KIT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog|This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3815)
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Genes

346 genes differentially expressed following the KIT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CALR3 calreticulin 3 3.98357
IGIP IgA-inducing protein 3.98357
MORC1 MORC family CW-type zinc finger 1 3.98357
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.98357
COL20A1 collagen, type XX, alpha 1 3.98357
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.98357
LMNTD2 lamin tail domain containing 2 3.98357
IL18R1 interleukin 18 receptor 1 3.98357
IRGM immunity-related GTPase family, M 3.98357
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 3.98357
TECRL trans-2,3-enoyl-CoA reductase-like 3.98357
DRP2 dystrophin related protein 2 3.98357
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.98357
LIME1 Lck interacting transmembrane adaptor 1 3.98357
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.98357
PADI4 peptidyl arginine deiminase, type IV 3.98357
PCDHGB1 protocadherin gamma subfamily B, 1 3.98357
UPK1B uroplakin 1B 3.98357
GPR52 G protein-coupled receptor 52 3.98357
APOA1 apolipoprotein A-I 3.98357
LYG2 lysozyme G-like 2 3.98357
NIM1K NIM1 serine/threonine protein kinase 3.98357
IFITM10 interferon induced transmembrane protein 10 3.98357
ARL13A ADP-ribosylation factor-like 13A 3.98357
AKR1C2 aldo-keto reductase family 1, member C2 3.97601
CSMD3 CUB and Sushi multiple domains 3 3.97601
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.97601
WDR87 WD repeat domain 87 3.97601
TM4SF4 transmembrane 4 L six family member 4 3.97601
CELF6 CUGBP, Elav-like family member 6 3.97601
PAX8 paired box 8 3.97601
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.97601
PLIN4 perilipin 4 3.97601
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.97601
ADRB2 adrenoceptor beta 2, surface 3.97601
SLC25A41 solute carrier family 25, member 41 3.97601
SIRPB1 signal-regulatory protein beta 1 3.97601
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.97601
TRIM74 tripartite motif containing 74 3.97601
GALR2 galanin receptor 2 3.97601
MYL7 myosin, light chain 7, regulatory 3.97601
TPPP tubulin polymerization promoting protein 3.97601
KCNU1 potassium channel, subfamily U, member 1 3.97601
RTP3 receptor (chemosensory) transporter protein 3 3.97601
LRG1 leucine-rich alpha-2-glycoprotein 1 3.97601
FGF6 fibroblast growth factor 6 3.97601
FGF9 fibroblast growth factor 9 3.97601
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.97601
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.97601
BMP3 bone morphogenetic protein 3 3.97601
AVP arginine vasopressin 3.97601
UNC45B unc-45 homolog B (C. elegans) 3.97601
OR1L6 olfactory receptor, family 1, subfamily L, member 6 3.97601
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.97601
LRRC10B leucine rich repeat containing 10B 3.97601
FAM229A family with sequence similarity 229, member A 3.97601
FAM89A family with sequence similarity 89, member A 3.97601
ACVRL1 activin A receptor type II-like 1 3.97601
GMNC geminin coiled-coil domain containing 3.97601
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.97601
SFTPB surfactant protein B 3.97601
SMIM39 small integral membrane protein 39 3.97601
GIPC3 GIPC PDZ domain containing family, member 3 3.97601
HAO2 hydroxyacid oxidase 2 (long chain) 3.97601
GBP2 guanylate binding protein 2, interferon-inducible 3.97601
UNC93A unc-93 homolog A (C. elegans) 3.97601
CXCL13 chemokine (C-X-C motif) ligand 13 3.97601
FMO3 flavin containing monooxygenase 3 3.97601
ANO3 anoctamin 3 3.97601
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.97601
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.97601
ANGPTL8 angiopoietin like 8 3.97601
STYXL2 serine/threonine/tyrosine interacting like 2 3.97601
MISP3 MISP family member 3 3.97601
HTD2 hydroxyacyl-thioester dehydratase type 2 3.97601
SPATA31F3 SPATA31 subfamily F member 3 3.97601
C19ORF85 chromosome 19 open reading frame 85 3.97601
H4C14 H4 clustered histone 14 3.97601
GSG1L2 GSG1 like 2 3.97601
TMEM225B transmembrane protein 225B 3.97601
