KLHDC8B Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description kelch domain containing 8B|This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 200942)
External Link https://ncbi.nlm.nih.gov/gene/200942
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Genes

498 genes differentially expressed following the KLHDC8B gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
IFI27 interferon, alpha-inducible protein 27 0.019072
SLPI secretory leukocyte peptidase inhibitor 0.0146929
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.01419
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.0141783
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.0141383
XIC X chromosome inactivation center 0.0137481
RGCC regulator of cell cycle 0.0125598
HSPA1A heat shock 70kDa protein 1A 0.0124813
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0123893
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 0.0121485
ABLIM1 actin binding LIM protein 1 0.012005
EGR1 early growth response 1 0.0117721
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.0117421
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.011718
NEBL nebulette 0.0112686
GSTP1 glutathione S-transferase pi 1 0.0112125
ANXA3 annexin A3 0.0111431
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0110703
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.0109434
MYBPC1 myosin binding protein C, slow type 0.0109312
CXCL8 chemokine (C-X-C motif) ligand 8 0.0108903
KRT14 keratin 14, type I 0.0107256
IFI44L interferon-induced protein 44-like 0.0105752
SCGB2A1 secretoglobin, family 2A, member 1 0.0104516
S100P S100 calcium binding protein P 0.0102369
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.010202
SGK1 serum/glucocorticoid regulated kinase 1 0.0101629
TGM2 transglutaminase 2 0.00996933
ISG15 ISG15 ubiquitin-like modifier 0.00996767
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00987495
MVP major vault protein 0.00965998
LTF lactotransferrin 0.0096543
LAMP3 lysosomal-associated membrane protein 3 0.00965106
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.00956389
SAT1 spermidine/spermine N1-acetyltransferase 1 0.00954696
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.00952428
AKR1C2 aldo-keto reductase family 1, member C2 0.00951984
GNAS GNAS complex locus 0.00935756
IL32 interleukin 32 0.00909175
C3 complement component 3 0.00903839
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00890714
TNNC1 troponin C type 1 (slow) 0.00890069
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00878904
CST1 cystatin SN 0.0087549
ASS1 argininosuccinate synthase 1 0.00874001
ISG20 interferon stimulated exonuclease gene 20kDa 0.00868072
VEGFA vascular endothelial growth factor A 0.00867658
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.008648
INHBB inhibin, beta B 0.00863972
KRT17 keratin 17, type I 0.00861856
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.00859314
PLAAT3 phospholipase A and acyltransferase 3 0.00853678
COG7 component of oligomeric golgi complex 7 0.0083864
HIST1H2AC histone cluster 1, H2ac 0.00838187
DAAM1 dishevelled associated activator of morphogenesis 1 0.00835401
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.00832563
NEU1 sialidase 1 (lysosomal sialidase) 0.00829996
BAMBI BMP and activin membrane-bound inhibitor 0.00822498
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.00819964
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00817507
NNMT nicotinamide N-methyltransferase 0.00814154
ATF3 activating transcription factor 3 0.00813791
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.00802823
MTUS1 microtubule associated tumor suppressor 1 0.00799743
KYNU kynureninase 0.00799077
BPIFA1 BPI fold containing family A, member 1 0.00796445
PRSS23 protease, serine, 23 0.00793924
UPK1B uroplakin 1B 0.00790451
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00786482
ANXA1 annexin A1 0.00782582
HIST1H2BD histone cluster 1, H2bd 0.00782558
KLK10 kallikrein-related peptidase 10 0.00777998
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.00774804
C1ORF54 chromosome 1 open reading frame 54 0.00767686
OXTR oxytocin receptor 0.00767379
ATF4 activating transcription factor 4 0.00765216
