KCNQ1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description potassium channel, voltage gated KQT-like subfamily Q, member 1|This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 3784)
External Link http://www.ncbi.nlm.nih.gov/gene/3784
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28 interacting proteins for KCNQ1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKAP9 A kinase (PRKA) anchor protein 9
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
CALM1 calmodulin 1 (phosphorylase kinase, delta)
GRB2 growth factor receptor-bound protein 2
HSPA4 heat shock 70kDa protein 4
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBC ubiquitin C
USP2 ubiquitin specific peptidase 2