransferase 2A 0.0232827
ZFR zinc finger RNA binding protein 0.023238
CLYBL citrate lyase beta like 0.0232372
BRD4 bromodomain containing 4 0.0232053
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0231316
KIF5B kinesin family member 5B 0.0229491
ATG7 autophagy related 7 0.0229116
WDR26 WD repeat domain 26 0.022911
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0228724
NUP205 nucleoporin 205kDa 0.0228244
CTTN cortactin 0.0228225
RAB5A RAB5A, member RAS oncogene family 0.0227434
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0226487
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.0226211
CBX5 chromobox homolog 5 0.022611
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0225466
DOCK11 dedicator of cytokinesis 11 0.0225402
RHCE Rh blood group, CcEe antigens 0.0224997
RNF145 ring finger protein 145 0.0224748
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0224604
MARCHF6 membrane associated ring-CH-type finger 6 0.0224175
CAAP1 caspase activity and apoptosis inhibitor 1 0.02235
C22ORF39 chromosome 22 open reading frame 39 0.022325
INTS6 integrator complex subunit 6 0.0223133
RAD23B RAD23 homolog B (S. cerevisiae) 0.0222019
CANX calnexin 0.0221745
RAB8B RAB8B, member RAS oncogene family 0.0221326
BMP2K BMP2 inducible kinase 0.0221231
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0220781
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0220712
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0220516
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0219468
MEF2A myocyte enhancer factor 2A 0.0218695
WARS1 tryptophanyl-tRNA synthetase 1 0.0216937
KIAA1958 KIAA1958 0.0216892
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0215401
TTC33 tetratricopeptide repeat domain 33 0.0215302
CCDC91 coiled-coil domain containing 91 0.0215214
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0215203
HIPK2 homeodomain interacting protein kinase 2 0.0214844
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.021462
RPL37 ribosomal protein L37 0.0214288
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0213876
FGF13 fibroblast growth factor 13 0.0213648
NSUN6 NOP2/Sun domain family, member 6 0.0213253
CKAP2L cytoskeleton associated protein 2-like 0.0212823
TEX15 testis expressed 15 0.0212756
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0212406
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.0212326
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0212123
PRDX5 peroxiredoxin 5 0.0211415
ANKRD26 ankyrin repeat domain 26 0.0211111
CUTA cutA divalent cation tolerance homolog (E. coli) 0.021055
CLTC clathrin, heavy chain (Hc) 0.0210496
RPL32 ribosomal protein L32 0.0210307
NQO2 NAD(P)H dehydrogenase, quinone 2 0.0210282
GPATCH2L G patch domain containing 2-like 0.0210023
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.0209783
DYM dymeclin 0.0209683
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.0209136
AGO4 argonaute RISC catalytic component 4 0.0208965
RPTOR regulatory associated protein of MTOR, complex 1 0.0208916
KIAA0586 KIAA0586 0.0208786
LRP12 low density lipoprotein receptor-related protein 12 0.0208443
RBM25 RNA binding motif protein 25 0.0208077
SLMAP sarcolemma associated protein 0.0208036
NAP1L1 nucleosome assembly protein 1-like 1 0.0207742
SLBP stem-loop binding protein 0.0207609
KAT2B K(lysine) acetyltransferase 2B 0.0207304
RPL8 ribosomal protein L8 0.0207211
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0207167
SMIM44 small integral membrane protein 44 0.0206386
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0206337
PGPEP1 pyroglutamyl-peptidase I 0.0205927
ATAD2 ATPase family, AAA domain containing 2 0.0204488
CCDC57 coiled-coil domain containing 57 0.0204389
MLXIP MLX interacting protein 0.0204113
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0203979
RSL1D1 ribosomal L1 domain containing 1 0.0203761
NEK1 NIMA-related kinase 1 0.0203603
BUD31 BUD31 homolog (S. cerevisiae) 0.0203181
ACTN1 actinin, alpha 1 0.0203094
GTPBP2 GTP binding protein 2 0.020291
TM9SF4 transmembrane 9 superfamily protein member 4 0.0201804
BTN3A3 butyrophilin, subfamily 3, member A3 0.0200919
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.0200328
SARS2 seryl-tRNA synthetase 2, mitochondrial 0.019961
KDM3A lysine (K)-specific demethylase 3A 0.0198282
CPED1 cadherin-like and PC-esterase domain containing 1 0.0198264
ZNF518A zinc finger protein 518A 0.0197691
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0197486
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0197304
TBC1D15 TBC1 domain family, member 15 0.0196933
MOB1B MOB kinase activator 1B 0.019651
LPIN1 lipin 1 0.0196142
HLA-E major histocompatibility complex, class I, E 0.0196064
ELOVL6 ELOVL fatty acid elongase 6 0.0195601
EPAS1 endothelial PAS domain protein 1 0.0195214
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0194346
FAT1 FAT atypical cadherin 1 0.0193563
CCSER2 coiled-coil serine-rich protein 2 0.0192365
TAGLN2 transgelin 2 0.0192331
DCHS2 dachsous cadherin-related 2 0.0191848