GPR137B G protein-coupled receptor 137B 0.0076453
TRIM29 tripartite motif containing 29 0.00763926
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00753834
GJA1 gap junction protein, alpha 1, 43kDa 0.0075186
FXYD3 FXYD domain containing ion transport regulator 3 0.00746368
CCL20 chemokine (C-C motif) ligand 20 0.00745737
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.00738269
TPST2 tyrosylprotein sulfotransferase 2 0.00733165
FOXO1 forkhead box O1 0.00732769
TUBB2A tubulin, beta 2A class IIa 0.00732276
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00726982
STC2 stanniocalcin 2 0.00724125
MALL mal, T-cell differentiation protein-like 0.00714302
MLPH melanophilin 0.00712247
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.0070751
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.00706449
TP53I3 tumor protein p53 inducible protein 3 0.00706409
KRT7 keratin 7, type II 0.00704649
TTN titin 0.00702146
CRYAB crystallin, alpha B 0.00701319
HSPH1 heat shock 105kDa/110kDa protein 1 0.00700577
CSTB cystatin B (stefin B) 0.00698381
FABP4 fatty acid binding protein 4, adipocyte 0.00698122
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 0.00697855
AQP4 aquaporin 4 0.00697018
IER5 immediate early response 5 0.00696877
REEP5 receptor accessory protein 5 0.00695222
CLIC3 chloride intracellular channel 3 0.00692951
RBM34 RNA binding motif protein 34 0.00686103
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.00684165
CAPG capping protein (actin filament), gelsolin-like 0.00682594
CD59 CD59 molecule, complement regulatory protein 0.00678846
AREG amphiregulin 0.00678779
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.0067834
PHF11 PHD finger protein 11 0.00674922
CHI3L2 chitinase 3-like 2 0.00674534
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00674445
C14ORF132 chromosome 14 open reading frame 132 0.00672557
HSPA2 heat shock 70kDa protein 2 0.00670378
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00667626
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00665196
LAMC2 laminin, gamma 2 0.00663476
MBD1 methyl-CpG binding domain protein 1 0.00659384
EDN1 endothelin 1 0.00657941
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.00657363
ABHD4 abhydrolase domain containing 4 0.0065304
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00652236
SLN sarcolipin 0.00649966
MYOF myoferlin 0.00647222
SCEL sciellin 0.00645887
SYNGR2 synaptogyrin 2 0.0064331
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.00640944
NPIPB3 nuclear pore complex interacting protein family, member B3 0.00638041
TARBP1 TAR (HIV-1) RNA binding protein 1 0.00637606
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.00637343
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.00637017
PRAME preferentially expressed antigen in melanoma 0.00637002
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00636391
TNIP1 TNFAIP3 interacting protein 1 0.0063287
FABP7 fatty acid binding protein 7, brain 0.00630788
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.00629651
PRDX1 peroxiredoxin 1 0.00626047
WDR7 WD repeat domain 7 0.00625584
PPA1 pyrophosphatase (inorganic) 1 0.00623174
GDE1 glycerophosphodiester phosphodiesterase 1 0.00623101
HBP1 HMG-box transcription factor 1 0.00622501
C10ORF10 chromosome 10 open reading frame 10 0.00622004
DMAC2L distal membrane arm assembly component 2 like 0.00621864
TNNT1 troponin T type 1 (skeletal, slow) 0.00620359
PLPP2 phospholipid phosphatase 2 0.00617798
CXCL13 chemokine (C-X-C motif) ligand 13 0.00617238
MAGEA3 melanoma antigen family A3 0.00616369
ZNF277 zinc finger protein 277 0.00614912
OSBPL9 oxysterol binding protein-like 9 0.00614185
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.00614174
VTI1B vesicle transport through interaction with t-SNAREs 1B 0.00613277
S100A9 S100 calcium binding protein A9 0.00612758
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.00612562
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.00610768
IFI6 interferon, alpha-inducible protein 6 0.00609851
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.00609669
ACOT13 acyl-CoA thioesterase 13 0.00609039
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00608914
AKR1C1 aldo-keto reductase family 1, member C1 0.0060876
