K562_SGI-1776 free base_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SGI-1776 free base 1µM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_SGI-1776 free base_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
ZEB2 zinc finger E-box binding homeobox 2 0.093298
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0812122
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.078202
ADGRB3 adhesion G protein-coupled receptor B3 0.0721226
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0687582
CHD4 chromodomain helicase DNA binding protein 4 0.06403
HBG1 hemoglobin, gamma A 0.0635708
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0614664
DLG1 discs, large homolog 1 (Drosophila) 0.0606169
SFMBT2 Scm-like with four mbt domains 2 0.0584419
ATXN2 ataxin 2 0.0552402
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0546007
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0537418
FLT1 fms-related tyrosine kinase 1 0.0536243
THOC2 THO complex 2 0.0532086
PHF21A PHD finger protein 21A 0.0526835
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0515383
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0509579
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0499869
WWOX WW domain containing oxidoreductase 0.0490783
ACACA acetyl-CoA carboxylase alpha 0.047327
CNST consortin, connexin sorting protein 0.0471667
SRRM1 serine/arginine repetitive matrix 1 0.0470001
RPL28 ribosomal protein L28 0.0465555
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0450449
FNBP1 formin binding protein 1 0.0444398
USP54 ubiquitin specific peptidase 54 0.0444154
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0430605
ORAI2 ORAI calcium release-activated calcium modulator 2 0.0430581
MCAM melanoma cell adhesion molecule 0.0426217
MTDH metadherin 0.0417203
KAZN kazrin, periplakin interacting protein 0.0416788
KRT18 keratin 18, type I 0.0413943
PLD3 phospholipase D family, member 3 0.0412095
NEBL nebulette 0.0407514
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0404996
PTBP2 polypyrimidine tract binding protein 2 0.0404619
RICTOR RPTOR independent companion of MTOR, complex 2 0.0397259
SRPK2 SRSF protein kinase 2 0.0394254
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0390097
BCAS3 breast carcinoma amplified sequence 3 0.0389659
NRF1 nuclear respiratory factor 1 0.038745
TLK1 tousled-like kinase 1 0.0381746
ARL15 ADP-ribosylation factor-like 15 0.037836
RORA RAR-related orphan receptor A 0.0375215
SCFD1 sec1 family domain containing 1 0.037124
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0368544
MED13L mediator complex subunit 13-like 0.03683
UBE2H ubiquitin-conjugating enzyme E2H 0.0365346
NAP1L1 nucleosome assembly protein 1-like 1 0.0365109
CLYBL citrate lyase beta like 0.0364647
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0361266
PARN poly(A)-specific ribonuclease 0.0361026
ASXL2 additional sex combs like transcriptional regulator 2 0.0356204
LOC112694756 uncharaterized LOC112694756 0.0355991
NSD2 nuclear receptor binding SET domain protein 2 0.0354721
ACTG1 actin gamma 1 0.0354392
GALK2 galactokinase 2 0.0353811
RPL35 ribosomal protein L35 0.0348804
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0348557
DOCK8 dedicator of cytokinesis 8 0.0345685
AKAP12 A kinase (PRKA) anchor protein 12 0.0341888
CENPF centromere protein F, 350/400kDa 0.03417
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.0341376
BSDC1 BSD domain containing 1 0.0341118
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0339103
NPEPPS aminopeptidase puromycin sensitive 0.033848
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0338437
TTC17 tetratricopeptide repeat domain 17 0.0337168
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0334335
DCAF5 DDB1 and CUL4 associated factor 5 0.0333415
EIF5B eukaryotic translation initiation factor 5B 0.0330722
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0328178
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0326562
CCAR1 cell division cycle and apoptosis regulator 1 0.0325326
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0323002
KAT6B K(lysine) acetyltransferase 6B 0.032226
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.032096
RAB5A RAB5A, member RAS oncogene family 0.0319143
TMEM131 transmembrane protein 131 0.0318285
UBE3C ubiquitin protein ligase E3C 0.0317118
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0315405
REPS1 RALBP1 associated Eps domain containing 1 0.0312331
IARS1 isoleucyl-tRNA synthetase 1 0.0311774
IPO9 importin 9 0.0311323
PKN2 protein kinase N2 0.0310397
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0307362
DNM2 dynamin 2 0.0305864
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.030349
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0302752
DCHS2 dachsous cadherin-related 2 0.0302617
UBAP2 ubiquitin associated protein 2 0.0301232
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.0300688
KATNA1 katanin p60 (ATPase containing) subunit A 1 0.0299698
PDE4A phosphodiesterase 4A, cAMP-specific 0.0299685
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.0299086
ZDHHC14 zinc finger, DHHC-type containing 14 0.0297162
ZFR zinc finger RNA binding protein 0.0295826
FCHSD2 FCH and double SH3 domains 2 0.0293825
PHIP pleckstrin homology domain interacting protein 0.0293341
SRRM2 serine/arginine repetitive matrix 2 0.0291138
SSR1 signal sequence receptor, alpha 0.028912
INTS4 integrator complex subunit 4 0.0288968
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0288636
NUCB1 nucleobindin 1 0.0286256
TPM3 tropomyosin 3 0.0285954
PRKCA protein kinase C, alpha 0.0285188
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.0284309
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0284243
RBM20 RNA binding motif protein 20 0.0284167
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.0284088
RPL8 ribosomal protein L8 0.0283617
PTK2 protein tyrosine kinase 2 0.0283488
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0283003
MKI67 marker of proliferation Ki-67 0.0281201
AVL9 AVL9 homolog (S. cerevisiase) 0.0280394
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0280134
JAK1 Janus kinase 1 0.028006
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0279368
COMT catechol-O-methyltransferase 0.0277973
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0277428
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0276697
RARS1 arginyl-tRNA synthetase 1 0.0276297
