KYSE-140 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: carcinoma, squamous cell (Cell Line Ontology, CLO_0007128)
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Genes

306 genes with high or low expression in KYSE-140 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
FXR1 fragile X mental retardation, autosomal homolog 1 3.60177
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 3.60177
ATP11B ATPase, class VI, type 11B 3.60177
SOX2 SRY (sex determining region Y)-box 2 3.55897
SUN1 Sad1 and UNC84 domain containing 1 3.47165
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 3.42798
IPO4 importin 4 3.22622
LGALS7 lectin, galactoside-binding, soluble, 7 3.04163
NADSYN1 NAD synthetase 1 3.03854
PTCD2 pentatricopeptide repeat domain 2 2.97027
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.94786
FBN2 fibrillin 2 2.87668
CHMP4A charged multivesicular body protein 4A 2.81229
NPR3 natriuretic peptide receptor 3 2.77544
DHCR7 7-dehydrocholesterol reductase 2.72993
HSPA9 heat shock 70kDa protein 9 (mortalin) 2.69541
CTAGE5 CTAGE family, member 5 2.57187
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.44522
LAMP3 lysosomal-associated membrane protein 3 2.43915
KLHL9 kelch-like family member 9 2.35212
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.34378
SNX6 sorting nexin 6 2.27185
PKP1 plakophilin 1 2.25292
CPT1A carnitine palmitoyltransferase 1A (liver) 2.21829
COL17A1 collagen, type XVII, alpha 1 2.18886
APCS amyloid P component, serum 2.1597
RNF31 ring finger protein 31 2.1514
FKBP9 FK506 binding protein 9, 63 kDa 2.09264
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.09058
TM9SF1 transmembrane 9 superfamily member 1 2.08882
KIF13A kinesin family member 13A 2.08646
LTBP4 latent transforming growth factor beta binding protein 4 2.07854
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.05633
KLHL24 kelch-like family member 24 2.0555
GLI1 GLI family zinc finger 1 2.05538
SOSTDC1 sclerostin domain containing 1 2.04942
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.04221
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 2.03995
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 1.98962
NUBPL nucleotide binding protein-like 1.98601
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 1.9644
BRD4 bromodomain containing 4 1.96325
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 1.94173
BMS1 BMS1 ribosome biogenesis factor 1.93112
SRP54 signal recognition particle 54kDa 1.92953
BICD2 bicaudal D homolog 2 (Drosophila) 1.92906
TFB1M transcription factor B1, mitochondrial 1.92699
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 1.91791
UPP1 uridine phosphorylase 1 1.91746
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 1.90523
ERLIN2 ER lipid raft associated 2 1.89989
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 1.87979
GFOD1 glucose-fructose oxidoreductase domain containing 1 1.87593
IFT38 intraflagellar transport 38 1.86839
PDCD10 programmed cell death 10 1.86502
PROSC proline synthetase co-transcribed homolog (bacterial) 1.85701
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.85359
EFNB2 ephrin-B2 1.84809
ARHGAP5 Rho GTPase activating protein 5 1.84072
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.83169
UBP1 upstream binding protein 1 (LBP-1a) 1.82869
SCFD1 sec1 family domain containing 1 1.82472
IGLV6-57 immunoglobulin lambda variable 6-57 1.81795
SF3B5 splicing factor 3b, subunit 5, 10kDa 1.81447
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1.81166
KIAA1045 KIAA1045 1.81073
CTTN cortactin 1.81029
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1.80802
DST dystonin 1.80571
CHIC2 cysteine-rich hydrophobic domain 2 1.79878
STK24 serine/threonine kinase 24 1.7908
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.7814
