Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
Category | transcriptomics |
Type | gene perturbation |
Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
External Link | http://www.broadinstitute.org/gsea/msigdb/cards/KRAS.DF.V1_UP |
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386 genes differentially expressed following the KRAS.DF.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Symbol | Name |
---|---|
ABHD10 | abhydrolase domain containing 10 |
ACADVL | acyl-CoA dehydrogenase, very long chain |
ADAM8 | ADAM metallopeptidase domain 8 |
ADGRE5 | adhesion G protein-coupled receptor E5 |
AKAP12 | A kinase (PRKA) anchor protein 12 |
AKR1C3 | aldo-keto reductase family 1, member C3 |
AKT3 | v-akt murine thymoma viral oncogene homolog 3 |
ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 |
ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 |
ALDOC | aldolase C, fructose-bisphosphate |
ANKRD36B | ankyrin repeat domain 36B |
ANKRD46 | ankyrin repeat domain 46 |
ANPEP | alanyl (membrane) aminopeptidase |
ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 |
ASMTL | acetylserotonin O-methyltransferase-like |
ASPH | aspartate beta-hydroxylase |
ATP9A | ATPase, class II, type 9A |
AURKB | aurora kinase B |
BBS9 | Bardet-Biedl syndrome 9 |
BCL2L1 | BCL2-like 1 |
BCL3 | B-cell CLL/lymphoma 3 |
BCL6 | B-cell CLL/lymphoma 6 |
BEX4 | brain expressed, X-linked 4 |
BMP2 | bone morphogenetic protein 2 |
BMP6 | bone morphogenetic protein 6 |
BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) |
BORA | bora, aurora kinase A activator |
CALHM2 | calcium homeostasis modulator 2 |
CAPRIN2 | caprin family member 2 |
CAT | catalase |
CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase |
CBR4 | carbonyl reductase 4 |
CCDC85B | coiled-coil domain containing 85B |
CCL20 | chemokine (C-C motif) ligand 20 |
CCNG2 | cyclin G2 |
CCNT2 | cyclin T2 |
CDA | cytidine deaminase |
CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) |
CLDN5 | claudin 5 |
CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin |
COL6A3 | collagen, type VI, alpha 3 |
CORO1A | coronin, actin binding protein, 1A |
CPVL | carboxypeptidase, vitellogenic-like |
CRYZ | crystallin, zeta (quinone reductase) |
CSF3 | colony stimulating factor 3 (granulocyte) |
CTNNBL1 | catenin, beta like 1 |
CUTC | cutC copper transporter |
CUX2 | cut-like homeobox 2 |
CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
CXCL3 | chemokine (C-X-C motif) ligand 3 |
CXCL5 | chemokine (C-X-C motif) ligand 5 |
CXCL8 | chemokine (C-X-C motif) ligand 8 |
DDB2 | damage-specific DNA binding protein 2, 48kDa |
DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 |
DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
DNASE1L1 | deoxyribonuclease I-like 1 |
DPYD | dihydropyrimidine dehydrogenase |
DPYSL2 | dihydropyrimidinase-like 2 |
DSN1 | DSN1, MIS12 kinetochore complex component |
E2F8 | E2F transcription factor 8 |
EHBP1L1 | EH domain binding protein 1-like 1 |
EIF4B | eukaryotic translation initiation factor 4B |
ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) |
EMP3 | epithelial membrane protein 3 |
ETFB | electron-transfer-flavoprotein, beta polypeptide |
ETNK1 | ethanolamine kinase 1 |
FADS2 | fatty acid desaturase 2 |
FAM168A | family with sequence similarity 168, member A |
FAM173A | family with sequence similarity 173, member A |
FAR2 | fatty acyl CoA reductase 2 |
FKBP1B | FK506 binding protein 1B, 12.6 kDa |
FLRT3 | fibronectin leucine rich transmembrane protein 3 |
FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) |
G6PD | glucose-6-phosphate dehydrogenase |
GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 |
GATA6 | GATA binding protein 6 |
GCH1 | GTP cyclohydrolase 1 |
GFPT2 | glutamine-fructose-6-phosphate transaminase 2 |
GK3P | glycerol kinase 3 pseudogene |
GLMN | glomulin, FKBP associated protein |
GLRX | glutaredoxin (thioltransferase) |
GLS2 | glutaminase 2 (liver, mitochondrial) |
GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
GREM1 | gremlin 1, DAN family BMP antagonist |
GSTT2 | glutathione S-transferase theta 2 (gene/pseudogene) |
HCLS1 | hematopoietic cell-specific Lyn substrate 1 |
HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
