KLK2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description kallikrein-related peptidase 2|This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 3817)
External Link http://www.ncbi.nlm.nih.gov/gene/3817
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Genes

22 interacting proteins for KLK2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
APP amyloid beta (A4) precursor protein
AR androgen receptor
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
RNF2 ring finger protein 2
SEMG1 semenogelin I
SEMG2 semenogelin II
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit