Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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284 genes differentially expressed following the KRAS.AMP.LUNG_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
AFP alpha-fetoprotein
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALLC allantoicase
ASIP agouti signaling protein
ATG10 autophagy related 10
ATXN3L ataxin 3-like
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BMPER BMP binding endothelial regulator
BTG4 B-cell translocation gene 4
C11ORF16 chromosome 11 open reading frame 16
C3AR1 complement component 3a receptor 1
C8B complement component 8, beta polypeptide
C8ORF59 chromosome 8 open reading frame 59
CA5A carbonic anhydrase VA, mitochondrial
CAMK1G calcium/calmodulin-dependent protein kinase IG
CCDC57 coiled-coil domain containing 57
CCL11 chemokine (C-C motif) ligand 11
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CELA2B chymotrypsin-like elastase family, member 2B
CFHR5 complement factor H-related 5
CLEC4A C-type lectin domain family 4, member A
CLEC5A C-type lectin domain family 5, member A
CLSTN2 calsyntenin 2
CLSTN3 calsyntenin 3
CRYBA1 crystallin, beta A1
CSN2 casein beta
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DEFA5 defensin, alpha 5, Paneth cell-specific
DKFZP434C153 DKFZP434C153 protein
DLX5 distal-less homeobox 5
DOCK3 dedicator of cytokinesis 3
DRICH1 aspartate-rich 1
DUSP9 dual specificity phosphatase 9
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFCAB6 EF-hand calcium binding domain 6
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EGF epidermal growth factor
F13A1 coagulation factor XIII, A1 polypeptide
FAM155B family with sequence similarity 155, member B
FAM174B family with sequence similarity 174, member B
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCRL2 Fc receptor-like 2
FGF7 fibroblast growth factor 7
FKBP6 FK506 binding protein 6, 36kDa
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCKR glucokinase (hexokinase 4) regulator
GIP gastric inhibitory polypeptide
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
GPR25 G protein-coupled receptor 25
GPR6 G protein-coupled receptor 6
GPR68 G protein-coupled receptor 68
GRP gastrin-releasing peptide
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HGFAC HGF activator
HIST1H2BB histone cluster 1, H2bb
HIST1H2BN histone cluster 1, H2bn
HPR haptoglobin-related protein
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSF1 heat shock transcription factor 1
HSPA1L heat shock 70kDa protein 1-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL26 interleukin 26
JAK3 Janus kinase 3
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KIAA0125 KIAA0125
KLK14 kallikrein-related peptidase 14
LENEP lens epithelial protein
LPL lipoprotein lipase
LRRC37A leucine rich repeat containing 37A
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LY75 lymphocyte antigen 75
MAGEA12 melanoma antigen family A12
MAGEA6 melanoma antigen family A6
MAGEB1 melanoma antigen family B1
MAN1C1 mannosidase, alpha, class 1C, member 1
MCF2L MCF.2 cell line derived transforming sequence-like
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MYOZ1 myozenin 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NELL2 NEL-like 2 (chicken)
NGF nerve growth factor (beta polypeptide)
NMUR1 neuromedin U receptor 1
NOVA1 neuro-oncological ventral antigen 1
NPAS3 neuronal PAS domain protein 3
NPBWR2 neuropeptides B/W receptor 2
NPHP1 nephronophthisis 1 (juvenile)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
OPRK1 opioid receptor, kappa 1
OSBP2 oxysterol binding protein 2
OTOR otoraplin
PAGE4 P antigen family, member 4 (prostate associated)
PAX4 paired box 4
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PNMA3 paraneoplastic Ma antigen 3
PPIEL peptidylprolyl isomerase E-like pseudogene
PRKG2 protein kinase, cGMP-dependent, type II
PTGDR2 prostaglandin D2 receptor 2
RAB30 RAB30, member RAS oncogene family
RBM12B-AS1 RBM12B antisense RNA 1
RCAN2 regulator of calcineurin 2
REST RE1-silencing transcription factor
RPL23AP53 ribosomal protein L23a pseudogene 53
SDCCAG8 serologically defined colon cancer antigen 8
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SOX12 SRY (sex determining region Y)-box 12
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SPTA1 spectrin, alpha, erythrocytic 1
SSTR1 somatostatin receptor 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
TDRD1 tudor domain containing 1
TMEM35 transmembrane protein 35
TNNT2 troponin T type 2 (cardiac)
TTLL3 tubulin tyrosine ligase-like family member 3
TUBA8 tubulin, alpha 8
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
