KLK7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description kallikrein-related peptidase 7|This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011] (NCBI Entrez Gene Database, 5650)
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Genes

311 genes differentially expressed following the KLK7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHB10 protocadherin beta 10 2.77323
CFHR3 complement factor H-related 3 2.77323
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.77323
CARD16 caspase recruitment domain family, member 16 2.77323
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.77323
PROKR1 prokineticin receptor 1 2.77323
GPR162 G protein-coupled receptor 162 2.77323
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.77323
DUXA double homeobox A 2.77323
IZUMO3 IZUMO family member 3 2.77323
CFHR5 complement factor H-related 5 2.77323
SRL sarcalumenin 2.77323
SLC35D3 solute carrier family 35, member D3 2.77323
CAPN11 calpain 11 2.77323
ACOT1 acyl-CoA thioesterase 1 2.77323
IZUMO1 izumo sperm-egg fusion 1 2.77323
ZNF597 zinc finger protein 597 2.77323
FAM3D family with sequence similarity 3, member D 2.77323
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.77323
NRN1 neuritin 1 2.77323
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.77323
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.77323
CD1C CD1c molecule 2.77323
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.77323
CA7 carbonic anhydrase VII 2.77323
GUCY2F guanylate cyclase 2F, retinal 2.77323
TDRD6 tudor domain containing 6 2.77323
LCN12 lipocalin 12 2.77323
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.77323
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.77323
SYCE3 synaptonemal complex central element protein 3 2.77323
MUC22 mucin 22 2.77323
ATOH7 atonal homolog 7 (Drosophila) 2.77323
MFAP5 microfibrillar associated protein 5 2.77323
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.77323
NXPH4 neurexophilin 4 2.77323
PGAM4 phosphoglycerate mutase family member 4 2.77323
DNASE1L2 deoxyribonuclease I-like 2 2.77323
ZNF662 zinc finger protein 662 2.77323
ZNF467 zinc finger protein 467 2.77323
SLC25A45 solute carrier family 25, member 45 2.77323
AADACL2 arylacetamide deacetylase-like 2 2.77323
PAX9 paired box 9 2.77323
OLIG1 oligodendrocyte transcription factor 1 2.77323
TSHZ1 teashirt zinc finger homeobox 1 2.77323
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.77323
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 2.77323
PLN phospholamban 2.77323
FRG2C FSHD region gene 2 family, member C 2.77323
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.77323
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.77323
TMPRSS4 transmembrane protease, serine 4 2.77323
PAPOLB poly(A) polymerase beta (testis specific) 2.77323
MYL10 myosin, light chain 10, regulatory 2.77323
OR52E6 olfactory receptor, family 52, subfamily E, member 6 2.77323
AVPR1B arginine vasopressin receptor 1B 2.77323
HAO2 hydroxyacid oxidase 2 (long chain) 2.77323
CATSPERH catsper channel auxiliary subunit eta 2.77323
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.77323
SPMIP11 sperm microtubule inner protein 11 2.77323
CIMIP2A ciliary microtubule inner protein 2A 2.77323
TEX53 testis expressed 53 2.77323
EXOC1L exocyst complex component 1 like 2.77323
NFILZ NFIL3 like basic leucine zipper 2.77323
DEFB131B defensin beta 131B 2.77323
BEX3 brain expressed X-linked 3 2.77323
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.77323
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.77323
MLANA melan-A 2.77323
OVOL3 ovo-like zinc finger 3 2.77323
IL5 interleukin 5 2.77323
ZIC4 Zic family member 4 2.77323
TMCO2 transmembrane and coiled-coil domains 2 2.77323
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.77323
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.77323