RPS14 ribosomal protein S14 0.0191709
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0191405
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 0.0191164
TAFA2 TAFA chemokine like family member 2 0.0191142
ADGRV1 adhesion G protein-coupled receptor V1 0.0191029
CPT1A carnitine palmitoyltransferase 1A (liver) 0.0190865
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0190329
CDK13 cyclin-dependent kinase 13 0.0190053
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.0190004
LMTK2 lemur tyrosine kinase 2 0.0189947
LAS1L LAS1-like (S. cerevisiae) 0.0189876
TRIM38 tripartite motif containing 38 0.0189743
CALU calumenin 0.0189354
FOXJ3 forkhead box J3 0.0188784
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.018797
LARS1 leucyl-tRNA synthetase 1 0.0187947
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0187881
PFN1 profilin 1 0.0187566
AARS1 alanyl-tRNA synthetase 1 0.0187106
SRP54 signal recognition particle 54kDa 0.0185827
NBAS neuroblastoma amplified sequence 0.0185694
RNF10 ring finger protein 10 0.0185623
CSNK1D casein kinase 1, delta 0.0185497
NEMF nuclear export mediator factor 0.0185461
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0184976
RPS16 ribosomal protein S16 0.018468
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0184571
WASL Wiskott-Aldrich syndrome-like 0.0184366
NPEPPS aminopeptidase puromycin sensitive 0.0183941
DENND4C DENN/MADD domain containing 4C 0.0183546
EGR1 early growth response 1 0.0183388
FYB1 FYN binding protein 1 0.0183021
PUM2 pumilio RNA-binding family member 2 0.0183012
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0182373
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.018221
PHF21A PHD finger protein 21A 0.0182178
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 0.0181586
GOSR1 golgi SNAP receptor complex member 1 0.018132
SLA2 Src-like-adaptor 2 0.0180463
DENND5A DENN/MADD domain containing 5A 0.0180393
TCAIM T cell activation inhibitor, mitochondrial 0.0179939
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.0179774
TPT1 tumor protein, translationally-controlled 1 0.0179763
PGRMC1 progesterone receptor membrane component 1 0.0179619
SECISBP2L SECIS binding protein 2-like 0.0179204
COPG2 coatomer protein complex, subunit gamma 2 0.0179171
PLIN3 perilipin 3 0.0178677
INTS2 integrator complex subunit 2 0.0178113
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0177901
MAPK1 mitogen-activated protein kinase 1 0.0177546
CHD7 chromodomain helicase DNA binding protein 7 0.0177533
PCM1 pericentriolar material 1 0.0177506
KAT6B K(lysine) acetyltransferase 6B 0.0177419
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.017735
CLTCL1 clathrin, heavy chain-like 1 0.0177216
RNASE3 ribonuclease, RNase A family, 3 0.0176514
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0175462
MED13L mediator complex subunit 13-like 0.0175332
MOSMO modulator of smoothened 0.0175126
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.017504
RPL27A ribosomal protein L27a 0.01747
FDPS farnesyl diphosphate synthase 0.0174607
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.017458
ACTG1 actin gamma 1 0.0174046
SMIM12 small integral membrane protein 12 0.0173846
UBAP1 ubiquitin associated protein 1 0.0173621
ICE2 interactor of little elongation complex ELL subunit 2 0.0173489
PPHLN1 periphilin 1 0.0173429
MYLIP myosin regulatory light chain interacting protein 0.0173135
CFAP97 cilia and flagella associated protein 97 0.0173034
PEX26 peroxisomal biogenesis factor 26 0.0172174
CALB1 calbindin 1, 28kDa 0.0172042
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.0171961
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0171869
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0171831
MANBA mannosidase, beta A, lysosomal 0.0171559
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.017147
PHACTR2 phosphatase and actin regulator 2 0.017081
ZNF385A zinc finger protein 385A 0.0170656
KDM5C lysine (K)-specific demethylase 5C 0.0170387
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.0169886
USP53 ubiquitin specific peptidase 53 0.0169517
LDHA lactate dehydrogenase A 0.0169513
PHF19 PHD finger protein 19 0.0169501
KIFBP kinesin family binding protein 0.0169435
STIM2 stromal interaction molecule 2 0.0168868
NLK nemo-like kinase 0.0168861
BRWD1 bromodomain and WD repeat domain containing 1 0.0168849
COP1 COP1 E3 ubiquitin ligase 0.016858
RBMX RNA binding motif protein, X-linked 0.0168406
RPL13A ribosomal protein L13a 0.0168139
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.0167835
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.016773
VRK3 vaccinia related kinase 3 0.0167663
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.0167631
ACO2 aconitase 2, mitochondrial 0.0167432
RNF215 ring finger protein 215 0.0167363
CALR calreticulin 0.0167253
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0167179
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.0167102
ZMIZ1 zinc finger, MIZ-type containing 1 0.0166984