ATP5MGL ATP synthase membrane subunit g like 3.97601
DUSP29 dual specificity phosphatase 29 3.97601
PLPP4 phospholipid phosphatase 4 3.97601
SMIM38 small integral membrane protein 38 3.97601
SMIM41 small integral membrane protein 41 3.97601
GATA6 GATA binding protein 6 3.97601
PRDM6 PR domain containing 6 3.97601
CSAG3 CSAG family, member 3 3.97601
AKR1D1 aldo-keto reductase family 1, member D1 3.97601
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.97601
CCDC13 coiled-coil domain containing 13 3.97601
RHOXF2 Rhox homeobox family, member 2 3.97601
ACTL8 actin-like 8 3.97601
ZNF436 zinc finger protein 436 3.97601
ATP13A4 ATPase type 13A4 3.97601
USH1G Usher syndrome 1G (autosomal recessive) 3.97601
GPR75 G protein-coupled receptor 75 3.97601
SIX3 SIX homeobox 3 3.97601
GOLGA7B golgin A7 family, member B 3.97601
DMBX1 diencephalon/mesencephalon homeobox 1 3.97601
IL4 interleukin 4 3.97601
CNTN5 contactin 5 3.97601
BEST1 bestrophin 1 3.97601
ARMC12 armadillo repeat containing 12 3.97601
C7 complement component 7 3.97601
CNTFR ciliary neurotrophic factor receptor 3.97601
OR2L8 olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene) 3.97601
OR2L5 olfactory receptor, family 2, subfamily L, member 5 3.97601
HSPB6 heat shock protein, alpha-crystallin-related, B6 3.97601
GDF10 growth differentiation factor 10 3.97601
ADGRG1 adhesion G protein-coupled receptor G1 3.97601
CST11 cystatin 11 3.97601
TTBK1 tau tubulin kinase 1 3.97601
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 3.97601
TBC1D10C TBC1 domain family, member 10C 3.97601
ADAM2 ADAM metallopeptidase domain 2 3.97601
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.97601
APOC2 apolipoprotein C-II 3.97601
CYS1 cystin 1 3.97601
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 3.97601
NUPR1 nuclear protein, transcriptional regulator, 1 3.97601
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.97601
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.97601
KLHL6 kelch-like family member 6 3.97601
APOH apolipoprotein H (beta-2-glycoprotein I) 3.97601
CCL25 chemokine (C-C motif) ligand 25 3.97601
IFNL4 interferon, lambda 4 (gene/pseudogene) 3.97601
GAGE10 G antigen 10 3.97601
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.97601
LCT lactase 3.97601
AMIGO1 adhesion molecule with Ig-like domain 1 3.97601
CSTA cystatin A (stefin A) 3.97601
CST7 cystatin F (leukocystatin) 3.97601
DHH desert hedgehog 3.97601
SST somatostatin 3.97601
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 3.97601
LRRN4 leucine rich repeat neuronal 4 3.97601
TEX29 testis expressed 29 3.97601
ZPBP zona pellucida binding protein 3.97601
NPM2 nucleophosmin/nucleoplasmin 2 3.97601
GOLGA8N golgin A8 family, member N 3.97601
GOLGA8O golgin A8 family, member O 3.97601
GOLGA8R golgin A8 family, member R 3.97601
UPK1A uroplakin 1A 3.97601
LGALS14 lectin, galactoside-binding, soluble, 14 3.97601
PFN4 profilin family, member 4 3.97601
ZNF843 zinc finger protein 843 3.97601
FSHR follicle stimulating hormone receptor 3.97601
ART1 ADP-ribosyltransferase 1 3.97601
ZC3H12D zinc finger CCCH-type containing 12D 3.97601
TPPP3 tubulin polymerization-promoting protein family member 3 3.97601
CRHBP corticotropin releasing hormone binding protein 3.97601
OTOP2 otopetrin 2 3.97601
CTSW cathepsin W 3.97601
CA5A carbonic anhydrase VA, mitochondrial 3.97601
CRTAM cytotoxic and regulatory T cell molecule 3.97601
PODN podocan 3.97601
ITLN2 intelectin 2 3.97601
C5AR2 complement component 5a receptor 2 3.97601
CARD6 caspase recruitment domain family, member 6 3.97601
MAEL maelstrom spermatogenic transposon silencer 3.97601
EPX eosinophil peroxidase 3.97601
DAND5 DAN domain family member 5, BMP antagonist 3.97601
LRRC74B leucine rich repeat containing 74B 3.97601
MNX1 motor neuron and pancreas homeobox 1 3.97601
PPY pancreatic polypeptide 3.97601
SNTN sentan, cilia apical structure protein 3.97601
IFNE interferon, epsilon 3.97601
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.97601
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.97601
MYOZ1 myozenin 1 3.97601
KIF19 kinesin family member 19 3.97601
WFDC13 WAP four-disulfide core domain 13 3.97601
