KLF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Kruppel-like factor 2|Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011] (NCBI Entrez Gene Database, 10365)
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Genes

363 genes differentially expressed following the KLF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ELOA2 elongin A2 2.97958
RSPO3 R-spondin 3 2.97958
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.97958
WNT16 wingless-type MMTV integration site family, member 16 2.97958
SYCP1 synaptonemal complex protein 1 2.97958
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.97958
MAGIX MAGI family member, X-linked 2.97958
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.97958
TDRD6 tudor domain containing 6 2.97958
DAND5 DAN domain family member 5, BMP antagonist 2.97958
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.97958
BTNL9 butyrophilin-like 9 2.97958
MAMLD1 mastermind-like domain containing 1 2.97958
CYS1 cystin 1 2.97958
KLF4 Kruppel-like factor 4 (gut) 2.97958
SIX1 SIX homeobox 1 2.97958
PMP2 peripheral myelin protein 2 2.97958
IGFL4 IGF-like family member 4 2.97958
ANGPTL5 angiopoietin-like 5 2.97958
NIM1K NIM1 serine/threonine protein kinase 2.97958
ACRBP acrosin binding protein 2.97958
ADRA1B adrenoceptor alpha 1B 2.97958
HRG histidine-rich glycoprotein 2.97958
IZUMO3 IZUMO family member 3 2.97958
ARHGAP36 Rho GTPase activating protein 36 2.93218
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.93218
ASB17 ankyrin repeat and SOCS box containing 17 2.93218
FFAR4 free fatty acid receptor 4 2.93218
OSR2 odd-skipped related transciption factor 2 2.93218
CD1C CD1c molecule 2.93218
TSGA13 testis specific, 13 2.93218
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.93218
NCF1 neutrophil cytosolic factor 1 2.93218
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.93218
MILR1 mast cell immunoglobulin-like receptor 1 2.93218
TM4SF1 transmembrane 4 L six family member 1 2.93218
TMEM151A transmembrane protein 151A 2.93218
ASB14 ankyrin repeat and SOCS box containing 14 2.93218
RPE65 retinal pigment epithelium-specific protein 65kDa 2.93218
MUC22 mucin 22 2.93218
BMP5 bone morphogenetic protein 5 2.93218
LOC124900192 uncharacterized LOC124900192 2.93218
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.93218
ATG4A autophagy related 4A, cysteine peptidase 2.93218
HMX3 H6 family homeobox 3 2.93218
DSPP dentin sialophosphoprotein 2.93218
OIT3 oncoprotein induced transcript 3 2.93218
HIC1 hypermethylated in cancer 1 2.93218
ARSH arylsulfatase family, member H 2.93218
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.93218
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.93218
GPR20 G protein-coupled receptor 20 2.93218
MYOM3 myomesin 3 2.93218
TRIM74 tripartite motif containing 74 2.93218
FAM221B family with sequence similarity 221, member B 2.93218
PRODH proline dehydrogenase (oxidase) 1 2.93218
C1ORF146 chromosome 1 open reading frame 146 2.93218
CRH corticotropin releasing hormone 2.93218
CPB1 carboxypeptidase B1 (tissue) 2.93218
IFI6 interferon, alpha-inducible protein 6 2.93218
GMNC geminin coiled-coil domain containing 2.93218
PODN podocan 2.93218
SPMIP9 sperm microtubule inner protein 9 2.93218
SPEM1 spermatid maturation 1 2.93218
KRT81 keratin 81, type II 2.93218
MLN motilin 2.93218
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.93218
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.93218
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.93218
TMPRSS4 transmembrane protease, serine 4 2.93218
TSPAN1 tetraspanin 1 2.93218
VSIG8 V-set and immunoglobulin domain containing 8 2.93218
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.93218
ACER1 alkaline ceramidase 1 2.93218
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.93218
PRR20G proline rich 20G 2.93218
PRRT1B proline rich transmembrane protein 1B 2.93218
LOC124902436 talanin 2.93218
CD8B2 CD8b2 molecule 2.93218
IQCN IQ motif containing N 2.93218
GARIN6 golgi associated RAB2 interactor family member 6 2.93218
SPACDR sperm acrosome developmental regulator 2.93218
RACK1 receptor for activated C kinase 1 2.93218
MISP3 MISP family member 3 2.93218
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.93218
LTA lymphotoxin alpha 2.93218
PRG4 proteoglycan 4 2.93218
CCR9 chemokine (C-C motif) receptor 9 2.93218
TAS2R5 taste receptor, type 2, member 5 2.93218
PDILT protein disulfide isomerase-like, testis expressed 2.93218