EGFL7 EGF-like-domain, multiple 7 0.0166752
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0166594
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.016656
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.0166395
IL1R1 interleukin 1 receptor, type I 0.0166261
CHD1L chromodomain helicase DNA binding protein 1-like 0.0166038
USP45 ubiquitin specific peptidase 45 0.016594
MED12 mediator complex subunit 12 0.0165912
LNPEP leucyl/cystinyl aminopeptidase 0.0165792
HBA1 hemoglobin, alpha 1 0.0165682
STRN3 striatin, calmodulin binding protein 3 0.0165604
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.0165586
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.0165387
BIRC6 baculoviral IAP repeat containing 6 0.0165119
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0164762
ZNF160 zinc finger protein 160 0.0164642
OXA1L oxidase (cytochrome c) assembly 1-like 0.0164268
CTSC cathepsin C 0.0164116
AFG1L AFG1 like ATPase 0.0164113
TMEM41B transmembrane protein 41B 0.016395
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0163861
RPL37A ribosomal protein L37a 0.0163828
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0163315
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0163239
SOCS4 suppressor of cytokine signaling 4 0.0163144
STK24 serine/threonine kinase 24 0.016293
RNFT2 ring finger protein, transmembrane 2 0.016279
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 0.016217
CNST consortin, connexin sorting protein 0.0162084
REEP3 receptor accessory protein 3 0.016188
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0161794
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.0161728
PRR12 proline rich 12 0.016143
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0161259
TLE3 transducin-like enhancer of split 3 0.016121
ZNF282 zinc finger protein 282 0.0161108
FAM135A family with sequence similarity 135, member A 0.0160937
EIF3H eukaryotic translation initiation factor 3, subunit H 0.016074
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0160703
FUBP3 far upstream element (FUSE) binding protein 3 0.0160604
CAMTA1 calmodulin binding transcription activator 1 0.016036
PHTF1 putative homeodomain transcription factor 1 0.01602
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0159856
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0159837
ECE1 endothelin converting enzyme 1 0.015972
CAMKMT calmodulin-lysine N-methyltransferase 0.0159445
SASS6 spindle assembly 6 homolog (C. elegans) 0.01593
CRTAC1 cartilage acidic protein 1 0.0159241
NAMPT nicotinamide phosphoribosyltransferase 0.0159192
SKAP2 src kinase associated phosphoprotein 2 0.015884
CS citrate synthase 0.0158697
ELP2 elongator acetyltransferase complex subunit 2 0.0158694
PPT1 palmitoyl-protein thioesterase 1 0.0158514
ITSN1 intersectin 1 (SH3 domain protein) 0.0158172
PTH2R parathyroid hormone 2 receptor 0.015803
NT5DC3 5'-nucleotidase domain containing 3 0.0157965
CEPT1 choline/ethanolamine phosphotransferase 1 0.015764
ZSWIM6 zinc finger, SWIM-type containing 6 0.0157571
PPA1 pyrophosphatase (inorganic) 1 0.0157294
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 0.0157149
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0156743
AAMDC adipogenesis associated, Mth938 domain containing 0.0156677
KLHL3 kelch-like family member 3 0.0156659
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0156403
MORC3 MORC family CW-type zinc finger 3 0.015617
C2CD2 C2 calcium-dependent domain containing 2 0.0155705
GPATCH2 G patch domain containing 2 0.0155499
ZNF26 zinc finger protein 26 0.0155388
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0154895
CDC42 cell division cycle 42 0.0154756
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0154743
TMEM248 transmembrane protein 248 0.0154699
SPATS2 spermatogenesis associated, serine-rich 2 0.0154288
BLTP2 bridge-like lipid transfer protein family member 2 0.0153997
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 0.0153647
TBC1D23 TBC1 domain family, member 23 0.0153374
TXNL4A thioredoxin-like 4A 0.0153211
CALN1 calneuron 1 0.0153166
PRPF4 pre-mRNA processing factor 4 0.0153094
RAB31 RAB31, member RAS oncogene family 0.0153037
TMED9 transmembrane emp24 protein transport domain containing 9 0.0152927
RABL6 RAB, member RAS oncogene family-like 6 0.0152926
NANS N-acetylneuraminic acid synthase 0.0152896
SMYD4 SET and MYND domain containing 4 0.0152747
BRCA1 breast cancer 1, early onset 0.015273
DYNC2I1 dynein 2 intermediate chain 1 0.0152492
SCFD1 sec1 family domain containing 1 0.0152489
NAP1L4 nucleosome assembly protein 1-like 4 0.015211

decreased expression

Symbol Name Standardized Value
RABGAP1L RAB GTPase activating protein 1-like -0.112113
PRKCA protein kinase C, alpha -0.0967093
SETD2 SET domain containing 2 -0.0834026
FAF1 Fas (TNFRSF6) associated factor 1 -0.0800966
MACF1 microtubule-actin crosslinking factor 1 -0.0730022
MSI2 musashi RNA-binding protein 2 -0.0713216
CENPP centromere protein P -0.0630679
SMYD3 SET and MYND domain containing 3 -0.0607236