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.97601
AGR3 anterior gradient 3 3.97601
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.97601
DYTN dystrotelin 3.97601
SHOX short stature homeobox 3.97601
ADAM11 ADAM metallopeptidase domain 11 3.85067
PDE7B phosphodiesterase 7B 3.63367
FMN1 formin 1 3.48129
FIGNL1 fidgetin-like 1 3.39852
TSSC4 tumor suppressing subtransferable candidate 4 3.38376
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.1906
METAP1 methionyl aminopeptidase 1 3.11512
NKRF NFKB repressing factor 3.02715
PAPOLG poly(A) polymerase gamma 2.94064
WDR93 WD repeat domain 93 2.90706
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 2.89738
LNX2 ligand of numb-protein X 2 2.87803
ZBTB8A zinc finger and BTB domain containing 8A 2.8058
TSLP thymic stromal lymphopoietin 2.78358
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.78358
CNTN2 contactin 2 (axonal) 2.78358
SGK2 serum/glucocorticoid regulated kinase 2 2.78358
IAPP islet amyloid polypeptide 2.78358
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.70538
TMEM39A transmembrane protein 39A 2.66835
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 2.66835
SLC66A3 solute carrier family 66 member 3 2.63728
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 2.59137
TXNDC17 thioredoxin domain containing 17 2.51693
ACLY ATP citrate lyase 2.47034
ZNF585B zinc finger protein 585B 2.47034
AKIRIN1 akirin 1 2.45339
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.45339
TRMT6 tRNA methyltransferase 6 2.44522
GDE1 glycerophosphodiester phosphodiesterase 1 2.44322
MAT2A methionine adenosyltransferase II, alpha 2.41788
RPL18A ribosomal protein L18a 2.41631
FAM219B family with sequence similarity 219, member B 2.40662
MZT2A mitotic spindle organizing protein 2A 2.39553
CLIC1 chloride intracellular channel 1 2.3807
PPCDC phosphopantothenoylcysteine decarboxylase 2.36217
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.35558
CMTR2 cap methyltransferase 2 2.29569
TMEM255A transmembrane protein 255A 2.29258
IQCB1 IQ motif containing B1 2.28862
MGAM maltase-glucoamylase 2.28862
REPIN1 replication initiator 1 2.26457
MRS2 MRS2 magnesium transporter 2.26457
FLACC1 flagellum associated containing coiled-coil domains 1 2.25949
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 2.2483
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.2483
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.2483
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.2483
INO80 INO80 complex subunit 2.21991
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.2115
FTL ferritin, light polypeptide 2.17751
ZNF69 zinc finger protein 69 2.16949
PREP prolyl endopeptidase 2.15095
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.10654
PHLDB1 pleckstrin homology-like domain, family B, member 1 2.10654
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2.09983
CERS6 ceramide synthase 6 2.06898
RAD1 RAD1 checkpoint DNA exonuclease 2.05069
ZNF536 zinc finger protein 536 2.04352
ZBTB39 zinc finger and BTB domain containing 39 2.03032
DCDC2C doublecortin domain containing 2C 2.01688

decreased expression

Symbol Name Standardized Value
BHLHE41 basic helix-loop-helix family, member e41 -3.98357
EID3 EP300 interacting inhibitor of differentiation 3 -3.98357
CIMAP2 ciliary microtubule associated protein 2 -3.98357
SNAP25 synaptosomal-associated protein, 25kDa -3.98357
C12ORF42 chromosome 12 open reading frame 42 -3.98357
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -3.98357
CATSPERT catsper channel auxiliary subunit tau -3.97601
PCDHGB4 protocadherin gamma subfamily B, 4 -3.97601
CCDC158 coiled-coil domain containing 158 -3.97601
MAMLD1 mastermind-like domain containing 1 -3.97601
CXCR4 chemokine (C-X-C motif) receptor 4 -3.97601
HSPA1L heat shock 70kDa protein 1-like -3.97601
STAB1 stabilin 1 -3.97601
STMND1 stathmin domain containing 1 -3.97601
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -3.97601
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -3.97601
MIXL1 Mix paired-like homeobox -3.97601
SLC16A6 solute carrier family 16, member 6 -3.97601
RIMBP2 RIMS binding protein 2 -3.97601
PCDHB4 protocadherin beta 4 -3.97601
