KARPAS-422 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human B cell lymphoma cell line; established from the pleural effusion of a 73-year-old woman with B cell non-Hodgkin lymphoma (intraabdominal, diffuse large cell lymphoma, refractory, terminal) in 1987. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004981)
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Genes

451 genes mutated in the KARPAS-422 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABI3 ABI family, member 3
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ADAM9 ADAM metallopeptidase domain 9
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAMTSL2 ADAMTS-like 2
ADAMTSL3 ADAMTS-like 3
AFF1 AF4/FMR2 family, member 1
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGBL4 ATP/GTP binding protein-like 4
AKAP6 A kinase (PRKA) anchor protein 6
ALK anaplastic lymphoma receptor tyrosine kinase
AMPD1 adenosine monophosphate deaminase 1
AMPH amphiphysin
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANKRD30A ankyrin repeat domain 30A
ANKRD55 ankyrin repeat domain 55
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARID1A AT rich interactive domain 1A (SWI-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASIC5 acid sensing (proton gated) ion channel family member 5
ATF6B activating transcription factor 6 beta
ATF7IP2 activating transcription factor 7 interacting protein 2
ATG4A autophagy related 4A, cysteine peptidase
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
AVL9 AVL9 homolog (S. cerevisiase)
BABAM1 BRISC and BRCA1 A complex member 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL2 B-cell CLL/lymphoma 2
BICC1 BicC family RNA binding protein 1
BLNK B-cell linker
BMP15 bone morphogenetic protein 15
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMKMT calmodulin-lysine N-methyltransferase
CARD11 caspase recruitment domain family, member 11
CASC3 cancer susceptibility candidate 3
CASC4 cancer susceptibility candidate 4
CCDC120 coiled-coil domain containing 120
CCDC129 coiled-coil domain containing 129
CCDC50 coiled-coil domain containing 50
CCDC85A coiled-coil domain containing 85A
CCNB3 cyclin B3
CD14 CD14 molecule
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CDCP1 CUB domain containing protein 1
CDCP2 CUB domain containing protein 2
CDH23 cadherin-related 23
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDYL chromodomain protein, Y-like
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHAD chondroadherin
CHD1L chromodomain helicase DNA binding protein 1-like
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CIITA class II, major histocompatibility complex, transactivator
CLIC5 chloride intracellular channel 5
CLRN2 clarin 2
CLVS2 clavesin 2
CNGA4 cyclic nucleotide gated channel alpha 4
CNTN5 contactin 5
CNTNAP3B contactin associated protein-like 3B
COL18A1 collagen, type XVIII, alpha 1
COL5A3 collagen, type V, alpha 3
COL6A3 collagen, type VI, alpha 3
COL6A6 collagen, type VI, alpha 6
COQ10A coenzyme Q10 homolog A (S. cerevisiae)
CP ceruloplasmin (ferroxidase)
CPXM2 carboxypeptidase X (M14 family), member 2
CREBBP CREB binding protein
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1
CRTAP cartilage associated protein
CTNND2 catenin (cadherin-associated protein), delta 2
CUL4A cullin 4A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXXC4 CXXC finger protein 4
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2
DAO D-amino-acid oxidase
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1
DCHS2 dachsous cadherin-related 2
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DENND2D DENN/MADD domain containing 2D
DLG2 discs, large homolog 2 (Drosophila)
DLG5 discs, large homolog 5 (Drosophila)
DMD dystrophin
DNAH17 dynein, axonemal, heavy chain 17
DNAH5 dynein, axonemal, heavy chain 5
DNAH6 dynein, axonemal, heavy chain 6
DOCK2 dedicator of cytokinesis 2
DOCK9 dedicator of cytokinesis 9
DOK6 docking protein 6
DST dystonin
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUOX2 dual oxidase 2
DUSP27 dual specificity phosphatase 27 (putative)
