KEAP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description kelch-like ECH-associated protein 1|This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9817)
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Genes

338 genes differentially expressed following the KEAP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ISM2 isthmin 2 3.08859
NANOS2 nanos homolog 2 (Drosophila) 3.08859
SLC35G6 solute carrier family 35, member G6 3.08859
RAB1B RAB1B, member RAS oncogene family 3.08859
PKP1 plakophilin 1 3.08859
HORMAD1 HORMA domain containing 1 3.08859
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.08859
UMOD uromodulin 3.08859
TMEM191B transmembrane protein 191B 3.08859
GJB4 gap junction protein, beta 4, 30.3kDa 3.08859
CSTL1 cystatin-like 1 3.08859
CELF3 CUGBP, Elav-like family member 3 3.08859
ENTHD1 ENTH domain containing 1 3.08859
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.08859
TSSK4 testis-specific serine kinase 4 3.08859
CFHR4 complement factor H-related 4 3.08859
COL20A1 collagen, type XX, alpha 1 3.08859
SELPLG selectin P ligand 3.08859
USP26 ubiquitin specific peptidase 26 3.08859
SCGN secretagogin, EF-hand calcium binding protein 3.08859
GPR55 G protein-coupled receptor 55 3.08859
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.08859
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.08859
SYCP3 synaptonemal complex protein 3 3.08859
OLFM4 olfactomedin 4 3.08859
TAS2R13 taste receptor, type 2, member 13 3.08859
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 3.08859
MYO1G myosin IG 3.08859
CPLX4 complexin 4 3.08859
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.08859
SPAG6 sperm associated antigen 6 3.08859
KIAA1755 KIAA1755 3.08859
EPHB3 EPH receptor B3 3.08859
FGF9 fibroblast growth factor 9 3.08859
PRSS21 protease, serine, 21 (testisin) 3.08859
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.08859
NPIPA8 nuclear pore complex interacting protein family, member A8 3.08859
RSPO1 R-spondin 1 3.08859
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.08859
MYOM2 myomesin 2 3.08859
ANKRD34A ankyrin repeat domain 34A 3.08859
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.08859
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.08859
OCM2 oncomodulin 2 3.08859
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.08859
F2 coagulation factor II (thrombin) 3.08859
OC90 otoconin 90 3.08859
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.08859
SPMAP1 sperm microtubule associated protein 1 3.08859
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.08859
CAPN9 calpain 9 3.08859
RD3 retinal degeneration 3 3.08859
STX11 syntaxin 11 3.08859
PKD2L1 polycystic kidney disease 2-like 1 3.08859
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.08859
ADRB3 adrenoceptor beta 3 3.08859
MYEOV myeloma overexpressed 3.08859
SPATA25 spermatogenesis associated 25 3.08859
MAGIX MAGI family member, X-linked 3.08859
OTOA otoancorin 3.08859
NSG2 neuronal vesicle trafficking associated 2 3.08859
EXOC1L exocyst complex component 1 like 3.08859
STRIT1 small transmembrane regulator of ion transport 1 3.08859
WASL-DT WASL divergent transcript 3.08859
LOC124902436 talanin 3.08859
CIBAR2 CBY1 interacting BAR domain containing 2 3.08859
CCDC190 coiled-coil domain containing 190 3.08859
RTL5 retrotransposon Gag like 5 3.08859
CRACDL CRACD like 3.08859
G6PC1 glucose-6-phosphatase catalytic subunit 1 3.08859
LORICRIN loricrin cornified envelope precursor protein 3.08859
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 3.08859
F5 coagulation factor V (proaccelerin, labile factor) 3.08859
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.08859
SIM2 single-minded family bHLH transcription factor 2 3.08859
ANXA13 annexin A13 3.08859
AKR1D1 aldo-keto reductase family 1, member D1 3.08859
PYDC1 PYD (pyrin domain) containing 1 3.08859
IRF5 interferon regulatory factor 5 3.08859
MAGEB1 melanoma antigen family B1 3.08859
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.08859
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.08859
RHOXF2 Rhox homeobox family, member 2 3.08859
