K562_SNS-314 Mesylate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 10nM perturbation in K562 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the K562_SNS-314 Mesylate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MUSK muscle, skeletal, receptor tyrosine kinase 0.138444
STXBP5 syntaxin binding protein 5 (tomosyn) 0.128859
MBNL1 muscleblind-like splicing regulator 1 0.128219
SMYD3 SET and MYND domain containing 3 0.0953262
CNKSR3 CNKSR family member 3 0.0763066
MAML2 mastermind-like 2 (Drosophila) 0.0640334
MOB1B MOB kinase activator 1B 0.0636203
RABGAP1L RAB GTPase activating protein 1-like 0.0632586
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0609855
HBG1 hemoglobin, gamma A 0.0598522
USP32 ubiquitin specific peptidase 32 0.059723
RNF24 ring finger protein 24 0.0585288
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0573787
FAM222B family with sequence similarity 222, member B 0.0569272
SCFD2 sec1 family domain containing 2 0.0555397
AFF1 AF4/FMR2 family, member 1 0.0553082
MAN1A1 mannosidase, alpha, class 1A, member 1 0.054682
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0543638
ZMYND8 zinc finger, MYND-type containing 8 0.053415
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0532661
CPED1 cadherin-like and PC-esterase domain containing 1 0.0518692
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0509931
TAOK3 TAO kinase 3 0.0507451
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0503874
PLCL1 phospholipase C-like 1 0.0501165
OLA1 Obg-like ATPase 1 0.0491946
EPB41 erythrocyte membrane protein band 4.1 0.049183
SEPTIN6 septin 6 0.0487217
HMBOX1 homeobox containing 1 0.048611
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0485618
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0483992
ARHGAP6 Rho GTPase activating protein 6 0.0473278
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0471491
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0470919
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0468685
TMEM135 transmembrane protein 135 0.0462678
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.0456389
RICTOR RPTOR independent companion of MTOR, complex 2 0.0447734
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0445542
SSBP2 single-stranded DNA binding protein 2 0.0443987
RAP1A RAP1A, member of RAS oncogene family 0.0438377
FGF13 fibroblast growth factor 13 0.043695
ZCCHC7 zinc finger, CCHC domain containing 7 0.0436042
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 0.0431104
NSD2 nuclear receptor binding SET domain protein 2 0.0427857
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0423378
FAF1 Fas (TNFRSF6) associated factor 1 0.0421834
CLOCK clock circadian regulator 0.0421107
VWA8 von Willebrand factor A domain containing 8 0.0419514
PUM2 pumilio RNA-binding family member 2 0.0412776
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0410465
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0410036
ESYT2 extended synaptotagmin-like protein 2 0.0409688
PRR16 proline rich 16 0.0407719
CCDC91 coiled-coil domain containing 91 0.0406849
ATP11B ATPase, class VI, type 11B 0.0403839
ERBIN erbb2 interacting protein 0.0403629
ABHD18 abhydrolase domain containing 18 0.0400626
ANKRD17 ankyrin repeat domain 17 0.0398925
R3HDM1 R3H domain containing 1 0.0396194
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0393109
DMD dystrophin 0.0391374
ARHGAP24 Rho GTPase activating protein 24 0.0389984
NBAS neuroblastoma amplified sequence 0.0389757
ANAPC5 anaphase promoting complex subunit 5 0.038768
RHAG Rh-associated glycoprotein 0.0386773
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0386202
ENOSF1 enolase superfamily member 1 0.0379563
NIPBL Nipped-B homolog (Drosophila) 0.0376086
FOXJ3 forkhead box J3 0.037385
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0372264
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0371169
FTL ferritin, light polypeptide 0.0369534
AARS1 alanyl-tRNA synthetase 1 0.0369235
BCL2L1 BCL2-like 1 0.0365462
RSRP1 arginine/serine-rich protein 1 0.0365009
KMT2E lysine (K)-specific methyltransferase 2E 0.0364435
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0363284
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0362109
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0352878
SRPK2 SRSF protein kinase 2 0.0352437
ASXL2 additional sex combs like transcriptional regulator 2 0.035107
MEF2C myocyte enhancer factor 2C 0.0349503
SEC31A SEC31 homolog A (S. cerevisiae) 0.0347532
TOM1L2 target of myb1-like 2 (chicken) 0.034749
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.0346096
KIF5B kinesin family member 5B 0.0344502
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0339024
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0337921
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0337171
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0336854
ANAPC1 anaphase promoting complex subunit 1 0.0335722
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.0335703
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0327127
TET1 tet methylcytosine dioxygenase 1 0.03261
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0323178
SIK3 SIK family kinase 3 0.0322448
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0321707
THOC2 THO complex 2 0.0319975
ZFAND3 zinc finger, AN1-type domain 3 0.0319555
NMU neuromedin U 0.0318411
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0316543
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0313072
SGMS1 sphingomyelin synthase 1 0.0312976
USP34 ubiquitin specific peptidase 34 0.0307497
CREB5 cAMP responsive element binding protein 5 0.0307274
ANO10 anoctamin 10 0.03045
PHTF2 putative homeodomain transcription factor 2 0.0304156
CCAR1 cell division cycle and apoptosis regulator 1 0.0303281
MARCHF3 membrane associated ring-CH-type finger 3 0.030275
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.0302282
SEPTIN11 septin 11 0.0301866
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 0.0299938
NEK1 NIMA-related kinase 1 0.0296782
STRN striatin, calmodulin binding protein 0.0294469
P3H1 prolyl 3-hydroxylase 1 0.0294424
XRN1 5'-3' exoribonuclease 1 0.0294181
GON4L gon-4-like (C. elegans) 0.0294035
ACACA acetyl-CoA carboxylase alpha 0.0293124
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0292864
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0291526
