K562_SNS-314 Mesylate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 1µM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_SNS-314 Mesylate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0951856
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0921165
FGF13 fibroblast growth factor 13 0.0856341
MUSK muscle, skeletal, receptor tyrosine kinase 0.0846971
EXOC4 exocyst complex component 4 0.0824326
FAM13A family with sequence similarity 13, member A 0.0761114
MARCHF3 membrane associated ring-CH-type finger 3 0.0761046
AFF1 AF4/FMR2 family, member 1 0.0727319
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0712571
SMYD3 SET and MYND domain containing 3 0.0684317
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0665418
NFIA nuclear factor I/A 0.0624912
NIPBL Nipped-B homolog (Drosophila) 0.0618256
MED13L mediator complex subunit 13-like 0.060758
CPED1 cadherin-like and PC-esterase domain containing 1 0.0605776
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0596239
GOLGA4 golgin A4 0.0592414
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0591251
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0583067
HBG1 hemoglobin, gamma A 0.055012
HMBOX1 homeobox containing 1 0.0531026
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0525231
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0521171
RUNX1 runt-related transcription factor 1 0.0518014
FBXO11 F-box protein 11 0.0512484
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0496712
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.0493598
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 0.0492834
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0481557
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0480434
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.047998
GMPR guanosine monophosphate reductase 0.0476064
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0473082
UNC13D unc-13 homolog D (C. elegans) 0.0472421
RORA RAR-related orphan receptor A 0.046771
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0464231
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0463961
DYNC2I1 dynein 2 intermediate chain 1 0.0455435
AKAP9 A kinase (PRKA) anchor protein 9 0.0454209
QKI QKI, KH domain containing, RNA binding 0.0445937
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.0439668
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0435996
ZEB2 zinc finger E-box binding homeobox 2 0.0425706
TNRC6B trinucleotide repeat containing 6B 0.0424944
UBE2H ubiquitin-conjugating enzyme E2H 0.0421783
LEPROT leptin receptor overlapping transcript 0.0416431
H2AC6 H2A clustered histone 6 0.0416352
R3HDM1 R3H domain containing 1 0.0415749
ADGRV1 adhesion G protein-coupled receptor V1 0.0414909
RTN4 reticulon 4 0.0408706
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.0406894
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.039972
HBG2 hemoglobin, gamma G 0.0395231
INVS inversin 0.0391973
GDNF glial cell derived neurotrophic factor 0.0387334
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0387136
PDIA3 protein disulfide isomerase family A, member 3 0.0387058
UHMK1 U2AF homology motif (UHM) kinase 1 0.0385189
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0383584
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.0383521
USP15 ubiquitin specific peptidase 15 0.0381541
SSBP3 single stranded DNA binding protein 3 0.0380873
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 0.0380206
SUMF1 sulfatase modifying factor 1 0.0378699
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.037579
DMD dystrophin 0.0374884
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0371475
STIL SCL/TAL1 interrupting locus 0.0368315
RLF rearranged L-myc fusion 0.0367463
AFDN afadin, adherens junction formation factor 0.036699
FNBP4 formin binding protein 4 0.0360909
DCAF6 DDB1 and CUL4 associated factor 6 0.0358038
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.0357949
KDM6A lysine (K)-specific demethylase 6A 0.0357738
LATS1 large tumor suppressor kinase 1 0.0355958
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 0.0353286
SFMBT2 Scm-like with four mbt domains 2 0.0347678
CERT1 ceramide transporter 1 0.0343011
PTPRB protein tyrosine phosphatase, receptor type, B 0.0337584
RPLP1 ribosomal protein, large, P1 0.0337162
CD46 CD46 molecule, complement regulatory protein 0.0334402
ELOVL6 ELOVL fatty acid elongase 6 0.0333699
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0333658
ZMYND8 zinc finger, MYND-type containing 8 0.033171
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.0328291
EMC3 ER membrane protein complex subunit 3 0.0325416
SASH1 SAM and SH3 domain containing 1 0.0323734
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0323181
FBXL20 F-box and leucine-rich repeat protein 20 0.0321601
HM13 histocompatibility (minor) 13 0.0321146
OLA1 Obg-like ATPase 1 0.0321107
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 0.0320895
ADGRB3 adhesion G protein-coupled receptor B3 0.0320606
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0320314
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.0319206
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0318712
CNST consortin, connexin sorting protein 0.0317231
EPS15 epidermal growth factor receptor pathway substrate 15 0.0317158
CKAP2 cytoskeleton associated protein 2 0.0316837
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0311234
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0310923
PARD3B par-3 family cell polarity regulator beta 0.0310054
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.0309726
PCDH9 protocadherin 9 0.0309365
STRN striatin, calmodulin binding protein 0.0309097
ELP4 elongator acetyltransferase complex subunit 4 0.0307053
NBR1 neighbor of BRCA1 gene 1 0.0304861
YME1L1 YME1-like 1 ATPase 0.0304488
RBM33 RNA binding motif protein 33 0.0302729
NCAM2 neural cell adhesion molecule 2 0.0300161
NSD3 nuclear receptor binding SET domain protein 3 0.0298656
RAB10 RAB10, member RAS oncogene family 0.0297925
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0297482
HEATR5B HEAT repeat containing 5B 0.0296462
KLHL20 kelch-like family member 20 0.0294136
PHF14 PHD finger protein 14 0.0293797
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.0293549
ZFPM2 zinc finger protein, FOG family member 2 0.0293426
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0292696