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.08859
SPDYC speedy/RINGO cell cycle regulator family member C 3.08859
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.08859
CNTN6 contactin 6 3.08859
LRRN4CL LRRN4 C-terminal like 3.08859
LTB lymphotoxin beta (TNF superfamily, member 3) 3.08859
IL16 interleukin 16 3.08859
C6 complement component 6 3.08859
C7ORF57 chromosome 7 open reading frame 57 3.08859
PLB1 phospholipase B1 3.08859
UTS2 urotensin 2 3.08859
GJD4 gap junction protein, delta 4, 40.1kDa 3.08859
IL12RB1 interleukin 12 receptor, beta 1 3.08859
HRG histidine-rich glycoprotein 3.08859
CDH10 cadherin 10, type 2 (T2-cadherin) 3.08859
MATN3 matrilin 3 3.08859
A3GALT2 alpha 1,3-galactosyltransferase 2 3.08859
APOD apolipoprotein D 3.08859
TTBK1 tau tubulin kinase 1 3.08859
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.08859
FGR FGR proto-oncogene, Src family tyrosine kinase 3.08859
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.08859
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.08859
BCL2A1 BCL2-related protein A1 3.08859
CTSW cathepsin W 3.08859
KRT17 keratin 17, type I 3.08859
ZMYND10 zinc finger, MYND-type containing 10 3.08859
PRSS50 protease, serine, 50 3.08859
SH2D1B SH2 domain containing 1B 3.08859
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.08859
HMGB4 high mobility group box 4 3.08859
TMEM132D transmembrane protein 132D 3.08859
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.08859
RSAD2 radical S-adenosyl methionine domain containing 2 3.08859
TREH trehalase (brush-border membrane glycoprotein) 3.08859
CGB1 chorionic gonadotropin, beta polypeptide 1 3.08859
DRD3 dopamine receptor D3 3.08859
EVPLL envoplakin-like 3.08859
IL1A interleukin 1, alpha 3.08859
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.08859
ADAMDEC1 ADAM-like, decysin 1 3.08859
TEKT2 tektin 2 (testicular) 3.08859
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.08859
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.08859
GP2 glycoprotein 2 (zymogen granule membrane) 3.08859
ZNF596 zinc finger protein 596 3.08859
CFAP47 cilia and flagella associated protein 47 3.08859
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.08859
CT55 cancer/testis antigen 55 3.08859
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3.08859
SLITRK6 SLIT and NTRK-like family, member 6 3.08859
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.08859
PADI4 peptidyl arginine deiminase, type IV 3.08859
NLRP7 NLR family, pyrin domain containing 7 3.08859
LMX1B LIM homeobox transcription factor 1, beta 3.08859
EFCAB3 EF-hand calcium binding domain 3 3.08859
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.08859
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.08859
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.08859
SSTR1 somatostatin receptor 1 3.08859
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.08859
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.08859
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.08859
ASCL1 achaete-scute family bHLH transcription factor 1 3.08859
BOD1L2 biorientation of chromosomes in cell division 1-like 2 3.08859
RDH16 retinol dehydrogenase 16 (all-trans) 3.08859
AMIGO3 adhesion molecule with Ig-like domain 3 3.08859
ADAM18 ADAM metallopeptidase domain 18 3.08859
MOBP myelin-associated oligodendrocyte basic protein 3.08859
ORM1 orosomucoid 1 3.08859
SLC25A34 solute carrier family 25, member 34 3.08859
IGIP IgA-inducing protein 3.08859
POTEJ POTE ankyrin domain family, member J 3.08859
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.08859
HHIPL2 HHIP-like 2 3.08859
DMRTC2 DMRT-like family C2 3.08859
AZU1 azurocidin 1 3.08859
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 3.08859
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.08859
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.08859
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.08859
SUMF2 sulfatase modifying factor 2 3.00774
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.99918
PTX3 pentraxin 3, long 2.99918
FAM240C family with sequence similarity 240 member C 2.99918
