KPT-330 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/71481097
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Genes

197 proteins with high or low expression in KPT-330 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
TP53 tumor protein p53 4.12
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 3.52
TP53I3 tumor protein p53 inducible protein 3 2.93
EPN3 epsin 3 2.56
ASB8 ankyrin repeat and SOCS box containing 8 2.25
ZNF296 zinc finger protein 296 2.24
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.99
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.94
CD82 CD82 molecule 1.89
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.89
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.89
CAPN5 calpain 5 1.85
ADGRG1 adhesion G protein-coupled receptor G1 1.84
RBIS ribosomal biogenesis factor 1.82
F10 coagulation factor X 1.81
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.81
AKR1C3 aldo-keto reductase family 1, member C3 1.77
FAS Fas cell surface death receptor 1.77
RND3 Rho family GTPase 3 1.76
ZBTB5 zinc finger and BTB domain containing 5 1.74
SNAI1 snail family zinc finger 1 1.73
F5 coagulation factor V (proaccelerin, labile factor) 1.72
EPHB3 EPH receptor B3 1.7
RYBP RING1 and YY1 binding protein 1.65
TBX3 T-box 3 1.6
TDG thymine-DNA glycosylase 1.59
BRD8 bromodomain containing 8 1.56
PPARD peroxisome proliferator-activated receptor delta 1.55
CSRNP2 cysteine-serine-rich nuclear protein 2 1.54
CCND1 cyclin D1 1.54
PLK2 polo-like kinase 2 1.49
TGFBR3 transforming growth factor, beta receptor III 1.47
GDF15 growth differentiation factor 15 1.47
C4BPA complement component 4 binding protein, alpha 1.46
FDXR ferredoxin reductase 1.43
PIWIL2 piwi-like RNA-mediated gene silencing 2 1.41
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.38
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.38
SESN1 sestrin 1 1.38
PLCD1 phospholipase C, delta 1 1.37
SP6 Sp6 transcription factor 1.37
FN1 fibronectin 1 1.37
RAET1G retinoic acid early transcript 1G 1.34
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.33
BPGM 2,3-bisphosphoglycerate mutase 1.32
RAB40C RAB40C, member RAS oncogene family 1.31
SCNM1 sodium channel modifier 1 1.3
HSPA4L heat shock 70kDa protein 4-like 1.3
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 1.3
SLC44A2 solute carrier family 44 (choline transporter), member 2 1.29
GEM GTP binding protein overexpressed in skeletal muscle 1.28
SESN2 sestrin 2 1.27
GATA2 GATA binding protein 2 1.26
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 1.26
MATR3 matrin 3 1.26
C18ORF32 chromosome 18 open reading frame 32 1.24
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.24
SQSTM1 sequestosome 1 1.23
GLUL glutamate-ammonia ligase 1.22
PREPL prolyl endopeptidase-like 1.22
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.21
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 1.2
TRIM21 tripartite motif containing 21 1.19
CCN1 cellular communication network factor 1 1.18
WSB1 WD repeat and SOCS box containing 1 1.18
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 1.18
FRS2 fibroblast growth factor receptor substrate 2 1.17
MAPKBP1 mitogen-activated protein kinase binding protein 1 1.17
IRS2 insulin receptor substrate 2 1.16
CPE carboxypeptidase E 1.16
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.16
TRPM4 transient receptor potential cation channel, subfamily M, member 4 1.16
COQ8A coenzyme Q8A 1.15
GLRX glutaredoxin (thioltransferase) 1.14
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 1.14
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.13
SAT2 spermidine/spermine N1-acetyltransferase family member 2 1.11
LRP10 low density lipoprotein receptor-related protein 10 1.11
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.11
HBA1 hemoglobin, alpha 1 1.11
PER2 period circadian clock 2 1.11
RAB27B RAB27B, member RAS oncogene family 1.11
PML promyelocytic leukemia 1.11
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.1
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 1.1
TOB1 transducer of ERBB2, 1 1.1
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.1
ZNF697 zinc finger protein 697 1.09
EPPK1 epiplakin 1 1.08
MSX1 msh homeobox 1 1.08
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.07
LRATD2 LRAT domain containing 2 1.06
CCND3 cyclin D3 1.06
ASB7 ankyrin repeat and SOCS box containing 7 1.05
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 1.04
C5 complement component 5 1.04
PLCL2 phospholipase C-like 2 1.04
FGFBP1 fibroblast growth factor binding protein 1 1.04
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 1.03
CCNDBP1 cyclin D-type binding-protein 1 1.02