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.0292179
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0291473
SRPK2 SRSF protein kinase 2 0.029082
PHKB phosphorylase kinase, beta 0.0289413
NKTR natural killer cell triggering receptor 0.0287528
KIDINS220 kinase D-interacting substrate, 220kDa 0.0285431
DCP2 decapping mRNA 2 0.0285185
CCDC66 coiled-coil domain containing 66 0.0283766
RC3H1 ring finger and CCCH-type domains 1 0.0282242
UBE3D ubiquitin protein ligase E3D 0.0281047
ENSA endosulfine alpha 0.0280876
ABHD3 abhydrolase domain containing 3 0.0280473
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0280392
PRRC2B proline-rich coiled-coil 2B 0.0280021
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0279773
TRAK1 trafficking protein, kinesin binding 1 0.0279757
DENND4A DENN/MADD domain containing 4A 0.027931
PDLIM5 PDZ and LIM domain 5 0.027665
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0276406
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0276188
TENM1 teneurin transmembrane protein 1 0.0275777
TTC7B tetratricopeptide repeat domain 7B 0.0275586
MFGE8 milk fat globule-EGF factor 8 protein 0.0274843
SET SET nuclear proto-oncogene 0.0273791
M6PR mannose-6-phosphate receptor (cation dependent) 0.0272328
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.0271869
TMEM87A transmembrane protein 87A 0.0271844
KIF3B kinesin family member 3B 0.0271537
PRR14L proline rich 14-like 0.0271094
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 0.0269932
HIP1 huntingtin interacting protein 1 0.0269391
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0268417
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0264196
RCOR1 REST corepressor 1 0.0263999
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0263711
ECD ecdysoneless homolog (Drosophila) 0.0263112
NOL10 nucleolar protein 10 0.0262493
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0262285
FERMT3 fermitin family member 3 0.0261144
XKR3 XK, Kell blood group complex subunit-related family, member 3 0.0259314
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.0258451
SNAP29 synaptosomal-associated protein, 29kDa 0.0257762
CR1L complement component (3b/4b) receptor 1-like 0.0254757
PICALM phosphatidylinositol binding clathrin assembly protein 0.0254021
UBE2B ubiquitin-conjugating enzyme E2B 0.0253604
DAND5 DAN domain family member 5, BMP antagonist 0.025337
NUCB1 nucleobindin 1 0.025315
UBE3C ubiquitin protein ligase E3C 0.0253123
NCOA1 nuclear receptor coactivator 1 0.0253001
TNRC6C trinucleotide repeat containing 6C 0.0252642
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.0251164
TRIM38 tripartite motif containing 38 0.0250992
NLK nemo-like kinase 0.0249889
POM121 POM121 transmembrane nucleoporin 0.0248594
KDM7A lysine (K)-specific demethylase 7A 0.0248407
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0248097
YEATS2 YEATS domain containing 2 0.0247365
ZFAND6 zinc finger, AN1-type domain 6 0.0247164
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0246264
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.024357
RPS29 ribosomal protein S29 0.0243412
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.024336
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0242889
CCDC91 coiled-coil domain containing 91 0.0242679
TYK2 tyrosine kinase 2 0.0242675
AFTPH aftiphilin 0.0242133
SERP1 stress-associated endoplasmic reticulum protein 1 0.0241876
PBRM1 polybromo 1 0.0241321
MGME1 mitochondrial genome maintenance exonuclease 1 0.0240581
TBC1D14 TBC1 domain family, member 14 0.0240159
TMEM164 transmembrane protein 164 0.0239858
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) 0.0239853
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0238782
ZCCHC7 zinc finger, CCHC domain containing 7 0.0238623
USP9X ubiquitin specific peptidase 9, X-linked 0.023751
MBD5 methyl-CpG binding domain protein 5 0.0237344
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.0237123
RAB27B RAB27B, member RAS oncogene family 0.0235914
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.023541
NEBL nebulette 0.0234448
HBA2 hemoglobin, alpha 2 0.0234062
RNF4 ring finger protein 4 0.0233982
KDM4C lysine (K)-specific demethylase 4C 0.023373
RPL23A ribosomal protein L23a 0.0233363
IREB2 iron-responsive element binding protein 2 0.0232317
DOCK8 dedicator of cytokinesis 8 0.0231905
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0231898
ARL8B ADP-ribosylation factor-like 8B 0.0231811
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0231571
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0231351
ATG4B autophagy related 4B, cysteine peptidase 0.02313
SPIDR scaffolding protein involved in DNA repair 0.0230852
MDK midkine (neurite growth-promoting factor 2) 0.0230496
KMT2E lysine (K)-specific methyltransferase 2E 0.0229561
SYCP2L synaptonemal complex protein 2-like 0.022943
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.022865
ADGRE2 adhesion G protein-coupled receptor E2 0.0228036
SOS1 son of sevenless homolog 1 (Drosophila) 0.0227976
CNTN5 contactin 5 0.0227781
FNDC3A fibronectin type III domain containing 3A 0.0227047
WDR70 WD repeat domain 70 0.0226753
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0226462
H3-3B H3.3 histone B 0.0226306
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0226249
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.0224987
IARS1 isoleucyl-tRNA synthetase 1 0.0224731
BRD4 bromodomain containing 4 0.022427
ACER3 alkaline ceramidase 3 0.022406
SLC10A7 solute carrier family 10, member 7 0.0224001
SORT1 sortilin 1 0.0223746
RPS6 ribosomal protein S6 0.0223316
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.0222827
MBTD1 mbt domain containing 1 0.0222693
PHF21A PHD finger protein 21A 0.022214
RAP1A RAP1A, member of RAS oncogene family 0.0220443
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0220191
RPL4 ribosomal protein L4 0.0220128
TBL1X transducin (beta)-like 1X-linked 0.0219003
DOCK2 dedicator of cytokinesis 2 0.0218534
RNF121 ring finger protein 121 0.021824
CLTCL1 clathrin, heavy chain-like 1 0.021796
LDB2 LIM domain binding 2 0.0217924
APTX aprataxin 0.0217777
GPC5 glypican 5 0.0217718
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0217503
KEL Kell blood group, metallo-endopeptidase 0.0216177
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0216021
