KRAS.DF.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/KRAS.DF.V1_UP
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Genes

386 genes differentially expressed following the KRAS.DF.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ACADVL acyl-CoA dehydrogenase, very long chain
ADAM8 ADAM metallopeptidase domain 8
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANKRD36B ankyrin repeat domain 36B
ANKRD46 ankyrin repeat domain 46
ANPEP alanyl (membrane) aminopeptidase
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASMTL acetylserotonin O-methyltransferase-like
ASPH aspartate beta-hydroxylase
ATP9A ATPase, class II, type 9A
AURKB aurora kinase B
BBS9 Bardet-Biedl syndrome 9
BCL2L1 BCL2-like 1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BMP2 bone morphogenetic protein 2
BMP6 bone morphogenetic protein 6
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BORA bora, aurora kinase A activator
CALHM2 calcium homeostasis modulator 2
CAPRIN2 caprin family member 2
CAT catalase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CBR4 carbonyl reductase 4
CCDC85B coiled-coil domain containing 85B
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCNT2 cyclin T2
CDA cytidine deaminase
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLDN5 claudin 5
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COL6A3 collagen, type VI, alpha 3
CORO1A coronin, actin binding protein, 1A
CPVL carboxypeptidase, vitellogenic-like
CRYZ crystallin, zeta (quinone reductase)
CSF3 colony stimulating factor 3 (granulocyte)
CTNNBL1 catenin, beta like 1
CUTC cutC copper transporter
CUX2 cut-like homeobox 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNASE1L1 deoxyribonuclease I-like 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DSN1 DSN1, MIS12 kinetochore complex component
E2F8 E2F transcription factor 8
EHBP1L1 EH domain binding protein 1-like 1
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
ETFB electron-transfer-flavoprotein, beta polypeptide
ETNK1 ethanolamine kinase 1
FADS2 fatty acid desaturase 2
FAM168A family with sequence similarity 168, member A
FAM173A family with sequence similarity 173, member A
FAR2 fatty acyl CoA reductase 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G6PD glucose-6-phosphate dehydrogenase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GK3P glycerol kinase 3 pseudogene
GLMN glomulin, FKBP associated protein
GLRX glutaredoxin (thioltransferase)
GLS2 glutaminase 2 (liver, mitochondrial)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HCLS1 hematopoietic cell-specific Lyn substrate 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HRSP12 heat-responsive protein 12
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1RL1 interleukin 1 receptor-like 1
ING2 inhibitor of growth family, member 2
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5F inositol polyphosphate-5-phosphatase F
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JAK2 Janus kinase 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF3A kinesin family member 3A
KIN Kin17 DNA and RNA binding protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC81691 exonuclease NEF-sp
LOXL2 lysyl oxidase-like 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTBP3 latent transforming growth factor beta binding protein 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MED24 mediator complex subunit 24
MMP1 matrix metallopeptidase 1
MPI mannose phosphate isomerase
MTAP methylthioadenosine phosphorylase
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NRP1 neuropilin 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PDLIM2 PDZ and LIM domain 2 (mystique)
PDPN podoplanin
PELI1 pellino E3 ubiquitin protein ligase 1
PID1 phosphotyrosine interaction domain containing 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCH2 phospholipase C, eta 2
PLIN3 perilipin 3
PPAP2C phosphatidic acid phosphatase type 2C
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRG1 p53-responsive gene 1
PROCR protein C receptor, endothelial
PRSS3 protease, serine, 3
PTPRG protein tyrosine phosphatase, receptor type, G
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASIP1 Ras interacting protein 1
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS17 regulator of G-protein signaling 17
RGS2 regulator of G-protein signaling 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAD Ras-related associated with diabetes
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SCAND1 SCAN domain containing 1
SCG5 secretogranin V
SEC24D SEC24 family member D
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMTN smoothelin
SMYD3 SET and MYND domain containing 3
SPAG4 sperm associated antigen 4
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK4 serine/threonine kinase 4
STX4 syntaxin 4
SUGCT succinyl-CoA:glutarate-CoA transferase
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TIMP4 TIMP metallopeptidase inhibitor 4
TLR2 toll-like receptor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM135 transmembrane protein 135
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM160 transmembrane protein 160
TP53I3 tumor protein p53 inducible protein 3
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSPAN5 tetraspanin 5
TUBG2 tubulin, gamma 2
UBE2W ubiquitin-conjugating enzyme E2W (putative)
VCAN versican
VEGFC vascular endothelial growth factor C
ZMYND8 zinc finger, MYND-type containing 8
ZNF654 zinc finger protein 654