SORBS1 sorbin and SH3 domain containing 1 0.0276157
LYPLA1 lysophospholipase I 0.0276022
TRAPPC8 trafficking protein particle complex 8 0.027584
HMGA1 high mobility group AT-hook 1 0.0274753
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0273804
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0271677
LAPTM4B lysosomal protein transmembrane 4 beta 0.0271417
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.0270767
SAE1 SUMO1 activating enzyme subunit 1 0.0270124
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0270041
PRKD2 protein kinase D2 0.0269626
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.0267442
ZNF804B zinc finger protein 804B 0.0267351
RRBP1 ribosome binding protein 1 0.0266401
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0265873
STIM1 stromal interaction molecule 1 0.0265685
ZFAND6 zinc finger, AN1-type domain 6 0.0265685
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0264442
FLNC filamin C, gamma 0.0264107
ZYG11B zyg-11 family member B, cell cycle regulator 0.0263616
HAT1 histone acetyltransferase 1 0.0263173
SERGEF secretion regulating guanine nucleotide exchange factor 0.0262259
TRAP1 TNF receptor-associated protein 1 0.0260902
SMIM44 small integral membrane protein 44 0.0259521
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.0258601
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.025783
MEF2C myocyte enhancer factor 2C 0.0257197
BLTP1 bridge-like lipid transfer protein family member 1 0.025677
DCAF7 DDB1 and CUL4 associated factor 7 0.0256593
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.0256185
KLHDC10 kelch domain containing 10 0.0256033
LRP10 low density lipoprotein receptor-related protein 10 0.0255985
CREB1 cAMP responsive element binding protein 1 0.0255272
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.0254364
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.0253928
CAMKMT calmodulin-lysine N-methyltransferase 0.0253596
SRSF10 serine/arginine-rich splicing factor 10 0.0253487
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 0.0252565
LIMS1 LIM and senescent cell antigen-like domains 1 0.0250952
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0250022
YME1L1 YME1-like 1 ATPase 0.0249318
SNX8 sorting nexin 8 0.0249084
GTPBP4 GTP binding protein 4 0.0248684
PRRC2B proline-rich coiled-coil 2B 0.0248476
R3HDM2 R3H domain containing 2 0.0248453
WNK1 WNK lysine deficient protein kinase 1 0.024839
GNS glucosamine (N-acetyl)-6-sulfatase 0.0248011
GAB2 GRB2-associated binding protein 2 0.0246957
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0246956
HDAC5 histone deacetylase 5 0.0245365
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0243706
AHCTF1 AT hook containing transcription factor 1 0.0243593
LTBP1 latent transforming growth factor beta binding protein 1 0.0243577
RCC1 regulator of chromosome condensation 1 0.0243506
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0243258
RPL37 ribosomal protein L37 0.0243186
XXYLT1 xyloside xylosyltransferase 1 0.0242418
ADAMTSL4 ADAMTS-like 4 0.0242381
NUP160 nucleoporin 160kDa 0.024231
CEP57 centrosomal protein 57kDa 0.0240482
AKR1C2 aldo-keto reductase family 1, member C2 0.0240371
RAB10 RAB10, member RAS oncogene family 0.0239006
SCAMP4 secretory carrier membrane protein 4 0.0238944
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.0238275
UBA6 ubiquitin-like modifier activating enzyme 6 0.0238255
PTH2R parathyroid hormone 2 receptor 0.0237902
MAP2K5 mitogen-activated protein kinase kinase 5 0.023768
USP32 ubiquitin specific peptidase 32 0.0237289
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0237204
ZFC3H1 zinc finger, C3H1-type containing 0.0236261
LMBR1 limb development membrane protein 1 0.0236121
USP49 ubiquitin specific peptidase 49 0.023606
CENPT centromere protein T 0.0235185
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.023513
ACTN4 actinin, alpha 4 0.0234687
STK4 serine/threonine kinase 4 0.0234576
TFCP2 transcription factor CP2 0.0234285
METTL15 methyltransferase like 15 0.0233981
ERI1 exoribonuclease 1 0.023388
RPL38 ribosomal protein L38 0.0233721
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0233275
GPR137 G protein-coupled receptor 137 0.0232295
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.0231731
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 0.0231298
NCOA1 nuclear receptor coactivator 1 0.0231116
GRB10 growth factor receptor-bound protein 10 0.0231003
RPS9 ribosomal protein S9 0.0230393
TMCO1 transmembrane and coiled-coil domains 1 0.023021
NEB nebulin 0.0230028
PLEC plectin 0.0229847
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0229547
ATP5F1B ATP synthase F1 subunit beta 0.0229301
CHD9 chromodomain helicase DNA binding protein 9 0.0228355
KDM3B lysine (K)-specific demethylase 3B 0.0227929
AGO3 argonaute RISC catalytic component 3 0.0227827
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0227485
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.0227384
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0226743
TPD52L1 tumor protein D52-like 1 0.0226049
TAGLN2 transgelin 2 0.0225796
RBM5 RNA binding motif protein 5 0.0225682
LDLR low density lipoprotein receptor 0.0225267
CANX calnexin 0.0224966
USP9X ubiquitin specific peptidase 9, X-linked 0.0224748
CSDE1 cold shock domain containing E1, RNA-binding 0.0221487
TTC28 tetratricopeptide repeat domain 28 0.0221371
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.022104
GTF2I general transcription factor IIi 0.0220489
EXOC6 exocyst complex component 6 0.0220146
NFE2L2 nuclear factor, erythroid 2-like 2 0.0219985
SERINC3 serine incorporator 3 0.0219798
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0219264
SMAD2 SMAD family member 2 0.0218464
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0218449
TRAF3 TNF receptor-associated factor 3 0.0218298
FTL ferritin, light polypeptide 0.0217809
DGCR2 DiGeorge syndrome critical region gene 2 0.0217675
MCFD2 multiple coagulation factor deficiency 2 0.0217175
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.02161
RPL31 ribosomal protein L31 0.0215848
FLNA filamin A, alpha 0.021431
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.021396
RNF24 ring finger protein 24 0.0213946
SCYL2 SCY1-like 2 (S. cerevisiae) 0.0213327
ATG7 autophagy related 7 0.0212676
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0212512