TRA2A transformer 2 alpha homolog (Drosophila) 0.0215417
ACD adrenocortical dysplasia homolog (mouse) 0.0214499
SIMC1 SUMO-interacting motifs containing 1 0.0214379
HIPK3 homeodomain interacting protein kinase 3 0.0214077
ANKRD28 ankyrin repeat domain 28 0.0213703
RNF217 ring finger protein 217 0.0213416
KDM2A lysine (K)-specific demethylase 2A 0.0213268
WASF2 WAS protein family, member 2 0.0212963
KAZN kazrin, periplakin interacting protein 0.0212911
RNF145 ring finger protein 145 0.0211857
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0211686
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0211657
XPO7 exportin 7 0.0211481
PDIA6 protein disulfide isomerase family A, member 6 0.0210992
ACVR1 activin A receptor, type I 0.0210111
CDK19 cyclin-dependent kinase 19 0.0210036
VCP valosin containing protein 0.0209877
C2CD3 C2 calcium-dependent domain containing 3 0.0209655
RPLP0 ribosomal protein, large, P0 0.0209393
SAFB scaffold attachment factor B 0.0209303
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0207058
WASL Wiskott-Aldrich syndrome-like 0.0206885
DTNBP1 dystrobrevin binding protein 1 0.0206829
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.0206625
BET1 Bet1 golgi vesicular membrane trafficking protein 0.0206411
MSR1 macrophage scavenger receptor 1 0.0206367
CREBBP CREB binding protein 0.0205583
LMNA lamin A/C 0.0205489
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0204649
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 0.020442
WRN Werner syndrome, RecQ helicase-like 0.0204147
RPL15 ribosomal protein L15 0.0204022
HCFC1 host cell factor C1 0.0203684
PRR16 proline rich 16 0.0203204
ABHD2 abhydrolase domain containing 2 0.0203134
N4BP2L2 NEDD4 binding protein 2-like 2 0.0203015
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0201452
RNF216 ring finger protein 216 0.0201264
LRP6 low density lipoprotein receptor-related protein 6 0.0200354
FAM20B family with sequence similarity 20, member B 0.0200165
XPO6 exportin 6 0.0199777
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 0.019965
GOLM2 golgi membrane protein 2 0.0199186
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0198929
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0198862
WAPL WAPL cohesin release factor 0.0198766
GRB10 growth factor receptor-bound protein 10 0.0198678
MORF4L1 mortality factor 4 like 1 0.0198581
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0198517
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0198195
OSBP oxysterol binding protein 0.019779
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0197679
TTC19 tetratricopeptide repeat domain 19 0.0197609
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0197243
H2BC11 H2B clustered histone 11 0.0197024
WDR44 WD repeat domain 44 0.0196863
CCNC cyclin C 0.0196087
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0195749
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0195707
UBE2K ubiquitin-conjugating enzyme E2K 0.0195595
RPL3 ribosomal protein L3 0.019547
BID BH3 interacting domain death agonist 0.0195372
HOMER2 homer scaffolding protein 2 0.0195356
INTS10 integrator complex subunit 10 0.0195121
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0194735
MYO9B myosin IXB 0.0194475
NUP62 nucleoporin 62kDa 0.0194468
COG5 component of oligomeric golgi complex 5 0.0194434
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0193847
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0193809
SUCO SUN domain containing ossification factor 0.0193538
TARS1 threonyl-tRNA synthetase 1 0.0193381
VIM vimentin 0.0193038
RNF115 ring finger protein 115 0.0192762
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.0192734
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0192678
XRRA1 X-ray radiation resistance associated 1 0.0191176
TMEM267 transmembrane protein 267 0.0191071
RFX7 regulatory factor X, 7 0.0190978
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0190937
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 0.019071
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0190501
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0190498
RPL31 ribosomal protein L31 0.0190295
RTF2 replication termination factor 2 0.0190235
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0189769
STEAP1B STEAP family member 1B 0.0189363
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0189178
METTL8 methyltransferase like 8 0.0188841
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0188129
CEP20 centrosomal protein 20 0.0187889
WNK1 WNK lysine deficient protein kinase 1 0.018744
SWI5 SWI5 recombination repair homolog (yeast) 0.0187322
GRIPAP1 GRIP1 associated protein 1 0.0186706
PCNT pericentrin 0.0186631
STK26 serine/threonine protein kinase 26 0.0186494
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0185752
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.0185467
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.0184875
LAMP1 lysosomal-associated membrane protein 1 0.0184245
MORC3 MORC family CW-type zinc finger 3 0.0184208
RPL30 ribosomal protein L30 0.0184176
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0184136
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.0184112
VWA8 von Willebrand factor A domain containing 8 0.018382
RHOBTB3 Rho-related BTB domain containing 3 0.0183563
ZMYM2 zinc finger, MYM-type 2 0.018334
TBCK TBC1 domain containing kinase 0.0183082
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0183061
MACO1 macoilin 1 0.0183028
R3HDM2 R3H domain containing 2 0.0182866
RAB6A RAB6A, member RAS oncogene family 0.0182634
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0182586
COPA coatomer protein complex, subunit alpha 0.0182155
DYM dymeclin 0.0181107
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0181071
MARF1 meiosis regulator and mRNA stability factor 1 0.0180904
ICA1 islet cell autoantigen 1, 69kDa 0.0180757
FAM222B family with sequence similarity 222, member B 0.0180091
STAT5B signal transducer and activator of transcription 5B 0.0180028
HEATR5A HEAT repeat containing 5A 0.0179934
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.0179924
CERS6 ceramide synthase 6 0.0179704
GOLPH3L golgi phosphoprotein 3-like 0.0179251
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0178891
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0178595
MED23 mediator complex subunit 23 0.0178457
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.0177956
