KLHDC8B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description kelch domain containing 8B|This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 200942)
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Genes

307 genes differentially expressed following the KLHDC8B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HLX H2.0-like homeobox 3.62743
TGM6 transglutaminase 6 3.62743
MOGAT3 monoacylglycerol O-acyltransferase 3 3.62743
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.62743
REEP1 receptor accessory protein 1 3.62743
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.62743
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.62743
GPR37L1 G protein-coupled receptor 37 like 1 3.62743
LAMP3 lysosomal-associated membrane protein 3 3.62743
RERGL RERG/RAS-like 3.62743
SPMAP2L sperm microtubule associated protein 2 like 3.62743
STMND1 stathmin domain containing 1 3.62743
ATP13A4 ATPase type 13A4 3.62743
TMPRSS11F transmembrane protease, serine 11F 3.62743
MYORG myogenesis regulating glycosidase (putative) 3.62743
PADI4 peptidyl arginine deiminase, type IV 3.62743
TRHR thyrotropin-releasing hormone receptor 3.62743
BCL2A1 BCL2-related protein A1 3.62743
SYT5 synaptotagmin V 3.62743
CIMIP2A ciliary microtubule inner protein 2A 3.62743
RHOJ ras homolog family member J 3.62743
CBLIF cobalamin binding intrinsic factor 3.62743
H3C13 H3 clustered histone 13 3.62743
GPR179 G protein-coupled receptor 179 3.62743
FGF7 fibroblast growth factor 7 3.55611
RBP4 retinol binding protein 4, plasma 3.55611
ASB10 ankyrin repeat and SOCS box containing 10 3.55611
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.55611
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.55611
CLEC19A C-type lectin domain family 19, member A 3.55611
PANO1 proapoptotic nucleolar protein 1 3.55611
MT1HL1 metallothionein 1H-like 1 3.55611
TDO2 tryptophan 2,3-dioxygenase 3.55611
PDYN prodynorphin 3.55611
TMEM176A transmembrane protein 176A 3.55611
ANKRD22 ankyrin repeat domain 22 3.55611
CELF3 CUGBP, Elav-like family member 3 3.55611
SP6 Sp6 transcription factor 3.55611
TLX3 T-cell leukemia homeobox 3 3.55611
ALPK2 alpha-kinase 2 3.55611
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.55611
RNASE6 ribonuclease, RNase A family, k6 3.55611
KRT72 keratin 72, type II 3.55611
IL2RA interleukin 2 receptor, alpha 3.55611
SCIN scinderin 3.55611
NT5M 5',3'-nucleotidase, mitochondrial 3.55611
S100A5 S100 calcium binding protein A5 3.55611
TAS2R19 taste receptor, type 2, member 19 3.55611
LCN12 lipocalin 12 3.55611
TAS2R13 taste receptor, type 2, member 13 3.55611
RFPL3 ret finger protein-like 3 3.55611
SPDEF SAM pointed domain containing ETS transcription factor 3.55611
CD19 CD19 molecule 3.55611
SCN2B sodium channel, voltage gated, type II beta subunit 3.55611
ZNF503 zinc finger protein 503 3.55611
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.55611
MYZAP myocardial zonula adherens protein 3.55611
AVPR1A arginine vasopressin receptor 1A 3.55611
ALDOB aldolase B, fructose-bisphosphate 3.55611
DEFB108B defensin, beta 108B 3.55611
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.55611
SQOR sulfide quinone oxidoreductase 3.55611
VSIR V-set immunoregulatory receptor 3.55611
H3-5 H3.5 histone 3.55611
CCN3 cellular communication network factor 3 3.55611
TMEM271 transmembrane protein 271 3.55611
ACOD1 aconitate decarboxylase 1 3.55611
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.55611
IHO1 interactor of HORMAD1 1 3.55611
CPNE8-AS1 CPNE8 antisense RNA 1 3.55611
SPDYE14 speedy/RINGO cell cycle regulator family member E14 3.55611
CIMIP7 ciliary microtubule inner protein 7 3.55611
TRIM31 tripartite motif containing 31 3.55611