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.0212383
WDR59 WD repeat domain 59 0.0212196
CREM cAMP responsive element modulator 0.0211879
RPS29 ribosomal protein S29 0.0211598
UNC13D unc-13 homolog D (C. elegans) 0.0211296
TOP2B topoisomerase (DNA) II beta 180kDa 0.0211193
SGMS1 sphingomyelin synthase 1 0.0211192
SPTA1 spectrin, alpha, erythrocytic 1 0.0210149
UBL4A ubiquitin-like 4A 0.0209443
POFUT3 protein O-fucosyltransferase 3 0.0208982
TRIM28 tripartite motif containing 28 0.0208525
PRPF4B pre-mRNA processing factor 4B 0.0208254
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0208229
SEPTIN6 septin 6 0.0207807
MAVS mitochondrial antiviral signaling protein 0.0207555
LCOR ligand dependent nuclear receptor corepressor 0.0207549
RUNX1 runt-related transcription factor 1 0.0207416
VMP1 vacuole membrane protein 1 0.0206913
RSRP1 arginine/serine-rich protein 1 0.02067
DAAM1 dishevelled associated activator of morphogenesis 1 0.0206464
TET1 tet methylcytosine dioxygenase 1 0.0206239
SUGP2 SURP and G patch domain containing 2 0.0205898
EML4 echinoderm microtubule associated protein like 4 0.0205668
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0205381
AATF apoptosis antagonizing transcription factor 0.0205218
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.020492
DOCK9 dedicator of cytokinesis 9 0.0204853
ZXDC ZXD family zinc finger C 0.020482
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0204045
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.020401
MACROD1 MACRO domain containing 1 0.0203654
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0203622
FAM222B family with sequence similarity 222, member B 0.0202968
CUX1 cut-like homeobox 1 0.0202866
KTN1 kinectin 1 (kinesin receptor) 0.0202366
FBXL19 F-box and leucine-rich repeat protein 19 0.0202318
ZFAND3 zinc finger, AN1-type domain 3 0.0202305
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0202215
CCDC85C coiled-coil domain containing 85C 0.0201711
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0201105
TRAK1 trafficking protein, kinesin binding 1 0.0199991
SCAP SREBF chaperone 0.0199599
TTBK2 tau tubulin kinase 2 0.0199509
C2CD3 C2 calcium-dependent domain containing 3 0.0198936
ENTR1 endosome associated trafficking regulator 1 0.0198169
ZNF175 zinc finger protein 175 0.0198121
DLG5 discs, large homolog 5 (Drosophila) 0.019782
RPL37A ribosomal protein L37a 0.0197731
SCLT1 sodium channel and clathrin linker 1 0.0197618
SIK2 salt-inducible kinase 2 0.0197376
XPO5 exportin 5 0.0197365
TMEM117 transmembrane protein 117 0.0197276
ZCCHC7 zinc finger, CCHC domain containing 7 0.0196963
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.0196898
PRKN parkin RBR E3 ubiquitin protein ligase 0.0196621
RILPL1 Rab interacting lysosomal protein-like 1 0.0196533
EZR ezrin 0.0196493
WDR73 WD repeat domain 73 0.0196184
FAM133B family with sequence similarity 133, member B 0.0196164
PHKA2 phosphorylase kinase, alpha 2 (liver) 0.0195508
PEX14 peroxisomal biogenesis factor 14 0.0195421
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.019529
ATF6 activating transcription factor 6 0.0193771
NPC1 Niemann-Pick disease, type C1 0.0193417
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0192794
MIGA2 mitoguardin 2 0.0192595
ZDHHC8 zinc finger, DHHC-type containing 8 0.0192084
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0192079
RABGAP1 RAB GTPase activating protein 1 0.0191837
HSPB1 heat shock 27kDa protein 1 0.019171
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.019155
ZNF638 zinc finger protein 638 0.0191372
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0191173
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0190759
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.0190755
SMAP2 small ArfGAP2 0.0189785
ZNG1B Zn regulated GTPase metalloprotein activator 1B 0.0189745
CUEDC1 CUE domain containing 1 0.0189725
RANBP2 RAN binding protein 2 0.0189683
LGALS8 lectin, galactoside-binding, soluble, 8 0.0189295
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0189194
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.0188983
BROX BRO1 domain and CAAX motif containing 0.0188832
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0188677
DEPDC5 DEP domain containing 5 0.0188239
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0187918
MAGT1 magnesium transporter 1 0.0187755
TUBGCP5 tubulin, gamma complex associated protein 5 0.0187725
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.018755
PCLAF PCNA clamp associated factor 0.0187221
ARL5A ADP-ribosylation factor-like 5A 0.018663
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0186599
TRIR telomerase RNA component interacting RNase 0.0186377
BMP2K BMP2 inducible kinase 0.0186271
RHOBTB3 Rho-related BTB domain containing 3 0.0185951
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0185522
FANCD2 Fanconi anemia, complementation group D2 0.0185508
RPL5 ribosomal protein L5 0.018485
NUP43 nucleoporin 43kDa 0.0184824
LONP1 lon peptidase 1, mitochondrial 0.0184493
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0184171
INTS6L integrator complex subunit 6 like 0.0184069
GPATCH8 G patch domain containing 8 0.0183664
USP3 ubiquitin specific peptidase 3 0.0183565
SLC44A5 solute carrier family 44, member 5 0.018343
ADCY8 adenylate cyclase 8 (brain) 0.0183365
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.018304
EDRF1 erythroid differentiation regulatory factor 1 0.0182988
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.0182766
KRT8 keratin 8, type II 0.0182072
TTF1 transcription termination factor, RNA polymerase I 0.0181737
TRIM38 tripartite motif containing 38 0.0181536
DARS1 aspartyl-tRNA synthetase 1 0.0181287
STK17A serine/threonine kinase 17a 0.0180961
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0180874
TCERG1 transcription elongation regulator 1 0.0180818
SMIM7 small integral membrane protein 7 0.0180529
PA2G4 proliferation-associated 2G4, 38kDa 0.0180274
ETNK1 ethanolamine kinase 1 0.0179951
AHI1 Abelson helper integration site 1 0.0179699
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0179186
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0179122
TET3 tet methylcytosine dioxygenase 3 0.0179117
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.0179079
RAB1A RAB1A, member RAS oncogene family 0.0178984
ZNF3 zinc finger protein 3 0.0178885
PTCD3 pentatricopeptide repeat domain 3 0.0178477
PCNX4 pecanex 4 0.0178