DUT deoxyuridine triphosphatase
DVL2 dishevelled segment polarity protein 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EBF1 early B-cell factor 1
EED embryonic ectoderm development
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EMX2 empty spiracles homeobox 2
EP300 E1A binding protein p300
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA6 EPH receptor A6
EPPK1 epiplakin 1
ERAS ES cell expressed Ras
EXOC6B exocyst complex component 6B
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM122C family with sequence similarity 122C
FAM169A family with sequence similarity 169, member A
FAM227A family with sequence similarity 227, member A
FAM86B1 family with sequence similarity 86, member B1
FAM86C1 family with sequence similarity 86, member C1
FAS Fas cell surface death receptor
FAT1 FAT atypical cadherin 1
FAT2 FAT atypical cadherin 2
FAT3 FAT atypical cadherin 3
FBN1 fibrillin 1
FBN3 fibrillin 3
FBRS fibrosin
FBXL5 F-box and leucine-rich repeat protein 5
FER1L6 fer-1-like family member 6
FLNB filamin B, beta
FRMPD1 FERM and PDZ domain containing 1
GAA glucosidase, alpha; acid
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGT7 gamma-glutamyltransferase 7
GLA galactosidase, alpha
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAS GNAS complex locus
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GOLGB1 golgin B1
GPKOW G patch domain and KOW motifs
GPR15 G protein-coupled receptor 15
GPR158 G protein-coupled receptor 158
GPR52 G protein-coupled receptor 52
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GREB1 growth regulation by estrogen in breast cancer 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRM1 glutamate receptor, metabotropic 1
GRM8 glutamate receptor, metabotropic 8
GSTT1 glutathione S-transferase theta 1
GTF2B general transcription factor IIB
HBS1L HBS1-like translational GTPase
HDAC5 histone deacetylase 5
HEATR4 HEAT repeat containing 4
HHIPL1 HHIP-like 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HIP1R huntingtin interacting protein 1 related
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HLA-B major histocompatibility complex, class I, B
HOXA3 homeobox A3
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HVCN1 hydrogen voltage gated channel 1
HYAL1 hyaluronoglucosaminidase 1
HYDIN HYDIN, axonemal central pair apparatus protein
IBSP integrin-binding sialoprotein
IFNA10 interferon, alpha 10
IFT88 intraflagellar transport 88
IGSF10 immunoglobulin superfamily, member 10
IGSF3 immunoglobulin superfamily, member 3
IL13RA1 interleukin 13 receptor, alpha 1
IL17C interleukin 17C
IL6ST interleukin 6 signal transducer
ILDR2 immunoglobulin-like domain containing receptor 2
IMPG2 interphotoreceptor matrix proteoglycan 2
IRF2BP2 interferon regulatory factor 2 binding protein 2
ISPD isoprenoid synthase domain containing
ITGA1 integrin, alpha 1
KALRN kalirin, RhoGEF kinase
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNG4 potassium channel, voltage gated modifier subfamily G, member 4
KDM4C lysine (K)-specific demethylase 4C
KIAA1109 KIAA1109
KIAA1217 KIAA1217
KIAA1324L KIAA1324-like
KIF13A kinesin family member 13A
KIF3B kinesin family member 3B
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRBA2 KRAB-A domain containing 2
KRI1 KRI1 homolog (S. cerevisiae)
KRT25 keratin 25, type I
KRTAP1-3 keratin associated protein 1-3
KRTAP19-1 keratin associated protein 19-1
KRTAP19-4 keratin associated protein 19-4
KRTAP5-2 keratin associated protein 5-2
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMA2 laminin, alpha 2
LDHB lactate dehydrogenase B
LECT1 leukocyte cell derived chemotaxin 1
LHCGR luteinizing hormone/choriogonadotropin receptor
LHFPL3 lipoma HMGIC fusion partner-like 3
LMO4 LIM domain only 4
LRP1 low density lipoprotein receptor-related protein 1
LRP10 low density lipoprotein receptor-related protein 10
LRRC15 leucine rich repeat containing 15
LRRC36 leucine rich repeat containing 36
LRRC66 leucine rich repeat containing 66
LRRC7 leucine rich repeat containing 7
