KLF5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Kruppel-like factor 5 (intestinal)|This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] (NCBI Entrez Gene Database, 688)
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Genes

330 genes differentially expressed following the KLF5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PHACTR3 phosphatase and actin regulator 3 2.68224
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.68224
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.68224
RGPD4 RANBP2-like and GRIP domain containing 4 2.68224
GOLGA6B golgin A6 family, member B 2.68224
CDKN2A cyclin-dependent kinase inhibitor 2A 2.68224
STRA8 stimulated by retinoic acid 8 2.68224
TEX19 testis expressed 19 2.68224
GFI1B growth factor independent 1B transcription repressor 2.68224
ANKRD55 ankyrin repeat domain 55 2.68224
GFAP glial fibrillary acidic protein 2.68224
VTCN1 V-set domain containing T cell activation inhibitor 1 2.68224
ASB9 ankyrin repeat and SOCS box containing 9 2.68224
CDH19 cadherin 19, type 2 2.68224
SIGLECL1 SIGLEC family like 1 2.68224
ARMH2 armadillo like helical domain containing 2 2.68224
GAGE10 G antigen 10 2.68224
LMX1A LIM homeobox transcription factor 1, alpha 2.68224
IMPG1 interphotoreceptor matrix proteoglycan 1 2.68224
NT5DC4 5'-nucleotidase domain containing 4 2.68224
CLEC12A C-type lectin domain family 12, member A 2.62201
ZNF503 zinc finger protein 503 2.62201
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.62201
GJA10 gap junction protein, alpha 10, 62kDa 2.62201
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.62201
CXORF65 chromosome X open reading frame 65 2.62201
VWA5B2 von Willebrand factor A domain containing 5B2 2.62201
TSGA10 testis specific, 10 2.62201
GFRA4 GDNF family receptor alpha 4 2.62201
BLNK B-cell linker 2.62201
NRAP nebulin-related anchoring protein 2.62201
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.62201
SSTR1 somatostatin receptor 1 2.62201
GPR55 G protein-coupled receptor 55 2.62201
FFAR4 free fatty acid receptor 4 2.62201
LRRC63 leucine rich repeat containing 63 2.62201
PRDM12 PR domain containing 12 2.62201
LGALS2 lectin, galactoside-binding, soluble, 2 2.62201
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.62201
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.62201
FAM9C family with sequence similarity 9, member C 2.62201
STAP1 signal transducing adaptor family member 1 2.62201
KRTAP5-2 keratin associated protein 5-2 2.62201
PODN podocan 2.62201
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.62201
CLEC5A C-type lectin domain family 5, member A 2.62201
CD68 CD68 molecule 2.62201
UCN3 urocortin 3 2.62201
MT1HL1 metallothionein 1H-like 1 2.62201
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.62201
TLX2 T-cell leukemia homeobox 2 2.62201
LYNX1 Ly6/neurotoxin 1 2.62201
ADAMTSL5 ADAMTS-like 5 2.62201
GUCY2F guanylate cyclase 2F, retinal 2.62201
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.62201
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.62201
FAM81B family with sequence similarity 81, member B 2.62201
WASL-DT WASL divergent transcript 2.62201
PNMA8B PNMA family member 8B 2.62201
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.62201
OTOS otospiralin 2.62201
GBP1 guanylate binding protein 1, interferon-inducible 2.62201
NIN ninein (GSK3B interacting protein) 2.62201
ZNF726 zinc finger protein 726 2.62201
ROPN1L rhophilin associated tail protein 1-like 2.62201
PMIS2 PMIS2 transmembrane protein 2.62201
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.62201
ODAD1 outer dynein arm docking complex subunit 1 2.62201
RAB6D RAB6D, member RAS oncogene family 2.62201
LOC124903372 uncharacterized LOC124903372 2.62201
SMIM43 small integral membrane protein 43 2.62201
H3C3 H3 clustered histone 3 2.62201
TEX13C TEX13 family member C 2.62201
ELOA2 elongin A2 2.62201
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 2.62201
CIROP ciliated left-right organizer metallopeptidase 2.62201
PLAAT2 phospholipase A and acyltransferase 2 2.62201
MYOCOS myocilin opposite strand 2.62201
HTRA4 HtrA serine peptidase 4 2.62201