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.00608715
HBEGF heparin-binding EGF-like growth factor 0.00607859
PLP1 proteolipid protein 1 0.0060738
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00606791
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.00606493
APOD apolipoprotein D 0.0060618
ZMAT3 zinc finger, matrin-type 3 0.00604916
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00603143
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.00602071
EGR2 early growth response 2 0.00602006
STATH statherin 0.00601395
CTSD cathepsin D 0.00600745
SYT17 synaptotagmin XVII 0.00600239
TUBA4A tubulin, alpha 4a 0.00596875
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.00595266
SMPX small muscle protein, X-linked 0.00594645
AKAP9 A kinase (PRKA) anchor protein 9 0.0059244
CCL4 chemokine (C-C motif) ligand 4 0.00590945
USP9X ubiquitin specific peptidase 9, X-linked 0.0059092
DDIT3 DNA-damage-inducible transcript 3 0.00589494
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.00588977
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.00588895
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.00588677
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.00587626
IL1RN interleukin 1 receptor antagonist 0.00587509
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.00586785
KLF4 Kruppel-like factor 4 (gut) 0.00586449
OFD1 oral-facial-digital syndrome 1 0.00586401
HSPB1 heat shock 27kDa protein 1 0.00586258
POPDC3 popeye domain containing 3 0.00585795
SELE selectin E 0.00584844
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 0.00584495
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.0058061
LAT2 linker for activation of T cells family, member 2 0.00578241
ZFP36 ZFP36 ring finger protein 0.00577496
FTH1 ferritin, heavy polypeptide 1 0.0057698
C6ORF48 chromosome 6 open reading frame 48 0.00576367
CAPN3 calpain 3, (p94) 0.00576258
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.00575786
CNTN1 contactin 1 0.00575383
FHL2 four and a half LIM domains 2 0.00574691
RND3 Rho family GTPase 3 0.00574041
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.00573985
KRT6A keratin 6A, type II 0.00573572
RPL26 ribosomal protein L26 0.00571353
PRKCQ protein kinase C, theta 0.00568839
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.00568734
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00567968
HMOX1 heme oxygenase 1 0.0056748
FXR1 fragile X mental retardation, autosomal homolog 1 0.00567426
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.00565055
NCF1C neutrophil cytosolic factor 1C pseudogene 0.00564148
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.00563159
KRT5 keratin 5, type II 0.00562957
AVPI1 arginine vasopressin-induced 1 0.00561283
MICB MHC class I polypeptide-related sequence B 0.00561187
TAGLN2 transgelin 2 0.005608
OXA1L oxidase (cytochrome c) assembly 1-like 0.00559332
TACSTD2 tumor-associated calcium signal transducer 2 0.0055912
SFTPD surfactant protein D 0.00558185
RHOF ras homolog family member F (in filopodia) 0.0055778
BUD31 BUD31 homolog (S. cerevisiae) 0.00557499
ZIC1 Zic family member 1 0.00557185
MCM2 minichromosome maintenance complex component 2 0.00555736
SHTN1 shootin 1 0.00555444
INHBA inhibin, beta A 0.00554982
MOBP myelin-associated oligodendrocyte basic protein 0.00554815
KRT23 keratin 23, type I 0.0055453
NRBF2 nuclear receptor binding factor 2 0.00554512
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.00552794
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00552492
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.00549307
DMTF1 cyclin D binding myb-like transcription factor 1 0.00548493
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00545524
KLK11 kallikrein-related peptidase 11 0.00545257
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.00544721
BCL2A1 BCL2-related protein A1 0.00544281
LCMT1 leucine carboxyl methyltransferase 1 0.0054316
PLIN3 perilipin 3 0.00542548
VAMP8 vesicle-associated membrane protein 8 0.00541917
MSLN mesothelin 0.00539813
ICAM1 intercellular adhesion molecule 1 0.00539209
IRF9 interferon regulatory factor 9 0.00537944
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 0.00535236