NUDC nudC nuclear distribution protein 0.0177928
ZNF398 zinc finger protein 398 0.0177779
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0177431
COASY CoA synthase 0.0177297
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.0177093
EXD3 exonuclease 3'-5' domain containing 3 0.0176888
THOC1 THO complex 1 0.0176546
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.017629
MAP4 microtubule-associated protein 4 0.0176255
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.0176028
GON4L gon-4-like (C. elegans) 0.0175991
BMPR1A bone morphogenetic protein receptor, type IA 0.0175934
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0175634
PGPEP1 pyroglutamyl-peptidase I 0.0175564
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0175242
EIF4E eukaryotic translation initiation factor 4E 0.0175018
GATAD2A GATA zinc finger domain containing 2A 0.0174807
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0174703
BCAP31 B-cell receptor-associated protein 31 0.0174536
LAMP1 lysosomal-associated membrane protein 1 0.0174504
CLIP2 CAP-GLY domain containing linker protein 2 0.0174459
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0174095
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0174044
S100A10 S100 calcium binding protein A10 0.0173896
PTRH2 peptidyl-tRNA hydrolase 2 0.0173583
ANKRD26 ankyrin repeat domain 26 0.0173559
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0173436
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0173432
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.0173173
SNX4 sorting nexin 4 0.0173088
MGST3 microsomal glutathione S-transferase 3 0.0172302
DNAH8 dynein, axonemal, heavy chain 8 0.0171625
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0171446
CCDC88A coiled-coil domain containing 88A 0.0170936
RCSD1 RCSD domain containing 1 0.0170903
CR1L complement component (3b/4b) receptor 1-like 0.017076
RPL6 ribosomal protein L6 0.0170472
SNX25 sorting nexin 25 0.0170249
NKTR natural killer cell triggering receptor 0.0170139
KLHL23 kelch-like family member 23 0.0169525
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.016948
LIN52 lin-52 DREAM MuvB core complex component 0.0169261
RERG RAS-like, estrogen-regulated, growth inhibitor 0.016892
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0168889
STRBP spermatid perinuclear RNA binding protein 0.0168664
RIPOR3 RIPOR family member 3 0.0168447
SYNRG synergin, gamma 0.0168138
PXDN peroxidasin 0.0167863
SOS2 son of sevenless homolog 2 (Drosophila) 0.0167633
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0167583
CCDC138 coiled-coil domain containing 138 0.0167491
TBCD tubulin folding cofactor D 0.016711
RB1 retinoblastoma 1 0.0166928
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0166744
TEX2 testis expressed 2 0.0166708
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0166586
NFE2L1 nuclear factor, erythroid 2-like 1 0.0166156
MAPK9 mitogen-activated protein kinase 9 0.0166057
PPP1R16A protein phosphatase 1, regulatory subunit 16A 0.016603
ACOT7 acyl-CoA thioesterase 7 0.0166014
AGO4 argonaute RISC catalytic component 4 0.0165965
GRAP2 GRB2-related adaptor protein 2 0.0165917
TESK2 testis-specific kinase 2 0.016579
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.0165693
MOB3A MOB kinase activator 3A 0.0165653
LIMA1 LIM domain and actin binding 1 0.0164895
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0164829
NGLY1 N-glycanase 1 0.0164756
ADAR adenosine deaminase, RNA-specific 0.0164735
GATAD2B GATA zinc finger domain containing 2B 0.016454
FBL fibrillarin 0.01643
GSTO1 glutathione S-transferase omega 1 0.0163884
SNTA1 syntrophin, alpha 1 0.0163816
CEP95 centrosomal protein 95kDa 0.0163653
ZFPM2 zinc finger protein, FOG family member 2 0.0163553
TTLL11 tubulin tyrosine ligase-like family member 11 0.0163249
DYM dymeclin 0.016304
CEP89 centrosomal protein 89kDa 0.0163027
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.0162779
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0162712
ZBTB20 zinc finger and BTB domain containing 20 0.0162593
TSLIG1 tRNA splicing ligase complex subunit 1 0.0162459
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.0162449
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0162283
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0162034
BCCIP BRCA2 and CDKN1A interacting protein 0.0161851
EIF5 eukaryotic translation initiation factor 5 0.0161348
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.0161181
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0160968
RRP1B ribosomal RNA processing 1B 0.0160807
ARHGAP11B Rho GTPase activating protein 11B 0.0160605
CDK12 cyclin-dependent kinase 12 0.0160465
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 0.0160347
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0160319
TMEM168 transmembrane protein 168 0.0160047
EVI5 ecotropic viral integration site 5 0.0160026
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0159959
NEK7 NIMA-related kinase 7 0.0159914
DGKI diacylglycerol kinase, iota 0.0159806
ANGPT1 angiopoietin 1 0.015979
ATOSA atos homolog A 0.0159102
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0159047
SNX29 sorting nexin 29 0.0158977
LIMK2 LIM domain kinase 2 0.0158845
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.0158822
TBL1X transducin (beta)-like 1X-linked 0.015877
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0158533
COPB1 coatomer protein complex, subunit beta 1 0.0158531
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.01583
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.01582
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.015789
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.015789
GUSB glucuronidase, beta 0.0157537
KIF13A kinesin family member 13A 0.0157477
MRPL47 mitochondrial ribosomal protein L47 0.0157311
MYH10 myosin, heavy chain 10, non-muscle 0.0157282
GDF15 growth differentiation factor 15 0.0156752
FTO fat mass and obesity associated 0.0156619
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0156541
DCAF17 DDB1 and CUL4 associated factor 17 0.0156417
CATSPERB catsper channel auxiliary subunit beta 0.0156214
MCEE methylmalonyl CoA epimerase 0.0156048
RUBCN rubicon autophagy regulator 0.0155933

decreased expression

Symbol Name Standardized Value
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0769649
FGF13 fibroblast growth factor 13 -0.0767917
