KISS1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description KiSS-1 metastasis-suppressor|This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 3814)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_KISS1
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Genes

48 co-expressed genes for KISS1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ALPP alkaline phosphatase, placental
CAPN6 calpain 6
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CRH corticotropin releasing hormone
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
EBI3 Epstein-Barr virus induced 3
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
ENDOU endonuclease, polyU-specific
FBN2 fibrillin 2
GCM1 glial cells missing homolog 1 (Drosophila)
GDF15 growth differentiation factor 15
GH2 growth hormone 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IGFBP1 insulin-like growth factor binding protein 1
INSL4 insulin-like 4 (placenta)
KISS1 KiSS-1 metastasis-suppressor
LEP leptin
LGALS13 lectin, galactoside-binding, soluble, 13
LGALS14 lectin, galactoside-binding, soluble, 14
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MMP11 matrix metallopeptidase 11
PAGE4 P antigen family, member 4 (prostate associated)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PLAC1 placenta-specific 1
PLAC4 placenta-specific 4
PSG1 pregnancy specific beta-1-glycoprotein 1
PSG2 pregnancy specific beta-1-glycoprotein 2
PSG3 pregnancy specific beta-1-glycoprotein 3
PSG4 pregnancy specific beta-1-glycoprotein 4
PSG5 pregnancy specific beta-1-glycoprotein 5
PSG6 pregnancy specific beta-1-glycoprotein 6
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PSG9 pregnancy specific beta-1-glycoprotein 9
RHOBTB1 Rho-related BTB domain containing 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC16A4 solute carrier family 16, member 4
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAC3 tachykinin 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP2 TIMP metallopeptidase inhibitor 2
VGLL1 vestigial-like family member 1