TCERG1L transcription elongation regulator 1-like 2.62201
MYH13 myosin, heavy chain 13, skeletal muscle 2.62201
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.62201
CD79A CD79a molecule, immunoglobulin-associated alpha 2.62201
GGT5 gamma-glutamyltransferase 5 2.62201
PCDHA2 protocadherin alpha 2 2.62201
ISM2 isthmin 2 2.62201
USH1G Usher syndrome 1G (autosomal recessive) 2.62201
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.62201
ZACN zinc activated ligand-gated ion channel 2.62201
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.62201
FAM186A family with sequence similarity 186, member A 2.62201
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.62201
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.62201
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.62201
DOK2 docking protein 2, 56kDa 2.62201
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.62201
ACE2 angiotensin I converting enzyme 2 2.62201
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.62201
SAA2 serum amyloid A2 2.62201
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.62201
RASL10A RAS-like, family 10, member A 2.62201
ALMS1 Alstrom syndrome protein 1 2.62201
FNDC9 fibronectin type III domain containing 9 2.62201
LRCOL1 leucine rich colipase-like 1 2.62201
ZNF366 zinc finger protein 366 2.62201
CLEC9A C-type lectin domain family 9, member A 2.62201
NGB neuroglobin 2.62201
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.62201
CTSS cathepsin S 2.62201
PGR progesterone receptor 2.62201
CCNI2 cyclin I family, member 2 2.62201
LGALS14 lectin, galactoside-binding, soluble, 14 2.62201
C5AR2 complement component 5a receptor 2 2.62201
FAM53C family with sequence similarity 53, member C 2.62201
POMT2 protein-O-mannosyltransferase 2 2.62201
SHOX2 short stature homeobox 2 2.62201
AQP7 aquaporin 7 2.62201
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.62201
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.62201
KISS1 KiSS-1 metastasis-suppressor 2.62201
SERINC4 serine incorporator 4 2.62201
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.62201
RNF225 ring finger protein 225 2.62201
IGF2 insulin-like growth factor 2 2.62201
KLK6 kallikrein-related peptidase 6 2.62201
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.62201
ANKRD63 ankyrin repeat domain 63 2.62201
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.62201
UTS2B urotensin 2B 2.62201
CTXN2 cortexin 2 2.62201
USP35 ubiquitin specific peptidase 35 2.62201
FITM1 fat storage-inducing transmembrane protein 1 2.62201
CHRM4 cholinergic receptor, muscarinic 4 2.62201
SLN sarcolipin 2.62201
GPR179 G protein-coupled receptor 179 2.62201
CHRDL2 chordin-like 2 2.62201
NLRP8 NLR family, pyrin domain containing 8 2.62201
MAGEC3 melanoma antigen family C3 2.62201
CLEC18B C-type lectin domain family 18, member B 2.62201
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.62201
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.62201
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.62201
DCST1 DC-STAMP domain containing 1 2.62201
ACADL acyl-CoA dehydrogenase, long chain 2.62201
ZC2HC1B zinc finger, C2HC-type containing 1B 2.62201
LRRC24 leucine rich repeat containing 24 2.62201
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.62201
PRM1 protamine 1 2.62201
IL37 interleukin 37 2.62201
IGIP IgA-inducing protein 2.62201
PCSK4 proprotein convertase subtilisin/kexin type 4 2.62201
RHAG Rh-associated glycoprotein 2.62201
SLC51B solute carrier family 51, beta subunit 2.62201
FOXP3 forkhead box P3 2.62201
MEPE matrix extracellular phosphoglycoprotein 2.62201
PADI1 peptidyl arginine deiminase, type I 2.62201
TAS2R41 taste receptor, type 2, member 41 2.62201
LRRN4 leucine rich repeat neuronal 4 2.62201
PNN pinin, desmosome associated protein 2.62178
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.62178
NT5DC1 5'-nucleotidase domain containing 1 2.61265
EEIG2 EEIG family member 2 2.60506
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 2.6027
CXCL5 chemokine (C-X-C motif) ligand 5 2.57623
GBX1 gastrulation brain homeobox 1 2.55841