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0666156
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0659118
TFRC transferrin receptor -0.0624827
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0614366
SMYD3 SET and MYND domain containing 3 -0.0523788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0515775
SLC38A1 solute carrier family 38, member 1 -0.0490622
PRRC2C proline-rich coiled-coil 2C -0.0486613
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.048012
RBM15 RNA binding motif protein 15 -0.0477991
JARID2 jumonji, AT rich interactive domain 2 -0.0452213
PDIA6 protein disulfide isomerase family A, member 6 -0.0445141
SLMAP sarcolemma associated protein -0.0444239
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.0431731
COG5 component of oligomeric golgi complex 5 -0.0430372
ERBIN erbb2 interacting protein -0.0429588
HBG2 hemoglobin, gamma G -0.042826
NIBAN1 niban apoptosis regulator 1 -0.0427692
TPR translocated promoter region, nuclear basket protein -0.042411
TNIK TRAF2 and NCK interacting kinase -0.0419764
DIAPH3 diaphanous-related formin 3 -0.0409403
WSB1 WD repeat and SOCS box containing 1 -0.0406392
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0405285
MEIS2 Meis homeobox 2 -0.0405276
H2AC6 H2A clustered histone 6 -0.0402937
NVL nuclear VCP-like -0.0397249
ANKRD17 ankyrin repeat domain 17 -0.0395037
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0394168
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0390107
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0390041
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0387166
RFWD3 ring finger and WD repeat domain 3 -0.038605
PICALM phosphatidylinositol binding clathrin assembly protein -0.0385136
ADD3 adducin 3 (gamma) -0.0385014
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0384153
SMC4 structural maintenance of chromosomes 4 -0.038044
JMJD1C jumonji domain containing 1C -0.0377184
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0374556
ATAD2B ATPase family, AAA domain containing 2B -0.0374008
RABGAP1L RAB GTPase activating protein 1-like -0.0373775
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0371536
NUP205 nucleoporin 205kDa -0.0371135
KMT2C lysine (K)-specific methyltransferase 2C -0.0368427
USP48 ubiquitin specific peptidase 48 -0.0366975
CCNI cyclin I -0.0366062
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0365461
KAT6A K(lysine) acetyltransferase 6A -0.0362845
PRAME preferentially expressed antigen in melanoma -0.0359906
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0359812
CNKSR3 CNKSR family member 3 -0.035916
MUSK muscle, skeletal, receptor tyrosine kinase -0.0358287
NUP214 nucleoporin 214kDa -0.0356239
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0352334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0351849
EPB41 erythrocyte membrane protein band 4.1 -0.0349594
KMT2A lysine (K)-specific methyltransferase 2A -0.0347703
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0344513
CFAP161 cilia and flagella associated protein 161 -0.0343235
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0337588
MPHOSPH9 M-phase phosphoprotein 9 -0.0335777
KIDINS220 kinase D-interacting substrate, 220kDa -0.0331171
CEP170 centrosomal protein 170kDa -0.0330279
NBAS neuroblastoma amplified sequence -0.0329832
KIAA1328 KIAA1328 -0.0328208
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.0327614
MRPS27 mitochondrial ribosomal protein S27 -0.0326151
HELZ helicase with zinc finger -0.0324573
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0323885
RNF149 ring finger protein 149 -0.0320169
CA8 carbonic anhydrase VIII -0.0319389
TNPO3 transportin 3 -0.0315676
QSER1 glutamine and serine rich 1 -0.0315213
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.031508
UBN2 ubinuclein 2 -0.0314256
ANAPC5 anaphase promoting complex subunit 5 -0.0311628
NUSAP1 nucleolar and spindle associated protein 1 -0.0311064
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.0310949
PARD3B par-3 family cell polarity regulator beta -0.031011
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.03087
MED13 mediator complex subunit 13 -0.0306788
DSCAM Down syndrome cell adhesion molecule -0.0304576
GDNF glial cell derived neurotrophic factor -0.0303917
GMPR guanosine monophosphate reductase -0.0302798
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0302238
SETD2 SET domain containing 2 -0.03016
XYLB xylulokinase homolog (H. influenzae) -0.030008
DHDDS dehydrodolichyl diphosphate synthase -0.029753
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0297231
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0296504
GLUL glutamate-ammonia ligase -0.0294903
PPARD peroxisome proliferator-activated receptor delta -0.0293799
PRRC2A proline-rich coiled-coil 2A -0.0292889
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -0.0292484
CLASP2 cytoplasmic linker associated protein 2 -0.0292049
VCL vinculin -0.0289542
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.028777
BBX bobby sox homolog (Drosophila) -0.0287764
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0284963
TCF12 transcription factor 12 -0.0284773
CALU calumenin -0.0284131
CXXC5 CXXC finger protein 5 -0.0283764
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0282012
TGFBR3 transforming growth factor, beta receptor III -0.0280605
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0280178
BLTP2 bridge-like lipid transfer protein family member 2 -0.0279783
FAM120A family with sequence similarity 120A -0.0279707
RPL27A ribosomal protein L27a -0.027957
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0279138
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0278241
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0277944
STRN3 striatin, calmodulin binding protein 3 -0.0276996
RCOR1 REST corepressor 1 -0.0273738
NCOA4 nuclear receptor coactivator 4 -0.0272689
MCU mitochondrial calcium uniporter -0.0271965
MRPL13 mitochondrial ribosomal protein L13 -0.0270644
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.026856
RNF217 ring finger protein 217 -0.0267866
ZNF609 zinc finger protein 609 -0.0267725
ARHGAP18 Rho GTPase activating protein 18 -0.0267028
DCAF10 DDB1 and CUL4 associated factor 10 -0.0266903
FAM171A1 family with sequence similarity 171, member A1 -0.0265293
RAD23B RAD23 homolog B (S. cerevisiae) -0.0265009
TMEM209 transmembrane protein 209 -0.0263955