WWOX WW domain containing oxidoreductase -0.0598785
ACACA acetyl-CoA carboxylase alpha -0.0593938
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0524133
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0521103
TNIK TRAF2 and NCK interacting kinase -0.051139
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0506533
NUP153 nucleoporin 153kDa -0.0503175
ZNF609 zinc finger protein 609 -0.0493418
GPBP1 GC-rich promoter binding protein 1 -0.0492048
TAOK3 TAO kinase 3 -0.04864
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0483579
SRRM2 serine/arginine repetitive matrix 2 -0.0467233
ZEB2 zinc finger E-box binding homeobox 2 -0.0466012
BCR breakpoint cluster region -0.0462738
IPO7 importin 7 -0.0457647
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0456338
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0453687
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.045225
PKP4 plakophilin 4 -0.0445595
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0445132
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.043989
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0437536
CDK6 cyclin-dependent kinase 6 -0.0435286
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0432701
CTBP2 C-terminal binding protein 2 -0.0430621
RBL1 retinoblastoma-like 1 -0.0426767
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0422813
MAML2 mastermind-like 2 (Drosophila) -0.0419674
RORA RAR-related orphan receptor A -0.0401709
PRKCSH protein kinase C substrate 80K-H -0.0400608
FNBP4 formin binding protein 4 -0.0397585
DIAPH3 diaphanous-related formin 3 -0.0392668
RELN reelin -0.0389335
MYO3B myosin IIIB -0.0385327
PBRM1 polybromo 1 -0.0380686
LMBR1 limb development membrane protein 1 -0.0376098
LIN28B lin-28 homolog B (C. elegans) -0.0375837
RAD51B RAD51 paralog B -0.0375285
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0373562
NFIA nuclear factor I/A -0.0372671
SRPK2 SRSF protein kinase 2 -0.0368975
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0366032
CNKSR3 CNKSR family member 3 -0.0365573
USP32 ubiquitin specific peptidase 32 -0.0365402
SOS1 son of sevenless homolog 1 (Drosophila) -0.0360991
CLASP2 cytoplasmic linker associated protein 2 -0.0356485
ACTN4 actinin, alpha 4 -0.0354257
RSRC1 arginine/serine-rich coiled-coil 1 -0.0352731
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0350429
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0346225
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0340482
CENPF centromere protein F, 350/400kDa -0.0334965
USP49 ubiquitin specific peptidase 49 -0.0334769
KNL1 kinetochore scaffold 1 -0.0329851
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.032933
JARID2 jumonji, AT rich interactive domain 2 -0.0328612
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0328343
ARL15 ADP-ribosylation factor-like 15 -0.032697
CUX1 cut-like homeobox 1 -0.0326458
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0325939
TRAP1 TNF receptor-associated protein 1 -0.032576
SSBP3 single stranded DNA binding protein 3 -0.0324284
ADGRB3 adhesion G protein-coupled receptor B3 -0.0323344
ECPAS Ecm29 proteasome adaptor and scaffold -0.0321226
NUP210 nucleoporin 210kDa -0.0316743
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0311925
DST dystonin -0.030739
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0304301
RBBP4 retinoblastoma binding protein 4 -0.0304117
VRK1 vaccinia related kinase 1 -0.0302765
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0302404
WWC2 WW and C2 domain containing 2 -0.0302122
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0300418
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.030026
SRPK1 SRSF protein kinase 1 -0.02993
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0298606
MYB v-myb avian myeloblastosis viral oncogene homolog -0.0298324
ACBD6 acyl-CoA binding domain containing 6 -0.0297666
SCAF8 SR-related CTD-associated factor 8 -0.0297428
NRDC nardilysin convertase -0.0295872
BPTF bromodomain PHD finger transcription factor -0.0293474
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0293303
TNPO3 transportin 3 -0.0292677
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.029112
TGFBR3 transforming growth factor, beta receptor III -0.0288327
GPHN gephyrin -0.0287276
SFPQ splicing factor proline/glutamine-rich -0.0286889
FTO fat mass and obesity associated -0.0286011
NSD1 nuclear receptor binding SET domain protein 1 -0.0285007
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0283415
RPSA ribosomal protein SA -0.0278191
RC3H1 ring finger and CCCH-type domains 1 -0.0278019
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0277628
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0276601
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0276267
ARID1A AT rich interactive domain 1A (SWI-like) -0.0273693
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.0273501
CDC14A cell division cycle 14A -0.0271049
SLC39A11 solute carrier family 39, member 11 -0.0268643