TET3 tet methylcytosine dioxygenase 3 2.5329
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.5316
SPX spexin hormone 2.5316
DEUP1 deuterosome assembly protein 1 2.5316
DHRSX dehydrogenase/reductase (SDR family) X-linked 2.51963
RORB RAR-related orphan receptor B 2.47684
C9ORF78 chromosome 9 open reading frame 78 2.46172
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.44703
MOB3B MOB kinase activator 3B 2.3913
ETAA1 Ewing tumor-associated antigen 1 2.3877
TPCN1 two pore segment channel 1 2.35993
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 2.35141
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.34338
MEIOC meiosis specific with coiled-coil domain 2.34103
PDCD2L programmed cell death 2-like 2.33493
ATF7 activating transcription factor 7 2.30353
SOWAHD sosondowah ankyrin repeat domain family member D 2.30353
ODF2 outer dense fiber of sperm tails 2 2.29474
MPZL3 myelin protein zero-like 3 2.28469
PYGO2 pygopus family PHD finger 2 2.24777
RAB6B RAB6B, member RAS oncogene family 2.24777
ACSS3 acyl-CoA synthetase short-chain family member 3 2.22295
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 2.21295
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.21087
IZUMO3 IZUMO family member 3 2.19327
EPO erythropoietin 2.19327
P3H1 prolyl 3-hydroxylase 1 2.18052
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2.17412
SAXO6 stabilizer of axonemal microtubules 6 2.1714
NINL ninein-like 2.1714
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 2.13518
TFB2M transcription factor B2, mitochondrial 2.13124
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.11704
TRA2A transformer 2 alpha homolog (Drosophila) 2.10981
GGT1 gamma-glutamyltransferase 1 2.10651
C1QL1 complement component 1, q subcomponent-like 1 2.10651
TOR1AIP1 torsin A interacting protein 1 2.10323
ERVK3-1 endogenous retrovirus group K3, member 1 2.09888
TOR1B torsin family 1, member B (torsin B) 2.09572
PHF8 PHD finger protein 8 2.09241
CRACD capping protein inhibiting regulator of actin dynamics 2.08662
EGR1 early growth response 1 2.08171
CNGA4 cyclic nucleotide gated channel alpha 4 2.08171
TMPRSS11E transmembrane protease, serine 11E 2.08171
MBD5 methyl-CpG binding domain protein 5 2.08103
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 2.08099
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 2.07981
NMRK1 nicotinamide riboside kinase 1 2.07556
COL21A1 collagen, type XXI, alpha 1 2.07556
GEMIN7 gem (nuclear organelle) associated protein 7 2.05183
WDR83OS WD repeat domain 83 opposite strand 2.05104
MAPK8 mitogen-activated protein kinase 8 2.04915
FSTL1 follistatin-like 1 2.04915
PGK1 phosphoglycerate kinase 1 2.04551
SSPN sarcospan 2.0126
PIAS1 protein inhibitor of activated STAT, 1 2.00717
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.00004

decreased expression

Symbol Name Standardized Value
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.68224
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.68224
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.68224
TRIM47 tripartite motif containing 47 -2.68224
DRP2 dystrophin related protein 2 -2.68224
MOK MOK protein kinase -2.68224
POLR1B polymerase (RNA) I polypeptide B, 128kDa -2.62201
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -2.62201
SLC46A3 solute carrier family 46, member 3 -2.62201
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.62201
TMPRSS11F transmembrane protease, serine 11F -2.62201
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -2.62201
NUTM2G NUT family member 2G -2.62201
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -2.62201
GJB3 gap junction protein, beta 3, 31kDa -2.62201
ALPK2 alpha-kinase 2 -2.62201
MTERF3 mitochondrial transcription termination factor 3 -2.62201
THRSP thyroid hormone responsive -2.62201
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.62201
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -2.62201
CORO6 coronin 6 -2.62201
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.62201
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.62201
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -2.62201