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.0177846
COX5A cytochrome c oxidase subunit Va 0.0177689
EIF4E eukaryotic translation initiation factor 4E 0.0177505
SUGP2 SURP and G patch domain containing 2 0.0177389
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0177376
GCC2 GRIP and coiled-coil domain containing 2 0.017734
RAB8B RAB8B, member RAS oncogene family 0.0177325
LRRC4B leucine rich repeat containing 4B 0.0176855
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0176822
TRAPPC8 trafficking protein particle complex 8 0.0176767
SNX13 sorting nexin 13 0.0176616
ICE2 interactor of little elongation complex ELL subunit 2 0.0176197
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.0176177
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0175956
ECM1 extracellular matrix protein 1 0.0175806
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0175649
RAB2A RAB2A, member RAS oncogene family 0.0175225
CLASP1 cytoplasmic linker associated protein 1 0.0175078
INTS2 integrator complex subunit 2 0.0174277
NOL9 nucleolar protein 9 0.0173809
PHIP pleckstrin homology domain interacting protein 0.0173641
CDC73 cell division cycle 73 0.0173268
H2BC4 H2B clustered histone 4 0.017227
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.0172168
UXT ubiquitously-expressed, prefoldin-like chaperone 0.0172111
SCAF8 SR-related CTD-associated factor 8 0.0171521
NBAS neuroblastoma amplified sequence 0.0171109
ATAD2B ATPase family, AAA domain containing 2B 0.0170911
EXOC3L2 exocyst complex component 3-like 2 0.0170692
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.017051
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0170472
RB1CC1 RB1-inducible coiled-coil 1 0.017044
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0170435
ZER1 zyg-11 related, cell cycle regulator 0.0170213
HBZ hemoglobin, zeta 0.0170128
MCUR1 mitochondrial calcium uniporter regulator 1 0.0170029
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0169707
SFSWAP splicing factor, suppressor of white-apricot family 0.0169421
PDE7A phosphodiesterase 7A 0.0169293
ANKRD10 ankyrin repeat domain 10 0.0168752
MARCHF8 membrane associated ring-CH-type finger 8 0.0168734
LIN54 lin-54 DREAM MuvB core complex component 0.0168484
SOD2 superoxide dismutase 2, mitochondrial 0.0168381
MLH1 mutL homolog 1 0.0168356
MEGF9 multiple EGF-like-domains 9 0.0168196
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0168081
CAPNS1 calpain, small subunit 1 0.0167956
CISD2 CDGSH iron sulfur domain 2 0.0167211
ATP5F1C ATP synthase F1 subunit gamma 0.0167126
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.0167046
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.0167004
CMC1 C-x(9)-C motif containing 1 0.0166778
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0166701
DLC1 DLC1 Rho GTPase activating protein 0.0166404
ALG8 ALG8, alpha-1,3-glucosyltransferase 0.0166204
FCHSD2 FCH and double SH3 domains 2 0.01662
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.0165944
LMBRD1 LMBR1 domain containing 1 0.0165744
RBMX RNA binding motif protein, X-linked 0.0165736
DSG2 desmoglein 2 0.0165701
CNOT6 CCR4-NOT transcription complex, subunit 6 0.01656
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0165523
RAD17 RAD17 homolog (S. pombe) 0.016497
IGSF1 immunoglobulin superfamily, member 1 0.0164776
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0164464
CALN1 calneuron 1 0.0164397
PDLIM1 PDZ and LIM domain 1 0.0164275
TNNT1 troponin T type 1 (skeletal, slow) 0.0164124
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0163859
APOE apolipoprotein E 0.0163821
FKBP14 FK506 binding protein 14, 22 kDa 0.0163689
SESN1 sestrin 1 0.0163668
LTBP1 latent transforming growth factor beta binding protein 1 0.0163561
TMEM41A transmembrane protein 41A 0.0163196
MIS18BP1 MIS18 binding protein 1 0.0163188
ZNF282 zinc finger protein 282 0.016312
CAPRIN1 cell cycle associated protein 1 0.016293
NUP54 nucleoporin 54kDa 0.0162649
RNF24 ring finger protein 24 0.0162632
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0162554
UTRN utrophin 0.0162387
ZFYVE9 zinc finger, FYVE domain containing 9 0.0162228
KIF14 kinesin family member 14 0.0162178
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0162131
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0162031
TTC28 tetratricopeptide repeat domain 28 0.0161971
GOPC golgi-associated PDZ and coiled-coil motif containing 0.0161951
RRBP1 ribosome binding protein 1 0.0161714
DMXL2 Dmx-like 2 0.0161712
SH3GL3 SH3-domain GRB2-like 3 0.0161482
TACC1 transforming, acidic coiled-coil containing protein 1 0.0160952
DIAPH3 diaphanous-related formin 3 0.016084
ODF2 outer dense fiber of sperm tails 2 0.0160718
OXSR1 oxidative stress responsive 1 0.0160562
TMEM184C transmembrane protein 184C 0.0160133
STX8 syntaxin 8 0.0160094
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0160052
MTMR1 myotubularin related protein 1 0.0159867
TBK1 TANK-binding kinase 1 0.0159841
SPG11 spastic paraplegia 11 (autosomal recessive) 0.015979
KDM2B lysine (K)-specific demethylase 2B 0.0159721
GALK2 galactokinase 2 0.0159482
ZNF143 zinc finger protein 143 0.0159406
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.0158904
BPTF bromodomain PHD finger transcription factor 0.0158775
ODR4 odr-4 GPCR localization factor homolog 0.0158451
ADPGK ADP-dependent glucokinase 0.0158351
ADAMTSL4 ADAMTS-like 4 0.0158151
USPL1 ubiquitin specific peptidase like 1 0.0157917
CASS4 Cas scaffolding protein family member 4 0.0157675
HSDL2 hydroxysteroid dehydrogenase like 2 0.0157575
GPBP1 GC-rich promoter binding protein 1 0.0157557
CABIN1 calcineurin binding protein 1 0.0157484
ATP5F1D ATP synthase F1 subunit delta 0.015739
KRTAP11-1 keratin associated protein 11-1 0.0157327
RBM26 RNA binding motif protein 26 0.015715
LYPLAL1 lysophospholipase-like 1 0.0157045
BRIX1 BRX1, biogenesis of ribosomes 0.0157014
AFF4 AF4/FMR2 family, member 4 0.0156967
ANKMY1 ankyrin repeat and MYND domain containing 1 0.0156924
AFG2A AFG2 AAA ATPase homolog A 0.0156878
GATAD1 GATA zinc finger domain containing 1 0.0156705
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0156607
COMMD1 copper metabolism (Murr1) domain containing 1 0.0156308
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0156221
MSL2 male-specific lethal 2 homolog (Drosophila) 0.0156218

decreased expression