CDK6 cyclin-dependent kinase 6 0.0290869
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.028971
CCDC82 coiled-coil domain containing 82 0.0289171
PDLIM5 PDZ and LIM domain 5 0.0287191
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0286847
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0286487
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0286052
PDIA6 protein disulfide isomerase family A, member 6 0.0285123
ATM ATM serine/threonine kinase 0.0284664
PTBP3 polypyrimidine tract binding protein 3 0.0283241
MAP2K1 mitogen-activated protein kinase kinase 1 0.0282775
GFOD1 glucose-fructose oxidoreductase domain containing 1 0.0282155
HOOK3 hook microtubule-tethering protein 3 0.0280691
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0279336
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0279203
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0279189
EPS15 epidermal growth factor receptor pathway substrate 15 0.0278811
BTF3L4 basic transcription factor 3-like 4 0.0276633
RPLP1 ribosomal protein, large, P1 0.0275958
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.0275845
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0275156
ANGPT1 angiopoietin 1 0.0274218
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0273363
UBE3D ubiquitin protein ligase E3D 0.0273042
SRSF4 serine/arginine-rich splicing factor 4 0.0271615
SETD2 SET domain containing 2 0.027137
CD2AP CD2-associated protein 0.0270357
PRAME preferentially expressed antigen in melanoma 0.0269519
USP15 ubiquitin specific peptidase 15 0.0269361
FAM178B family with sequence similarity 178, member B 0.0266444
WASF2 WAS protein family, member 2 0.026427
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0264033
SEC24D SEC24 family member D 0.0263945
NEBL nebulette 0.0261817
VWDE von Willebrand factor D and EGF domains 0.0259959
LATS1 large tumor suppressor kinase 1 0.0258167
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0257965
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0257544
MAPK8 mitogen-activated protein kinase 8 0.0257283
COMMD1 copper metabolism (Murr1) domain containing 1 0.0256464
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0256082
FOXK2 forkhead box K2 0.0255458
GLG1 golgi glycoprotein 1 0.025467
TTC21B tetratricopeptide repeat domain 21B 0.0254522
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0253607
XPO7 exportin 7 0.0253566
CYRIB CYFIP related Rac1 interactor B 0.0252328
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0251163
ADD1 adducin 1 (alpha) 0.0250517
HM13 histocompatibility (minor) 13 0.0249611
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0249524
CDC42 cell division cycle 42 0.0249214
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0248678
RPS12 ribosomal protein S12 0.0247799
UBE2K ubiquitin-conjugating enzyme E2K 0.0247566
SUCO SUN domain containing ossification factor 0.0247051
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0246104
DENND5A DENN/MADD domain containing 5A 0.0245073
TMEM164 transmembrane protein 164 0.0242167
EXOC6 exocyst complex component 6 0.0242165
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0240695
BCAP29 B-cell receptor-associated protein 29 0.0240078
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0239799
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0239557
SEC11A SEC11 homolog A (S. cerevisiae) 0.0238396
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.023711
ARHGAP21 Rho GTPase activating protein 21 0.0236799
STYXL1 serine/threonine/tyrosine interacting-like 1 0.0236277
KIAA0232 KIAA0232 0.0236039
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0235737
ABHD3 abhydrolase domain containing 3 0.0235611
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0235544
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0235276
PDLIM7 PDZ and LIM domain 7 (enigma) 0.0235236
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0234888
MEIS2 Meis homeobox 2 0.0234336
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0234237
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0233981
TLK1 tousled-like kinase 1 0.0233806
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0233206
MYB v-myb avian myeloblastosis viral oncogene homolog 0.0233138
FAM135A family with sequence similarity 135, member A 0.0232484
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.0232398
GSK3B glycogen synthase kinase 3 beta 0.0232215
OSBPL8 oxysterol binding protein-like 8 0.0232079
ITGB5 integrin, beta 5 0.023201
MAPK14 mitogen-activated protein kinase 14 0.0231901
EZR ezrin 0.0231755
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.023146
GALM galactose mutarotase (aldose 1-epimerase) 0.0230035
NCOA1 nuclear receptor coactivator 1 0.0229354
SOCS4 suppressor of cytokine signaling 4 0.0229256
ACTG1 actin gamma 1 0.0229197
MED27 mediator complex subunit 27 0.022785
RLF rearranged L-myc fusion 0.0227372
CNOT6 CCR4-NOT transcription complex, subunit 6 0.022729
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0227108
SEC63 SEC63 homolog (S. cerevisiae) 0.0226822
ZMYM2 zinc finger, MYM-type 2 0.0226746
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.022653
ELOA elongin A 0.0226257
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.022621
CCND3 cyclin D3 0.0225845
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0224915
ZBTB35 zinc finger and BTB domain containing 35 0.0224485
FHIT fragile histidine triad 0.0224265
ANKRD12 ankyrin repeat domain 12 0.0224169
HIRA histone cell cycle regulator 0.0223653
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.0223061
RANBP9 RAN binding protein 9 0.0222903
MTIF2 mitochondrial translational initiation factor 2 0.0222571
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.0222546
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0222242
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0221744
SND1 staphylococcal nuclease and tudor domain containing 1 0.0221421
FBXO42 F-box protein 42 0.0220189
RPL18 ribosomal protein L18 0.0220039
TMEM116 transmembrane protein 116 0.0219555
RNF216 ring finger protein 216 0.0219006
MYO1D myosin ID 0.0218835
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.0218229
AGO2 argonaute RISC catalytic component 2 0.0217381
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0216874
MEGF9 multiple EGF-like-domains 9 0.0216643
LAMP1 lysosomal-associated membrane protein 1 0.021629