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0268474
SLC38A1 solute carrier family 38, member 1 -0.0268467
ARRB1 arrestin, beta 1 -0.0267892
GRB2 growth factor receptor-bound protein 2 -0.0267798
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0266658
STIL SCL/TAL1 interrupting locus -0.0265735
AHCYL2 adenosylhomocysteinase-like 2 -0.0265463
FANCD2 Fanconi anemia, complementation group D2 -0.0264129
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0261828
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -0.0261437
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0261211
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0259928
UCK2 uridine-cytidine kinase 2 -0.0258894
GOLGA2 golgin A2 -0.0256945
MAP1B microtubule-associated protein 1B -0.0256529
DGCR2 DiGeorge syndrome critical region gene 2 -0.0255765
PWWP2A PWWP domain containing 2A -0.0255121
FOXK2 forkhead box K2 -0.0253416
NPAT nuclear protein, ataxia-telangiectasia locus -0.0250875
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0249898
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0249812
RNF130 ring finger protein 130 -0.0248305
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0247543
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -0.0247088
DIDO1 death inducer-obliterator 1 -0.0246365
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0245739
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0245329
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0244913
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.0244411
CD2AP CD2-associated protein -0.0242644
PHF20 PHD finger protein 20 -0.0241739
BICD1 bicaudal D homolog 1 (Drosophila) -0.0241573
MSH2 mutS homolog 2 -0.0241132
MACC1 metastasis associated in colon cancer 1 -0.0241033
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0240917
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.0240417
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0239607
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0238148
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0237204
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.023626
CD58 CD58 molecule -0.0234092
AOPEP aminopeptidase O (putative) -0.0233219
STON2 stonin 2 -0.0232726
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0232565
RSBN1L round spermatid basic protein 1-like -0.0232324
PROS1 protein S (alpha) -0.0231358
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.0230762
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0230451
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0229361
MDN1 MDN1, midasin homolog (yeast) -0.0228892
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0228796
ATAD2B ATPase family, AAA domain containing 2B -0.0228589
FOXP1 forkhead box P1 -0.0228509
MYO1D myosin ID -0.0227863
PTK2 protein tyrosine kinase 2 -0.0227602
SCAI suppressor of cancer cell invasion -0.0227477
COMT catechol-O-methyltransferase -0.0226877
RYBP RING1 and YY1 binding protein -0.022661
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0226591
PHGDH phosphoglycerate dehydrogenase -0.0226574
HM13 histocompatibility (minor) 13 -0.0226221
SEPTIN9 septin 9 -0.0226219
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0225953
ELOVL5 ELOVL fatty acid elongase 5 -0.0225594
TFCP2 transcription factor CP2 -0.0224792
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0224027
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0223947
RPS15 ribosomal protein S15 -0.0223042
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0222782
STIP1 stress-induced phosphoprotein 1 -0.0222135
RPL7A ribosomal protein L7a -0.0220983
KTN1 kinectin 1 (kinesin receptor) -0.0220478
TPX2 TPX2, microtubule-associated -0.0219545
CCM2 cerebral cavernous malformation 2 -0.0219496
TUT4 terminal uridylyl transferase 4 -0.0218774
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0218572
DCAF6 DDB1 and CUL4 associated factor 6 -0.0218455
GSTP1 glutathione S-transferase pi 1 -0.0218303
HIC2 hypermethylated in cancer 2 -0.0217652
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0216609
CCND3 cyclin D3 -0.0216512
RPS17 ribosomal protein S17 -0.0216509
ASPH aspartate beta-hydroxylase -0.0216491
AIG1 androgen-induced 1 -0.0216231
DLG5 discs, large homolog 5 (Drosophila) -0.0215789
COG5 component of oligomeric golgi complex 5 -0.0215511
MRPS27 mitochondrial ribosomal protein S27 -0.021549
TASOR transcription activation suppressor -0.0215482
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0214796
SOGA1 suppressor of glucose, autophagy associated 1 -0.021466
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0214405
ARHGAP15 Rho GTPase activating protein 15 -0.0214122
CELF2 CUGBP, Elav-like family member 2 -0.0213954
VEZT vezatin, adherens junctions transmembrane protein -0.021385
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0213579
DLG1 discs, large homolog 1 (Drosophila) -0.0212535
C21ORF58 chromosome 21 open reading frame 58 -0.0211659
RCL1 RNA terminal phosphate cyclase-like 1 -0.0211243
