KPT-185 Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

94 genes differentially expressed following the KPT-185 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
FRS2 fibroblast growth factor receptor substrate 2 6.67763
E2F2 E2F transcription factor 2 4.85342
ALDOC aldolase C, fructose-bisphosphate 4.45272
RHOBTB1 Rho-related BTB domain containing 1 4.44085
RALGDS ral guanine nucleotide dissociation stimulator 4.29976
COPS7A COP9 signalosome subunit 7A 4.2061
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 4.13404
GADD45B growth arrest and DNA-damage-inducible, beta 4.01654
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 4.00688
SESN1 sestrin 1 3.85394
ANGPTL2 angiopoietin-like 2 3.7351
MAGEA11 melanoma antigen family A11 3.65162
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.63685
ING4 inhibitor of growth family, member 4 3.62212
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 3.62197
ASPA aspartoacylase 3.60648
TP53I3 tumor protein p53 inducible protein 3 3.58961
PDK2 pyruvate dehydrogenase kinase, isozyme 2 3.53588
SP100 SP100 nuclear antigen 3.51769
SCGB1D2 secretoglobin, family 1D, member 2 3.47346
ZNF415 zinc finger protein 415 3.4606
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.44797
TENT5A terminal nucleotidyltransferase 5A 3.38173
NOX4 NADPH oxidase 4 3.34489
MT1E metallothionein 1E 3.29486
MX2 MX dynamin-like GTPase 2 3.29333
H2BC12 H2B clustered histone 12 3.27962
BTBD3 BTB (POZ) domain containing 3 3.25238
IFITM2 interferon induced transmembrane protein 2 3.24457
PBX2P1 pre-B-cell leukemia homeobox 2 pseudogene 1 3.23944
IFITM3 interferon induced transmembrane protein 3 3.23702
FMO4 flavin containing monooxygenase 4 3.23255
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.23184
FAM32A family with sequence similarity 32, member A 3.22447
FABP4 fatty acid binding protein 4, adipocyte 3.22089
TRIM21 tripartite motif containing 21 3.21187
DUSP14 dual specificity phosphatase 14 3.20809
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 3.19119
FDXR ferredoxin reductase 3.19011
PELI2 pellino E3 ubiquitin protein ligase family member 2 3.18643
SPATA7 spermatogenesis associated 7 3.16776
CTSL cathepsin L 3.15971
PRSS23 protease, serine, 23 3.15908
ZNF155 zinc finger protein 155 3.15671
TLR3 toll-like receptor 3 3.1326
CLSTN2 calsyntenin 2 3.12945
AAMDC adipogenesis associated, Mth938 domain containing 3.1242
SV2B synaptic vesicle glycoprotein 2B 3.11988
MT1H metallothionein 1H 3.08745
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.07097
ABHD4 abhydrolase domain containing 4 3.0705
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 3.06234
CTAG2 cancer/testis antigen 2 3.03164
NOTCH4 notch 4 3.01603
ZNF83 zinc finger protein 83 3.00914
PHTF1 putative homeodomain transcription factor 1 3.00195
SP110 SP110 nuclear body protein 3.0013

decreased expression

Symbol Name Standardized Value
MYO1D myosin ID -4.02539
RPS5 ribosomal protein S5 -3.99938
LBR lamin B receptor -3.90095
PTDSS1 phosphatidylserine synthase 1 -3.87306
TCEA1 transcription elongation factor A (SII), 1 -3.83966
XPOT exportin, tRNA -3.79856
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -3.79312
CREB3L2 cAMP responsive element binding protein 3-like 2 -3.73232
COPZ1 coatomer protein complex, subunit zeta 1 -3.62792
PYCR1 pyrroline-5-carboxylate reductase 1 -3.57065
RIOX2 ribosomal oxygenase 2 -3.54039
FTH1 ferritin, heavy polypeptide 1 -3.4719
GMPS guanine monphosphate synthase -3.47091
PAX5 paired box 5 -3.44002
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -3.42587
OLA1 Obg-like ATPase 1 -3.42323
NSD2 nuclear receptor binding SET domain protein 2 -3.41086
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.40778
PSAT1 phosphoserine aminotransferase 1 -3.31808
ATP11B ATPase, class VI, type 11B -3.31194
YARS1 tyrosyl-tRNA synthetase 1 -3.3007
ODC1 ornithine decarboxylase 1 -3.29168
CBS cystathionine-beta-synthase -3.27432
RUFY1 RUN and FYVE domain containing 1 -3.25249
GTSE1 G-2 and S-phase expressed 1 -3.24428
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -3.20253
CCNB1 cyclin B1 -3.18759
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.17372
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -3.09611
TACC3 transforming, acidic coiled-coil containing protein 3 -3.05043
DESI1 desumoylating isopeptidase 1 -3.04534
ENOPH1 enolase-phosphatase 1 -3.04278
PBK PDZ binding kinase -3.03633
GSTZ1 glutathione S-transferase zeta 1 -3.03176
BRCA1 breast cancer 1, early onset -3.03068
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -3.02239
CHD1L chromodomain helicase DNA binding protein 1-like -3.00549