Symbol Name Standardized Value
PRKCB protein kinase C, beta -0.0750319
MACF1 microtubule-actin crosslinking factor 1 -0.0687319
IPO7 importin 7 -0.0661616
CHD4 chromodomain helicase DNA binding protein 4 -0.0651498
CTBP2 C-terminal binding protein 2 -0.064787
KRT8 keratin 8, type II -0.0644811
SMIM44 small integral membrane protein 44 -0.064041
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0608272
ARL15 ADP-ribosylation factor-like 15 -0.0608075
LOC112694756 uncharaterized LOC112694756 -0.0594587
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0576208
IQGAP1 IQ motif containing GTPase activating protein 1 -0.056031
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0549862
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0507454
SQLE squalene epoxidase -0.0486938
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0479891
ACACA acetyl-CoA carboxylase alpha -0.0474332
STRN3 striatin, calmodulin binding protein 3 -0.0469081
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0465605
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0464578
FAF1 Fas (TNFRSF6) associated factor 1 -0.0463079
MAP4 microtubule-associated protein 4 -0.0457625
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0454961
ANKRD11 ankyrin repeat domain 11 -0.0445757
ECPAS Ecm29 proteasome adaptor and scaffold -0.0414235
MKI67 marker of proliferation Ki-67 -0.0410214
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -0.0408141
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.040488
ENO1 enolase 1, (alpha) -0.0392454
ANKRD17 ankyrin repeat domain 17 -0.0388995
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0383253
CMIP c-Maf inducing protein -0.0381416
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0381342
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0372034
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0365234
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0364374
WAC WW domain containing adaptor with coiled-coil -0.035594
RSRC1 arginine/serine-rich coiled-coil 1 -0.035259
FAM168A family with sequence similarity 168, member A -0.035213
AGO3 argonaute RISC catalytic component 3 -0.0346109
KPNB1 karyopherin (importin) beta 1 -0.034516
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0342793
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0337946
RPS16 ribosomal protein S16 -0.0336704
TMEM209 transmembrane protein 209 -0.0335261
CDC27 cell division cycle 27 -0.0330831
EPB41 erythrocyte membrane protein band 4.1 -0.0330519
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.032994
FLNA filamin A, alpha -0.0327417
DIAPH1 diaphanous-related formin 1 -0.0322405
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0322339
MAML2 mastermind-like 2 (Drosophila) -0.0322244
DLG5 discs, large homolog 5 (Drosophila) -0.0321871
SCARB1 scavenger receptor class B, member 1 -0.0321098
SEC24B SEC24 family member B -0.032056
TPX2 TPX2, microtubule-associated -0.0319799
RACK1 receptor for activated C kinase 1 -0.0315162
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0314942
EPHB6 EPH receptor B6 -0.0313594
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0308392
FBXO42 F-box protein 42 -0.0306766
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0305243
TRAPPC9 trafficking protein particle complex 9 -0.030522
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0305015
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0304547
C6ORF89 chromosome 6 open reading frame 89 -0.0301006
TNPO3 transportin 3 -0.029702
ZFC3H1 zinc finger, C3H1-type containing -0.0295535
BICD1 bicaudal D homolog 1 (Drosophila) -0.0292932
TNIK TRAF2 and NCK interacting kinase -0.0292622
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0290189
KNTC1 kinetochore associated 1 -0.0289308
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0287575
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0287087
KAT6A K(lysine) acetyltransferase 6A -0.0286453
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.028556
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0285504
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.028541
RPL22 ribosomal protein L22 -0.0281731
SEPTIN9 septin 9 -0.0280966
YARS1 tyrosyl-tRNA synthetase 1 -0.0280049
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0279949
TGFB1 transforming growth factor, beta 1 -0.0279367
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0279194
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0278828
MBNL1 muscleblind-like splicing regulator 1 -0.027881
ZZZ3 zinc finger, ZZ-type containing 3 -0.0278599
NPEPPS aminopeptidase puromycin sensitive -0.0276961
ZFAND3 zinc finger, AN1-type domain 3 -0.0274213
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0271332
SMC4 structural maintenance of chromosomes 4 -0.0270576
CAPN15 calpain 15 -0.026445
CDK8 cyclin-dependent kinase 8 -0.026442
TRAP1 TNF receptor-associated protein 1 -0.0263278
BRWD1 bromodomain and WD repeat domain containing 1 -0.0262801
CCND3 cyclin D3 -0.026226
SCAF11 SR-related CTD-associated factor 11 -0.0259885
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0259245
DCAF10 DDB1 and CUL4 associated factor 10 -0.0258069
TXNRD1 thioredoxin reductase 1 -0.0257831
KIF13A kinesin family member 13A -0.0257693
KIF5B kinesin family member 5B -0.0257686
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0257425
RNF213 ring finger protein 213 -0.0257386
ZNRF3 zinc and ring finger 3 -0.0254486
KIF21A kinesin family member 21A -0.0254061
MAP2K1 mitogen-activated protein kinase kinase 1 -0.025352
C21ORF58 chromosome 21 open reading frame 58 -0.0253307
DSCAM Down syndrome cell adhesion molecule -0.025269
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0251629
ZNF367 zinc finger protein 367 -0.0250625
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0250335
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -0.0250065
NRDC nardilysin convertase -0.0249502
ANGPT1 angiopoietin 1 -0.0248345
TNPO1 transportin 1 -0.0247972
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0244729
TPM4 tropomyosin 4 -0.0244424
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0243859
RPL19 ribosomal protein L19 -0.0242583
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0242345
TRIM28 tripartite motif containing 28 -0.0241971
ACTN4 actinin, alpha 4 -0.0241804
RCL1 RNA terminal phosphate cyclase-like 1 -0.0239915
ZNF207 zinc finger protein 207 -0.023955