VENTX VENT homeobox
VTN vitronectin
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZNF257 zinc finger protein 257
ZNF835 zinc finger protein 835

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE1 adhesion G protein-coupled receptor E1
ADRA2C adrenoceptor alpha 2C
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APC2 adenomatosis polyposis coli 2
BARX2 BARX homeobox 2
C19ORF73 chromosome 19 open reading frame 73
C22ORF46 chromosome 22 open reading frame 46
C2ORF54 chromosome 2 open reading frame 54
C5 complement component 5
CA1 carbonic anhydrase I
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCAR2 cell cycle and apoptosis regulator 2
CCDC82 coiled-coil domain containing 82
CD300A CD300a molecule
CD34 CD34 molecule
CEND1 cell cycle exit and neuronal differentiation 1
CEP41 centrosomal protein 41kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHL1 cell adhesion molecule L1-like
CLDN16 claudin 16
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CORO2B coronin, actin binding protein, 2B
CPLX2 complexin 2
CRY2 cryptochrome circadian clock 2
CTF1 cardiotrophin 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
DBF4B DBF4 zinc finger B
DCC DCC netrin 1 receptor
DGKQ diacylglycerol kinase, theta 110kDa
DNM1 dynamin 1
DPPA4 developmental pluripotency associated 4
DRD5 dopamine receptor D5
DTNB dystrobrevin, beta
EMILIN2 elastin microfibril interfacer 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41 erythrocyte membrane protein band 4.1
EPYC epiphycan
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGL2 fibrinogen-like 2
FSHB follicle stimulating hormone, beta polypeptide
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF10 growth differentiation factor 10
GDF2 growth differentiation factor 2
GMIP GEM interacting protein
GNAT3 guanine nucleotide binding protein, alpha transducing 3
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR17 G protein-coupled receptor 17
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRIK5 glutamate receptor, ionotropic, kainate 5
GVINP1 GTPase, very large interferon inducible pseudogene 1
H2AFJ H2A histone family, member J
HBA1 hemoglobin, alpha 1
HDAC7 histone deacetylase 7
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HHLA1 HERV-H LTR-associating 1
HIST1H1T histone cluster 1, H1t
HIST1H2BJ histone cluster 1, H2bj
HIST1H3A histone cluster 1, H3a
HOXC11 homeobox C11
HOXC8 homeobox C8
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
ICAM2 intercellular adhesion molecule 2
IFNA10 interferon, alpha 10
IFNA7 interferon, alpha 7
IGF2-AS IGF2 antisense RNA
IL12B interleukin 12B
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KMT2A lysine (K)-specific methyltransferase 2A
KREMEN2 kringle containing transmembrane protein 2
KRT32 keratin 32, type I
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MMP13 matrix metallopeptidase 13
MXD3 MAX dimerization protein 3
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
ODF1 outer dense fiber of sperm tails 1
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PAIP2B poly(A) binding protein interacting protein 2B
PDCD1 programmed cell death 1
PDE11A phosphodiesterase 11A
PGPEP1 pyroglutamyl-peptidase I
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCH2 phospholipase C, eta 2
PODNL1 podocan-like 1
POU2F3 POU class 2 homeobox 3
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRODH proline dehydrogenase (oxidase) 1
PROM1 prominin 1
PTPRH protein tyrosine phosphatase, receptor type, H
PYHIN1 pyrin and HIN domain family, member 1
RAG1 recombination activating gene 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOBTB1 Rho-related BTB domain containing 1
RPA4 replication protein A4, 30kDa
SCARF1 scavenger receptor class F, member 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SDS serine dehydratase
SETD1A SET domain containing 1A
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A16 solute carrier family 6, member 16
SNCB synuclein, beta
SNTG1 syntrophin, gamma 1
SPAG11A sperm associated antigen 11A
ST20 suppressor of tumorigenicity 20
STARD8 StAR-related lipid transfer (START) domain containing 8
SYNGR3 synaptogyrin 3
SYNPO2L synaptopodin 2-like
TBR1 T-box, brain, 1
TBXAS1 thromboxane A synthase 1 (platelet)
TF transferrin
TLR4 toll-like receptor 4
TRHDE thyrotropin-releasing hormone degrading enzyme
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSGA10 testis specific, 10
USP53 ubiquitin specific peptidase 53
WDR33 WD repeat domain 33
WISP2 WNT1 inducible signaling pathway protein 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF134 zinc finger protein 134
ZNF480 zinc finger protein 480
ZNF862 zinc finger protein 862