PDGFA platelet-derived growth factor alpha polypeptide 1.78102
ANGPT2 angiopoietin 2 1.77861
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.77759
DNAAF5 dynein, axonemal, assembly factor 5 1.77342
BRDT bromodomain, testis-specific 1.76982
XPA xeroderma pigmentosum, complementation group A 1.75946
GSTA4 glutathione S-transferase alpha 4 1.74818
DCAF11 DDB1 and CUL4 associated factor 11 1.74104
NBR2 neighbor of BRCA1 gene 2 (non-protein coding) 1.73883
COL11A2 collagen, type XI, alpha 2 1.7374
RABGGTA Rab geranylgeranyltransferase, alpha subunit 1.73667
HRASLS2 HRAS-like suppressor 2 1.73659
PABPN1 poly(A) binding protein, nuclear 1 1.73043
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 1.72951
PRODH proline dehydrogenase (oxidase) 1 1.72702
FAM53C family with sequence similarity 53, member C 1.72671
TMPRSS11D transmembrane protease, serine 11D 1.72402
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 1.72365
FOLH1B folate hydrolase 1B 1.72216
DHRS1 dehydrogenase/reductase (SDR family) member 1 1.71912
IRAK4 interleukin-1 receptor-associated kinase 4 1.70877
GJB5 gap junction protein, beta 5, 31.1kDa 1.70465
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.69438
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 1.69244
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 1.68179
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 1.67986
TMEM106B transmembrane protein 106B 1.67824
BTF3 basic transcription factor 3 1.676
FOXE1 forkhead box E1 1.67486
ADSS adenylosuccinate synthase 1.67467
APOM apolipoprotein M 1.66541
ZNF148 zinc finger protein 148 1.66399
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 1.66227
IQGAP1 IQ motif containing GTPase activating protein 1 1.66031
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.65956
DUOX1 dual oxidase 1 1.65775
SNW1 SNW domain containing 1 1.65686
LTB4R leukotriene B4 receptor 1.65303
FGFR2 fibroblast growth factor receptor 2 1.64659
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 1.64182
JAG2 jagged 2 1.63931
GAST gastrin 1.63821
TLE3 transducin-like enhancer of split 3 1.62499
KCNQ1DN KCNQ1 downstream neighbor (non-protein coding) 1.61793
NSUN5 NOP2/Sun domain family, member 5 1.59964
GARS glycyl-tRNA synthetase 1.59568
CYB5R2 cytochrome b5 reductase 2 1.59419
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 1.59253
RBP4 retinol binding protein 4, plasma 1.58516
COL15A1 collagen, type XV, alpha 1 1.58264
PRSS21 protease, serine, 21 (testisin) 1.58034
GLUD1 glutamate dehydrogenase 1 1.58018
USP12 ubiquitin specific peptidase 12 1.57898
DEC1 deleted in esophageal cancer 1 1.57614
KRT5 keratin 5, type II 1.56073
DCTN2 dynactin 2 (p50) 1.56073
PCDH17 protocadherin 17 1.55965
TLN2 talin 2 1.54968
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.54555
RABGAP1 RAB GTPase activating protein 1 1.54489
GPC3 glypican 3 1.53911
CHD3 chromodomain helicase DNA binding protein 3 1.53398
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 1.52984
EWSR1 EWS RNA-binding protein 1 1.52101
COPZ2 coatomer protein complex, subunit zeta 2 1.51747
DLK2 delta-like 2 homolog (Drosophila) 1.5157
TP63 tumor protein p63 1.51392
POU3F3 POU class 3 homeobox 3 1.50872
TNNT2 troponin T type 2 (cardiac) 1.50196
KRT17 keratin 17, type I 1.50088
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 1.49785
KPNA1 karyopherin alpha 1 (importin alpha 5) 1.49088
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.48902
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 1.48145
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 1.48073
FADD Fas (TNFRSF6)-associated via death domain 1.48055
PCNXL2 pecanex-like 2 (Drosophila) 1.47437
TTLL3 tubulin tyrosine ligase-like family member 3 1.47252
NDE1 nudE neurodevelopment protein 1 1.47021
MTMR1 myotubularin related protein 1 1.46997