PCDHB4 protocadherin beta 4 2.98235
XKR6 XK, Kell blood group complex subunit-related family, member 6 2.74928
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.73643
FTL ferritin, light polypeptide 2.72765
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.71497
ADPRHL1 ADP-ribosylhydrolase like 1 2.70698
NQO1 NAD(P)H dehydrogenase, quinone 1 2.70698
KCNK17 potassium channel, two pore domain subfamily K, member 17 2.6374
CAVIN1 caveolae associated protein 1 2.58125
NRCAM neuronal cell adhesion molecule 2.53646
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.50655
C2ORF42 chromosome 2 open reading frame 42 2.49397
TIMELESS timeless circadian clock 2.49238
KPNB1 karyopherin (importin) beta 1 2.42921
SP3 Sp3 transcription factor 2.40985
APP-DT APP divergent transcript 2.40086
JARID2 jumonji, AT rich interactive domain 2 2.38111
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 2.38056
TBP TATA box binding protein 2.37934
PNMA2 paraneoplastic Ma antigen 2 2.37207
BMP6 bone morphogenetic protein 6 2.33775
KCTD12 potassium channel tetramerization domain containing 12 2.33344
ZBTB44 zinc finger and BTB domain containing 44 2.33344
SKI SKI proto-oncogene 2.33034
NOL4L nucleolar protein 4-like 2.32539
BRDT bromodomain, testis-specific 2.29754
GBX2 gastrulation brain homeobox 2 2.29754
DMTF1 cyclin D binding myb-like transcription factor 1 2.26349
ZNHIT3 zinc finger, HIT-type containing 3 2.26163
LUC7L LUC7-like (S. cerevisiae) 2.24304
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.23144
GPRIN3 GPRIN family member 3 2.23144
CHMP4A charged multivesicular body protein 4A 2.23144
ATP5MC3 ATP synthase membrane subunit c locus 3 2.23144
SERINC1 serine incorporator 1 2.2309
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog 2.22424
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.21266
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2.21266
KCTD6 potassium channel tetramerization domain containing 6 2.21247
SNTG2 syntrophin, gamma 2 2.20431
MYO1B myosin IB 2.18763
ZNF398 zinc finger protein 398 2.16842
GTSE1 G-2 and S-phase expressed 1 2.15374
ODAD4 outer dynein arm docking complex subunit 4 2.15374
TNIP1 TNFAIP3 interacting protein 1 2.13414
PLD2 phospholipase D2 2.13267
MICA MHC class I polypeptide-related sequence A 2.13258
SH3BP4 SH3-domain binding protein 4 2.11825
LRRN2 leucine rich repeat neuronal 2 2.1144
ZIC5 Zic family member 5 2.10246
TMPO thymopoietin 2.10246
MAML3 mastermind-like 3 (Drosophila) 2.0892
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.0892
TSPAN16 tetraspanin 16 2.06316
TMPRSS4 transmembrane protease, serine 4 2.06316
ZFP3 ZFP3 zinc finger protein 2.06316
EFHB EF-hand domain family, member B 2.06316
FCRL5 Fc receptor-like 5 2.06316
SYNRG synergin, gamma 2.06089
LRRC3B leucine rich repeat containing 3B 2.05635
TRABD2A TraB domain containing 2A 2.03556
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 2.02365
TULP2 tubby like protein 2 2.02138
IPCEF1 interaction protein for cytohesin exchange factors 1 2.00612
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.00446
UBXN2A UBX domain protein 2A 2.00134

decreased expression

Symbol Name Standardized Value
KIF12 kinesin family member 12 -3.08859
TPRN taperin -3.08859
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -3.08859
NDOR1 NADPH dependent diflavin oxidoreductase 1 -3.08859
KPNA7 karyopherin alpha 7 (importin alpha 8) -3.08859
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -3.08859
SLA2 Src-like-adaptor 2 -3.08859
CAPN11 calpain 11 -3.08859
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.08859
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -3.08859
MST1 macrophage stimulating 1 -3.08859
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.08859
WAS Wiskott-Aldrich syndrome -3.08859
CRYGN crystallin, gamma N -3.08859
ZNF878 zinc finger protein 878 -3.08859
TDRD6 tudor domain containing 6 -3.08859
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -3.08859
IGFL4 IGF-like family member 4 -3.08859
PI15 peptidase inhibitor 15 -3.08859
TMIE transmembrane inner ear -3.08859