CCR6 chemokine (C-C motif) receptor 6 2.77323
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.77323
CLDN9 claudin 9 2.77323
TLR8 toll-like receptor 8 2.77323
SLAMF1 signaling lymphocytic activation molecule family member 1 2.77323
LGSN lengsin, lens protein with glutamine synthetase domain 2.77323
IL1R1 interleukin 1 receptor, type I 2.77323
BLNK B-cell linker 2.77323
PGA5 pepsinogen 5, group I (pepsinogen A) 2.77323
GTSF1 gametocyte specific factor 1 2.77323
OBP2A odorant binding protein 2A 2.77323
GJD2 gap junction protein, delta 2, 36kDa 2.77323
C6ORF118 chromosome 6 open reading frame 118 2.77323
C1QL2 complement component 1, q subcomponent-like 2 2.77323
CCDC13 coiled-coil domain containing 13 2.77323
VCX variable charge, X-linked 2.77323
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.77323
POF1B premature ovarian failure, 1B 2.77323
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.77323
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.77323
PCP2 Purkinje cell protein 2 2.77323
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.77323
HOXD1 homeobox D1 2.77323
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.77323
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.77323
CERS3 ceramide synthase 3 2.77323
DYDC1 DPY30 domain containing 1 2.77323
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.77323
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.77323
AGR2 anterior gradient 2 2.77323
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.77323
SETMAR SET domain and mariner transposase fusion gene 2.77323
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.77323
ZNF366 zinc finger protein 366 2.77323
CH25H cholesterol 25-hydroxylase 2.77323
BRDT bromodomain, testis-specific 2.77323
TRIM55 tripartite motif containing 55 2.77323
C8ORF89 chromosome 8 open reading frame 89 2.77323
TEX11 testis expressed 11 2.77323
SLC38A3 solute carrier family 38, member 3 2.77323
QRFP pyroglutamylated RFamide peptide 2.77323
ORM2 orosomucoid 2 2.77323
KRTAP10-3 keratin associated protein 10-3 2.77323
MEPE matrix extracellular phosphoglycoprotein 2.77323
CXORF58 chromosome X open reading frame 58 2.77323
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.77323
GOLGA8H golgin A8 family, member H 2.77323
SLC38A8 solute carrier family 38, member 8 2.77323
ERH enhancer of rudimentary homolog (Drosophila) 2.77323
CA5A carbonic anhydrase VA, mitochondrial 2.77323
MUC7 mucin 7, secreted 2.77323
VSTM1 V-set and transmembrane domain containing 1 2.77323
OCM oncomodulin 2.77323
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.77323
TF transferrin 2.77323
NT5DC4 5'-nucleotidase domain containing 4 2.77323
VAV1 vav 1 guanine nucleotide exchange factor 2.77323
PRSS33 protease, serine, 33 2.77323
GOLGA8R golgin A8 family, member R 2.77323
NMUR1 neuromedin U receptor 1 2.77323
IFNK interferon, kappa 2.77323
KIF15 kinesin family member 15 2.77323
DCST1 DC-STAMP domain containing 1 2.77323
SOST sclerostin 2.77323
WNK4 WNK lysine deficient protein kinase 4 2.77323
SACK1A scaffolding CK1 anchoring protein A 2.77323
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.77323
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.77323
EFCC1 EF-hand and coiled-coil domain containing 1 2.77323
SCIN scinderin 2.77323
PRSS22 protease, serine, 22 2.77323
BTBD19 BTB (POZ) domain containing 19 2.77323
CCDC87 coiled-coil domain containing 87 2.77323
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.77323
CD8B CD8b molecule 2.77323
IL18R1 interleukin 18 receptor 1 2.77323
HES2 hes family bHLH transcription factor 2 2.77323
CLCNKB chloride channel, voltage-sensitive Kb 2.77323
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.77323
ROM1 retinal outer segment membrane protein 1 2.77323
ANKRD37 ankyrin repeat domain 37 2.77323
SLC7A4 solute carrier family 7, member 4 2.77323
ANKRD33 ankyrin repeat domain 33 2.77323