INSM1 insulinoma-associated 1 -2.62201
CEP128 centrosomal protein 128kDa -2.62201
BANP BTG3 associated nuclear protein -2.62201
MSMP microseminoprotein, prostate associated -2.62201
GPR146 G protein-coupled receptor 146 -2.62201
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.62201
PRRT1B proline rich transmembrane protein 1B -2.62201
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.62201
BRDT bromodomain, testis-specific -2.62201
C8G complement component 8, gamma polypeptide -2.62201
SOAT2 sterol O-acyltransferase 2 -2.62201
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.62201
ALG10B ALG10B, alpha-1,2-glucosyltransferase -2.62201
HPX hemopexin -2.62201
C1QL3 complement component 1, q subcomponent-like 3 -2.62201
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.62201
IRGM immunity-related GTPase family, M -2.62201
ZDHHC2 zinc finger, DHHC-type containing 2 -2.61265
MAST1 microtubule associated serine/threonine kinase 1 -2.59945
MBD2 methyl-CpG binding domain protein 2 -2.59746
IL17C interleukin 17C -2.5768
CHD5 chromodomain helicase DNA binding protein 5 -2.5768
CRHR1 corticotropin releasing hormone receptor 1 -2.57257
HJURP Holliday junction recognition protein -2.53723
ZNF33B zinc finger protein 33B -2.51809
PPHLN1 periphilin 1 -2.46389
LCN2 lipocalin 2 -2.46172
VAC14 Vac14 homolog (S. cerevisiae) -2.39869
STEAP1 six transmembrane epithelial antigen of the prostate 1 -2.37675
SEC24D SEC24 family member D -2.35202
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.33493
CDCA7L cell division cycle associated 7-like -2.30002
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.27999
TSPAN2 tetraspanin 2 -2.27959
TBC1D30 TBC1 domain family, member 30 -2.26968
GTSE1 G-2 and S-phase expressed 1 -2.26311
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.25643
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.23982
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.23628
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.23628
SCARF1 scavenger receptor class F, member 1 -2.23628
ZC3H3 zinc finger CCCH-type containing 3 -2.23628
GMPS guanine monphosphate synthase -2.22914
CPN1 carboxypeptidase N, polypeptide 1 -2.22312
USP27X ubiquitin specific peptidase 27, X-linked -2.21087
PAH phenylalanine hydroxylase -2.21087
DBF4 DBF4 zinc finger -2.21087
DNAAF19 dynein axonemal assembly factor 19 -2.21087
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.20801
H2AC25 H2A clustered histone 25 -2.20686
UBALD1 UBA-like domain containing 1 -2.18123
ATRN attractin -2.18034
GNAS GNAS complex locus -2.1714
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.17136
SIKE1 suppressor of IKBKE 1 -2.15708
TFCP2L1 transcription factor CP2-like 1 -2.13312
DHCR7 7-dehydrocholesterol reductase -2.10981
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.10651
MTMR9 myotubularin related protein 9 -2.10387
SNW1 SNW domain containing 1 -2.10323
CYB5R2 cytochrome b5 reductase 2 -2.10323
FGF19 fibroblast growth factor 19 -2.09572
AKAP10 A kinase (PRKA) anchor protein 10 -2.08662
PPARA peroxisome proliferator-activated receptor alpha -2.08453
TARS1 threonyl-tRNA synthetase 1 -2.08171
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.08103
SYNM synemin, intermediate filament protein -2.07613
EIF5B eukaryotic translation initiation factor 5B -2.07556
VIPR1 vasoactive intestinal peptide receptor 1 -2.07556
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.07556
LPIN1 lipin 1 -2.06974
MBLAC2 metallo-beta-lactamase domain containing 2 -2.06843
ZBTB24 zinc finger and BTB domain containing 24 -2.06692
POC1B-DUSP6 POC1B-DUSP6 readthrough -2.06386
AXIN1 axin 1 -2.053
IER5 immediate early response 5 -2.05251
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.05104
STX17 syntaxin 17 -2.04915
CALM3 calmodulin 3 (phosphorylase kinase, delta) -2.04519
MAP6D1 MAP6 domain containing 1 -2.04519
NSUN7 NOP2/Sun domain family, member 7 -2.02812
TOMM70 translocase of outer mitochondrial membrane 70 -2.01957
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.01435
STAT2 signal transducer and activator of transcription 2, 113kDa -2.0126