low expression

Symbol Name Standardized Value
MT2A metallothionein 2A -3.77
TRAIP TRAF interacting protein -3.07
CDKN3 cyclin-dependent kinase inhibitor 3 -2.63
PSRC1 proline/serine-rich coiled-coil 1 -2.6
KIF18B kinesin family member 18B -2.51
IRX4 iroquois homeobox 4 -2.47
ARHGAP11A Rho GTPase activating protein 11A -2.39
WDR76 WD repeat domain 76 -2.33
CCNA2 cyclin A2 -2.3
DIAPH3 diaphanous-related formin 3 -2.27
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -2.24
CKAP2L cytoskeleton associated protein 2-like -2.24
PCLAF PCNA clamp associated factor -2.2
PLK1 polo-like kinase 1 -2.18
RNF115 ring finger protein 115 -2.18
DONSON downstream neighbor of SON -2.16
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.13
KIF18A kinesin family member 18A -2.12
KIFC1 kinesin family member C1 -2.11
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.07
SAPCD2 suppressor APC domain containing 2 -2.03
CCNB1 cyclin B1 -1.98
CDC25B cell division cycle 25B -1.98
CDC7 cell division cycle 7 -1.93
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -1.89
NEIL3 nei endonuclease VIII-like 3 (E. coli) -1.88
SLC38A2 solute carrier family 38, member 2 -1.86
KIF22 kinesin family member 22 -1.86
AURKB aurora kinase B -1.85
CLSPN claspin -1.85
KMT5A lysine methyltransferase 5A -1.85
AURKA aurora kinase A -1.85
KIAA0556 KIAA0556 -1.83
USP1 ubiquitin specific peptidase 1 -1.83
TPX2 TPX2, microtubule-associated -1.81
MCM10 minichromosome maintenance complex component 10 -1.81
CDC20 cell division cycle 20 -1.81
AUNIP aurora kinase A and ninein interacting protein -1.8
RRM2 ribonucleotide reductase M2 -1.8
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.79
CENPF centromere protein F, 350/400kDa -1.79
CDC6 cell division cycle 6 -1.78
DEPDC1 DEP domain containing 1 -1.78
CCNA1 cyclin A1 -1.77
TNS4 tensin 4 -1.76
CEP55 centrosomal protein 55kDa -1.76
TBC1D30 TBC1 domain family, member 30 -1.76
ADAM19 ADAM metallopeptidase domain 19 -1.74
STIL SCL/TAL1 interrupting locus -1.72
TYRO3 TYRO3 protein tyrosine kinase -1.72
CCDC85B coiled-coil domain containing 85B -1.71
HJURP Holliday junction recognition protein -1.69
CCNB2 cyclin B2 -1.68
STC2 stanniocalcin 2 -1.66
MELK maternal embryonic leucine zipper kinase -1.64
BRCA1 breast cancer 1, early onset -1.64
SGO1 shugoshin 1 -1.63
GMNN geminin, DNA replication inhibitor -1.63
CBX6 chromobox homolog 6 -1.63
GTSE1 G-2 and S-phase expressed 1 -1.63
IVNS1ABP influenza virus NS1A binding protein -1.63
POC1A POC1 centriolar protein A -1.62
FAM111B family with sequence similarity 111, member B -1.62
RAD54L RAD54-like (S. cerevisiae) -1.61
SCLT1 sodium channel and clathrin linker 1 -1.61
RIOK3 RIO kinase 3 -1.59
KNL1 kinetochore scaffold 1 -1.58
FAM53B family with sequence similarity 53, member B -1.58
TTK TTK protein kinase -1.58
PTTG1 pituitary tumor-transforming 1 -1.56
EXO1 exonuclease 1 -1.56
CIP2A cellular inhibitor of PP2A -1.56
CDCA8 cell division cycle associated 8 -1.54
KIF20B kinesin family member 20B -1.52
GEN1 GEN1 Holliday junction 5' flap endonuclease -1.51
CDC25C cell division cycle 25C -1.51
CCDC77 coiled-coil domain containing 77 -1.51
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -1.51
M1AP meiosis 1 associated protein -1.51
FAM161A family with sequence similarity 161, member A -1.5
KIF20A kinesin family member 20A -1.5
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -1.49
DBF4 DBF4 zinc finger -1.48
MCPH1 microcephalin 1 -1.48
ZGRF1 zinc finger, GRF-type containing 1 -1.48
USP37 ubiquitin specific peptidase 37 -1.48
WNT16 wingless-type MMTV integration site family, member 16 -1.47
ECT2 epithelial cell transforming 2 -1.47
AMD1 adenosylmethionine decarboxylase 1 -1.46
FOXM1 forkhead box M1 -1.46
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.45
UBE2C ubiquitin-conjugating enzyme E2C -1.45
ATAD5 ATPase family, AAA domain containing 5 -1.44
CENPE centromere protein E, 312kDa -1.43
RTEL1 regulator of telomere elongation helicase 1 -1.43
SASS6 spindle assembly 6 homolog (C. elegans) -1.43
RAD51 RAD51 recombinase -1.43