decreased expression

Symbol Name
ACTL6A actin-like 6A
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALOX5 arachidonate 5-lipoxygenase
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP26 Rho GTPase activating protein 26
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AUTS2 autism susceptibility candidate 2
BCAM basal cell adhesion molecule (Lutheran blood group)
BDKRB1 bradykinin receptor B1
BMP4 bone morphogenetic protein 4
C12ORF49 chromosome 12 open reading frame 49
C1ORF109 chromosome 1 open reading frame 109
C3ORF14 chromosome 3 open reading frame 14
C6ORF15 chromosome 6 open reading frame 15
CAMKV CaM kinase-like vesicle-associated
CBX4 chromobox homolog 4
CD2 CD2 molecule
CDK18 cyclin-dependent kinase 18
CDK20 cyclin-dependent kinase 20
CHRM5 cholinergic receptor, muscarinic 5
CLDN1 claudin 1
CLDN17 claudin 17
CNR2 cannabinoid receptor 2 (macrophage)
CNTFR ciliary neurotrophic factor receptor
COBL cordon-bleu WH2 repeat protein
COG5 component of oligomeric golgi complex 5
COL11A2 collagen, type XI, alpha 2
COL4A5 collagen, type IV, alpha 5
COPZ2 coatomer protein complex, subunit zeta 2
CTAGE9 CTAGE family, member 9
CXADR coxsackie virus and adenovirus receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYTH4 cytohesin 4
DCAF10 DDB1 and CUL4 associated factor 10
DEFB4A defensin, beta 4A
DUSP2 dual specificity phosphatase 2
DVL3 dishevelled segment polarity protein 3
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPPK1 epiplakin 1
ERN1 endoplasmic reticulum to nucleus signaling 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC7 exosome component 7
FAM153A family with sequence similarity 153, member A
FAM63A family with sequence similarity 63, member A
FANCE Fanconi anemia, complementation group E
FBN2 fibrillin 2
GAP43 growth associated protein 43
GCC1 GRIP and coiled-coil domain containing 1
GJB4 gap junction protein, beta 4, 30.3kDa
GLIPR1 GLI pathogenesis-related 1
GPATCH2 G patch domain containing 2
HDAC9 histone deacetylase 9
HIST1H2BH histone cluster 1, H2bh
HIST2H2AA3 histone cluster 2, H2aa3
HMGN3 high mobility group nucleosomal binding domain 3
HOMER2 homer scaffolding protein 2
HOXA11 homeobox A11
HOXC8 homeobox C8
HPX hemopexin
HRH2 histamine receptor H2
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HUS1 HUS1 checkpoint homolog (S. pombe)
IFNA17 interferon, alpha 17
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL24 interleukin 24
KDM6A lysine (K)-specific demethylase 6A
KIF21B kinesin family member 21B
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF11 Kruppel-like factor 11
KLF15 Kruppel-like factor 15
KLF4 Kruppel-like factor 4 (gut)
KLK2 kallikrein-related peptidase 2
KLK5 kallikrein-related peptidase 5
KLK8 kallikrein-related peptidase 8
LAMP3 lysosomal-associated membrane protein 3
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCAT lecithin-cholesterol acyltransferase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRRC61 leucine rich repeat containing 61
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM4 LYR motif containing 4
MALT1 MALT1 paracaspase
MAP7 microtubule-associated protein 7
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MAVS mitochondrial antiviral signaling protein
MEX3D mex-3 RNA binding family member D
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP25 matrix metallopeptidase 25
MOGAT2 monoacylglycerol O-acyltransferase 2
MPC1 mitochondrial pyruvate carrier 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MXRA8 matrix-remodelling associated 8
MYO5C myosin VC
NCR1 natural cytotoxicity triggering receptor 1
NEUROD2 neuronal differentiation 2
NGF nerve growth factor (beta polypeptide)
NRP2 neuropilin 2
NUP153 nucleoporin 153kDa
NUPL2 nucleoporin like 2
ODF1 outer dense fiber of sperm tails 1
OGFRL1 opioid growth factor receptor-like 1
OMG oligodendrocyte myelin glycoprotein
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR1F1 olfactory receptor, family 1, subfamily F, member 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAPPA2 pappalysin 2
PAX5 paired box 5
PCBP3 poly(rC) binding protein 3
PCLO piccolo presynaptic cytomatrix protein
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PGLYRP4 peptidoglycan recognition protein 4
PHF7 PHD finger protein 7
POM121 POM121 transmembrane nucleoporin
PRAMEF10 PRAME family member 10
PRAMEF5 PRAME family member 5
PRSS8 protease, serine, 8
PSPH phosphoserine phosphatase
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PXDC1 PX domain containing 1
PYY2 peptide YY, 2 (pseudogene)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB6B RAB6B, member RAS oncogene family
RDH16 retinol dehydrogenase 16 (all-trans)
RET ret proto-oncogene
RNF122 ring finger protein 122
RNF186 ring finger protein 186
RNF39 ring finger protein 39
RNF43 ring finger protein 43
RNMT RNA (guanine-7-) methyltransferase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCN2A sodium channel, voltage gated, type II alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEZ6L seizure related 6 homolog (mouse)-like
SF3A2 splicing factor 3a, subunit 2, 66kDa
SIGLEC6 sialic acid binding Ig-like lectin 6
SIRPA signal-regulatory protein alpha
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLMO2 slowmo homolog 2 (Drosophila)
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAP1 small ArfGAP 1
SP1 Sp1 transcription factor
SP2 Sp2 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1B small proline-rich protein 1B
SRF serum response factor (c-fos serum response element-binding transcription factor)
SSTR3 somatostatin receptor 3
STX3 syntaxin 3
SYNE1 spectrin repeat containing, nuclear envelope 1
SYP synaptophysin
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAGLN transgelin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCL1A T-cell leukemia/lymphoma 1A
TGFB3 transforming growth factor, beta 3
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THUMPD1 THUMP domain containing 1
TJP3 tight junction protein 3
TMEM168 transmembrane protein 168
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNXB tenascin XB
TRA2A transformer 2 alpha homolog (Drosophila)
TRAPPC10 trafficking protein particle complex 10
TSPYL1 TSPY-like 1
TUFT1 tuftelin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WASF1 WAS protein family, member 1
WNT6 wingless-type MMTV integration site family, member 6
ZFHX3 zinc finger homeobox 3
ZNF239 zinc finger protein 239
ZNF512B zinc finger protein 512B
ZNF764 zinc finger protein 764