MYEOV myeloma overexpressed 3.55611
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.55611
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.55611
NCALD neurocalcin delta 3.55611
CD5 CD5 molecule 3.55611
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.55611
TMPRSS11A transmembrane protease, serine 11A 3.55611
HBA2 hemoglobin, alpha 2 3.55611
LIPF lipase, gastric 3.55611
TMEM229A transmembrane protein 229A 3.55611
NKX2-5 NK2 homeobox 5 3.55611
GGT5 gamma-glutamyltransferase 5 3.55611
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.55611
SIM2 single-minded family bHLH transcription factor 2 3.55611
EXOC3L1 exocyst complex component 3-like 1 3.55611
FOXI2 forkhead box I2 3.55611
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.55611
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 3.55611
LRRC73 leucine rich repeat containing 73 3.55611
OR56B2 olfactory receptor family 56 subfamily B member 2 3.55611
GAL3ST2 galactose-3-O-sulfotransferase 2 3.55611
C11ORF16 chromosome 11 open reading frame 16 3.55611
C5AR2 complement component 5a receptor 2 3.55611
SPATA3 spermatogenesis associated 3 3.55611
TRIM50 tripartite motif containing 50 3.55611
C2CD4B C2 calcium-dependent domain containing 4B 3.55611
TECRL trans-2,3-enoyl-CoA reductase-like 3.55611
LMOD2 leiomodin 2 (cardiac) 3.55611
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.55611
MT3 metallothionein 3 3.55611
COX7B2 cytochrome c oxidase subunit VIIb2 3.55611
TMEM86A transmembrane protein 86A 3.55611
TPSB2 tryptase beta 2 (gene/pseudogene) 3.55611
PRM3 protamine 3 3.55611
KLHL41 kelch-like family member 41 3.55611
A3GALT2 alpha 1,3-galactosyltransferase 2 3.55611
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.55611
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.55611
CYBB cytochrome b-245, beta polypeptide 3.55611
S100A12 S100 calcium binding protein A12 3.55611
CPSF4L cleavage and polyadenylation specific factor 4-like 3.55611
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.55611
ANKRD62 ankyrin repeat domain 62 3.55611
IL12B interleukin 12B 3.55611
ECM1 extracellular matrix protein 1 3.55611
CDHR5 cadherin-related family member 5 3.55611
ISL2 ISL LIM homeobox 2 3.55611
ZCCHC12 zinc finger, CCHC domain containing 12 3.55611
C8ORF89 chromosome 8 open reading frame 89 3.55611
BPIFC BPI fold containing family C 3.55611
PADI1 peptidyl arginine deiminase, type I 3.55611
SOSTDC1 sclerostin domain containing 1 3.55611
CTRB1 chymotrypsinogen B1 3.55611
QRFP pyroglutamylated RFamide peptide 3.55611
RAB7B RAB7B, member RAS oncogene family 3.55611
ADIPOR2 adiponectin receptor 2 3.55611
PHGR1 proline/histidine/glycine-rich 1 3.55611
MRGPRX3 MAS-related GPR, member X3 3.55611
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.55611
CD33 CD33 molecule 3.55611
PIP prolactin-induced protein 3.55611
EPHA3 EPH receptor A3 3.55611
EDN3 endothelin 3 3.55611
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.55611
COL6A5 collagen, type VI, alpha 5 3.55611
TBX1 T-box 1 3.55611
ZBED6 zinc finger, BED-type containing 6 3.55611
CD8B CD8b molecule 3.55611
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.55611
PTCRA pre T-cell antigen receptor alpha 3.55611
TG thyroglobulin 3.55611
SYTL4 synaptotagmin-like 4 3.55611
CCDC166 coiled-coil domain containing 166 3.55611
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.55611
KRTAP1-5 keratin associated protein 1-5 3.55611
PRB2 proline-rich protein BstNI subfamily 2 3.534
ARHGAP30 Rho GTPase activating protein 30 3.26485
ACOT2 acyl-CoA thioesterase 2 3.13895
CLTCL1 clathrin, heavy chain-like 1 3.10127
RGS8 regulator of G-protein signaling 8 3.08176
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.05136