KIF18A kinesin family member 18A -0.0210167
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0210162
MTFR1 mitochondrial fission regulator 1 -0.0209991
POM121C POM121 transmembrane nucleoporin C -0.020942
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0208539
RAB7A RAB7A, member RAS oncogene family -0.020833
DSTYK dual serine/threonine and tyrosine protein kinase -0.0208111
INTS9 integrator complex subunit 9 -0.020765
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.0206878
TRIT1 tRNA isopentenyltransferase 1 -0.0206672
MAST2 microtubule associated serine/threonine kinase 2 -0.0206247
AFG3L2 AFG3-like AAA ATPase 2 -0.0205327
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.020518
ADAMTSL4 ADAMTS-like 4 -0.0204728
SDCCAG8 serologically defined colon cancer antigen 8 -0.0204417
WDR33 WD repeat domain 33 -0.020416
CEP152 centrosomal protein 152kDa -0.0203786
RACK1 receptor for activated C kinase 1 -0.0203693
LMNB1 lamin B1 -0.0203646
MTMR3 myotubularin related protein 3 -0.0203321
ARFIP1 ADP-ribosylation factor interacting protein 1 -0.0202465
PCDH9 protocadherin 9 -0.0202398
KSR1 kinase suppressor of ras 1 -0.0202389
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0202307
NUP155 nucleoporin 155kDa -0.020163
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.020145
HDAC4 histone deacetylase 4 -0.0201386
CFDP1 craniofacial development protein 1 -0.0200431
CHD3 chromodomain helicase DNA binding protein 3 -0.0199359
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0199185
MRTFB myocardin related transcription factor B -0.019918
USP24 ubiquitin specific peptidase 24 -0.0198943
ZNF146 zinc finger protein 146 -0.0198926
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0198774
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0198611
SENP5 SUMO1/sentrin specific peptidase 5 -0.0198566
RAB10 RAB10, member RAS oncogene family -0.0198326
UBP1 upstream binding protein 1 (LBP-1a) -0.0198182
LCLAT1 lysocardiolipin acyltransferase 1 -0.0197804
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0197771
AFG2A AFG2 AAA ATPase homolog A -0.0197702
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -0.0197493
TTC7B tetratricopeptide repeat domain 7B -0.0197236
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -0.0196489
EXT1 exostosin glycosyltransferase 1 -0.019628
MYO19 myosin XIX -0.0195984
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 -0.019559
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0195497
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -0.0195473
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0195175
KNTC1 kinetochore associated 1 -0.0194983
SCFD2 sec1 family domain containing 2 -0.0194884
NUMB numb homolog (Drosophila) -0.0193568
NNT nicotinamide nucleotide transhydrogenase -0.0192664
SIK3 SIK family kinase 3 -0.0192317
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -0.0192185
EVI5 ecotropic viral integration site 5 -0.0191577
WAPL WAPL cohesin release factor -0.019156
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -0.0191451
SUMF2 sulfatase modifying factor 2 -0.019051
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B -0.0190313
RBM15 RNA binding motif protein 15 -0.0190192
KIF13A kinesin family member 13A -0.0189182
KIF11 kinesin family member 11 -0.0189062
UTP4 UTP4 small subunit processome component -0.0188804
RBM41 RNA binding motif protein 41 -0.0188422
VAC14 Vac14 homolog (S. cerevisiae) -0.0188388
CDC27 cell division cycle 27 -0.0188165
RHOBTB3 Rho-related BTB domain containing 3 -0.0188077
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0188029
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -0.0187187
USP15 ubiquitin specific peptidase 15 -0.0186996
FNBP1 formin binding protein 1 -0.0186754
MAVS mitochondrial antiviral signaling protein -0.0186343
CBR4 carbonyl reductase 4 -0.0186195
ADCY7 adenylate cyclase 7 -0.0185618
H2AZ2 H2A.Z variant histone 2 -0.0185492
EDARADD EDAR-associated death domain -0.0185435
NOL9 nucleolar protein 9 -0.0185235
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -0.0185147
GDA guanine deaminase -0.0184685
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0184668
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0184604
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.0184134
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0184049
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0183952
MTRFR mitochondrial translation release factor in rescue -0.0183596
ICAM1 intercellular adhesion molecule 1 -0.0183288
KIF4A kinesin family member 4A -0.0183269
RIPOR3 RIPOR family member 3 -0.0183159
TSC22D2 TSC22 domain family, member 2 -0.0181929
DENND4A DENN/MADD domain containing 4A -0.0181692
RPL4 ribosomal protein L4 -0.0181685
CFH complement factor H -0.0181666
OSBPL9 oxysterol binding protein-like 9 -0.0181442
TMEM63A transmembrane protein 63A -0.018106
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0180509
ANLN anillin, actin binding protein -0.0179968
FANCI Fanconi anemia, complementation group I -0.0179669