LRRTM3 leucine rich repeat transmembrane neuronal 3
LSR lipolysis stimulated lipoprotein receptor
LTBP3 latent transforming growth factor beta binding protein 3
LTBP4 latent transforming growth factor beta binding protein 4
LTN1 listerin E3 ubiquitin protein ligase 1
LYPD6B LY6/PLAUR domain containing 6B
MACF1 microtubule-actin crosslinking factor 1
MAGEA8 melanoma antigen family A8
MAGEC1 melanoma antigen family C1
MAGEE1 melanoma antigen family E1
MAGEE2 melanoma antigen family E2
MAMDC2 MAM domain containing 2
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MC5R melanocortin 5 receptor
MED12 mediator complex subunit 12
MED13L mediator complex subunit 13-like
MED26 mediator complex subunit 26
MFSD7 major facilitator superfamily domain containing 7
MINPP1 multiple inositol-polyphosphate phosphatase 1
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MOB3A MOB kinase activator 3A
MPPED2 metallophosphoesterase domain containing 2
MRPL47 mitochondrial ribosomal protein L47
MTO1 mitochondrial tRNA translation optimization 1
MUC12 mucin 12, cell surface associated
MUC16 mucin 16, cell surface associated
MUC17 mucin 17, cell surface associated
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MUC7 mucin 7, secreted
MXRA5 matrix-remodelling associated 5
MYBBP1A MYB binding protein (P160) 1a
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYLK myosin light chain kinase
MYO16 myosin XVI
MYO18B myosin XVIIIB
MYO3A myosin IIIA
NAIF1 nuclear apoptosis inducing factor 1
NALCN sodium leak channel, non selective
NAP1L3 nucleosome assembly protein 1-like 3
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NBEAL2 neurobeachin-like 2
NCOA3 nuclear receptor coactivator 3
NDC80 NDC80 kinetochore complex component
NEB nebulin
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NID2 nidogen 2 (osteonidogen)
NLRP7 NLR family, pyrin domain containing 7
NOX1 NADPH oxidase 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPAT nuclear protein, ataxia-telangiectasia locus
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NWD1 NACHT and WD repeat domain containing 1
NWD2 NACHT and WD repeat domain containing 2
OCA2 oculocutaneous albinism II
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPRM1 opioid receptor, mu 1
OR13G1 olfactory receptor, family 13, subfamily G, member 1
OR9G1 olfactory receptor, family 9, subfamily G, member 1
OSBPL5 oxysterol binding protein-like 5
OTOG otogelin
OTUD7A OTU deubiquitinase 7A
PALM2 paralemmin 2
PARD3 par-3 family cell polarity regulator
PARP10 poly (ADP-ribose) polymerase family, member 10
PCDHA7 protocadherin alpha 7
PCDHB3 protocadherin beta 3
PCLO piccolo presynaptic cytomatrix protein
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZD4 PDZ domain containing 4
PFKL phosphofructokinase, liver
PHF6 PHD finger protein 6
PHF7 PHD finger protein 7
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PKDREJ polycystin (PKD) family receptor for egg jelly
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLCG1 phospholipase C, gamma 1
PLEKHA8P1 pleckstrin homology domain containing, family A member 8 pseudogene 1
PLIN4 perilipin 4
PODNL1 podocan-like 1
POLR2M polymerase (RNA) II (DNA directed) polypeptide M
POM121L12 POM121 transmembrane nucleoporin-like 12
PPME1 protein phosphatase methylesterase 1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRB2 proline-rich protein BstNI subfamily 2
PRDM15 PR domain containing 15
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
PSD3 pleckstrin and Sec7 domain containing 3
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTEN phosphatase and tensin homolog
PTK2B protein tyrosine kinase 2 beta
PTPRM protein tyrosine phosphatase, receptor type, M
RAB18 RAB18, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RANBP3 RAN binding protein 3
RAP1GAP2 RAP1 GTPase activating protein 2
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RBM43 RNA binding motif protein 43
RBM46 RNA binding motif protein 46
RBP3 retinol binding protein 3, interstitial
REST RE1-silencing transcription factor