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00535009
KLHL24 kelch-like family member 24 0.00534896
YPEL5 yippee-like 5 (Drosophila) 0.00534579
RGS13 regulator of G-protein signaling 13 0.00534539
TXNL1 thioredoxin-like 1 0.00534485

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0212397
SSBP2 single-stranded DNA binding protein 2 -0.0203567
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -0.0137654
TXLNA taxilin alpha -0.0132348
OLFM4 olfactomedin 4 -0.0127726
LYZ lysozyme -0.011714
CDCA4 cell division cycle associated 4 -0.0116281
ANPEP alanyl (membrane) aminopeptidase -0.0115058
KRT19 keratin 19, type I -0.0113372
ACAT2 acetyl-CoA acetyltransferase 2 -0.0112497
PRDX2 peroxiredoxin 2 -0.0108138
DACH1 dachshund family transcription factor 1 -0.010571
KANK2 KN motif and ankyrin repeat domains 2 -0.0105586
FRZB frizzled-related protein -0.0103752
AEBP1 AE binding protein 1 -0.010358
PCP4 Purkinje cell protein 4 -0.0102275
TPSAB1 tryptase alpha/beta 1 -0.010044
SUB1 SUB1 homolog (S. cerevisiae) -0.00995938
METRN meteorin, glial cell differentiation regulator -0.00995046
ZBTB18 zinc finger and BTB domain containing 18 -0.00992719
NELL2 NEL-like 2 (chicken) -0.00984228
GAS1 growth arrest-specific 1 -0.00960838
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -0.00946287
RAPSN receptor-associated protein of the synapse -0.0092717
ESR1 estrogen receptor 1 -0.00925681
PLN phospholamban -0.00906892
SEPP1 selenoprotein P, plasma, 1 -0.00898319
LOXL1 lysyl oxidase-like 1 -0.00890054
CPVL carboxypeptidase, vitellogenic-like -0.00888327
IL13RA2 interleukin 13 receptor, alpha 2 -0.00887705
JCHAIN joining chain of multimeric IgA and IgM -0.00884247
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00879624
CPB1 carboxypeptidase B1 (tissue) -0.00872356
SEC23A Sec23 homolog A (S. cerevisiae) -0.00870417
SFRP1 secreted frizzled-related protein 1 -0.00865607
CPE carboxypeptidase E -0.00861137
PDZRN3 PDZ domain containing ring finger 3 -0.00844027
HBB hemoglobin, beta -0.00837188
CPA3 carboxypeptidase A3 (mast cell) -0.00829184
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.00826366
KDM5D lysine (K)-specific demethylase 5D -0.00809981
ARHGAP29 Rho GTPase activating protein 29 -0.00807074
CD302 CD302 molecule -0.00804573
COL14A1 collagen, type XIV, alpha 1 -0.00801189
COL6A2 collagen, type VI, alpha 2 -0.00799758
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00794851
FABP1 fatty acid binding protein 1, liver -0.00793781
PDGFC platelet derived growth factor C -0.00792689
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.00786247
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.00777646
FBLN1 fibulin 1 -0.0077735
ZNF217 zinc finger protein 217 -0.00773041
CDH3 cadherin 3, type 1, P-cadherin (placental) -0.00772454
REG3A regenerating islet-derived 3 alpha -0.0077142
THAP12 THAP domain containing 12 -0.00769521
WT1 Wilms tumor 1 -0.00767994
CXCL14 chemokine (C-X-C motif) ligand 14 -0.00765461
OLFM1 olfactomedin 1 -0.00760387
IGFBP5 insulin-like growth factor binding protein 5 -0.00757538
NPM3 nucleophosmin/nucleoplasmin 3 -0.0074927
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0074847
LMNB1 lamin B1 -0.00746098
FGFR1 fibroblast growth factor receptor 1 -0.00743911
ELN elastin -0.00743221
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0074132
NCAM1 neural cell adhesion molecule 1 -0.00740198
TRAF5 TNF receptor-associated factor 5 -0.00735609
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.00732602
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.00731435
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00727958
MDFIC MyoD family inhibitor domain containing -0.00727771
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -0.00723613
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.00721753
GREM1 gremlin 1, DAN family BMP antagonist -0.00720367
REG1A regenerating islet-derived 1 alpha -0.00715308
ZSCAN18 zinc finger and SCAN domain containing 18 -0.00712603
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.00712034
METTL7A methyltransferase like 7A -0.00710095
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.00708055
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.00707485