HRSP12 | heat-responsive protein 12 |
HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 |
HSPA2 | heat shock 70kDa protein 2 |
IFI27 | interferon, alpha-inducible protein 27 |
IFI35 | interferon-induced protein 35 |
IFI44 | interferon-induced protein 44 |
IFI44L | interferon-induced protein 44-like |
IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
IFITM1 | interferon induced transmembrane protein 1 |
IL13RA2 | interleukin 13 receptor, alpha 2 |
IL1RL1 | interleukin 1 receptor-like 1 |
ING2 | inhibitor of growth family, member 2 |
INHBA | inhibin, beta A |
INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa |
INPP5F | inositol polyphosphate-5-phosphatase F |
IRF9 | interferon regulatory factor 9 |
ISG20 | interferon stimulated exonuclease gene 20kDa |
JAK2 | Janus kinase 2 |
KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 |
KIF3A | kinesin family member 3A |
KIN | Kin17 DNA and RNA binding protein |
LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein |
LOC81691 | exonuclease NEF-sp |
LOXL2 | lysyl oxidase-like 2 |
LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
LTBP3 | latent transforming growth factor beta binding protein 3 |
MAP3K6 | mitogen-activated protein kinase kinase kinase 6 |
MED24 | mediator complex subunit 24 |
MMP1 | matrix metallopeptidase 1 |
MPI | mannose phosphate isomerase |
MTAP | methylthioadenosine phosphorylase |
MUM1 | melanoma associated antigen (mutated) 1 |
MVP | major vault protein |
NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
NRP1 | neuropilin 1 |
OBFC1 | oligonucleotide/oligosaccharide-binding fold containing 1 |
OPLAH | 5-oxoprolinase (ATP-hydrolysing) |
PDLIM2 | PDZ and LIM domain 2 (mystique) |
PDPN | podoplanin |
PELI1 | pellino E3 ubiquitin protein ligase 1 |
PID1 | phosphotyrosine interaction domain containing 1 |
PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 |
PLAT | plasminogen activator, tissue |
PLAU | plasminogen activator, urokinase |
PLCH2 | phospholipase C, eta 2 |
PLIN3 | perilipin 3 |
PPAP2C | phosphatidic acid phosphatase type 2C |
PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
PPP2R3B | protein phosphatase 2, regulatory subunit B'', beta |
PRG1 | p53-responsive gene 1 |
PROCR | protein C receptor, endothelial |
PRSS3 | protease, serine, 3 |
PTPRG | protein tyrosine phosphatase, receptor type, G |
PXDN | peroxidasin |
QPRT | quinolinate phosphoribosyltransferase |
RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
RASIP1 | Ras interacting protein 1 |
RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) |
RGS17 | regulator of G-protein signaling 17 |
RGS2 | regulator of G-protein signaling 2 |
RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
RRAD | Ras-related associated with diabetes |
S100P | S100 calcium binding protein P |
SAP30 | Sin3A-associated protein, 30kDa |
SCAND1 | SCAN domain containing 1 |
SCG5 | secretogranin V |
SEC24D | SEC24 family member D |
SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 |
SLC26A2 | solute carrier family 26 (anion exchanger), member 2 |
SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 |
SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 |
SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
SMTN | smoothelin |
SMYD3 | SET and MYND domain containing 3 |
SPAG4 | sperm associated antigen 4 |
SPRY2 | sprouty homolog 2 (Drosophila) |
SRPX | sushi-repeat containing protein, X-linked |
STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
STK4 | serine/threonine kinase 4 |
STX4 | syntaxin 4 |
SUGCT | succinyl-CoA:glutarate-CoA transferase |
TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) |
TFPI2 | tissue factor pathway inhibitor 2 |
TIMP4 | TIMP metallopeptidase inhibitor 4 |
TLR2 | toll-like receptor 2 |
TM4SF1 | transmembrane 4 L six family member 1 |
TMEM135 | transmembrane protein 135 |
TMEM158 | transmembrane protein 158 (gene/pseudogene) |
TMEM160 | transmembrane protein 160 |
TP53I3 | tumor protein p53 inducible protein 3 |
TRPC1 | transient receptor potential cation channel, subfamily C, member 1 |
TSPAN5 | tetraspanin 5 |
TUBG2 | tubulin, gamma 2 |
UBE2W | ubiquitin-conjugating enzyme E2W (putative) |
VCAN | versican |
VEGFC | vascular endothelial growth factor C |