AQP8 aquaporin 8 -3.08859
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -3.08859
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -3.08859
DNAAF8 dynein axonemal assembly factor 8 -3.08859
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 -3.08859
LYPD5 LY6/PLAUR domain containing 5 -3.08859
RNF227 ring finger protein 227 -3.08859
LOC124906010 uncharacterized LOC124906010 -3.08859
BCL6 B-cell CLL/lymphoma 6 -3.08859
ACE angiotensin I converting enzyme -3.08859
CCDC121 coiled-coil domain containing 121 -3.08859
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -3.08859
ESR1 estrogen receptor 1 -3.08859
ZNF575 zinc finger protein 575 -3.08859
DOT1L DOT1-like histone H3K79 methyltransferase -3.00774
ZNF823 zinc finger protein 823 -2.88723
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.85956
ZSWIM8 zinc finger, SWIM-type containing 8 -2.85718
ZNF79 zinc finger protein 79 -2.74928
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -2.73039
VASP vasodilator-stimulated phosphoprotein -2.71854
PPP1R3D protein phosphatase 1, regulatory subunit 3D -2.712
CCNDBP1 cyclin D-type binding-protein 1 -2.70698
METTL5 methyltransferase like 5 -2.64878
TLL1 tolloid-like 1 -2.61637
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -2.592
INPP5F inositol polyphosphate-5-phosphatase F -2.56643
MAD2L1BP MAD2L1 binding protein -2.53646
MMP14 matrix metallopeptidase 14 (membrane-inserted) -2.52135
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.49238
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.48729
PADI3 peptidyl arginine deiminase, type III -2.47839
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.47839
H2BC12 H2B clustered histone 12 -2.45831
CA14 carbonic anhydrase XIV -2.43895
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 -2.43283
ZRANB3 zinc finger, RAN-binding domain containing 3 -2.41073
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.39319
S100A13 S100 calcium binding protein A13 -2.39172
SNCAIP synuclein, alpha interacting protein -2.35817
TUSC3 tumor suppressor candidate 3 -2.29754
MTRF1L mitochondrial translational release factor 1-like -2.29354
KREMEN2 kringle containing transmembrane protein 2 -2.29233
TUBA1B tubulin, alpha 1b -2.25448
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.25448
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.23925
IER3IP1 immediate early response 3 interacting protein 1 -2.23861
PRMT9 protein arginine methyltransferase 9 -2.23144
TMEM196 transmembrane protein 196 -2.2309
INO80 INO80 complex subunit -2.22292
XG Xg blood group -2.21266
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.21001
GGPS1 geranylgeranyl diphosphate synthase 1 -2.20784
SSB Sjogren syndrome antigen B (autoantigen La) -2.19292
FAAP100 FA core complex associated protein 100 -2.15374
HFE hemochromatosis -2.15301
YJU2 YJU2 splicing factor homolog -2.15301
AGER advanced glycosylation end product-specific receptor -2.15301
PLK5 polo-like kinase 5 -2.15301
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.14646
FBRSL1 fibrosin-like 1 -2.13414
NAV2 neuron navigator 2 -2.13414
KIFBP kinesin family binding protein -2.11825
ADD1 adducin 1 (alpha) -2.11825
SYNM synemin, intermediate filament protein -2.1143
TIPIN TIMELESS interacting protein -2.10658
REEP2 receptor accessory protein 2 -2.10246
INPP5K inositol polyphosphate-5-phosphatase K -2.10243
HPSE2 heparanase 2 (inactive) -2.09861
ZNF446 zinc finger protein 446 -2.0892
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.07104
FAM107A family with sequence similarity 107, member A -2.06316
ANGPT4 angiopoietin 4 -2.06316
PON3 paraoxonase 3 -2.06316
ASPG asparaginase -2.06316
INHBA inhibin, beta A -2.06316
ENHO energy homeostasis associated -2.06089
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.04717
DRC9 dynein regulatory complex subunit 9 -2.03487
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -2.03447
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.03228
CHRM5 cholinergic receptor, muscarinic 5 -2.02675
CEP76 centrosomal protein 76kDa -2.02149
MYT1L myelin transcription factor 1-like -2.00612