ATP5PO ATP synthase peripheral stalk subunit OSCP 3.02214
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.00855
TRAK2 trafficking protein, kinesin binding 2 2.90937
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.83495
ALOX12 arachidonate 12-lipoxygenase 2.74965
AATF apoptosis antagonizing transcription factor 2.74965
ASTN2 astrotactin 2 2.72992
ADISSP adipose secreted signaling protein 2.70515
STK31 serine/threonine kinase 31 2.6705
KIAA0930 KIAA0930 2.65331
PLPPR1 phospholipid phosphatase related 1 2.65271
TRA2B transformer 2 beta homolog (Drosophila) 2.62601
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.61961
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 2.61383
FASTKD1 FAST kinase domains 1 2.59496
SYNGR2 synaptogyrin 2 2.58443
POLI polymerase (DNA directed) iota 2.58443
KARS1 lysyl-tRNA synthetase 1 2.58199
TSPAN7 tetraspanin 7 2.57244
CCDC78 coiled-coil domain containing 78 2.54565
PCDH20 protocadherin 20 2.54565
PLA2G10 phospholipase A2, group X 2.54565
NELL1 NEL-like 1 (chicken) 2.54565
C4ORF50 chromosome 4 open reading frame 50 2.54565
BOLL boule-like RNA-binding protein 2.54565
HES4 hes family bHLH transcription factor 4 2.54565
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.54565
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.45472
C11ORF42 chromosome 11 open reading frame 42 2.44149
ESR1 estrogen receptor 1 2.44149
FAM120A family with sequence similarity 120A 2.4087
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.38721
R3HCC1L R3H domain and coiled-coil containing 1-like 2.36072
TUBB1 tubulin, beta 1 class VI 2.32124
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.32124
B2M beta-2-microglobulin 2.31565
SNTG2 syntrophin, gamma 2 2.28762
STK32C serine/threonine kinase 32C 2.28762
TCAIM T cell activation inhibitor, mitochondrial 2.27086
ATOX1 antioxidant 1 copper chaperone 2.228
MT1M metallothionein 1M 2.228
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2.228
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.20595
MYL7 myosin, light chain 7, regulatory 2.20595
RWDD3 RWD domain containing 3 2.18511
C21ORF58 chromosome 21 open reading frame 58 2.16212
GTF3A general transcription factor IIIA 2.12149
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.12149
BCAS4 breast carcinoma amplified sequence 4 2.09535
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.08473
ODAD2 outer dynein arm docking complex subunit 2 2.06126
LZTS1 leucine zipper, putative tumor suppressor 1 2.01811
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2.00976
BMAL1 basic helix-loop-helix ARNT like 1 2.00885
KEL Kell blood group, metallo-endopeptidase 2.00806

decreased expression

Symbol Name Standardized Value
ZNF624 zinc finger protein 624 -3.62743
FAM167B family with sequence similarity 167, member B -3.60528
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -3.55611
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -3.55611
MAMLD1 mastermind-like domain containing 1 -3.55611
TREH trehalase (brush-border membrane glycoprotein) -3.55611
IL2RB interleukin 2 receptor, beta -3.55611
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -3.55611
MINDY4B MINDY family member 4B -3.55611
TNR tenascin R -3.55611
NLRC3 NLR family, CARD domain containing 3 -3.55611
SLFN11 schlafen family member 11 -3.55611
CCDC152 coiled-coil domain containing 152 -3.55611
AQP1 aquaporin 1 (Colton blood group) -3.55611
BBS5 Bardet-Biedl syndrome 5 -3.55611
IL5RA interleukin 5 receptor, alpha -3.55611
OXCT2 3-oxoacid CoA transferase 2 -3.55611
GOLGA6L10 golgin A6 family-like 10 -3.55611
SH2D7 SH2 domain containing 7 -3.55611
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -3.55611