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RIOK2 RIO kinase 2
RORB RAR-related orphan receptor B
RTN4R reticulon 4 receptor
RYR1 ryanodine receptor 1 (skeletal)
SALL4 spalt-like transcription factor 4
SAMHD1 SAM domain and HD domain 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SELM selenoprotein M
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPT2 septin 2
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGSM1 small G protein signaling modulator 1
SH2B2 SH2B adaptor protein 2
SH3GL3 SH3-domain GRB2-like 3
SH3RF2 SH3 domain containing ring finger 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SI sucrase-isomaltase (alpha-glucosidase)
SIDT1 SID1 transmembrane family, member 1
SIX6 SIX homeobox 6
SKAP2 src kinase associated phosphoprotein 2
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
SLC25A52 solute carrier family 25, member 52
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC35F3 solute carrier family 35, member F3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNX5 sorting nexin 5
SORBS2 sorbin and SH3 domain containing 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPAG1 sperm associated antigen 1
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
STAB2 stabilin 2
STAMBPL1 STAM binding protein-like 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STXBP5L syntaxin binding protein 5-like
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3
SVIL supervillin
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYTL2 synaptotagmin-like 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TAL1 T-cell acute lymphocytic leukemia 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBCC tubulin folding cofactor C
TBCE tubulin folding cofactor E
TBPL2 TATA box binding protein like 2
TCERG1 transcription elongation regulator 1
TEAD4 TEA domain family member 4
TECRL trans-2,3-enoyl-CoA reductase-like
TET3 tet methylcytosine dioxygenase 3
TFDP3 transcription factor Dp family, member 3
TG thyroglobulin
THBS2 thrombospondin 2
THPO thrombopoietin
THRAP3 thyroid hormone receptor associated protein 3
THSD7B thrombospondin, type I, domain containing 7B
TICAM1 toll-like receptor adaptor molecule 1
TLN1 talin 1
TLR7 toll-like receptor 7
TLX2 T-cell leukemia homeobox 2
TMEM131 transmembrane protein 131
TMEM239 transmembrane protein 239
TMEM87B transmembrane protein 87B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNPO2 transportin 2
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast)
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TP53I11 tumor protein p53 inducible protein 11
TPRX1 tetra-peptide repeat homeobox 1
TRAPPC2 trafficking protein particle complex 2
TRIM49C tripartite motif containing 49C
TRIM68 tripartite motif containing 68
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TTC7B tetratricopeptide repeat domain 7B
TTN titin
TUBA4A tubulin, alpha 4a
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UNC13A unc-13 homolog A (C. elegans)
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
UTRN utrophin
VAX1 ventral anterior homeobox 1
VN1R4 vomeronasal 1 receptor 4
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VRTN vertebrae development associated
WDR1 WD repeat domain 1
WDR33 WD repeat domain 33
WDR72 WD repeat domain 72
WNK2 WNK lysine deficient protein kinase 2
WNT2 wingless-type MMTV integration site family member 2
XKRX XK, Kell blood group complex subunit-related, X-linked
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZFP28 ZFP28 zinc finger protein
ZNF17 zinc finger protein 17
ZNF180 zinc finger protein 180
ZNF213 zinc finger protein 213
ZNF227 zinc finger protein 227
ZNF274 zinc finger protein 274
ZNF283 zinc finger protein 283
ZNF33A zinc finger protein 33A
ZNF425 zinc finger protein 425
ZNF440 zinc finger protein 440
ZNF516 zinc finger protein 516
ZNF562 zinc finger protein 562
ZNF570 zinc finger protein 570
ZNF580 zinc finger protein 580
ZNF638 zinc finger protein 638
ZNF780B zinc finger protein 780B
ZNF84 zinc finger protein 84
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1