GJA9 gap junction protein, alpha 9, 59kDa 2.93218
STKLD1 serine/threonine kinase-like domain containing 1 2.93218
LRRD1 leucine-rich repeats and death domain containing 1 2.93218
ZNF503 zinc finger protein 503 2.93218
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.93218
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.93218
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.93218
FBXL8 F-box and leucine-rich repeat protein 8 2.93218
EFHB EF-hand domain family, member B 2.93218
LIPJ lipase, family member J 2.93218
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 2.93218
LSP1 lymphocyte-specific protein 1 2.93218
FAM186A family with sequence similarity 186, member A 2.93218
TLR4 toll-like receptor 4 2.93218
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.93218
CCDC17 coiled-coil domain containing 17 2.93218
GGT5 gamma-glutamyltransferase 5 2.93218
PRB4 proline-rich protein BstNI subfamily 4 2.93218
MTNR1B melatonin receptor 1B 2.93218
ACTL10 actin-like 10 2.93218
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.93218
CD33 CD33 molecule 2.93218
OR2V2 olfactory receptor, family 2, subfamily V, member 2 2.93218
PCDHGA3 protocadherin gamma subfamily A, 3 2.93218
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.93218
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.93218
EDN3 endothelin 3 2.93218
TIPE2 TNF alpha induced protein 8 like 2 2.93218
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.93218
CFAP47 cilia and flagella associated protein 47 2.93218
PRSS55 protease, serine, 55 2.93218
PRSS57 protease, serine, 57 2.93218
ZFP69 ZFP69 zinc finger protein 2.93218
ITGB7 integrin, beta 7 2.93218
RUFY4 RUN and FYVE domain containing 4 2.93218
ANKRD55 ankyrin repeat domain 55 2.93218
DRD2 dopamine receptor D2 2.93218
TTC9B tetratricopeptide repeat domain 9B 2.93218
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.93218
EFCAB3 EF-hand calcium binding domain 3 2.93218
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.93218
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.93218
CST1 cystatin SN 2.93218
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.93218
PRM1 protamine 1 2.93218
ADAM7 ADAM metallopeptidase domain 7 2.93218
ERICH4 glutamate-rich 4 2.93218
HAMP hepcidin antimicrobial peptide 2.93218
HPX hemopexin 2.93218
PCDHGB2 protocadherin gamma subfamily B, 2 2.93218
KRT15 keratin 15, type I 2.93218
C11ORF91 chromosome 11 open reading frame 91 2.93218
NUTM2A NUT family member 2A 2.93218
FCAR Fc fragment of IgA receptor 2.93218
SIGLEC5 sialic acid binding Ig-like lectin 5 2.93218
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.93218
ADORA3 adenosine A3 receptor 2.93218
SYTL4 synaptotagmin-like 4 2.93218
NKPD1 NTPase, KAP family P-loop domain containing 1 2.93218
GOLGA8K golgin A8 family, member K 2.93218
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.93218
SYNRG synergin, gamma 2.93218
TGM6 transglutaminase 6 2.93218
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.93218
LMX1A LIM homeobox transcription factor 1, alpha 2.93218
DUOXA1 dual oxidase maturation factor 1 2.93218
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.93218
CFI complement factor I 2.93218
SP100 SP100 nuclear antigen 2.93218
GHRH growth hormone releasing hormone 2.93218
SLITRK6 SLIT and NTRK-like family, member 6 2.93218
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.93218
PENK proenkephalin 2.93218
LHX5 LIM homeobox 5 2.93218
CFAP126 cilia and flagella associated protein 126 2.93218
NMBR neuromedin B receptor 2.93218
PHGR1 proline/histidine/glycine-rich 1 2.93218
VPREB3 pre-B lymphocyte 3 2.93218
WFDC10A WAP four-disulfide core domain 10A 2.93218
NXF2 nuclear RNA export factor 2 2.93218
TLCD5 TLC domain containing 5 2.91982
PGBD4 piggyBac transposable element derived 4 2.87268
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.87268
PROX1 prospero homeobox 1 2.87268
NOAZFP nucleolar atypical zinc finger 2.87268
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.80903
PDCD6 programmed cell death 6 2.80903
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.80408
APLP2 amyloid beta (A4) precursor-like protein 2 2.77379
MACIR macrophage immunometabolism regulator 2.71574
ZFP69B ZFP69 zinc finger protein B 2.70176
SESTD1 SEC14 and spectrin domains 1 2.68106
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.66834
SV2B synaptic vesicle glycoprotein 2B 2.64576