USP34 ubiquitin specific peptidase 34 -0.0263163
SEC63 SEC63 homolog (S. cerevisiae) -0.0262948
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0261623
TMEM245 transmembrane protein 245 -0.0260756
CLASP1 cytoplasmic linker associated protein 1 -0.0258757
CDCA2 cell division cycle associated 2 -0.0257666
FBH1 F-box DNA helicase 1 -0.0257311
QPRT quinolinate phosphoribosyltransferase -0.025427
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0253492
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0253207
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0252462
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.0252323
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0251623
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0250659
SCAF11 SR-related CTD-associated factor 11 -0.0248013
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0247671
HDAC1 histone deacetylase 1 -0.0247513
NUP133 nucleoporin 133kDa -0.0246864
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0246523
COP1 COP1 E3 ubiquitin ligase -0.0246186
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0245568
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0243939
USP42 ubiquitin specific peptidase 42 -0.0242347
PDCD11 programmed cell death 11 -0.0241738
KDM5B lysine (K)-specific demethylase 5B -0.0241338
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0240688
TMEM131L transmembrane 131 like -0.0240302
ARHGAP6 Rho GTPase activating protein 6 -0.0240276
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -0.024019
MBNL1 muscleblind-like splicing regulator 1 -0.0239561
INVS inversin -0.0239437
CTR9 CTR9, Paf1/RNA polymerase II complex component -0.023919
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0237967
FAM193A family with sequence similarity 193, member A -0.0236934
SIK3 SIK family kinase 3 -0.0235859
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0235711
CNTNAP2 contactin associated protein-like 2 -0.023564
UBE3A ubiquitin protein ligase E3A -0.0235093
LARS1 leucyl-tRNA synthetase 1 -0.0234601
MAPK1 mitogen-activated protein kinase 1 -0.0234072
EPS15 epidermal growth factor receptor pathway substrate 15 -0.023355
LRRC8B leucine rich repeat containing 8 family, member B -0.0232672
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -0.0231834
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.023085
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0230558
NIPSNAP2 nipsnap homolog 2 -0.0229779
NDFIP1 Nedd4 family interacting protein 1 -0.0229631
NF1 neurofibromin 1 -0.0229579
SSH2 slingshot protein phosphatase 2 -0.0229508
RAI14 retinoic acid induced 14 -0.0229231
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.022884
FBXL13 F-box and leucine-rich repeat protein 13 -0.0228472
KEAP1 kelch-like ECH-associated protein 1 -0.0228435
SMC1A structural maintenance of chromosomes 1A -0.0228419
TGOLN2 trans-golgi network protein 2 -0.0228126
POTEF POTE ankyrin domain family, member F -0.022666
TBC1D22A TBC1 domain family, member 22A -0.0226652
ZNF592 zinc finger protein 592 -0.0226172
MTF2 metal response element binding transcription factor 2 -0.0226018
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0225857
GIGYF2 GRB10 interacting GYF protein 2 -0.0225713
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0225687
SORCS1 sortilin-related VPS10 domain containing receptor 1 -0.0225111
DPP9 dipeptidyl-peptidase 9 -0.022438
GNAS GNAS complex locus -0.0224379
MYB v-myb avian myeloblastosis viral oncogene homolog -0.0224297
KIF20B kinesin family member 20B -0.0223939
KRIT1 KRIT1, ankyrin repeat containing -0.0223725
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.0223543
WDFY2 WD repeat and FYVE domain containing 2 -0.0223488
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0222969
RPLP0 ribosomal protein, large, P0 -0.0220778
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0220296
CPEB1 cytoplasmic polyadenylation element binding protein 1 -0.0217804
RHEB Ras homolog enriched in brain -0.0217752
DEPDC1B DEP domain containing 1B -0.0217619
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0217602
SEPTIN9 septin 9 -0.0217514
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 -0.0217483
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0217305
ZC3H4 zinc finger CCCH-type containing 4 -0.0217026
RPS18 ribosomal protein S18 -0.0216983
CDC37 cell division cycle 37 -0.0216476
MVD mevalonate (diphospho) decarboxylase -0.0216416
TMEM181 transmembrane protein 181 -0.021411
DNAAF9 dynein axonemal assembly factor 9 -0.0213446
CTSC cathepsin C -0.021334
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) -0.021271
VTA1 vesicle (multivesicular body) trafficking 1 -0.021252
MARF1 meiosis regulator and mRNA stability factor 1 -0.0212279
PDLIM5 PDZ and LIM domain 5 -0.0212241
SUSD1 sushi domain containing 1 -0.0211379
PCM1 pericentriolar material 1 -0.0211065
OTUD7B OTU deubiquitinase 7B -0.0210596
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0210473
RNF111 ring finger protein 111 -0.0210283
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0209735
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0208704
MTMR3 myotubularin related protein 3 -0.0208599
PRKCSH protein kinase C substrate 80K-H -0.0208511
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -0.0207212
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.020671
ANKFY1 ankyrin repeat and FYVE domain containing 1 -0.0206676
ANKRD10 ankyrin repeat domain 10 -0.020618
DIDO1 death inducer-obliterator 1 -0.0205641
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0205371
NAV1 neuron navigator 1 -0.0205356
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -0.0205324
ABI1 abl-interactor 1 -0.0204746
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0204683
ATXN10 ataxin 10 -0.0204604
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0204519
CDC73 cell division cycle 73 -0.02044
CFAP20DC CFAP20 domain containing -0.0204292
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0204243
CCNY cyclin Y -0.0203761
MON2 MON2 homolog (S. cerevisiae) -0.0203654
ZNF789 zinc finger protein 789 -0.0203515
UBE2K ubiquitin-conjugating enzyme E2K -0.0203499
SEC24B SEC24 family member B -0.0203489
PRPF38A pre-mRNA processing factor 38A -0.0203266
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0203257
RPS7 ribosomal protein S7 -0.0203079
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0202843