ZMYND8 | zinc finger, MYND-type containing 8 |
ZNF654 | zinc finger protein 654 |
Symbol | Name |
---|---|
ACTL6A | actin-like 6A |
ADRB2 | adrenoceptor beta 2, surface |
AHR | aryl hydrocarbon receptor |
ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit |
ALOX12P2 | arachidonate 12-lipoxygenase pseudogene 2 |
ALOX5 | arachidonate 5-lipoxygenase |
ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 |
ARHGAP26 | Rho GTPase activating protein 26 |
ARID3B | AT rich interactive domain 3B (BRIGHT-like) |
ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 |
AUTS2 | autism susceptibility candidate 2 |
BCAM | basal cell adhesion molecule (Lutheran blood group) |
BDKRB1 | bradykinin receptor B1 |
BMP4 | bone morphogenetic protein 4 |
C12ORF49 | chromosome 12 open reading frame 49 |
C1ORF109 | chromosome 1 open reading frame 109 |
C3ORF14 | chromosome 3 open reading frame 14 |
C6ORF15 | chromosome 6 open reading frame 15 |
CAMKV | CaM kinase-like vesicle-associated |
CBX4 | chromobox homolog 4 |
CD2 | CD2 molecule |
CDK18 | cyclin-dependent kinase 18 |
CDK20 | cyclin-dependent kinase 20 |
CHRM5 | cholinergic receptor, muscarinic 5 |
CLDN1 | claudin 1 |
CLDN17 | claudin 17 |
CNR2 | cannabinoid receptor 2 (macrophage) |
CNTFR | ciliary neurotrophic factor receptor |
COBL | cordon-bleu WH2 repeat protein |
COG5 | component of oligomeric golgi complex 5 |
COL11A2 | collagen, type XI, alpha 2 |
COL4A5 | collagen, type IV, alpha 5 |
COPZ2 | coatomer protein complex, subunit zeta 2 |
CTAGE9 | CTAGE family, member 9 |
CXADR | coxsackie virus and adenovirus receptor |
CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 |
CYTH4 | cytohesin 4 |
DCAF10 | DDB1 and CUL4 associated factor 10 |
DEFB4A | defensin, beta 4A |
DUSP2 | dual specificity phosphatase 2 |
DVL3 | dishevelled segment polarity protein 3 |
EPB41L4B | erythrocyte membrane protein band 4.1 like 4B |
EPPK1 | epiplakin 1 |
ERN1 | endoplasmic reticulum to nucleus signaling 1 |
ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
EXOSC7 | exosome component 7 |
FAM153A | family with sequence similarity 153, member A |
FAM63A | family with sequence similarity 63, member A |
FANCE | Fanconi anemia, complementation group E |
FBN2 | fibrillin 2 |
GAP43 | growth associated protein 43 |
GCC1 | GRIP and coiled-coil domain containing 1 |
GJB4 | gap junction protein, beta 4, 30.3kDa |
GLIPR1 | GLI pathogenesis-related 1 |
GPATCH2 | G patch domain containing 2 |
HDAC9 | histone deacetylase 9 |
HIST1H2BH | histone cluster 1, H2bh |
HIST2H2AA3 | histone cluster 2, H2aa3 |
HMGN3 | high mobility group nucleosomal binding domain 3 |
HOMER2 | homer scaffolding protein 2 |
HOXA11 | homeobox A11 |
HOXC8 | homeobox C8 |
HPX | hemopexin |
HRH2 | histamine receptor H2 |
HSPB6 | heat shock protein, alpha-crystallin-related, B6 |
HTR3A | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
HUS1 | HUS1 checkpoint homolog (S. pombe) |
IFNA17 | interferon, alpha 17 |
IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
IGFBP3 | insulin-like growth factor binding protein 3 |
IL24 | interleukin 24 |
KDM6A | lysine (K)-specific demethylase 6A |
KIF21B | kinesin family member 21B |
KIR2DL1 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 |
KIR2DL5A | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A |
KLF11 | Kruppel-like factor 11 |
KLF15 | Kruppel-like factor 15 |
KLF4 | Kruppel-like factor 4 (gut) |
KLK2 | kallikrein-related peptidase 2 |
KLK5 | kallikrein-related peptidase 5 |
KLK8 | kallikrein-related peptidase 8 |
LAMP3 | lysosomal-associated membrane protein 3 |
LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) |
LCAT | lecithin-cholesterol acyltransferase |
LCP1 | lymphocyte cytosolic protein 1 (L-plastin) |
LETM1 | leucine zipper-EF-hand containing transmembrane protein 1 |
LLGL1 | lethal giant larvae homolog 1 (Drosophila) |
LRRC61 | leucine rich repeat containing 61 |
LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae) |
LYRM4 | LYR motif containing 4 |
MALT1 | MALT1 paracaspase |
MAP7 | microtubule-associated protein 7 |
MAS1 | MAS1 proto-oncogene, G protein-coupled receptor |
MAVS | mitochondrial antiviral signaling protein |
MEX3D | mex-3 RNA binding family member D |
MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 |
MMP25 | matrix metallopeptidase 25 |
MOGAT2 | monoacylglycerol O-acyltransferase 2 |
MPC1 | mitochondrial pyruvate carrier 1 |
MPP3 | membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) |
MXRA8 | matrix-remodelling associated 8 |
MYO5C | myosin VC |
NCR1 | natural cytotoxicity triggering receptor 1 |
NEUROD2 | neuronal differentiation 2 |
NGF | nerve growth factor (beta polypeptide) |
NRP2 | neuropilin 2 |
NUP153 | nucleoporin 153kDa |
NUPL2 | nucleoporin like 2 |
ODF1 | outer dense fiber of sperm tails 1 |
OGFRL1 | opioid growth factor receptor-like 1 |
OMG | oligodendrocyte myelin glycoprotein |
OR10H3 | olfactory receptor, family 10, subfamily H, member 3 |
OR1F1 | olfactory receptor, family 1, subfamily F, member 1 |
OR7E47P | olfactory receptor, family 7, subfamily E, member 47 pseudogene |
PAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 |
PAPPA2 | pappalysin 2 |
PAX5 | paired box 5 |
PCBP3 | poly(rC) binding protein 3 |
PCLO | piccolo presynaptic cytomatrix protein |
PDGFA | platelet-derived growth factor alpha polypeptide |
PER2 | period circadian clock 2 |
PGLYRP4 | peptidoglycan recognition protein 4 |
PHF7 | PHD finger protein 7 |
POM121 | POM121 transmembrane nucleoporin |
PRAMEF10 | PRAME family member 10 |
PRAMEF5 | PRAME family member 5 |
PRSS8 | protease, serine, 8 |
PSPH | phosphoserine phosphatase |
PTGER1 | prostaglandin E receptor 1 (subtype EP1), 42kDa |
PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
PTPN14 | protein tyrosine phosphatase, non-receptor type 14 |
PXDC1 | PX domain containing 1 |
PYY2 | peptide YY, 2 (pseudogene) |
RAB3IL1 | RAB3A interacting protein (rabin3)-like 1 |
RAB6B | RAB6B, member RAS oncogene family |
RDH16 | retinol dehydrogenase 16 (all-trans) |
RET | ret proto-oncogene |
RNF122 | ring finger protein 122 |
RNF186 | ring finger protein 186 |
RNF39 | ring finger protein 39 |
RNF43 | ring finger protein 43 |
RNMT | RNA (guanine-7-) methyltransferase |
ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) |
RPRM | reprimo, TP53 dependent G2 arrest mediator candidate |
SCN2A | sodium channel, voltage gated, type II alpha subunit |
SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
SEZ6L | seizure related 6 homolog (mouse)-like |
SF3A2 | splicing factor 3a, subunit 2, 66kDa |
SIGLEC6 | sialic acid binding Ig-like lectin 6 |
SIRPA | signal-regulatory protein alpha |
SLC17A1 | solute carrier family 17 (organic anion transporter), member 1 |
SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 |
SLC30A3 | solute carrier family 30 (zinc transporter), member 3 |
SLMO2 | slowmo homolog 2 (Drosophila) |
SMAD6 | SMAD family member 6 |
SMAD7 | SMAD family member 7 |
SMAP1 | small ArfGAP 1 |
SP1 | Sp1 transcription factor |
SP2 | Sp2 transcription factor |
SPINK5 | serine peptidase inhibitor, Kazal type 5 |
SPRR1B | small proline-rich protein 1B |
SRF | serum response factor (c-fos serum response element-binding transcription factor) |
SSTR3 | somatostatin receptor 3 |
STX3 | syntaxin 3 |
SYNE1 | spectrin repeat containing, nuclear envelope 1 |
SYP | synaptophysin |
TAF4 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa |
TAGLN | transgelin |
TCFL5 | transcription factor-like 5 (basic helix-loop-helix) |
TCL1A | T-cell leukemia/lymphoma 1A |
TGFB3 | transforming growth factor, beta 3 |
THNSL2 | threonine synthase-like 2 (S. cerevisiae) |
THUMPD1 | THUMP domain containing 1 |
TJP3 | tight junction protein 3 |
TMEM168 | transmembrane protein 168 |
TMEM45A | transmembrane protein 45A |
TNC | tenascin C |
TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 |
TNXB | tenascin XB |
TRA2A | transformer 2 alpha homolog (Drosophila) |
TRAPPC10 | trafficking protein particle complex 10 |
TSPYL1 | TSPY-like 1 |
TUFT1 | tuftelin 1 |
UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
URB1 | URB1 ribosome biogenesis 1 homolog (S. cerevisiae) |
VWA5A | von Willebrand factor A domain containing 5A |
WASF1 | WAS protein family, member 1 |
WNT6 | wingless-type MMTV integration site family, member 6 |
ZFHX3 | zinc finger homeobox 3 |
ZNF239 | zinc finger protein 239 |
ZNF512B | zinc finger protein 512B |
ZNF764 | zinc finger protein 764 |