SMIM36 small integral membrane protein 36 2.64576
CHMP5 charged multivesicular body protein 5 2.61316
DENND5A DENN/MADD domain containing 5A 2.59641
SPATA12 spermatogenesis associated 12 2.56465
RASL12 RAS-like, family 12 2.56465
FBXL18 F-box and leucine-rich repeat protein 18 2.54454
ZNF471 zinc finger protein 471 2.43817
HSF5 heat shock transcription factor family member 5 2.43817
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.41517
ANAPC10 anaphase promoting complex subunit 10 2.39562
ATP10A ATPase, class V, type 10A 2.38476
TRIM47 tripartite motif containing 47 2.37145
PDCD5 programmed cell death 5 2.36965
CCKBR cholecystokinin B receptor 2.35972
COLEC10 collectin sub-family member 10 (C-type lectin) 2.35325
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.35325
ROM1 retinal outer segment membrane protein 1 2.35138
KLF5 Kruppel-like factor 5 (intestinal) 2.35138
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 2.35138
DKC1 dyskeratosis congenita 1, dyskerin 2.35072
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.34608
MUC4 mucin 4, cell surface associated 2.3188
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.2765
TMX1 thioredoxin-related transmembrane protein 1 2.26866
GAB3 GRB2-associated binding protein 3 2.26866
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.26866
FAM53A family with sequence similarity 53, member A 2.24613
ABHD12B abhydrolase domain containing 12B 2.23404
VWC2L von Willebrand factor C domain containing protein 2-like 2.22497
CXORF58 chromosome X open reading frame 58 2.22497
PPARA peroxisome proliferator-activated receptor alpha 2.2213
CDAN1 codanin 1 2.2213
SPICE1 spindle and centriole associated protein 1 2.2213
TMEM114 transmembrane protein 114 2.22028
PTPRA protein tyrosine phosphatase, receptor type, A 2.21781
IGHMBP2 immunoglobulin mu binding protein 2 2.21168
EFNA3 ephrin-A3 2.18825
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.18825
TEN1 TEN1 CST complex subunit 2.18653
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 2.14725
SUOX sulfite oxidase 2.14229
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.14119
RNF187 ring finger protein 187 2.13224
DENND2C DENN/MADD domain containing 2C 2.12801
CZIB CXXC motif containing zinc binding protein 2.11917
SFT2D2 SFT2 domain containing 2 2.11015
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.10143
UBE2E3 ubiquitin-conjugating enzyme E2E 3 2.09645
ZNF433 zinc finger protein 433 2.09532
LAMB1 laminin, beta 1 2.09532
WASF3 WAS protein family, member 3 2.087
EMX1 empty spiracles homeobox 1 2.07931
ZNF69 zinc finger protein 69 2.07931
GID4 GID complex subunit 4 2.07007
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.06925
MDFI MyoD family inhibitor 2.06317
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 2.06317
ZNF185 zinc finger protein 185 (LIM domain) 2.06155
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2.05172
PAPOLA poly(A) polymerase alpha 2.04185
FLNA filamin A, alpha 2.03123
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 2.03123
MACF1 microtubule-actin crosslinking factor 1 2.02757
CATSPERD catsper channel auxiliary subunit delta 2.02596
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 2.02596
C11ORF42 chromosome 11 open reading frame 42 2.02596
CARD11 caspase recruitment domain family, member 11 2.01713
CLU clusterin 2.00346
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 2.00277
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.00277

decreased expression

Symbol Name Standardized Value
TMEM67 transmembrane protein 67 -2.97958
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type -2.97958
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -2.93218
NSUN7 NOP2/Sun domain family, member 7 -2.93218
XIRP2 xin actin binding repeat containing 2 -2.93218
TBX6 T-box 6 -2.93218
ZFP90 ZFP90 zinc finger protein -2.93218
ZNF773 zinc finger protein 773 -2.93218
AKAP5 A kinase (PRKA) anchor protein 5 -2.93218
RILP Rab interacting lysosomal protein -2.93218
UBL5 ubiquitin-like 5 -2.93218
SLC15A5 solute carrier family 15, member 5 -2.87268
RTBDN retbindin -2.87268
RAI2 retinoic acid induced 2 -2.87268
EFCAB9 EF-hand calcium binding domain 9 -2.87268
DPPA3 developmental pluripotency associated 3 -2.87268
IER5L immediate early response 5-like -2.87268
TMEM121 transmembrane protein 121 -2.87268
CFAP221 cilia and flagella associated protein 221 -2.87268
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -2.87268