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0239464
KHSRP KH-type splicing regulatory protein -0.0239101
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0238994
KLHDC10 kelch domain containing 10 -0.0238841
RBM6 RNA binding motif protein 6 -0.0237463
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0237189
KSR1 kinase suppressor of ras 1 -0.0236037
TMEM181 transmembrane protein 181 -0.0234868
ASXL2 additional sex combs like transcriptional regulator 2 -0.0233742
ERI3 ERI1 exoribonuclease family member 3 -0.0233145
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0232811
RBM20 RNA binding motif protein 20 -0.0232467
SUMO2 small ubiquitin-like modifier 2 -0.0232414
LIMA1 LIM domain and actin binding 1 -0.023211
DOCK11 dedicator of cytokinesis 11 -0.0231302
JARID2 jumonji, AT rich interactive domain 2 -0.0230812
KIF2C kinesin family member 2C -0.023017
GPHN gephyrin -0.0229927
PLIN4 perilipin 4 -0.0229753
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0229298
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0229052
HDAC4 histone deacetylase 4 -0.0228772
STAT5A signal transducer and activator of transcription 5A -0.0228305
MYB v-myb avian myeloblastosis viral oncogene homolog -0.022782
MED12 mediator complex subunit 12 -0.0227233
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0226753
URI1 URI1, prefoldin-like chaperone -0.0226045
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0225772
MVD mevalonate (diphospho) decarboxylase -0.0223603
RPS19 ribosomal protein S19 -0.0223419
CENPF centromere protein F, 350/400kDa -0.0223113
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0223011
TMEM245 transmembrane protein 245 -0.0222542
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.022063
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.0220409
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0220327
FANCD2 Fanconi anemia, complementation group D2 -0.0220077
TBCE tubulin folding cofactor E -0.0219564
CNTNAP2 contactin associated protein-like 2 -0.0219391
ZNF124 zinc finger protein 124 -0.0219254
NUP98 nucleoporin 98kDa -0.0218863
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.0218466
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0218099
AP3M1 adaptor-related protein complex 3, mu 1 subunit -0.0217853
SRRM1 serine/arginine repetitive matrix 1 -0.0215866
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.021566
FOXJ3 forkhead box J3 -0.0215611
COG8 component of oligomeric golgi complex 8 -0.0215517
RDX radixin -0.0215454
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0215382
UBE2O ubiquitin-conjugating enzyme E2O -0.0213084
HOMER1 homer scaffolding protein 1 -0.0212489
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0211674
SKIC3 SKI3 subunit of superkiller complex -0.0211548
STIP1 stress-induced phosphoprotein 1 -0.0211082
KTN1 kinectin 1 (kinesin receptor) -0.0210925
SZRD1 SUZ RNA binding domain containing 1 -0.0209843
RPL37 ribosomal protein L37 -0.0209842
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0209609
METAP1 methionyl aminopeptidase 1 -0.0209075
CCNI cyclin I -0.0208901
ZNF83 zinc finger protein 83 -0.020877
ATP13A3 ATPase type 13A3 -0.0208759
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0207594
NLN neurolysin (metallopeptidase M3 family) -0.0207072
PTPRA protein tyrosine phosphatase, receptor type, A -0.0206855
FAM178B family with sequence similarity 178, member B -0.0206762
DLK1 delta-like 1 homolog (Drosophila) -0.0206397
CHEK2 checkpoint kinase 2 -0.0205642
NAE1 NEDD8 activating enzyme E1 subunit 1 -0.0205468
CELF1 CUGBP, Elav-like family member 1 -0.0205288
DESI2 desumoylating isopeptidase 2 -0.0205275
ANKFY1 ankyrin repeat and FYVE domain containing 1 -0.0204206
SNX9 sorting nexin 9 -0.0203167
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0203113
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0202149
PRELID2 PRELI domain containing 2 -0.0201486
IGF1R insulin-like growth factor 1 receptor -0.0201067
INO80D INO80 complex subunit D -0.0200817
ARB2A ARB2 cotranscriptional regulator A -0.0200202
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.0200068
ETF1 eukaryotic translation termination factor 1 -0.0199612
PITPNA phosphatidylinositol transfer protein, alpha -0.01996
RPL11 ribosomal protein L11 -0.0199548
SMAD3 SMAD family member 3 -0.0199444
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0199265
PHACTR4 phosphatase and actin regulator 4 -0.0198824
ARHGAP15 Rho GTPase activating protein 15 -0.0198122
CHD9 chromodomain helicase DNA binding protein 9 -0.0197869
CUTA cutA divalent cation tolerance homolog (E. coli) -0.0197789
CHKA choline kinase alpha -0.0196716
CCDC47 coiled-coil domain containing 47 -0.0196508
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.0195071
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -0.0195056
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0194917
NCOA7 nuclear receptor coactivator 7 -0.0194287
VCL vinculin -0.0194128
ATXN10 ataxin 10 -0.0193437
ELP3 elongator acetyltransferase complex subunit 3 -0.0192961
MAPK14 mitogen-activated protein kinase 14 -0.0192861
GLG1 golgi glycoprotein 1 -0.0192251
RANBP10 RAN binding protein 10 -0.0192009
CDYL chromodomain protein, Y-like -0.0191991
SPOP speckle-type POZ protein -0.0191485
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0191437
CDC42SE2 CDC42 small effector 2 -0.0191375
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0191334
ATAD3A ATPase family, AAA domain containing 3A -0.0191115
TGFBR3 transforming growth factor, beta receptor III -0.0190649
BLTP1 bridge-like lipid transfer protein family member 1 -0.0188683
MED13 mediator complex subunit 13 -0.0188332
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0188179
FLOT1 flotillin 1 -0.0188138
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0187888
TUBGCP4 tubulin, gamma complex associated protein 4 -0.0187851
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0187516
BSG basigin (Ok blood group) -0.0187142
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0186124
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0185756
NVL nuclear VCP-like -0.0185288
SGMS1 sphingomyelin synthase 1 -0.0185156
MYH9 myosin, heavy chain 9, non-muscle -0.0184536
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0184278
HDAC8 histone deacetylase 8 -0.018403
MPHOSPH9 M-phase phosphoprotein 9 -0.018302