KIF20B kinesin family member 20B -0.0178503
MTOR mechanistic target of rapamycin (serine/threonine kinase) -0.0177551
H2BC8 H2B clustered histone 8 -0.0177383
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0177366
DENND1B DENN/MADD domain containing 1B -0.0177266
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -0.0177213
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -0.0177096
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.017708
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0177061
XPO1 exportin 1 -0.0176842
ZNF804A zinc finger protein 804A -0.0176623
IPO11 importin 11 -0.017655
YLPM1 YLP motif containing 1 -0.0176078
FUBP1 far upstream element (FUSE) binding protein 1 -0.0175923
RCSD1 RCSD domain containing 1 -0.0175801
TMEM135 transmembrane protein 135 -0.0175213
EXOC4 exocyst complex component 4 -0.0175068
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.017502
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0174861
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0174801
GMDS GDP-mannose 4,6-dehydratase -0.0174236
POGZ pogo transposable element with ZNF domain -0.017413
HEPH hephaestin -0.0173888
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -0.0173511
NAV1 neuron navigator 1 -0.0173396
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.0172981
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0172853
RPAP2 RNA polymerase II associated protein 2 -0.0172538
RHOT1 ras homolog family member T1 -0.0171931
SNX3 sorting nexin 3 -0.0171649
PDZD8 PDZ domain containing 8 -0.0171631
MAP7D3 MAP7 domain containing 3 -0.0171433
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.0170962
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -0.017051
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0170422
PCDHB11 protocadherin beta 11 -0.0170369
TTC3 tetratricopeptide repeat domain 3 -0.0169614
F8 coagulation factor VIII, procoagulant component -0.0169553
POU2F1 POU class 2 homeobox 1 -0.0169469
ZBTB44 zinc finger and BTB domain containing 44 -0.0169377
MOB3B MOB kinase activator 3B -0.0168924
SCAND3 SCAN domain containing 3 -0.0168899
SNX29 sorting nexin 29 -0.016868
KAZN kazrin, periplakin interacting protein -0.0168617
PTK2B protein tyrosine kinase 2 beta -0.016851
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0168486
ZNF566 zinc finger protein 566 -0.0168415
PHB1 prohibitin 1 -0.0167822
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0167432
SPC25 SPC25, NDC80 kinetochore complex component -0.0167299
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0167171
AP3M1 adaptor-related protein complex 3, mu 1 subunit -0.0166722
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0166583
CKAP5 cytoskeleton associated protein 5 -0.0166394
CREBBP CREB binding protein -0.0166246
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0165737
IGSF1 immunoglobulin superfamily, member 1 -0.0165585
TMEM230 transmembrane protein 230 -0.0165577
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.0165358
ARHGAP11A Rho GTPase activating protein 11A -0.0165317
CR1L complement component (3b/4b) receptor 1-like -0.0165149
RUFY2 RUN and FYVE domain containing 2 -0.0164979
TMEM50B transmembrane protein 50B -0.0164844
RYR1 ryanodine receptor 1 (skeletal) -0.0164698
MCM9 minichromosome maintenance complex component 9 -0.0164567
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -0.0164539
TUBB6 tubulin, beta 6 class V -0.0164393
ERI3 ERI1 exoribonuclease family member 3 -0.0164327
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0163981
WRN Werner syndrome, RecQ helicase-like -0.0163737
LUZP1 leucine zipper protein 1 -0.0163666
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0163504
ATXN2 ataxin 2 -0.0163289
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -0.0163034
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0162721
CLIC1 chloride intracellular channel 1 -0.0162652
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0162499
CLSPN claspin -0.0162066
TNRC18 trinucleotide repeat containing 18 -0.0161806
SOX6 SRY (sex determining region Y)-box 6 -0.0161606
GEMIN5 gem (nuclear organelle) associated protein 5 -0.0161383
TTLL10 tubulin tyrosine ligase-like family member 10 -0.0161189
PUM1 pumilio RNA-binding family member 1 -0.0161076
BMAL2 basic helix-loop-helix ARNT like 2 -0.0160789
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -0.0160318
NUDC nudC nuclear distribution protein -0.0160314
FBXO17 F-box protein 17 -0.0160241
PARN poly(A)-specific ribonuclease -0.0160147
NEBL nebulette -0.0159863
RASA2 RAS p21 protein activator 2 -0.0159751
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0159687
MYO1E myosin IE -0.0159509
DBT dihydrolipoamide branched chain transacylase E2 -0.0158981
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0158673
ZBTB35 zinc finger and BTB domain containing 35 -0.0158562
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 -0.0157913
KYNU kynureninase -0.0157845
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -0.0157538