DARS1 aspartyl-tRNA synthetase 1 0.0216279
TMEM123 transmembrane protein 123 0.0216272
QKI QKI, KH domain containing, RNA binding 0.0215791
SNX14 sorting nexin 14 0.0214736
NCAM2 neural cell adhesion molecule 2 0.0214576
PRRC2B proline-rich coiled-coil 2B 0.021439
DGLUCY D-glutamate cyclase 0.0213889
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.0213163
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.021288
SLC35F5 solute carrier family 35, member F5 0.0211672
TCERG1 transcription elongation regulator 1 0.0211307
TMEM192 transmembrane protein 192 0.0210275
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0210043
MACROH2A1 macroH2A.1 histone 0.020987
CEPT1 choline/ethanolamine phosphotransferase 1 0.0209755
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0209374
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.0209304
AK3 adenylate kinase 3 0.0209182
SENP6 SUMO1/sentrin specific peptidase 6 0.020905
MON2 MON2 homolog (S. cerevisiae) 0.0208911
PTGES2 prostaglandin E synthase 2 0.0208827
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.0208798
AHCYL1 adenosylhomocysteinase-like 1 0.0208624
CREB1 cAMP responsive element binding protein 1 0.0208377
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0207249
TM9SF3 transmembrane 9 superfamily member 3 0.0206228
ZNF292 zinc finger protein 292 0.0206182
LARP4 La ribonucleoprotein domain family, member 4 0.0205457
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0205322
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0203846
SFT2D2 SFT2 domain containing 2 0.0203724
WDR37 WD repeat domain 37 0.0203489
AFG2A AFG2 AAA ATPase homolog A 0.0203396
FAM193A family with sequence similarity 193, member A 0.0202926
PCNP PEST proteolytic signal containing nuclear protein 0.0202642
ADAM10 ADAM metallopeptidase domain 10 0.0202106
CNST consortin, connexin sorting protein 0.0202086
MARF1 meiosis regulator and mRNA stability factor 1 0.0201765
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0201681
PHKB phosphorylase kinase, beta 0.0201537
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0201219
FBXL20 F-box and leucine-rich repeat protein 20 0.0200962
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.0200807
FKBP14 FK506 binding protein 14, 22 kDa 0.020038
RSF1 remodeling and spacing factor 1 0.0199521
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0198657
TNRC6C trinucleotide repeat containing 6C 0.0197675
ZNF367 zinc finger protein 367 0.0197611
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.0197321
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0196808
SAMTOR S-adenosylmethionine sensor upstream of mTORC1 0.0196639
MED23 mediator complex subunit 23 0.0196561
SNX25 sorting nexin 25 0.0196353
PRKX protein kinase, X-linked 0.0196233
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 0.0195623
TET2 tet methylcytosine dioxygenase 2 0.0195397
PDIA3 protein disulfide isomerase family A, member 3 0.0195177
BIRC6 baculoviral IAP repeat containing 6 0.0194405
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0194387
RSL1D1 ribosomal L1 domain containing 1 0.0194223
TOR1AIP2 torsin A interacting protein 2 0.019323
ELOVL6 ELOVL fatty acid elongase 6 0.0193081
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0192758
FBXL12 F-box and leucine-rich repeat protein 12 0.019118
TNK2 tyrosine kinase, non-receptor, 2 0.0190166
XRRA1 X-ray radiation resistance associated 1 0.0190115
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0190026
TAPT1 transmembrane anterior posterior transformation 1 0.0188945
PDE8A phosphodiesterase 8A 0.0188711
SSB Sjogren syndrome antigen B (autoantigen La) 0.0188214
DESI2 desumoylating isopeptidase 2 0.0187625
TP53BP1 tumor protein p53 binding protein 1 0.0187283
ECPAS Ecm29 proteasome adaptor and scaffold 0.0187186
UBN1 ubinuclein 1 0.0187157
ELP4 elongator acetyltransferase complex subunit 4 0.018713
ZEB1 zinc finger E-box binding homeobox 1 0.0186932
ZNF518A zinc finger protein 518A 0.0185791
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0185756
PRPF4 pre-mRNA processing factor 4 0.0185646
KAT6B K(lysine) acetyltransferase 6B 0.0185275
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.018506
NCOA2 nuclear receptor coactivator 2 0.0184789
SENP7 SUMO1/sentrin specific peptidase 7 0.0184723
NUP155 nucleoporin 155kDa 0.0184683
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.018399
ZNF800 zinc finger protein 800 0.0182864
CTPS2 CTP synthase 2 0.0182748
SIMC1 SUMO-interacting motifs containing 1 0.0182595
ITSN2 intersectin 2 0.0182114
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0181998
GABPB2 GA binding protein transcription factor, beta subunit 2 0.0181941
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0181543
FAM13A family with sequence similarity 13, member A 0.0180957
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0180876
CCDC6 coiled-coil domain containing 6 0.0180249
CYBRD1 cytochrome b reductase 1 0.0179948
CUL5 cullin 5 0.0179865
ANKRD13C ankyrin repeat domain 13C 0.0179841
RNF2 ring finger protein 2 0.0179169
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.0179049
HBS1L HBS1-like translational GTPase 0.0178585
RNF4 ring finger protein 4 0.0178063
ZFYVE28 zinc finger, FYVE domain containing 28 0.0177628
DGKH diacylglycerol kinase, eta 0.0177482
UBE3C ubiquitin protein ligase E3C 0.0177472
SOS1 son of sevenless homolog 1 (Drosophila) 0.0176916
CCHCR1 coiled-coil alpha-helical rod protein 1 0.0176503
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0176262
PTH2R parathyroid hormone 2 receptor 0.017604
GNG5 guanine nucleotide binding protein (G protein), gamma 5 0.0175921
MSMO1 methylsterol monooxygenase 1 0.0175902
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0175675
SLC39A11 solute carrier family 39, member 11 0.0175665
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.0175616
NELFA negative elongation factor complex member A 0.017541
TFB1M transcription factor B1, mitochondrial 0.0175366
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0175339
RAB5A RAB5A, member RAS oncogene family 0.0174561
SNX4 sorting nexin 4 0.0174236
AFG1L AFG1 like ATPase 0.0172933
ZNF124 zinc finger protein 124 0.0172429
GTF2IRD2B GTF2I repeat domain containing 2B 0.0172172
E2F6 E2F transcription factor 6 0.0172057
USP9X ubiquitin specific peptidase 9, X-linked 0.0171937
ZGRF1 zinc finger, GRF-type containing 1 0.0171832