TMEM86A transmembrane protein 86A 2.77323
FGF16 fibroblast growth factor 16 2.77323
LRRC74B leucine rich repeat containing 74B 2.77323
DNAH14 dynein, axonemal, heavy chain 14 2.71998
RACK1 receptor for activated C kinase 1 2.71279
NT5C 5', 3'-nucleotidase, cytosolic 2.67669
IFRD2 interferon-related developmental regulator 2 2.63229
ITPRID2 ITPR interacting domain containing 2 2.63062
RAI1 retinoic acid induced 1 2.62147
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 2.62147
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.60213
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 2.59279
C9ORF78 chromosome 9 open reading frame 78 2.58167
MYORG myogenesis regulating glycosidase (putative) 2.56439
DGCR2 DiGeorge syndrome critical region gene 2 2.54522
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.50846
UBE2K ubiquitin-conjugating enzyme E2K 2.46024
FOXD3 forkhead box D3 2.44108
MAP3K12 mitogen-activated protein kinase kinase kinase 12 2.38222
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 2.38222
PGLS 6-phosphogluconolactonase 2.38115
CCDC61 coiled-coil domain containing 61 2.34156
DUSP12 dual specificity phosphatase 12 2.31508
NHLRC4 NHL repeat containing 4 2.30945
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.28051
RBBP4 retinoblastoma binding protein 4 2.27483
SGF29 SAGA complex associated factor 29 2.24987
ILDR2 immunoglobulin-like domain containing receptor 2 2.21817
TSHZ2 teashirt zinc finger homeobox 2 2.2061
ADGRL1 adhesion G protein-coupled receptor L1 2.15629
PRNP prion protein 2.1522
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.12784
CFAP58 cilia and flagella associated protein 58 2.10595
BCAN brevican 2.10595
PRPF39 pre-mRNA processing factor 39 2.09309
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.08081
MSTO1 misato 1, mitochondrial distribution and morphology regulator 2.07643
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.06056
LAMC2 laminin, gamma 2 2.05102
MERTK MER proto-oncogene, tyrosine kinase 2.04901
PHF2 PHD finger protein 2 2.0405
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.03418
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 2.03418
MTX2 metaxin 2 2.02485
COPS5 COP9 signalosome subunit 5 2.01182
DPY30 dpy-30 homolog (C. elegans) 2.00061

decreased expression

Symbol Name Standardized Value
FCGBP Fc fragment of IgG binding protein -2.77323
ZNF804B zinc finger protein 804B -2.77323
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.77323
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.77323
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 -2.77323
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.77323
NABP1 nucleic acid binding protein 1 -2.77323
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.77323
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.77323
DCST2 DC-STAMP domain containing 2 -2.77323
CIMAP2 ciliary microtubule associated protein 2 -2.77323
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.77323
GOLGA6L4 golgin A6 family-like 4 -2.77323
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.77323
VLDLR very low density lipoprotein receptor -2.77323
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.77323
IL15RA interleukin 15 receptor, alpha -2.77323
SCNN1G sodium channel, non voltage gated 1 gamma subunit -2.77323
SFXN3 sideroflexin 3 -2.77323
FUCA1 fucosidase, alpha-L- 1, tissue -2.77323
C11ORF87 chromosome 11 open reading frame 87 -2.77323
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.77323
BAAT bile acid CoA:amino acid N-acyltransferase -2.77323
DRP2 dystrophin related protein 2 -2.77323
RGPD1 RANBP2-like and GRIP domain containing 1 -2.77323
DPF3 D4, zinc and double PHD fingers, family 3 -2.77323
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.77323
LBHD1 LBH domain containing 1 -2.77323
HBZ hemoglobin, zeta -2.77323