MDM4 MDM4, p53 regulator -0.015735
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -0.0156805
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0156766
TBC1D4 TBC1 domain family, member 4 -0.0156088
TNRC6A trinucleotide repeat containing 6A -0.015583
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0155643
TMEM131L transmembrane 131 like -0.0155565
LTAP1 lipid transport auxiliary protein 1 -0.0155136
EIF4B eukaryotic translation initiation factor 4B -0.0154716
DIAPH1 diaphanous-related formin 1 -0.0154706
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0154705
SUCO SUN domain containing ossification factor -0.0154645
ODF2 outer dense fiber of sperm tails 2 -0.0154297
DOCK7 dedicator of cytokinesis 7 -0.015402
PDS5A PDS5 cohesin associated factor A -0.0153976
CCNI cyclin I -0.0153949
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0153534
RPL29 ribosomal protein L29 -0.015319
FANCM Fanconi anemia, complementation group M -0.0153136
UBN2 ubinuclein 2 -0.015305
ELL2 elongation factor, RNA polymerase II, 2 -0.0152774
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0152607
ERBIN erbb2 interacting protein -0.0152314
WDR59 WD repeat domain 59 -0.0152151
ZNF207 zinc finger protein 207 -0.0152077
DAPK1 death-associated protein kinase 1 -0.0152064
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.015169
ENOSF1 enolase superfamily member 1 -0.015135
GALK2 galactokinase 2 -0.0151157
RPL23 ribosomal protein L23 -0.0150911
SBF2 SET binding factor 2 -0.0150878
NOP56 NOP56 ribonucleoprotein -0.0150787
QSER1 glutamine and serine rich 1 -0.0150715
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0150481
MTCH2 mitochondrial carrier 2 -0.0150401
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -0.0150211
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -0.0149883
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) -0.0149797
GLUL glutamate-ammonia ligase -0.014978
MYADM myeloid-associated differentiation marker -0.014977
ANKRD28 ankyrin repeat domain 28 -0.0149721
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -0.014932
POT1 protection of telomeres 1 -0.0149288
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0149171
SLC38A9 solute carrier family 38, member 9 -0.0149003
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0148376
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0147673
THOC5 THO complex 5 -0.0147507
AAGAB alpha- and gamma-adaptin binding protein -0.0147284
CEP170 centrosomal protein 170kDa -0.0147222
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0147166
COPS3 COP9 signalosome subunit 3 -0.0147079
TEX2 testis expressed 2 -0.0146649
PNKP polynucleotide kinase 3'-phosphatase -0.0146601
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0146316
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -0.014622
SMYD2 SET and MYND domain containing 2 -0.0145868
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -0.0145598
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -0.014518
TMEM165 transmembrane protein 165 -0.0144737
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0144413
PPA2 pyrophosphatase (inorganic) 2 -0.0143709
HDGF hepatoma-derived growth factor -0.014356
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0143462
UVRAG UV radiation resistance associated -0.0143123
RUBCN rubicon autophagy regulator -0.0143085
SUGP2 SURP and G patch domain containing 2 -0.0142875
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0142744
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0142688
CNTNAP2 contactin associated protein-like 2 -0.0142474
KDM4A lysine (K)-specific demethylase 4A -0.0142173
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0141864
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0141731
GTPBP10 GTP-binding protein 10 (putative) -0.0141677
PITPNA phosphatidylinositol transfer protein, alpha -0.0141673
EPN1 epsin 1 -0.0141671
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -0.014106
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -0.0140819
PPP1R16B protein phosphatase 1, regulatory subunit 16B -0.0140745
CLEC16A C-type lectin domain family 16, member A -0.0140622
PKN2 protein kinase N2 -0.0140533
DHCR24 24-dehydrocholesterol reductase -0.0140439
PTBP3 polypyrimidine tract binding protein 3 -0.0140339
MZT2A mitotic spindle organizing protein 2A -0.0140334
DNAAF9 dynein axonemal assembly factor 9 -0.0140252
AHCY adenosylhomocysteinase -0.0140217
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -0.014005
ANKRD11 ankyrin repeat domain 11 -0.0139274
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.013923
NMU neuromedin U -0.0139145
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0138074
CRLS1 cardiolipin synthase 1 -0.0137968
SPTA1 spectrin, alpha, erythrocytic 1 -0.0137834
SUN1 Sad1 and UNC84 domain containing 1 -0.013775
JAK1 Janus kinase 1 -0.0137593
DCAF12 DDB1 and CUL4 associated factor 12 -0.0137442
JAK2 Janus kinase 2 -0.0137326
TDRD3 tudor domain containing 3 -0.0137235