KEAP1-NFE2L2 pathway Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-9755511
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Genes

113 proteins participating in the KEAP1-NFE2L2 pathway pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADRM1 adhesion regulating molecule 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMER1 APC membrane recruitment protein 1
AREG amphiregulin
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CUL1 cullin 1
CUL3 cullin 3
CXCL8 chemokine (C-X-C motif) ligand 8
DPP3 dipeptidyl-peptidase 3
EGF epidermal growth factor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EP300 E1A binding protein p300
FBXL17 F-box and leucine-rich repeat protein 17
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTA3 glutathione S-transferase alpha 3
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KEAP1 kelch-like ECH-associated protein 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
PALB2 partner and localizer of BRCA2
PDGFA platelet-derived growth factor alpha polypeptide
PGD phosphogluconate dehydrogenase
PRDX1 peroxiredoxin 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS27A ribosomal protein S27a
SEM1 SEM1 26S proteasome subunit
SESN1 sestrin 1
SESN2 sestrin 2
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD3 superoxide dismutase 3, extracellular
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
SRXN1 sulfiredoxin 1
TALDO1 transaldolase 1
TKT transketolase
TRIM21 tripartite motif containing 21
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UFD1 ubiquitin recognition factor in ER associated degradation 1
VCP valosin containing protein
WIPF1 WAS/WASL interacting protein family, member 1