NAF1 nuclear assembly factor 1 ribonucleoprotein 0.0171768
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.017155
MPZ myelin protein zero 0.0171178
RCOR1 REST corepressor 1 0.017106
NBR1 neighbor of BRCA1 gene 1 0.0171026
TMEM165 transmembrane protein 165 0.0170703
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0170654
TMEM267 transmembrane protein 267 0.0170476
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.0170455
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.0170343
DCAF16 DDB1 and CUL4 associated factor 16 0.016936
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0169246
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0168279
ADD3 adducin 3 (gamma) 0.016807
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 0.0167829
AMBRA1 autophagy/beclin-1 regulator 1 0.016763
EEA1 early endosome antigen 1 0.0167511
MFSD2B major facilitator superfamily domain containing 2B 0.0167486
INTS6 integrator complex subunit 6 0.0166949
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.016685
FXN frataxin 0.0166515
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.0166232
CANX calnexin 0.0166221
DLAT dihydrolipoamide S-acetyltransferase 0.0166072
PLAA phospholipase A2-activating protein 0.0165096
VAC14 Vac14 homolog (S. cerevisiae) 0.0165063
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0164764
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0164611
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0164509
STIM1 stromal interaction molecule 1 0.0164437
COX5B cytochrome c oxidase subunit Vb 0.0163979
TJP1 tight junction protein 1 0.0163572
FOXP1 forkhead box P1 0.0163528
POU2F1 POU class 2 homeobox 1 0.0163486
SFXN4 sideroflexin 4 0.0163408
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.0163389
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.0163299
MAP2K5 mitogen-activated protein kinase kinase 5 0.0163253
FADS2 fatty acid desaturase 2 0.0163189
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.0163189
DLG1 discs, large homolog 1 (Drosophila) 0.0163027
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0162847
AQR aquarius intron-binding spliceosomal factor 0.0162432
MRPL20 mitochondrial ribosomal protein L20 0.0162399
PTDSS1 phosphatidylserine synthase 1 0.0162391
GTPBP10 GTP-binding protein 10 (putative) 0.0162336
RFX7 regulatory factor X, 7 0.0162314
EVI5 ecotropic viral integration site 5 0.0162233
SORT1 sortilin 1 0.0162143
JMY junction mediating and regulatory protein, p53 cofactor 0.0162004
RPS5 ribosomal protein S5 0.0161729
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.0161518
TBC1D15 TBC1 domain family, member 15 0.0161506
MED15 mediator complex subunit 15 0.0161409
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0160812
CKB creatine kinase, brain 0.0160564
ZNF33B zinc finger protein 33B 0.0160492
NOL4L nucleolar protein 4-like 0.0159929
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0159252
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.0159173
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0158997
GRB10 growth factor receptor-bound protein 10 0.0158997
FLOT1 flotillin 1 0.0158978
SCARB1 scavenger receptor class B, member 1 0.0158696
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.0158599
KLHDC10 kelch domain containing 10 0.0158445
MTERF1 mitochondrial transcription termination factor 1 0.0158348
CSDE1 cold shock domain containing E1, RNA-binding 0.0158019
EXOC1 exocyst complex component 1 0.01578
CD320 CD320 molecule 0.015765
DBT dihydrolipoamide branched chain transacylase E2 0.0156968
MAP4 microtubule-associated protein 4 0.0156967
TBC1D22B TBC1 domain family, member 22B 0.0156775
POLH polymerase (DNA directed), eta 0.0156485
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.0156191
RINT1 RAD50 interactor 1 0.0155932
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 0.0155728
TTC27 tetratricopeptide repeat domain 27 0.0155588
FAM117A family with sequence similarity 117, member A 0.0155357
SLMAP sarcolemma associated protein 0.0155169
RNASEH1 ribonuclease H1 0.0154619
NOSTRIN nitric oxide synthase trafficking 0.0154456
ZNF490 zinc finger protein 490 0.0154351
SLC10A7 solute carrier family 10, member 7 0.0154336
DCAF6 DDB1 and CUL4 associated factor 6 0.0153607
ZNF266 zinc finger protein 266 0.0153566
GALK2 galactokinase 2 0.0153562
RPS24 ribosomal protein S24 0.0153157
COG4 component of oligomeric golgi complex 4 0.0153015
AGK acylglycerol kinase 0.0152325
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.015222
ANKMY1 ankyrin repeat and MYND domain containing 1 0.0152102
CPPED1 calcineurin-like phosphoesterase domain containing 1 0.015209
TBC1D23 TBC1 domain family, member 23 0.0151821
RSPH3 radial spoke 3 homolog (Chlamydomonas) 0.0151763
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.0151611
MANBA mannosidase, beta A, lysosomal 0.015159
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0151496
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.0151364
TRAK2 trafficking protein, kinesin binding 2 0.0150963
SMG5 SMG5 nonsense mediated mRNA decay factor 0.0150817
ZNF846 zinc finger protein 846 0.0150652
CSPP1 centrosome and spindle pole associated protein 1 0.0150271
PHF7 PHD finger protein 7 0.0149948
NME7 NME/NM23 family member 7 0.0149933
SDK2 sidekick cell adhesion molecule 2 0.0149602
RBM26 RNA binding motif protein 26 0.0148878
POFUT4 protein O-fucosyltransferase 4 0.0148726
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0148711
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0148679
DNAH14 dynein, axonemal, heavy chain 14 0.014831
WDR70 WD repeat domain 70 0.0148262
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 0.0148159
UBE2N ubiquitin-conjugating enzyme E2N 0.0147959
TNRC6A trinucleotide repeat containing 6A 0.014768
CLINT1 clathrin interactor 1 0.0147678
RPL7L1 ribosomal protein L7-like 1 0.014766
ZFAND6 zinc finger, AN1-type domain 6 0.0147561
MRPS18B mitochondrial ribosomal protein S18B 0.014751
CFAP251 cilia and flagella associated protein 251 0.0147403
ZFC3H1 zinc finger, C3H1-type containing 0.0147381
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0147258
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0147147
GDI2 GDP dissociation inhibitor 2 0.0146182
GATA2 GATA binding protein 2 0.0146044
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.014596