FRMPD1 FERM and PDZ domain containing 1 -2.87268
SERTM1 serine-rich and transmembrane domain containing 1 -2.87268
CFAP53 cilia and flagella associated protein 53 -2.87268
HBA2 hemoglobin, alpha 2 -2.87268
GOLGA6B golgin A6 family, member B -2.87268
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 -2.87268
CPHXL2 cytoplasmic polyadenylated homeobox like 2 -2.87268
MARCHF5 membrane associated ring-CH-type finger 5 -2.87268
TSPAN16 tetraspanin 16 -2.87268
NLRP2 NLR family, pyrin domain containing 2 -2.87268
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.87268
CRYBA1 crystallin, beta A1 -2.87268
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.87268
CCDC121 coiled-coil domain containing 121 -2.87268
NPNT nephronectin -2.87268
ACOT1 acyl-CoA thioesterase 1 -2.87268
CHD8 chromodomain helicase DNA binding protein 8 -2.8535
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.736
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.736
CHEK2 checkpoint kinase 2 -2.68075
TRIL TLR4 interactor with leucine-rich repeats -2.66834
EVI2B ecotropic viral integration site 2B -2.66834
CERS1 ceramide synthase 1 -2.66679
ATAD3C ATPase family, AAA domain containing 3C -2.64488
ARMC10 armadillo repeat containing 10 -2.61993
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.61993
CAPZB capping protein (actin filament) muscle Z-line, beta -2.61983
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -2.59699
MRE11 MRE11 homolog, double strand break repair nuclease -2.55281
KANSL1L KAT8 regulatory NSL complex subunit 1-like -2.51249
DRG1 developmentally regulated GTP binding protein 1 -2.49004
RB1 retinoblastoma 1 -2.4765
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -2.46944
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.44772
TEKT3 tektin 3 -2.44772
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.43008
SECISBP2 SECIS binding protein 2 -2.37013
FAM110D family with sequence similarity 110, member D -2.35623
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -2.35623
MIIP migration and invasion inhibitory protein -2.35138
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.34355
EIF3L eukaryotic translation initiation factor 3, subunit L -2.33196
LMF1 lipase maturation factor 1 -2.32649
OSBPL10 oxysterol binding protein-like 10 -2.32649
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -2.32106
LRRC38 leucine rich repeat containing 38 -2.32106
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.32106
TJAP1 tight junction associated protein 1 (peripheral) -2.31484
L3MBTL2 l(3)mbt-like 2 (Drosophila) -2.31484
CPOX coproporphyrinogen oxidase -2.26866
PXMP4 peroxisomal membrane protein 4, 24kDa -2.25908
SIAE sialic acid acetylesterase -2.25908
ZNF227 zinc finger protein 227 -2.25897
PDZD7 PDZ domain containing 7 -2.2492
ELOVL4 ELOVL fatty acid elongase 4 -2.2492
FAM194C family with sequence similarity 149 member C -2.2492
TRIM68 tripartite motif containing 68 -2.24328
TRAPPC2 trafficking protein particle complex 2 -2.23874
TRAPPC12 trafficking protein particle complex 12 -2.2385
CPLX2 complexin 2 -2.2385
CHKB choline kinase beta -2.23404
PTPRD protein tyrosine phosphatase, receptor type, D -2.21288
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -2.20992
FOXM1 forkhead box M1 -2.20992
MED25 mediator complex subunit 25 -2.20639
POM121 POM121 transmembrane nucleoporin -2.20639
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.20639
ATG13 autophagy related 13 -2.17173
FBXO11 F-box protein 11 -2.15554
C10ORF95 chromosome 10 open reading frame 95 -2.15554
THYN1 thymocyte nuclear protein 1 -2.15016
PCDHA11 protocadherin alpha 11 -2.14178
ATP10B ATPase, class V, type 10B -2.14178
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.14178
TMEM63C transmembrane protein 63C -2.13376
LIN28B lin-28 homolog B (C. elegans) -2.12778
ARL2 ADP-ribosylation factor-like 2 -2.12744
WDR5 WD repeat domain 5 -2.12345
ZNF3 zinc finger protein 3 -2.09532
ARHGAP21 Rho GTPase activating protein 21 -2.08444
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.07931
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.06398
GRM3 glutamate receptor, metabotropic 3 -2.06155
NPTXR neuronal pentraxin receptor -2.04977
WDR43 WD repeat domain 43 -2.04626
LUC7L3 LUC7-like 3 (S. cerevisiae) -2.02757
ATG2A autophagy related 2A -2.02757
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.02596
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.02596