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 1.46996
BRD8 bromodomain containing 8 1.46941
S100A11 S100 calcium binding protein A11 1.44878
R3HDM2 R3H domain containing 2 1.44575
LGI2 leucine-rich repeat LGI family, member 2 1.44066
CALB1 calbindin 1, 28kDa 1.43981
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 1.43271
DOCK6 dedicator of cytokinesis 6 1.43174
STAG2 stromal antigen 2 1.43111
DUOX2 dual oxidase 2 1.43004
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 1.42919
HIST1H3D histone cluster 1, H3d 1.42851
GOLIM4 golgi integral membrane protein 4 1.42283
VSNL1 visinin-like 1 1.42198
TNPO1 transportin 1 1.42146
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 1.41919

low expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.53447
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -3.45749
CHEK2 checkpoint kinase 2 -2.72544
PLCG1 phospholipase C, gamma 1 -2.65757
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.61991
COMMD9 COMM domain containing 9 -2.55508
WDR4 WD repeat domain 4 -2.52651
GEMIN6 gem (nuclear organelle) associated protein 6 -2.46055
MDH1 malate dehydrogenase 1, NAD (soluble) -2.38874
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.37405
CAND1 cullin-associated and neddylation-dissociated 1 -2.32754
DGUOK deoxyguanosine kinase -2.31012
CCR9 chemokine (C-C motif) receptor 9 -2.21932
DIP interstitial pneumonitis, desquamative, familial -2.18352
FBXL4 F-box and leucine-rich repeat protein 4 -2.1803
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -2.18008
SP110 SP110 nuclear body protein -2.17838
MSL3 male-specific lethal 3 homolog (Drosophila) -2.106
RNF114 ring finger protein 114 -2.0995
ZNF8 zinc finger protein 8 -2.02985
SYT11 synaptotagmin XI -2.01149
NMB neuromedin B -2.00564
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.00316
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -1.98738
IFNAR2 interferon (alpha, beta and omega) receptor 2 -1.98346
RNF122 ring finger protein 122 -1.96078
EIF4B eukaryotic translation initiation factor 4B -1.95036
ZNF281 zinc finger protein 281 -1.9482
ADGRD2 adhesion G protein-coupled receptor D2 -1.9393
ZNF143 zinc finger protein 143 -1.91674
STK17B serine/threonine kinase 17b -1.89369
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -1.88932
RBBP7 retinoblastoma binding protein 7 -1.8775
FABP7 fatty acid binding protein 7, brain -1.87433
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -1.86217
MANBA mannosidase, beta A, lysosomal -1.86027
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -1.85488
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -1.849
HP1BP3 heterochromatin protein 1, binding protein 3 -1.84644
STAU2 staufen double-stranded RNA binding protein 2 -1.84011
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -1.82264
ROM1 retinal outer segment membrane protein 1 -1.81714
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -1.8161
STS steroid sulfatase (microsomal), isozyme S -1.81507
DIDO1 death inducer-obliterator 1 -1.80561
CYB5A cytochrome b5 type A (microsomal) -1.80211
B3GNT1 -1.79546
SGPP1 sphingosine-1-phosphate phosphatase 1 -1.78284
DRD2 dopamine receptor D2 -1.7755
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) -1.76831
PEX19 peroxisomal biogenesis factor 19 -1.76149
BTN2A1 butyrophilin, subfamily 2, member A1 -1.7604
DONSON downstream neighbor of SON -1.75709
HARS2 histidyl-tRNA synthetase 2, mitochondrial -1.75702
STAMBP STAM binding protein -1.74771
FBXL7 F-box and leucine-rich repeat protein 7 -1.74671
TXLNA taxilin alpha -1.74066
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) -1.73734
NOX1 NADPH oxidase 1 -1.73685
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -1.73172
FAT4 FAT atypical cadherin 4 -1.72789
TMEM131 transmembrane protein 131 -1.72495