FANCL Fanconi anemia, complementation group L 0.0145759
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0145463
TENM1 teneurin transmembrane protein 1 0.014513

decreased expression

Symbol Name Standardized Value
FLNA filamin A, alpha -0.0992151
DIAPH1 diaphanous-related formin 1 -0.0778755
TPR translocated promoter region, nuclear basket protein -0.0752368
ARL15 ADP-ribosylation factor-like 15 -0.0728074
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0698102
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0685434
CHD4 chromodomain helicase DNA binding protein 4 -0.0659287
KPNB1 karyopherin (importin) beta 1 -0.0630997
GSE1 Gse1 coiled-coil protein -0.0627418
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0618187
CALN1 calneuron 1 -0.0593871
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0572737
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0568653
PRKCA protein kinase C, alpha -0.0566068
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0556463
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0547641
VIM vimentin -0.0544115
PCDH9 protocadherin 9 -0.0539291
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0527667
MED13 mediator complex subunit 13 -0.0526603
NUP214 nucleoporin 214kDa -0.0510814
GRB2 growth factor receptor-bound protein 2 -0.0488866
MSI2 musashi RNA-binding protein 2 -0.0462564
MKI67 marker of proliferation Ki-67 -0.0452121
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0447477
BRWD1 bromodomain and WD repeat domain containing 1 -0.0431885
RTN4 reticulon 4 -0.0419574
CCDC57 coiled-coil domain containing 57 -0.0415889
KMT2A lysine (K)-specific methyltransferase 2A -0.0412241
MYO19 myosin XIX -0.0405965
HBG2 hemoglobin, gamma G -0.0400748
CALU calumenin -0.0399425
CUX1 cut-like homeobox 1 -0.0396894
MCAM melanoma cell adhesion molecule -0.0394643
LOC112694756 uncharaterized LOC112694756 -0.0386518
PRRC2C proline-rich coiled-coil 2C -0.038621
NCALD neurocalcin delta -0.0379626
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0377227
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0376129
PKM pyruvate kinase, muscle -0.0375931
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -0.036705
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.036702
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0366509
AOPEP aminopeptidase O (putative) -0.036423
FDPS farnesyl diphosphate synthase -0.0363768
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0361383
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0360256
ZNF83 zinc finger protein 83 -0.035862
ACTN4 actinin, alpha 4 -0.0358459
NLK nemo-like kinase -0.0357312
ENO1 enolase 1, (alpha) -0.0348664
RPL30 ribosomal protein L30 -0.034518
ATG7 autophagy related 7 -0.0343531
MTDH metadherin -0.0340814
MCPH1 microcephalin 1 -0.0337049
RABGAP1 RAB GTPase activating protein 1 -0.0336817
FBXO11 F-box protein 11 -0.0334963
VCL vinculin -0.033185
SBF2 SET binding factor 2 -0.0331291
SMIM44 small integral membrane protein 44 -0.0330934
HIP1 huntingtin interacting protein 1 -0.0330871
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0330817
RELN reelin -0.0328301
SPIDR scaffolding protein involved in DNA repair -0.0328008
FANCI Fanconi anemia, complementation group I -0.0324284
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0321346
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0320483
TSLIG1 tRNA splicing ligase complex subunit 1 -0.03188
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0318271
TXNRD1 thioredoxin reductase 1 -0.031305
IPO7 importin 7 -0.0312918
CLASP1 cytoplasmic linker associated protein 1 -0.0310859
RACK1 receptor for activated C kinase 1 -0.0310707
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.0308671
AK1 adenylate kinase 1 -0.0306295
RPS16 ribosomal protein S16 -0.0305522
PICALM phosphatidylinositol binding clathrin assembly protein -0.0303733
BSG basigin (Ok blood group) -0.0300062
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0292827
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0292641
DOCK8 dedicator of cytokinesis 8 -0.0292356
ELOVL5 ELOVL fatty acid elongase 5 -0.0291701
TNPO2 transportin 2 -0.0290226
MACF1 microtubule-actin crosslinking factor 1 -0.0289217
MACO1 macoilin 1 -0.0286294
OSBPL3 oxysterol binding protein-like 3 -0.0286166
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0284634
PBRM1 polybromo 1 -0.0283514
NALF1 NALCN channel auxiliary factor 1 -0.028014
MICU1 mitochondrial calcium uptake 1 -0.027913
BMP2K BMP2 inducible kinase -0.0275766
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0275552
BLTP3A bridge-like lipid transfer protein family member 3A -0.0273943
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -0.0272875
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0270558
KNL1 kinetochore scaffold 1 -0.0265647
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0265432
LUZP1 leucine zipper protein 1 -0.0263428
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0261494
TRAK1 trafficking protein, kinesin binding 1 -0.0259957
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0259012
GMPS guanine monphosphate synthase -0.0258691
NPEPPS aminopeptidase puromycin sensitive -0.0258424
CERS6 ceramide synthase 6 -0.0257602
POTEF POTE ankyrin domain family, member F -0.0257595
SRSF10 serine/arginine-rich splicing factor 10 -0.0256067
MCM3AP minichromosome maintenance complex component 3 associated protein -0.025434
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.0254225
TNRC18 trinucleotide repeat containing 18 -0.0251951
GPATCH8 G patch domain containing 8 -0.0251282
RPL8 ribosomal protein L8 -0.0250701
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.0250385
TPM3 tropomyosin 3 -0.0249973
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0248742
JARID2 jumonji, AT rich interactive domain 2 -0.0244701
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0243936
TACC3 transforming, acidic coiled-coil containing protein 3 -0.0242294
CDC27 cell division cycle 27 -0.0241449
RHCE Rh blood group, CcEe antigens -0.0241141
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0240717
KHSRP KH-type splicing regulatory protein -0.0240582
SFXN1 sideroflexin 1 -0.0240232
TMEM131 transmembrane protein 131 -0.0237329
TRIM24 tripartite motif containing 24 -0.0237235
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0236474
MBD5 methyl-CpG binding domain protein 5 -0.0236194
