Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link
Similar Terms
Downloads & Tools


285 genes differentially expressed following the KRAS.LUNG.BREAST_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAM19 ADAM metallopeptidase domain 19
ADAM8 ADAM metallopeptidase domain 8
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMELY amelogenin, Y-linked
ANGPTL4 angiopoietin-like 4
ATG10 autophagy related 10
BIRC3 baculoviral IAP repeat containing 3
BMP6 bone morphogenetic protein 6
CALB1 calbindin 1, 28kDa
CATR1 CATR tumorigenicity conversion 1
CCDC181 coiled-coil domain containing 181
CCL20 chemokine (C-C motif) ligand 20
CCR6 chemokine (C-C motif) receptor 6
CD1A CD1a molecule
CD247 CD247 molecule
CD37 CD37 molecule
CDSN corneodesmosin
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLPS colipase, pancreatic
CLSTN2 calsyntenin 2
CMKLR1 chemerin chemokine-like receptor 1
CRCT1 cysteine-rich C-terminal 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTNNA2 catenin (cadherin-associated protein), alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAH9 dynein, axonemal, heavy chain 9
DOCK4 dedicator of cytokinesis 4
ESM1 endothelial cell-specific molecule 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM155B family with sequence similarity 155, member B
FAM174B family with sequence similarity 174, member B
FCRL2 Fc receptor-like 2
FNDC8 fibronectin type III domain containing 8
G0S2 G0/G1 switch 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GFI1 growth factor independent 1 transcription repressor
GLRX glutaredoxin (thioltransferase)
GPR4 G protein-coupled receptor 4
GRP gastrin-releasing peptide
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HOXD11 homeobox D11
HPN hepsin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNA8 interferon, alpha 8
IGFBP3 insulin-like growth factor binding protein 3
IGHV3-48 immunoglobulin heavy variable 3-48
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
IL1RL1 interleukin 1 receptor-like 1
IL23A interleukin 23, alpha subunit p19
IL37 interleukin 37
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKA inositol-trisphosphate 3-kinase A
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNK15 potassium channel, two pore domain subfamily K, member 15
KIAA1549L KIAA1549-like
KIF5A kinesin family member 5A
KIF5C kinesin family member 5C
KRT34 keratin 34, type I
LAT2 linker for activation of T cells family, member 2
LDB3 LIM domain binding 3
LIF leukemia inhibitory factor
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
MGLL monoglyceride lipase
MKRN3 makorin ring finger protein 3
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NAV3 neuron navigator 3
NDOR1 NADPH dependent diflavin oxidoreductase 1
NELL2 NEL-like 2 (chicken)
NPPB natriuretic peptide B
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRL neural retina leucine zipper
NTM neurotrimin
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSBP2 oxysterol binding protein 2
OSGIN1 oxidative stress induced growth inhibitor 1
PDCD1LG2 programmed cell death 1 ligand 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
POLM polymerase (DNA directed), mu
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRDM1 PR domain containing 1, with ZNF domain
PRL prolactin
PRSS3 protease, serine, 3
PRY PTPN13-like, Y-linked
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
RBMXL2 RNA binding motif protein, X-linked-like 2
RBP4 retinol binding protein 4, plasma
RELN reelin
RETN resistin
RMST rhabdomyosarcoma 2 associated transcript (non-protein coding)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG5 secretogranin V
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SH2D2A SH2 domain containing 2A
SHOX short stature homeobox
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMPX small muscle protein, X-linked
SNAP25 synaptosomal-associated protein, 25kDa
SNAP91 synaptosomal-associated protein, 91kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STC1 stanniocalcin 1
TAAR5 trace amine associated receptor 5
TAGLN3 transgelin 3
TBX3 T-box 3
TERT telomerase reverse transcriptase
TFDP3 transcription factor Dp family, member 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRAF1 TNF receptor-associated factor 1
TSPAN1 tetraspanin 1
TSPY1 testis specific protein, Y-linked 1
TTC22 tetratricopeptide repeat domain 22
ZNF639 zinc finger protein 639
ZP4 zona pellucida glycoprotein 4

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADD2 adducin 2 (beta)
ADGRE1 adhesion G protein-coupled receptor E1
AKAP6 A kinase (PRKA) anchor protein 6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX12B arachidonate 12-lipoxygenase, 12R type