GLUD2 glutamate dehydrogenase 2 -3.55611
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -3.55611
ZEB2 zinc finger E-box binding homeobox 2 -3.55611
OR52A5 olfactory receptor, family 52, subfamily A, member 5 -3.55611
ACKR3 atypical chemokine receptor 3 -3.55611
DUXB double homeobox B -3.55611
AMN amnion associated transmembrane protein -3.55611
SPMIP9 sperm microtubule inner protein 9 -3.55611
ZNF843 zinc finger protein 843 -3.55611
ALX4 ALX homeobox 4 -3.55611
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -3.55611
RPL3L ribosomal protein L3-like -3.55611
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -3.46884
ZNF446 zinc finger protein 446 -3.46884
CYSRT1 cysteine-rich tail protein 1 -3.22483
TRIM65 tripartite motif containing 65 -3.19747
TSPAN2 tetraspanin 2 -2.88314
GAA glucosidase, alpha; acid -2.86082
JAG2 jagged 2 -2.79548
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.63593
MAP2 microtubule-associated protein 2 -2.63593
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.62601
PDGFB platelet-derived growth factor beta polypeptide -2.62206
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -2.59496
ZNF675 zinc finger protein 675 -2.58515
AVPI1 arginine vasopressin-induced 1 -2.54565
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.54565
IMMT inner membrane protein, mitochondrial -2.48739
FAM91A1 family with sequence similarity 91, member A1 -2.47547
MMP15 matrix metallopeptidase 15 (membrane-inserted) -2.46189
SHLD3 shieldin complex subunit 3 -2.44981
CCDC158 coiled-coil domain containing 158 -2.44981
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.44981
LRRC10B leucine rich repeat containing 10B -2.44981
F11 coagulation factor XI -2.42232
CCNL2 cyclin L2 -2.39544
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.37268
NRTN neurturin -2.32124
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.30903
WDR11 WD repeat domain 11 -2.3034
TGM2 transglutaminase 2 -2.30304
ITPRID1 ITPR interacting domain containing 1 -2.30304
TST thiosulfate sulfurtransferase (rhodanese) -2.28762
KLK13 kallikrein-related peptidase 13 -2.28762
DOCK2 dedicator of cytokinesis 2 -2.28762
TTC39A tetratricopeptide repeat domain 39A -2.26968
SERF1B small EDRK-rich factor 1B (centromeric) -2.25931
PON2 paraoxonase 2 -2.25446
GLRA1 glycine receptor, alpha 1 -2.24422
LRRC55 leucine rich repeat containing 55 -2.24422
TMEM175 transmembrane protein 175 -2.24422
ASXL2 additional sex combs like transcriptional regulator 2 -2.24399
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.24399
PDCD11 programmed cell death 11 -2.23838
SC5D sterol-C5-desaturase -2.23586
MATR3 matrin 3 -2.23464
EWSR1 EWS RNA-binding protein 1 -2.228
MSL1 male-specific lethal 1 homolog (Drosophila) -2.2107
MANEA mannosidase, endo-alpha -2.206
FAXC failed axon connections homolog (Drosophila) -2.18526
RBM28 RNA binding motif protein 28 -2.18511
ANKRD39 ankyrin repeat domain 39 -2.17798
FGF18 fibroblast growth factor 18 -2.17402
FUCA2 fucosidase, alpha-L- 2, plasma -2.16212
EHD2 EH-domain containing 2 -2.16037
SETD1A SET domain containing 1A -2.11976
MED15 mediator complex subunit 15 -2.11605
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 -2.11605
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -2.09051
FAM149B1 family with sequence similarity 149, member B1 -2.08942
SCUBE3 signal peptide, CUB domain, EGF-like 3 -2.08473
INA internexin neuronal intermediate filament protein, alpha -2.07865
CCNB1 cyclin B1 -2.04984
CCNT2 cyclin T2 -2.02346
CDH26 cadherin 26 -2.0229
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.00806
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -2.00806
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.00317