LGALS9 lectin, galactoside-binding, soluble, 9 -3.97601
GJA5 gap junction protein, alpha 5, 40kDa -3.97601
ACOT12 acyl-CoA thioesterase 12 -3.97601
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -3.97601
ADGRD1 adhesion G protein-coupled receptor D1 -3.97601
RASL11A RAS-like, family 11, member A -3.97601
CD27 CD27 molecule -3.97601
USP35 ubiquitin specific peptidase 35 -3.97601
MAOA monoamine oxidase A -3.97601
MOG myelin oligodendrocyte glycoprotein -3.97601
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -3.97601
C2ORF72 chromosome 2 open reading frame 72 -3.97601
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.97601
BHMT betaine--homocysteine S-methyltransferase -3.97601
ZDHHC11B zinc finger, DHHC-type containing 11B -3.97601
DCDC2B doublecortin domain containing 2B -3.97601
CNGB3 cyclic nucleotide gated channel beta 3 -3.97601
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -3.91611
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -3.80683
IRAK2 interleukin-1 receptor-associated kinase 2 -3.54488
TMTC3 transmembrane and tetratricopeptide repeat containing 3 -2.99003
ACHE acetylcholinesterase (Yt blood group) -2.84994
FAM24B family with sequence similarity 24, member B -2.84994
ELP6 elongator acetyltransferase complex subunit 6 -2.68285
ZNF385B zinc finger protein 385B -2.67105
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.66835
TXNRD1 thioredoxin reductase 1 -2.65854
MTMR1 myotubularin related protein 1 -2.61474
MYO15A myosin XVA -2.51693
DEPDC1 DEP domain containing 1 -2.50695
FANCE Fanconi anemia, complementation group E -2.49757
PCYT1B phosphate cytidylyltransferase 1, choline, beta -2.47637
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.47523
ZNF335 zinc finger protein 335 -2.47034
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.45615
ZNF222 zinc finger protein 222 -2.45615
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -2.44305
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.42297
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein -2.41742
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.38973
STBD1 starch binding domain 1 -2.37279
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.37279
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.36691
REXO5 RNA exonuclease 5 -2.36691
ALPK1 alpha-kinase 1 -2.36691
ATP5MC2 ATP synthase membrane subunit c locus 2 -2.36691
LONP1 lon peptidase 1, mitochondrial -2.36691
TMOD4 tropomodulin 4 (muscle) -2.35731
ZBTB12 zinc finger and BTB domain containing 12 -2.35731
HHIPL1 HHIP-like 1 -2.35731
HRC histidine rich calcium binding protein -2.35731
CHGB chromogranin B -2.35731
WDR45B WD repeat domain 45B -2.33615
NOVA2 neuro-oncological ventral antigen 2 -2.33615
WSCD2 WSC domain containing 2 -2.32961
PTGES2 prostaglandin E synthase 2 -2.31472
EDNRA endothelin receptor type A -2.31472
SP110 SP110 nuclear body protein -2.31131
ARHGAP32 Rho GTPase activating protein 32 -2.30603
NUP54 nucleoporin 54kDa -2.28862
FAF2 Fas associated factor family member 2 -2.2682
CEP76 centrosomal protein 76kDa -2.26488
DGKI diacylglycerol kinase, iota -2.25949
ZBTB24 zinc finger and BTB domain containing 24 -2.2418
ANGPTL1 angiopoietin-like 1 -2.2418
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.22979
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.19468
ZNF592 zinc finger protein 592 -2.18831
MYO1E myosin IE -2.17795
ANO5 anoctamin 5 -2.16147
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.1225
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 -2.10654
RSL1D1 ribosomal L1 domain containing 1 -2.10302
FRAS1 Fraser extracellular matrix complex subunit 1 -2.09494
C11ORF58 chromosome 11 open reading frame 58 -2.08981
BRCA1 breast cancer 1, early onset -2.08981
AGFG1 ArfGAP with FG repeats 1 -2.05069
C12ORF56 chromosome 12 open reading frame 56 -2.04672
MTLN mitoregulin -2.04354
PDE7A phosphodiesterase 7A -2.04354
CLCN2 chloride channel, voltage-sensitive 2 -2.01688
TRMO tRNA methyltransferase O -2.01688
GRK2 G protein-coupled receptor kinase 2 -2.01688
DTX2 deltex 2, E3 ubiquitin ligase -2.01227
FOXL2 forkhead box L2 -2.00333
SAP30L SAP30-like -2.00333
NOL11 nucleolar protein 11 -2.00136