AMBN ameloblastin (enamel matrix protein)
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APOB apolipoprotein B
ART1 ADP-ribosyltransferase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BDKRB1 bradykinin receptor B1
C5AR2 complement component 5a receptor 2
C6ORF10 chromosome 6 open reading frame 10
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CALCB calcitonin-related polypeptide beta
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CCDC121 coiled-coil domain containing 121
CCDC132 coiled-coil domain containing 132
CD248 CD248 molecule, endosialin
CD36 CD36 molecule (thrombospondin receptor)
CD6 CD6 molecule
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH16 cadherin 16, KSP-cadherin
CLCA2 chloride channel accessory 2
CLDN8 claudin 8
COBL cordon-bleu WH2 repeat protein
COL2A1 collagen, type II, alpha 1
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DEFB1 defensin, beta 1
DPT dermatopontin
DTNB dystrobrevin, beta
DTX2 deltex 2, E3 ubiquitin ligase
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
EPHX2 epoxide hydrolase 2, cytoplasmic
ERAP2 endoplasmic reticulum aminopeptidase 2
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FMO6P flavin containing monooxygenase 6 pseudogene
FRAS1 Fraser extracellular matrix complex subunit 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GDNF glial cell derived neurotrophic factor
GLS2 glutaminase 2 (liver, mitochondrial)
GLYAT glycine-N-acyltransferase
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HHLA1 HERV-H LTR-associating 1
HIST1H3A histone cluster 1, H3a
HRK harakiri, BCL2 interacting protein
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI44L interferon-induced protein 44-like
IFNA16 interferon, alpha 16
IGF2-AS IGF2 antisense RNA
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL5RA interleukin 5 receptor, alpha
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IVL involucrin
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF25 kinesin family member 25
KRT13 keratin 13, type I
KRT16 keratin 16, type I
KRT38 keratin 38, type I
KRT4 keratin 4, type II
LGALS7 lectin, galactoside-binding, soluble, 7
LGALS9 lectin, galactoside-binding, soluble, 9
LOC440895 two pore channel 3 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
MAP2K6 mitogen-activated protein kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MEGF8 multiple EGF-like-domains 8
METTL7A methyltransferase like 7A
MMP28 matrix metallopeptidase 28
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MXD3 MAX dimerization protein 3
MXRA8 matrix-remodelling associated 8
MYL9 myosin, light chain 9, regulatory
NCR3 natural cytotoxicity triggering receptor 3
NOS1 nitric oxide synthase 1 (neuronal)
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NSUN6 NOP2/Sun domain family, member 6
NTF3 neurotrophin 3
NYNRIN NYN domain and retroviral integrase containing
OLFML2A olfactomedin-like 2A
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PAQR6 progestin and adipoQ receptor family member VI
PARP3 poly (ADP-ribose) polymerase family, member 3
PBX1 pre-B-cell leukemia homeobox 1
PCDHB1 protocadherin beta 1
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTPRU protein tyrosine phosphatase, receptor type, U
PVALB parvalbumin
RAG1 recombination activating gene 1
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM17 RNA binding motif protein 17
RPL13P5 ribosomal protein L13 pseudogene 5
RTP4 receptor (chemosensory) transporter protein 4
RUNDC3B RUN domain containing 3B
RYR1 ryanodine receptor 1 (skeletal)
S100A7 S100 calcium binding protein A7
SCARF1 scavenger receptor class F, member 1
SCN7A sodium channel, voltage gated, type VII alpha subunit
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SIDT1 SID1 transmembrane family, member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SOBP sine oculis binding protein homolog (Drosophila)
SOX11 SRY (sex determining region Y)-box 11
SPAG11A sperm associated antigen 11A
SPTBN2 spectrin, beta, non-erythrocytic 2
SYNDIG1 synapse differentiation inducing 1
TAS2R4 taste receptor, type 2, member 4
TBR1 T-box, brain, 1
TGM1 transglutaminase 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TM4SF4 transmembrane 4 L six family member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNI3 troponin I type 3 (cardiac)
TRIM48 tripartite motif containing 48
TRIM9 tripartite motif containing 9
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSHB thyroid stimulating hormone, beta
TTLL1 tubulin tyrosine ligase-like family member 1
UPK3B uroplakin 3B
VAV3 vav 3 guanine nucleotide exchange factor
VAX2 ventral anterior homeobox 2
YPEL1 yippee-like 1 (Drosophila)