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.02025
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0202381
MMS22L MMS22-like, DNA repair protein -0.0202211
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0202152
PRC1 protein regulator of cytokinesis 1 -0.0201439
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -0.0201057
TENM1 teneurin transmembrane protein 1 -0.0200586
MIPOL1 mirror-image polydactyly 1 -0.0200284
RSF1 remodeling and spacing factor 1 -0.0200213
KYAT1 kynurenine aminotransferase 1 -0.0200158
IQCB1 IQ motif containing B1 -0.0199724
LCLAT1 lysocardiolipin acyltransferase 1 -0.0199572
ARID1A AT rich interactive domain 1A (SWI-like) -0.0199348
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.019895
RIC8B RIC8 guanine nucleotide exchange factor B -0.019885
NUP107 nucleoporin 107kDa -0.0198846
CENPE centromere protein E, 312kDa -0.0198819
SCFD2 sec1 family domain containing 2 -0.0198629
ST7L suppression of tumorigenicity 7 like -0.0197665
WDR7 WD repeat domain 7 -0.01974
QKI QKI, KH domain containing, RNA binding -0.0197285
NOP58 NOP58 ribonucleoprotein -0.0196759
RBM6 RNA binding motif protein 6 -0.0196097
RHAG Rh-associated glycoprotein -0.0196063
CEP128 centrosomal protein 128kDa -0.0194794
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0194321
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0194039
PPP1R8 protein phosphatase 1, regulatory subunit 8 -0.0193858
CDYL chromodomain protein, Y-like -0.0193775
GK5 glycerol kinase 5 (putative) -0.0193435
CARD11 caspase recruitment domain family, member 11 -0.0193402
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0193104
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -0.0192925
CLIP1 CAP-GLY domain containing linker protein 1 -0.0192907
TOMM70 translocase of outer mitochondrial membrane 70 -0.0192786
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0192718
ARHGAP35 Rho GTPase activating protein 35 -0.0192615
OSBPL3 oxysterol binding protein-like 3 -0.0192071
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -0.0192052
DCTN2 dynactin 2 (p50) -0.0191979
SREBF2 sterol regulatory element binding transcription factor 2 -0.0191377
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.019131
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0190965
CALR calreticulin -0.0190327
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.019004
WASF2 WAS protein family, member 2 -0.0190018
HSPG2 heparan sulfate proteoglycan 2 -0.0189459
ITCH itchy E3 ubiquitin protein ligase -0.0189435
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0189265
CENPK centromere protein K -0.0189066
MAML2 mastermind-like 2 (Drosophila) -0.0188734
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0188547
ACBD3 acyl-CoA binding domain containing 3 -0.0188388
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0188375
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -0.0187969
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0187552
ELOVL5 ELOVL fatty acid elongase 5 -0.0187235
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -0.0186919
TNRC18 trinucleotide repeat containing 18 -0.0186912
SERF2 small EDRK-rich factor 2 -0.0186643
SFPQ splicing factor proline/glutamine-rich -0.0186556
CELF1 CUGBP, Elav-like family member 1 -0.0186488
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0186142
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -0.018608
USP15 ubiquitin specific peptidase 15 -0.018588
ERP44 endoplasmic reticulum protein 44 -0.0185866
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0185412
ZNF346 zinc finger protein 346 -0.0185233
WAPL WAPL cohesin release factor -0.0184917
HCFC1 host cell factor C1 -0.0184911
SLC35F5 solute carrier family 35, member F5 -0.0184903
PRKCI protein kinase C, iota -0.0184903
FNBP4 formin binding protein 4 -0.018463
FKBP5 FK506 binding protein 5 -0.0184091
TPP2 tripeptidyl peptidase II -0.018346
UIMC1 ubiquitin interaction motif containing 1 -0.0183453
DSTYK dual serine/threonine and tyrosine protein kinase -0.0183029
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0182963
PHACTR1 phosphatase and actin regulator 1 -0.0182796
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.018224
GLO1 glyoxalase I -0.018216
SELENOI selenoprotein I -0.0181382
PHKB phosphorylase kinase, beta -0.0180308
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0180274
BCLAF1 BCL2-associated transcription factor 1 -0.0179583
TESC tescalcin -0.0179558
OPHN1 oligophrenin 1 -0.0179403
FRS2 fibroblast growth factor receptor substrate 2 -0.0179263
MRPL20 mitochondrial ribosomal protein L20 -0.0178888
LDAH lipid droplet associated hydrolase -0.017885
TAOK1 TAO kinase 1 -0.0178191
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -0.0178064
JUND jun D proto-oncogene -0.0177882
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0177755
TRAPPC11 trafficking protein particle complex 11 -0.0177715
ZNF236 zinc finger protein 236 -0.0177673
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0177604
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0177479
DDIT4 DNA-damage-inducible transcript 4 -0.0177316
ELP4 elongator acetyltransferase complex subunit 4 -0.0176609
GSK3B glycogen synthase kinase 3 beta -0.017634
FANCA Fanconi anemia, complementation group A -0.0176129
ANKRD28 ankyrin repeat domain 28 -0.0175638
DPY19L1 dpy-19-like 1 (C. elegans) -0.0175626
SECISBP2L SECIS binding protein 2-like -0.0175399
SELENOF selenoprotein F -0.0175156
KIAA1586 KIAA1586 -0.0175121
AFG2A AFG2 AAA ATPase homolog A -0.0174991
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -0.0174893
GOLM2 golgi membrane protein 2 -0.0174627
CELF2 CUGBP, Elav-like family member 2 -0.0174275
ARHGAP5 Rho GTPase activating protein 5 -0.0174257
SETD5 SET domain containing 5 -0.0174122
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0173821
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0173778
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0173059
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -0.0172977
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 -0.017284
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0172752
FBXO5 F-box protein 5 -0.0172531
CNTRL centriolin -0.0172092
RBM4 RNA binding motif protein 4 -0.0171989
FOXP1 forkhead box P1 -0.0171916
CLSPN claspin -0.0171596
TUBB tubulin, beta class I -0.0171515
RLF rearranged L-myc fusion -0.0170998
FAM3C family with sequence similarity 3, member C -0.0170739