AMD1 adenosylmethionine decarboxylase 1 -0.00705615
COQ8A coenzyme Q8A -0.00703225
DCLK1 doublecortin-like kinase 1 -0.00702565
MAP7 microtubule-associated protein 7 -0.0070009
CDCP1 CUB domain containing protein 1 -0.00695392
F13A1 coagulation factor XIII, A1 polypeptide -0.00694896
FGFR3 fibroblast growth factor receptor 3 -0.00694389
ISYNA1 inositol-3-phosphate synthase 1 -0.00692384
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.00687865
HEPH hephaestin -0.00687858
PLXNC1 plexin C1 -0.00687237
RASA4 RAS p21 protein activator 4 -0.00679577
THBS1 thrombospondin 1 -0.00672094
PROM1 prominin 1 -0.00671526
BICC1 BicC family RNA binding protein 1 -0.00670146
TBX3 T-box 3 -0.00669632
FST follistatin -0.00669212
SOCS5 suppressor of cytokine signaling 5 -0.00668983
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.00668022
RBPMS RNA binding protein with multiple splicing -0.00665068
CCND2 cyclin D2 -0.00664712
SVIL supervillin -0.00664411
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.00663146
CALD1 caldesmon 1 -0.00662677
CDC20 cell division cycle 20 -0.0066261
NBPF10 neuroblastoma breakpoint family, member 10 -0.00659536
PMP22 peripheral myelin protein 22 -0.00659115
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.00658541
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.00657865
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00656974
BMI1 BMI1 proto-oncogene, polycomb ring finger -0.00653648
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.00653553
HOXC6 homeobox C6 -0.00652857
CCNF cyclin F -0.00652097
CBX5 chromobox homolog 5 -0.00651097
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00650159
TACC3 transforming, acidic coiled-coil containing protein 3 -0.00648977
UNG uracil-DNA glycosylase -0.00647692
FUBP1 far upstream element (FUSE) binding protein 1 -0.00645669
HMGB1 high mobility group box 1 -0.0064538
DCXR dicarbonyl/L-xylulose reductase -0.00643608
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.00641719
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.00639578
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.00635586
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00630516
PFKL phosphofructokinase, liver -0.00629966
TMX4 thioredoxin-related transmembrane protein 4 -0.00628914
SLIT2 slit homolog 2 (Drosophila) -0.00628755
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -0.00627645
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -0.0062749
SDC2 syndecan 2 -0.00627179
TMPO thymopoietin -0.00625513
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -0.00624495
DPYSL2 dihydropyrimidinase-like 2 -0.00622222
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.00621396
LTBP2 latent transforming growth factor beta binding protein 2 -0.00620831
GATA2 GATA binding protein 2 -0.00619261
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.00618098
PAN2 PAN2 poly(A) specific ribonuclease subunit -0.00615503
TRMT5 tRNA methyltransferase 5 -0.0061462
FAM13A family with sequence similarity 13, member A -0.00613959
SELENBP1 selenium binding protein 1 -0.00613222
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.0061221
PNMA8A PNMA family member 8A -0.00611534
LBR lamin B receptor -0.00610698
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.00610474
PBX1 pre-B-cell leukemia homeobox 1 -0.0061017
TOX3 TOX high mobility group box family member 3 -0.00608652
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -0.00608425
LDOC1 leucine zipper, down-regulated in cancer 1 -0.00607303
TSPYL5 TSPY-like 5 -0.00605556
NID1 nidogen 1 -0.00605058
PSIP1 PC4 and SFRS1 interacting protein 1 -0.00603693
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.00602135
SMC4 structural maintenance of chromosomes 4 -0.00601669
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.00600959
CHRDL1 chordin-like 1 -0.00599476
ZMIZ1 zinc finger, MIZ-type containing 1 -0.00598125
EPHX2 epoxide hydrolase 2, cytoplasmic -0.00597898
CBX3 chromobox homolog 3 -0.00597719
CERK ceramide kinase -0.00594754
RNF144A ring finger protein 144A -0.00593325
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.00592837
FBXO5 F-box protein 5 -0.00590512
PRKCA protein kinase C, alpha -0.00590118