IL2RB interleukin 2 receptor, beta -2.77323
FITM2 fat storage-inducing transmembrane protein 2 -2.77323
ICE2 interactor of little elongation complex ELL subunit 2 -2.77323
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.77323
DEUP1 deuterosome assembly protein 1 -2.77323
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.77323
C2CD4D C2 calcium-dependent domain containing 4D -2.77323
KLK6 kallikrein-related peptidase 6 -2.77323
CDCA8 cell division cycle associated 8 -2.77323
LINC02798 long intergenic non-protein coding RNA 2798 -2.77323
ITGA10 integrin, alpha 10 -2.77323
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.77323
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.77323
NR5A1 nuclear receptor subfamily 5, group A, member 1 -2.77323
GPR149 G protein-coupled receptor 149 -2.77323
DRC10 dynein regulatory complex subunit 10 -2.77323
UPK1A uroplakin 1A -2.77323
SLC7A14 solute carrier family 7, member 14 -2.77323
UPK2 uroplakin 2 -2.77323
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.77323
LRRC32 leucine rich repeat containing 32 -2.77323
ZFP2 ZFP2 zinc finger protein -2.77323
TUBA4B tubulin, alpha 4b -2.77323
LEKR1 leucine, glutamate and lysine rich 1 -2.77323
ZNF703 zinc finger protein 703 -2.77323
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -2.77323
CCDC74B coiled-coil domain containing 74B -2.77323
CD70 CD70 molecule -2.77323
FIGN fidgetin -2.74222
PALM2AKAP2 PALM2 and AKAP2 fusion -2.70179
ANKRD45 ankyrin repeat domain 45 -2.67948
FOXI3 forkhead box I3 -2.67862
G0S2 G0/G1 switch 2 -2.67862
CNR1 cannabinoid receptor 1 (brain) -2.67862
EXOC3L2 exocyst complex component 3-like 2 -2.67862
ZFYVE19 zinc finger, FYVE domain containing 19 -2.67862
LEMD3 LEM domain containing 3 -2.66673
ZNF483 zinc finger protein 483 -2.64401
GRID1 glutamate receptor, ionotropic, delta 1 -2.60847
GARIN2 golgi associated RAB2 interactor family member 2 -2.60847
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.5856
BTBD9 BTB (POZ) domain containing 9 -2.46956
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.45705
KBTBD6 kelch repeat and BTB (POZ) domain containing 6 -2.35933
CDC42SE1 CDC42 small effector 1 -2.35695
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -2.35027
TSC22D1 TSC22 domain family, member 1 -2.3293
MITF microphthalmia-associated transcription factor -2.30945
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.29796
HINFP histone H4 transcription factor -2.27483
HSPB8 heat shock 22kDa protein 8 -2.25476
CNTN3 contactin 3 (plasmacytoma associated) -2.25476
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.24987
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.24987
RSPO2 R-spondin 2 -2.24987
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 -2.23018
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.23006
LEAP2 liver expressed antimicrobial peptide 2 -2.20838
EDNRB endothelin receptor type B -2.17908
PROSER1 proline and serine rich 1 -2.17497
CLIP1 CAP-GLY domain containing linker protein 1 -2.17094
MED20 mediator complex subunit 20 -2.15826
THEMIS2 thymocyte selection associated family member 2 -2.12811
FBXL3 F-box and leucine-rich repeat protein 3 -2.12811
MAPRE3 microtubule-associated protein, RP/EB family, member 3 -2.11165
KLHL29 kelch-like family member 29 -2.06737
NRXN3 neurexin 3 -2.05515
MRAP melanocortin 2 receptor accessory protein -2.05334
UNC79 unc-79 homolog (C. elegans) -2.05102
ZNF540 zinc finger protein 540 -2.04901
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.04901
GTSE1 G-2 and S-phase expressed 1 -2.04901
TMEM115 transmembrane protein 115 -2.0405
LACTB2 lactamase, beta 2 -2.0405
JADE1 jade family PHD finger 1 -2.03418
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -2.0196
HLA-DOA major histocompatibility complex, class II, DO alpha -2.0196
ASXL3 additional sex combs like transcriptional regulator 3 -2.01182