LUZP1 leucine zipper protein 1 -0.0182963
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0182833
OCIAD1 OCIA domain containing 1 -0.018148
MFSD12 major facilitator superfamily domain containing 12 -0.0181393
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -0.0181198
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0180534
EIF4B eukaryotic translation initiation factor 4B -0.0180448
CTNNBL1 catenin, beta like 1 -0.0180353
CD2AP CD2-associated protein -0.0179608
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0179421
NCOR1 nuclear receptor corepressor 1 -0.0179383
THOC2 THO complex 2 -0.0178671
MAPK6 mitogen-activated protein kinase 6 -0.0178654
FOXK1 forkhead box K1 -0.0178646
ACIN1 apoptotic chromatin condensation inducer 1 -0.017864
CASC3 cancer susceptibility candidate 3 -0.0178529
PRC1 protein regulator of cytokinesis 1 -0.017813
IST1 increased sodium tolerance 1 homolog (yeast) -0.0178001
TMEM41B transmembrane protein 41B -0.0177919
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0177786
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0177717
CLINT1 clathrin interactor 1 -0.0177332
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0177313
RPS28 ribosomal protein S28 -0.0177283
BTBD7 BTB (POZ) domain containing 7 -0.0177275
KMT2A lysine (K)-specific methyltransferase 2A -0.0177133
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0177058
MITF microphthalmia-associated transcription factor -0.0176947
GTF2I general transcription factor IIi -0.0176892
FGGY FGGY carbohydrate kinase domain containing -0.0176889
KDM5A lysine (K)-specific demethylase 5A -0.0176742
FN1 fibronectin 1 -0.0176556
PRKCA protein kinase C, alpha -0.0176018
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -0.0175949
SCAP SREBF chaperone -0.0175817
ZNF800 zinc finger protein 800 -0.0174768
ATAD5 ATPase family, AAA domain containing 5 -0.0174606
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0174028
FAM13B family with sequence similarity 13, member B -0.0173297
TRIR telomerase RNA component interacting RNase -0.0173202
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0173179
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.017312
ATXN2 ataxin 2 -0.0173086
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0173011
CNKSR3 CNKSR family member 3 -0.0172854
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0172584
CELF2 CUGBP, Elav-like family member 2 -0.0172442
KRT18 keratin 18, type I -0.0172222
ZNF148 zinc finger protein 148 -0.0171884
CDK13 cyclin-dependent kinase 13 -0.0171812
CFDP1 craniofacial development protein 1 -0.0171797
CHD8 chromodomain helicase DNA binding protein 8 -0.0171566
CDIN1 CDAN1 interacting nuclease 1 -0.0171395
TBCD tubulin folding cofactor D -0.017129
WARS1 tryptophanyl-tRNA synthetase 1 -0.0171016
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0170287
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0170057
LYRM7 LYR motif containing 7 -0.0169973
RNF149 ring finger protein 149 -0.0169921
NSUN4 NOP2/Sun domain family, member 4 -0.0169776
LSM12 LSM12 homolog (S. cerevisiae) -0.0169553
SLC38A1 solute carrier family 38, member 1 -0.0169153
CEP192 centrosomal protein 192kDa -0.0168253
PARVB parvin, beta -0.016824
SPTA1 spectrin, alpha, erythrocytic 1 -0.016795
NOL7 nucleolar protein 7, 27kDa -0.0167824
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -0.0167415
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0166704
EFHC2 EF-hand domain (C-terminal) containing 2 -0.0166279
RCSD1 RCSD domain containing 1 -0.0166184
SACK1A scaffolding CK1 anchoring protein A -0.0166168
ATP2A3 ATPase, Ca++ transporting, ubiquitous -0.0166017
EIF3E eukaryotic translation initiation factor 3, subunit E -0.016581
CCDC88C coiled-coil domain containing 88C -0.0165506
TUT4 terminal uridylyl transferase 4 -0.0165044
POMZP3 POM121 and ZP3 fusion -0.016445
RUSC2 RUN and SH3 domain containing 2 -0.0164359
TPST2 tyrosylprotein sulfotransferase 2 -0.0164325
FUBP3 far upstream element (FUSE) binding protein 3 -0.016425
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -0.0163197
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.016315
CFH complement factor H -0.016282
MED27 mediator complex subunit 27 -0.0162768
RPS9 ribosomal protein S9 -0.0162592
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.0162452
CNOT10 CCR4-NOT transcription complex, subunit 10 -0.0162354
PA2G4 proliferation-associated 2G4, 38kDa -0.0162214
FAF2 Fas associated factor family member 2 -0.0162137
SIRAL2 SIR2 antiphage like 2 -0.0161889
KYAT3 kynurenine aminotransferase 3 -0.0161761
REEP3 receptor accessory protein 3 -0.0161734
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0161397
MORF4L2 mortality factor 4 like 2 -0.0160963
FLNB filamin B, beta -0.016087
RPLP2 ribosomal protein, large, P2 -0.0160718
RPS3 ribosomal protein S3 -0.016043
VMP1 vacuole membrane protein 1 -0.0160353
PLCL1 phospholipase C-like 1 -0.0159974
RILPL1 Rab interacting lysosomal protein-like 1 -0.0159935
TMLHE trimethyllysine hydroxylase, epsilon -0.0159743
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0159577
LNPEP leucyl/cystinyl aminopeptidase -0.0159384
TTC3 tetratricopeptide repeat domain 3 -0.0159304
KDM4B lysine (K)-specific demethylase 4B -0.015926
DIS3L DIS3 like exosome 3'-5' exoribonuclease -0.0158853
KIF20B kinesin family member 20B -0.0158795
VGF VGF nerve growth factor inducible -0.0158521
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0158024
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -0.0157824
RCC1L RCC1 like -0.0157748
JAK1 Janus kinase 1 -0.0157676
PHB2 prohibitin 2 -0.0157645
MCAM melanoma cell adhesion molecule -0.0157091
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0157084
SEPTIN7 septin 7 -0.0156735
UBB ubiquitin B -0.0156671
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0156621
SCAF4 SR-related CTD-associated factor 4 -0.0156505
DOCK7 dedicator of cytokinesis 7 -0.0155896
TESK2 testis-specific kinase 2 -0.0155573
EGFL7 EGF-like-domain, multiple 7 -0.0155541
CDC25C cell division cycle 25C -0.0155339
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0155216
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0155154
PTGFRN prostaglandin F2 receptor inhibitor -0.0154943
SEC63 SEC63 homolog (S. cerevisiae) -0.0154784
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -0.0154656
POMP proteasome maturation protein -0.0154524