ADNP activity-dependent neuroprotector homeobox -1.72379
MPP1 membrane protein, palmitoylated 1, 55kDa -1.72307
ZDHHC17 zinc finger, DHHC-type containing 17 -1.71299
DTX4 deltex 4, E3 ubiquitin ligase -1.71134
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -1.70977
PHOX2A paired-like homeobox 2a -1.7083
NCOA6 nuclear receptor coactivator 6 -1.70242
EPOR erythropoietin receptor -1.69679
CCNG1 cyclin G1 -1.68306
NFS1 NFS1 cysteine desulfurase -1.67877
FYCO1 FYVE and coiled-coil domain containing 1 -1.67763
PPIE peptidylprolyl isomerase E (cyclophilin E) -1.67751
SH2B3 SH2B adaptor protein 3 -1.67743
CALHM2 calcium homeostasis modulator 2 -1.67738
PGK1 phosphoglycerate kinase 1 -1.67395
DNAI2 dynein, axonemal, intermediate chain 2 -1.67036
SMYD3 SET and MYND domain containing 3 -1.65683
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -1.63922
FRG1 FSHD region gene 1 -1.63521
PDE12 phosphodiesterase 12 -1.63052
PRDX4 peroxiredoxin 4 -1.62904
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -1.62537
FAS Fas cell surface death receptor -1.61997
NPR2 natriuretic peptide receptor 2 -1.60936
GRSF1 G-rich RNA sequence binding factor 1 -1.5983
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -1.59726
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -1.59703
TBK1 TANK-binding kinase 1 -1.59668
ICOSLG inducible T-cell co-stimulator ligand -1.59143
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -1.58392
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -1.58102
HPCAL4 hippocalcin like 4 -1.57561
SERTAD2 SERTA domain containing 2 -1.55663
MED12 mediator complex subunit 12 -1.55624
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -1.54533
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -1.54384
FECH ferrochelatase -1.53297
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -1.53239
DYNLRB1 dynein, light chain, roadblock-type 1 -1.5284
MORC3 MORC family CW-type zinc finger 3 -1.52281
ANKLE2 ankyrin repeat and LEM domain containing 2 -1.51852
PRDM10 PR domain containing 10 -1.51383
BBS7 Bardet-Biedl syndrome 7 -1.51157
LRRC2 leucine rich repeat containing 2 -1.51013
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -1.50919
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -1.50705
LRRC20 leucine rich repeat containing 20 -1.50331
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -1.50055
CTSA cathepsin A -1.50028
RAB23 RAB23, member RAS oncogene family -1.49632
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.49007
SOD1 superoxide dismutase 1, soluble -1.48691
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -1.48339
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -1.47548
CLCN4 chloride channel, voltage-sensitive 4 -1.47284
MMD monocyte to macrophage differentiation-associated -1.46877
ACP1 acid phosphatase 1, soluble -1.46804
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -1.46785
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -1.46643
BCAS1 breast carcinoma amplified sequence 1 -1.46599
TMEM177 transmembrane protein 177 -1.45635
FBXO22 F-box protein 22 -1.45127
IL17RC interleukin 17 receptor C -1.44779
GTF2A2 general transcription factor IIA, 2, 12kDa -1.4465
NDRG3 NDRG family member 3 -1.44589
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -1.44097
RUSC1 RUN and SH3 domain containing 1 -1.43408
ANK1 ankyrin 1, erythrocytic -1.4301
RP2 retinitis pigmentosa 2 (X-linked recessive) -1.42934
FAM111A family with sequence similarity 111, member A -1.42837
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -1.4262
CYB561D2 cytochrome b561 family, member D2 -1.42558
SAMHD1 SAM domain and HD domain 1 -1.42169
FTL ferritin, light polypeptide -1.42059
SERGEF secretion regulating guanine nucleotide exchange factor -1.41953
SPHAR S-phase response (cyclin related) -1.41943