| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | potassium channel, inwardly rectifying subfamily J, member 11|Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 3767) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/3767 |
| Similar Terms | |
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22 interacting proteins for KCNJ11 from the Pathway Commons Protein-Protein Interactions dataset.
| Symbol | Name |
|---|---|
| ABCC8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 |
| ANK2 | ankyrin 2, neuronal |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 |
| KCNJ8 | potassium channel, inwardly rectifying subfamily J, member 8 |
| LDHA | lactate dehydrogenase A |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta |
| PRKACG | protein kinase, cAMP-dependent, catalytic, gamma |
| RAPGEF3 | Rap guanine nucleotide exchange factor (GEF) 3 |
| RAPGEF4 | Rap guanine nucleotide exchange factor (GEF) 4 |
| UBC | ubiquitin C |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