PARK7 parkinson protein 7 -0.0170545
GFM1 G elongation factor, mitochondrial 1 -0.0170363
THUMPD2 THUMP domain containing 2 -0.0169978
CUL2 cullin 2 -0.0169976
RBBP6 retinoblastoma binding protein 6 -0.0169956
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -0.0169886
RDX radixin -0.0169264
HDLBP high density lipoprotein binding protein -0.0168745
RAP1B RAP1B, member of RAS oncogene family -0.0168106
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -0.0167898
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -0.0167793
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0167744
NCAM2 neural cell adhesion molecule 2 -0.01677
TASP1 taspase, threonine aspartase, 1 -0.0167697
MTMR14 myotubularin related protein 14 -0.0167599
ANAPC1 anaphase promoting complex subunit 1 -0.0167408
USP47 ubiquitin specific peptidase 47 -0.0166932
ASCC1 activating signal cointegrator 1 complex subunit 1 -0.0166761
KIAA0232 KIAA0232 -0.0166667
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0166531
TBPL1 TBP-like 1 -0.0166478
HIC2 hypermethylated in cancer 2 -0.0166356
OXR1 oxidation resistance 1 -0.0166322
SET SET nuclear proto-oncogene -0.0166231
METTL8 methyltransferase like 8 -0.0166216
ENKUR enkurin, TRPC channel interacting protein -0.0166056
BCL2L1 BCL2-like 1 -0.0165912
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.016553
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0165387
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0165116
KIAA0319L KIAA0319-like -0.0164959
ZNF706 zinc finger protein 706 -0.0164953
ARHGAP12 Rho GTPase activating protein 12 -0.0164703
POLE polymerase (DNA directed), epsilon, catalytic subunit -0.0164574
PRMT2 protein arginine methyltransferase 2 -0.016457
OSBPL8 oxysterol binding protein-like 8 -0.016419
CTBP2 C-terminal binding protein 2 -0.0163886
RINT1 RAD50 interactor 1 -0.0163789
DNAH14 dynein, axonemal, heavy chain 14 -0.0163742
LATS1 large tumor suppressor kinase 1 -0.0163712
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0163661
MCM6 minichromosome maintenance complex component 6 -0.0163303
H3-3B H3.3 histone B -0.016329
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0163285
SAMD8 sterile alpha motif domain containing 8 -0.0162624
GTF2IRD1 GTF2I repeat domain containing 1 -0.0162521
SKA2 spindle and kinetochore associated complex subunit 2 -0.016237
SLC39A11 solute carrier family 39, member 11 -0.016219
ZC3H15 zinc finger CCCH-type containing 15 -0.0162071
STAT5B signal transducer and activator of transcription 5B -0.0161882
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0161612
DMXL2 Dmx-like 2 -0.0161371
ITPK1 inositol-tetrakisphosphate 1-kinase -0.0161252
LIAS lipoic acid synthetase -0.0161213
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0160853
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.0160208
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0159812
CDC45 cell division cycle 45 -0.0159794
AARS1 alanyl-tRNA synthetase 1 -0.0159694
PANK3 pantothenate kinase 3 -0.0159491
ALDOC aldolase C, fructose-bisphosphate -0.0159385
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0159325
RANGAP1 Ran GTPase activating protein 1 -0.0159065
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -0.0159062
PRNP prion protein -0.0158414
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0158216
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0157952
POT1 protection of telomeres 1 -0.0157775
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0157756
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0157754
MZT2B mitotic spindle organizing protein 2B -0.0157626
XPC xeroderma pigmentosum, complementation group C -0.0157515
RAVER1 ribonucleoprotein, PTB-binding 1 -0.015688
FNIP2 folliculin interacting protein 2 -0.0156244
USP12 ubiquitin specific peptidase 12 -0.0155829
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0155506
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -0.0155475
SEC11A SEC11 homolog A (S. cerevisiae) -0.0155241
ARB2A ARB2 cotranscriptional regulator A -0.0155234
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0154846
DMWD dystrophia myotonica, WD repeat containing -0.0154799
ATG10 autophagy related 10 -0.0154777
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0154741
GCLM glutamate-cysteine ligase, modifier subunit -0.0154651
SETX senataxin -0.0153955
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0153953
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0153834
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -0.015359
RAI1 retinoic acid induced 1 -0.0153102
PANK2 pantothenate kinase 2 -0.0152976
TXNIP thioredoxin interacting protein -0.0152864
GRB2 growth factor receptor-bound protein 2 -0.0152734
MSMO1 methylsterol monooxygenase 1 -0.0152593
ANKMY2 ankyrin repeat and MYND domain containing 2 -0.015202
ATAD5 ATPase family, AAA domain containing 5 -0.0151969
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0151875
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0151759
ZMYM4 zinc finger, MYM-type 4 -0.015154
TMEM182 transmembrane protein 182 -0.0151368
SERP1 stress-associated endoplasmic reticulum protein 1 -0.0151288
SNRPG small nuclear ribonucleoprotein polypeptide G -0.0151275
PACRGL PARK2 co-regulated-like -0.0151199
PHF3 PHD finger protein 3 -0.0151073
RBM26 RNA binding motif protein 26 -0.0150993
APOE apolipoprotein E -0.0150908
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -0.0150855
ADTRP androgen-dependent TFPI-regulating protein -0.0150848
FAM13B family with sequence similarity 13, member B -0.0150812
CCDC14 coiled-coil domain containing 14 -0.0150797
LTBP4 latent transforming growth factor beta binding protein 4 -0.0150796
MED24 mediator complex subunit 24 -0.0150594
INTS2 integrator complex subunit 2 -0.0150558
SRBD1 S1 RNA binding domain 1 -0.0150521
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.0150339
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.014993
SQSTM1 sequestosome 1 -0.0149667
SRP54 signal recognition particle 54kDa -0.0149607
BAHD1 bromo adjacent homology domain containing 1 -0.0149356
TNPO1 transportin 1 -0.0149196
RHD Rh blood group, D antigen -0.0149118
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -0.0148865
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0148504
NPHP4 nephronophthisis 4 -0.0148328
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0148294