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.023582
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0235524
KLHL22 kelch-like family member 22 -0.0233107
CHD1L chromodomain helicase DNA binding protein 1-like -0.0232466
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0231771
PHACTR4 phosphatase and actin regulator 4 -0.0230818
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.0230564
CDCA2 cell division cycle associated 2 -0.0230552
WDFY3 WD repeat and FYVE domain containing 3 -0.0230027
SORCS1 sortilin-related VPS10 domain containing receptor 1 -0.0229979
MAPK1 mitogen-activated protein kinase 1 -0.0229562
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0229552
RPL28 ribosomal protein L28 -0.0229465
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0228204
REV1 REV1, polymerase (DNA directed) -0.0228111
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.0228081
TUBB tubulin, beta class I -0.022785
ADGRB3 adhesion G protein-coupled receptor B3 -0.0226822
MTREX Mtr4 exosome RNA helicase -0.0226815
THRAP3 thyroid hormone receptor associated protein 3 -0.0226305
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0225584
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.022542
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -0.0225394
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0223833
GMDS GDP-mannose 4,6-dehydratase -0.0223629
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0223603
GMPR guanosine monophosphate reductase -0.0223214
WAC WW domain containing adaptor with coiled-coil -0.0223203
RTN3 reticulon 3 -0.0222648
TAOK1 TAO kinase 1 -0.022244
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0221228
KIF18B kinesin family member 18B -0.0220914
ARHGAP12 Rho GTPase activating protein 12 -0.0220482
SCAF4 SR-related CTD-associated factor 4 -0.0220305
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0220274
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0220129
RRM1 ribonucleotide reductase M1 -0.0219108
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0217688
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0216843
NCOR1 nuclear receptor corepressor 1 -0.0216201
DIAPH3 diaphanous-related formin 3 -0.0215917
SOGA1 suppressor of glucose, autophagy associated 1 -0.0214946
SNAP29 synaptosomal-associated protein, 29kDa -0.0214682
PPHLN1 periphilin 1 -0.0213644
RFC2 replication factor C (activator 1) 2, 40kDa -0.0213166
RBBP4 retinoblastoma binding protein 4 -0.0212582
HELZ helicase with zinc finger -0.0212292
SQSTM1 sequestosome 1 -0.0211533
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -0.0211509
ARL8B ADP-ribosylation factor-like 8B -0.0210784
CENPK centromere protein K -0.0209953
RCC1 regulator of chromosome condensation 1 -0.0209776
RPS8 ribosomal protein S8 -0.0208958
CAVIN1 caveolae associated protein 1 -0.0208756
FAM168A family with sequence similarity 168, member A -0.0208595
PCED1B PC-esterase domain containing 1B -0.0208085
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0208059
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0207935
ZNF562 zinc finger protein 562 -0.0207401
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0207363
TANK TRAF family member-associated NFKB activator -0.0207032
RSBN1L round spermatid basic protein 1-like -0.0206995
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0205958
USP3 ubiquitin specific peptidase 3 -0.020586
PNN pinin, desmosome associated protein -0.020551
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0205194
MCM7 minichromosome maintenance complex component 7 -0.0204932
C1ORF159 chromosome 1 open reading frame 159 -0.0204765
YARS1 tyrosyl-tRNA synthetase 1 -0.020445
EIF3M eukaryotic translation initiation factor 3, subunit M -0.0203302
KDM6A lysine (K)-specific demethylase 6A -0.0202811
FNIP2 folliculin interacting protein 2 -0.0202772
VMP1 vacuole membrane protein 1 -0.0202447
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -0.0202446
CLIC1 chloride intracellular channel 1 -0.0202253
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase -0.0202152
CFLAR CASP8 and FADD-like apoptosis regulator -0.0201723
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -0.0201252
CHEK2 checkpoint kinase 2 -0.0198801
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.01979
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0197615
FNBP4 formin binding protein 4 -0.0196843
RILPL1 Rab interacting lysosomal protein-like 1 -0.0196748
CEP85L centrosomal protein 85kDa-like -0.0196746
WWOX WW domain containing oxidoreductase -0.0196608
AFTPH aftiphilin -0.0196523
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0195448
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0195283
TMPO thymopoietin -0.0194757
CHD8 chromodomain helicase DNA binding protein 8 -0.0194528
ELL2 elongation factor, RNA polymerase II, 2 -0.0193533
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0193094
BRCA1 breast cancer 1, early onset -0.0192827
FOXN2 forkhead box N2 -0.0192553
OXNAD1 oxidoreductase NAD-binding domain containing 1 -0.0192467
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -0.0192408
ZNRF3 zinc and ring finger 3 -0.0192171
MOSMO modulator of smoothened -0.0192116
TTC28 tetratricopeptide repeat domain 28 -0.0191992
SUMF2 sulfatase modifying factor 2 -0.0191415
DNM2 dynamin 2 -0.0190813
FKBP5 FK506 binding protein 5 -0.019076
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0190741
AATF apoptosis antagonizing transcription factor -0.0190731
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0190383
IGF1R insulin-like growth factor 1 receptor -0.0190165
RC3H2 ring finger and CCCH-type domains 2 -0.0189297
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -0.018913
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -0.0189123
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0188838
RPL4 ribosomal protein L4 -0.0188514
MLXIP MLX interacting protein -0.0188264
KCMF1 potassium channel modulatory factor 1 -0.0187716
ADAM17 ADAM metallopeptidase domain 17 -0.0187186
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.018705
XPC xeroderma pigmentosum, complementation group C -0.0186915
CD81 CD81 molecule -0.0186677
NUP210 nucleoporin 210kDa -0.018658
SMC4 structural maintenance of chromosomes 4 -0.0186508
KATNA1 katanin p60 (ATPase containing) subunit A 1 -0.01861
CNTNAP2 contactin associated protein-like 2 -0.0185708