USP1 ubiquitin specific peptidase 1 -0.00589697
PRKCB protein kinase C, beta -0.00587716
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.00586825
INSIG1 insulin induced gene 1 -0.0058632
NDC80 NDC80 kinetochore complex component -0.00585861
RAD23B RAD23 homolog B (S. cerevisiae) -0.00585285
TP53 tumor protein p53 -0.0058512
PHTF2 putative homeodomain transcription factor 2 -0.0058289
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.00581986
RPA3 replication protein A3, 14kDa -0.00579398
STC1 stanniocalcin 1 -0.00579191
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit -0.00578389
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.00576669
NFIB nuclear factor I/B -0.0057472
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00574234
IRX5 iroquois homeobox 5 -0.00573872
MST1 macrophage stimulating 1 -0.00573618
ANGPTL2 angiopoietin-like 2 -0.00573068
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.00573003
ITGA8 integrin, alpha 8 -0.00571163
IRAK3 interleukin-1 receptor-associated kinase 3 -0.00570133
COMP cartilage oligomeric matrix protein -0.00568839
RSBN1 round spermatid basic protein 1 -0.00568472
AXL AXL receptor tyrosine kinase -0.00567971
LGALS13 lectin, galactoside-binding, soluble, 13 -0.00566777
MPHOSPH9 M-phase phosphoprotein 9 -0.0056677
C1R complement component 1, r subcomponent -0.00566578
MCOLN1 mucolipin 1 -0.0056639
WDR61 WD repeat domain 61 -0.00566101
CDC7 cell division cycle 7 -0.00565183
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -0.00564889
NOTCH2 notch 2 -0.00564466
GSTM3 glutathione S-transferase mu 3 (brain) -0.0056421
PRC1 protein regulator of cytokinesis 1 -0.00563713
CD320 CD320 molecule -0.00563699
HMGN4 high mobility group nucleosomal binding domain 4 -0.00561362
PDLIM3 PDZ and LIM domain 3 -0.00560879
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -0.0056039
CEP57 centrosomal protein 57kDa -0.00559652
GLS glutaminase -0.00559516
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00559115
ZEB1 zinc finger E-box binding homeobox 1 -0.00557792
EDNRA endothelin receptor type A -0.00557639
TFPI2 tissue factor pathway inhibitor 2 -0.00556736
RACGAP1 Rac GTPase activating protein 1 -0.0055478
UBP1 upstream binding protein 1 (LBP-1a) -0.0055463
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.00552647
KLHL23 kelch-like family member 23 -0.00551132
TARDBP TAR DNA binding protein -0.00550601
NUP43 nucleoporin 43kDa -0.00550185
PID1 phosphotyrosine interaction domain containing 1 -0.00549104
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -0.005491
GPA33 glycoprotein A33 (transmembrane) -0.00547399
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -0.00546811
REG1B regenerating islet-derived 1 beta -0.00546708
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -0.00544946
FAM46C family with sequence similarity 46, member C -0.00544449
PER3 period circadian clock 3 -0.00543626
TTC37 tetratricopeptide repeat domain 37 -0.00542853
CLCA1 chloride channel accessory 1 -0.00542747
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -0.00542474
EMILIN1 elastin microfibril interfacer 1 -0.00542357
MMP3 matrix metallopeptidase 3 -0.00542351
VEZF1 vascular endothelial zinc finger 1 -0.0054206
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.00541816
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -0.00541132
KLF3-AS1 KLF3 antisense RNA 1 -0.0054096
JAG1 jagged 1 -0.00540768
NID2 nidogen 2 (osteonidogen) -0.00540707
RNF38 ring finger protein 38 -0.00540287
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -0.0053996
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.00538729
FOXM1 forkhead box M1 -0.00538458
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) -0.00537826
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -0.00537686
AZF1 azoospermia factor 1 -0.00537626
TSPAN4 tetraspanin 4 -0.00537609
MXRA5 matrix-remodelling associated 5 -0.00537525
CRIP2 cysteine-rich protein 2 -0.00537395
KAT2B K(lysine) acetyltransferase 2B -0.00537183
RAB20 RAB20, member RAS oncogene family -0.00536789
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00536743
NUP107 nucleoporin 107kDa -0.00536251
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -0.00535953