KCTD3 potassium channel tetramerization domain containing 3 -0.0154224
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.0154122
TECPR2 tectonin beta-propeller repeat containing 2 -0.0153835
MAST2 microtubule associated serine/threonine kinase 2 -0.0153512
PDIA4 protein disulfide isomerase family A, member 4 -0.015338
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -0.0153344
SLA2 Src-like-adaptor 2 -0.0153189
WDFY1 WD repeat and FYVE domain containing 1 -0.015313
SREBF2 sterol regulatory element binding transcription factor 2 -0.015295
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0152761
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.0152357
NOL11 nucleolar protein 11 -0.0152264
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0152174
UBAP1 ubiquitin associated protein 1 -0.0152085
KRT19 keratin 19, type I -0.0151963
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0150897
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.015088
BRAT1 BRCA1-associated ATM activator 1 -0.015048
MICALL1 MICAL-like 1 -0.0150316
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -0.0150224
IPO11 importin 11 -0.0150114
PCDHB16 protocadherin beta 16 -0.0149961
LMAN1 lectin, mannose-binding, 1 -0.0149881
SSRP1 structure specific recognition protein 1 -0.0149388
MMS22L MMS22-like, DNA repair protein -0.014933
CUL2 cullin 2 -0.0149319
FAR1 fatty acyl CoA reductase 1 -0.0149177
MACROD1 MACRO domain containing 1 -0.0148991
ITPRID2 ITPR interacting domain containing 2 -0.0148959
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.0148902
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.014856
BLM Bloom syndrome, RecQ helicase-like -0.014854
TUBB6 tubulin, beta 6 class V -0.0148353
GRK3 G protein-coupled receptor kinase 3 -0.0148336
TULP4 tubby like protein 4 -0.0148287
RPS17 ribosomal protein S17 -0.0148008
RAB27A RAB27A, member RAS oncogene family -0.0147666
AGPS alkylglycerone phosphate synthase -0.0147563
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0147463
SIL1 SIL1 nucleotide exchange factor -0.0147356
CEP295 centrosomal protein 295kDa -0.0147167
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0147099
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0146627
GTPBP10 GTP-binding protein 10 (putative) -0.0146616
TOM1L1 target of myb1 (chicken)-like 1 -0.0146361
RALGDS ral guanine nucleotide dissociation stimulator -0.014607
KIAA2026 KIAA2026 -0.0145961
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0145927
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0145491
DPP9 dipeptidyl-peptidase 9 -0.0145342
ATP5MC3 ATP synthase membrane subunit c locus 3 -0.0145073
DMWD dystrophia myotonica, WD repeat containing -0.0145005
THUMPD1 THUMP domain containing 1 -0.0144848
SACK1D scaffolding CK1 anchoring protein D -0.0144774
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0144743
AURKB aurora kinase B -0.0144724
FOXK2 forkhead box K2 -0.0144499
RAN RAN, member RAS oncogene family -0.0144154
TTC21B tetratricopeptide repeat domain 21B -0.0144132
NT5DC1 5'-nucleotidase domain containing 1 -0.0144088
FARSA phenylalanyl-tRNA synthetase, alpha subunit -0.0143815
ZNF644 zinc finger protein 644 -0.0143709
CHERP calcium homeostasis endoplasmic reticulum protein -0.014345
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0143417
TRIM37 tripartite motif containing 37 -0.0143296
YDJC YdjC homolog (bacterial) -0.0142945
SEC13 SEC13 homolog (S. cerevisiae) -0.0142645
MCM8 minichromosome maintenance complex component 8 -0.0142584
UBN1 ubinuclein 1 -0.0142326
AXIN1 axin 1 -0.0142095
ABI1 abl-interactor 1 -0.0142003
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0141905
CLU clusterin -0.0141894
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0141809
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0141587
TXNDC11 thioredoxin domain containing 11 -0.0141234
SNRPA small nuclear ribonucleoprotein polypeptide A -0.0141088
COXFA4 cytochrome c oxidase associated subunit FA4 -0.0141045
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0141024
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0140895
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0140799
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.0140383
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0140362
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0140134
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0139382
GPC6 glypican 6 -0.013928
ATP5F1B ATP synthase F1 subunit beta -0.0139073
RFC2 replication factor C (activator 1) 2, 40kDa -0.0138939
BCL2L13 BCL2-like 13 (apoptosis facilitator) -0.0138817
GFOD2 glucose-fructose oxidoreductase domain containing 2 -0.013869
HSPB1 heat shock 27kDa protein 1 -0.0138472
ETNK1 ethanolamine kinase 1 -0.0138373
ZHX3 zinc fingers and homeoboxes 3 -0.0138305
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0138054
PDE4DIP phosphodiesterase 4D interacting protein -0.0137857
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.0137599
USP25 ubiquitin specific peptidase 25 -0.0137051
CARD11 caspase recruitment domain family, member 11 -0.0136796
DIXDC1 DIX domain containing 1 -0.0136614
EIF1 eukaryotic translation initiation factor 1 -0.0136392
TDRD3 tudor domain containing 3 -0.0136346
NIBAN1 niban apoptosis regulator 1 -0.0136177
LMBR1 limb development membrane protein 1 -0.0136171
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.0136082
FNIP2 folliculin interacting protein 2 -0.0136019
UROD uroporphyrinogen decarboxylase -0.0135994
CDC45 cell division cycle 45 -0.0135781
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -0.013576
AGO1 argonaute RISC catalytic component 1 -0.0135516
DHRS7B dehydrogenase/reductase (SDR family) member 7B -0.0135251
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -0.0135167
PPARD peroxisome proliferator-activated receptor delta -0.0135098
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.0135048
STK24 serine/threonine kinase 24 -0.0134976
CAPN1 calpain 1, (mu/I) large subunit -0.0134954
VRK1 vaccinia related kinase 1 -0.0134815
ZNF106 zinc finger protein 106 -0.0134757
RCC1 regulator of chromosome condensation 1 -0.0134607
APRT adenine phosphoribosyltransferase -0.0133989
RAP1B RAP1B, member of RAS oncogene family -0.0133917
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) -0.0133906
RSL24D1 ribosomal L24 domain containing 1 -0.0133896