ADCY7 adenylate cyclase 7 -0.0185649
NMT1 N-myristoyltransferase 1 -0.018564
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0185446
RPL22 ribosomal protein L22 -0.0185443
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0185407
KRT18 keratin 18, type I -0.0185002
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0184997
MTPN myotrophin -0.0184282
TCP1 t-complex 1 -0.0184207
LZIC leucine zipper and CTNNBIP1 domain containing -0.0184145
AHI1 Abelson helper integration site 1 -0.018386
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -0.0183816
SUGP2 SURP and G patch domain containing 2 -0.0182892
RYBP RING1 and YY1 binding protein -0.0182797
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0182667
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0182367
ORC3 origin recognition complex, subunit 3 -0.0182329
ZHX3 zinc fingers and homeoboxes 3 -0.0181854
TASOR2 transcription activation suppressor family member 2 -0.0181389
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0180649
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0180646
CD44 CD44 molecule (Indian blood group) -0.0180507
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -0.0180165
RNF157 ring finger protein 157 -0.0179758
DHDDS dehydrodolichyl diphosphate synthase -0.0179282
EXOSC10 exosome component 10 -0.01791
OSBPL6 oxysterol binding protein-like 6 -0.0179025
ZEB2 zinc finger E-box binding homeobox 2 -0.0178039
PTPRS protein tyrosine phosphatase, receptor type, S -0.0177986
STIP1 stress-induced phosphoprotein 1 -0.0177664
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0177408
MCM6 minichromosome maintenance complex component 6 -0.0177392
NUP98 nucleoporin 98kDa -0.0177265
PRDX1 peroxiredoxin 1 -0.0176534
ARHGAP25 Rho GTPase activating protein 25 -0.0176276
RABEPK Rab9 effector protein with kelch motifs -0.0176235
NOL9 nucleolar protein 9 -0.0175871
CBX5 chromobox homolog 5 -0.0175619
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0175597
MYH10 myosin, heavy chain 10, non-muscle -0.0175068
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0175039
RPS11 ribosomal protein S11 -0.0174705
RIPOR3 RIPOR family member 3 -0.0174431
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0173984
SNX5 sorting nexin 5 -0.017381
EXOC2 exocyst complex component 2 -0.0173784
BTBD9 BTB (POZ) domain containing 9 -0.0173747
COASY CoA synthase -0.0173677
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -0.0173409
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.0173395
SIL1 SIL1 nucleotide exchange factor -0.017339
ERICH1 glutamate-rich 1 -0.0173234
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0173211
HOMER1 homer scaffolding protein 1 -0.0173139
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0172479
MCU mitochondrial calcium uniporter -0.0172451
MYO1E myosin IE -0.0172241
TUFM Tu translation elongation factor, mitochondrial -0.0172042
BBS4 Bardet-Biedl syndrome 4 -0.0171798
PTK2 protein tyrosine kinase 2 -0.0171296
ARRB1 arrestin, beta 1 -0.0171253
JPT1 Jupiter microtubule associated homolog 1 -0.0171133
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0171069
TPP2 tripeptidyl peptidase II -0.0170867
CDT1 chromatin licensing and DNA replication factor 1 -0.0170858
SAP130 Sin3A-associated protein, 130kDa -0.0168648
DIDO1 death inducer-obliterator 1 -0.0168334
ECE1 endothelin converting enzyme 1 -0.0167436
TLN1 talin 1 -0.0167048
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0166927
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0166669
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0166453
INTS8 integrator complex subunit 8 -0.0165899
ARG2 arginase 2 -0.0165756
KRIT1 KRIT1, ankyrin repeat containing -0.0165609
TBCD tubulin folding cofactor D -0.0165533
UBAP2 ubiquitin associated protein 2 -0.0164931
PRNP prion protein -0.0164542
MYDGF myeloid-derived growth factor -0.0164347
TEX2 testis expressed 2 -0.0164284
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0164261
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0164193
MRPL4 mitochondrial ribosomal protein L4 -0.016409
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0163885
FNBP1 formin binding protein 1 -0.0163151
NUP205 nucleoporin 205kDa -0.0163099
SLTM SAFB-like, transcription modulator -0.0163047
EXT1 exostosin glycosyltransferase 1 -0.0162832
H2AC6 H2A clustered histone 6 -0.0162792
DPP8 dipeptidyl-peptidase 8 -0.0162776
DCP1A decapping mRNA 1A -0.0162428
ADAM9 ADAM metallopeptidase domain 9 -0.0162382
EP300 E1A binding protein p300 -0.0162353
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -0.0162236
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0162213
SASH1 SAM and SH3 domain containing 1 -0.016197
SON SON DNA binding protein -0.0161769
SLC43A3 solute carrier family 43, member 3 -0.016082
NIBAN2 niban apoptosis regulator 2 -0.01608
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0160073
CTSL cathepsin L -0.0159992
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0159779
FUS FUS RNA binding protein -0.0159734
RPL13A ribosomal protein L13a -0.0159571
KRT8 keratin 8, type II -0.0159393
KDM1A lysine (K)-specific demethylase 1A -0.0159322
MTCL1 microtubule crosslinking factor 1 -0.0158668
RPS3 ribosomal protein S3 -0.0158637
NRDC nardilysin convertase -0.0158078
CLEC16A C-type lectin domain family 16, member A -0.0158017
H2BC11 H2B clustered histone 11 -0.0157635
WDR4 WD repeat domain 4 -0.0157452
RBM20 RNA binding motif protein 20 -0.0157357
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -0.0157015
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0156883
GCLC glutamate-cysteine ligase, catalytic subunit -0.01567
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0156561
KMT5B lysine methyltransferase 5B -0.0156196
MCM10 minichromosome maintenance complex component 10 -0.0156077
ZNF611 zinc finger protein 611 -0.0155909
HSPA8 heat shock 70kDa protein 8 -0.0155784
AHNAK AHNAK nucleoprotein -0.0155243
ORC4 origin recognition complex, subunit 4 -0.0155106
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0155006
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -0.0154848
URM1 ubiquitin related modifier 1 -0.0154759
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0154481
RCL1 RNA terminal phosphate cyclase-like 1 -0.0154349
RPL27A ribosomal protein L27a -0.015428
FANCM Fanconi anemia, complementation group M -0.0153895
KYAT1 kynurenine aminotransferase 1 -0.0153815
BRIX1 BRX1, biogenesis of ribosomes -0.0153756
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.0153362
SESN2 sestrin 2 -0.0153352
LETMD1 LETM1 domain containing 1 -0.0153179
CEP85 centrosomal protein 85kDa -0.0153106
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0152701
BMAL2 basic helix-loop-helix ARNT like 2 -0.015264
ARF1 ADP-ribosylation factor 1 -0.0152551
RPS9 ribosomal protein S9 -0.0152399
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0152298
EXOC4 exocyst complex component 4 -0.0152008
CDK4 cyclin-dependent kinase 4 -0.0151876
PARN poly(A)-specific ribonuclease -0.015157
POLR1B polymerase (RNA) I polypeptide B, 128kDa -0.0151156
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -0.0151082
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0150973
RHOBTB3 Rho-related BTB domain containing 3 -0.0150947
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -0.015094
KIF18A kinesin family member 18A -0.0150718
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -0.0150556
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.015047
LPIN1 lipin 1 -0.0150456
KIF14 kinesin family member 14 -0.0150368
ADGRE5 adhesion G protein-coupled receptor E5 -0.0150341
POGZ pogo transposable element with ZNF domain -0.0150194
ARHGAP11A Rho GTPase activating protein 11A -0.0150189
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.014952
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0149483
PITPNA phosphatidylinositol transfer protein, alpha -0.0149071
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0149027
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -0.0148562
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0148341
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -0.0148341
SLC37A3 solute carrier family 37, member 3 -0.0148282
RNF103-CHMP3 RNF103-CHMP3 readthrough -0.0148279
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0147259
ACO2 aconitase 2, mitochondrial -0.0146883
TPI1 triosephosphate isomerase 1 -0.0146396
CTR9 CTR9, Paf1/RNA polymerase II complex component -0.0146395
NIBAN1 niban apoptosis regulator 1 -0.0146115
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0145712
CASP2 caspase 2, apoptosis-related cysteine peptidase -0.0145475
HPCAL1 hippocalcin-like 1 -0.0144772
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0144751
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -0.0144564
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0144498
SF3A3 splicing factor 3a, subunit 3, 60kDa -0.014449
MRPS27 mitochondrial ribosomal protein S27 -0.0144418
MORF4L2 mortality factor 4 like 2 -0.0144336
ZNF804B zinc finger protein 804B -0.0144287
EVL Enah/Vasp-like -0.014416
GDA guanine deaminase -0.0144077
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0143967
SEC24A SEC24 family member A -0.0143689
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -0.0143601
SIN3A SIN3 transcription regulator family member A -0.0143458
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -0.0143142
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0142895
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0142851
PXDN peroxidasin -0.0142723
DAPK1 death-associated protein kinase 1 -0.0142637
RAB1A RAB1A, member RAS oncogene family -0.0142368
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0142252
MACROD1 MACRO domain containing 1 -0.0142154
TTL tubulin tyrosine ligase -0.0142084
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -0.0141933
TMOD3 tropomodulin 3 (ubiquitous) -0.0141839
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.0141718
CAPNS1 calpain, small subunit 1 -0.0141319
ATP5MG ATP synthase membrane subunit g -0.0140942
SAFB scaffold attachment factor B -0.0140907
DEAF1 DEAF1 transcription factor -0.0140779
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -0.0140774
EMP3 epithelial membrane protein 3 -0.01405
TOP2B topoisomerase (DNA) II beta 180kDa -0.014035
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0140171
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.013991
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0139865
LRP6 low density lipoprotein receptor-related protein 6 -0.0139852
CREBBP CREB binding protein -0.013978
NFE2 nuclear factor, erythroid 2 -0.013977
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0139725
AKAP1 A kinase (PRKA) anchor protein 1 -0.0139522
NR2C1 nuclear receptor subfamily 2, group C, member 1 -0.0139494
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.0139419
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0139247
USP39 ubiquitin specific peptidase 39 -0.0139165
TXNIP thioredoxin interacting protein -0.0139147
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0139106
RUFY2 RUN and FYVE domain containing 2 -0.0139096
RAB28 RAB28, member RAS oncogene family -0.0138913
C19ORF25 chromosome 19 open reading frame 25 -0.0138717
TAGLN2 transgelin 2 -0.0138657
WDR7 WD repeat domain 7 -0.0138579
ATAD5 ATPase family, AAA domain containing 5 -0.013843
RBBP8 retinoblastoma binding protein 8 -0.0138387
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.0138337
DNM1 dynamin 1 -0.0137994
SPPL2A signal peptide peptidase like 2A -0.0137926
KIF2A kinesin heavy chain member 2A -0.0137893
MGST3 microsomal glutathione S-transferase 3 -0.0137766
TRIM37 tripartite motif containing 37 -0.0137436
CEP120 centrosomal protein 120kDa -0.0137393
RAD51B RAD51 paralog B -0.013737
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -0.0136934
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0136836
TPM4 tropomyosin 4 -0.0136705
TMEM63A transmembrane protein 63A -0.0136679
INTS7 integrator complex subunit 7 -0.0136639
TBCE tubulin folding cofactor E -0.01365
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0136317
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -0.0135884
BICD1 bicaudal D homolog 1 (Drosophila) -0.0135831
GPC5 glypican 5 -0.0135722
AAK1 AP2 associated kinase 1 -0.0135527
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0135471
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -0.0135454
UBE2J2 ubiquitin-conjugating enzyme E2, J2 -0.0135453
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 -0.0135281
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 -0.0135037
XYLB xylulokinase homolog (H. influenzae) -0.0134883
RPL7A ribosomal protein L7a -0.0134793