KYSE-520 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: carcinoma, squamous cell (Cell Line Ontology, CLO_0007136)
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Genes

308 genes with high or low expression in KYSE-520 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
CDSN corneodesmosin 3.58871
MRPS17 mitochondrial ribosomal protein S17 2.87026
TLK1 tousled-like kinase 1 2.7301
METTL4 methyltransferase like 4 2.63255
PI3 peptidase inhibitor 3, skin-derived 2.61794
LCE2B late cornified envelope 2B 2.51242
PGGT1B protein geranylgeranyltransferase type I, beta subunit 2.50632
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.43214
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.37201
SEC61G Sec61 gamma subunit 2.32061
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2.31714
LOR loricrin 2.24687
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.21652
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.20853
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.1955
ZNF133 zinc finger protein 133 2.18802
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 2.18634
METTL5 methyltransferase like 5 2.18522
PRMT8 protein arginine methyltransferase 8 2.17421
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.13466
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.10081
FABP4 fatty acid binding protein 4, adipocyte 2.09907
TASP1 taspase, threonine aspartase, 1 2.09359
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.07881
COBLL1 cordon-bleu WH2 repeat protein-like 1 2.05578
SPRR1B small proline-rich protein 1B 2.02295
GBAS glioblastoma amplified sequence 2.0128
GAST gastrin 1.98173
ABHD3 abhydrolase domain containing 3 1.97962
CES1P1 carboxylesterase 1 pseudogene 1 1.96191
YES1 YES proto-oncogene 1, Src family tyrosine kinase 1.95335
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.95089
KRT1 keratin 1, type II 1.93275
NCKAP1 NCK-associated protein 1 1.92122
TGM1 transglutaminase 1 1.90675
CA2 carbonic anhydrase II 1.90497
MOB4 MOB family member 4, phocein 1.89754
TMED7 transmembrane emp24 protein transport domain containing 7 1.89326
THBD thrombomodulin 1.88063
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1.87098
RNF111 ring finger protein 111 1.86055
GLTP glycolipid transfer protein 1.83433
IGFBP6 insulin-like growth factor binding protein 6 1.83281
SERINC3 serine incorporator 3 1.82706
EGFR epidermal growth factor receptor 1.81528
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 1.81065
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.79103
SPRR1A small proline-rich protein 1A 1.78835
PGD phosphogluconate dehydrogenase 1.78786
ENOSF1 enolase superfamily member 1 1.77231
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.77071
DSC3 desmocollin 3 1.76015
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.75765
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.75706
SLURP1 secreted LY6/PLAUR domain containing 1 1.75447
ITFG1 integrin alpha FG-GAP repeat containing 1 1.73702
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 1.73056
CES1 carboxylesterase 1 1.72111
COMMD10 COMM domain containing 10 1.7151
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 1.71161
ANXA10 annexin A10 1.70448
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 1.69862
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 1.69381
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 1.68758
TMX2 thioredoxin-related transmembrane protein 2 1.68733
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 1.68729
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa 1.67681
SGPP1 sphingosine-1-phosphate phosphatase 1 1.66054
HSPB3 heat shock 27kDa protein 3 1.65727
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 1.64919
HKDC1 hexokinase domain containing 1 1.64557
ARTN artemin 1.64525
RYR1 ryanodine receptor 1 (skeletal) 1.6331
SEH1L SEH1-like (S. cerevisiae) 1.62833
MEGF9 multiple EGF-like-domains 9 1.62482
ACTC1 actin, alpha, cardiac muscle 1 1.60875
HAT1 histone acetyltransferase 1 1.60791
KLK8 kallikrein-related peptidase 8 1.60415
SLCO1B3 solute carrier organic anion transporter family, member 1B3 1.59491
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 1.58761
MAPK1 mitogen-activated protein kinase 1 1.58612
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 1.58304
DSG3 desmoglein 3 1.57973
TRIP4 thyroid hormone receptor interactor 4 1.57731
RBM7 RNA binding motif protein 7 1.5677
IL36G interleukin 36, gamma 1.56421
DDT D-dopachrome tautomerase 1.55777
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 1.55623
SPINK5 serine peptidase inhibitor, Kazal type 5 1.55526
TXN thioredoxin 1.5517
ZBTB14 zinc finger and BTB domain containing 14 1.54573
KLF5 Kruppel-like factor 5 (intestinal) 1.54051
RNF167 ring finger protein 167 1.52516
CHMP1B charged multivesicular body protein 1B 1.5217
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.52096
KRT33B keratin 33B, type I 1.52091
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.51702
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 1.50891
BMP7 bone morphogenetic protein 7 1.50139
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 1.49426
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.48388
CTSV cathepsin V 1.48115
MAP2K1 mitogen-activated protein kinase kinase 1 1.47961
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 1.47123
TUB tubby bipartite transcription factor 1.47033
ASB7 ankyrin repeat and SOCS box containing 7 1.46292
SNX16 sorting nexin 16 1.46175
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 1.45916
CUL5 cullin 5 1.45782
CEP76 centrosomal protein 76kDa 1.45599
SYCP2 synaptonemal complex protein 2 1.4557
MTX2 metaxin 2 1.44595
BRD7 bromodomain containing 7 1.44512
RDX radixin 1.43427
RXFP3 relaxin/insulin-like family peptide receptor 3 1.43343
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 1.43308
STK39 serine threonine kinase 39 1.43204
IL1RN interleukin 1 receptor antagonist 1.42824
BDKRB1 bradykinin receptor B1 1.42443
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 1.42363
TP63 tumor protein p63 1.41757
AKTIP AKT interacting protein 1.41744

low expression

Symbol Name Standardized Value
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -3.53395
VARS valyl-tRNA synthetase -3.52935
APOL2 apolipoprotein L, 2 -3.12993
NFRKB nuclear factor related to kappaB binding protein -3.10866
ASTN2 astrotactin 2 -3.09146
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.99956
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.99035
NCAPH2 non-SMC condensin II complex, subunit H2 -2.89113
UBA1 ubiquitin-like modifier activating enzyme 1 -2.88115
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.85659
LAS1L LAS1-like (S. cerevisiae) -2.66765
IQSEC2 IQ motif and Sec7 domain 2 -2.60072
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -2.5578
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -2.55138
GALK1 galactokinase 1 -2.49633
HIST1H3B histone cluster 1, H3b -2.46691
MCM3AP minichromosome maintenance complex component 3 associated protein -2.46636
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.41492
CPSF3L cleavage and polyadenylation specific factor 3-like -2.35648
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 -2.29063
TJAP1 tight junction associated protein 1 (peripheral) -2.27031
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2) -2.26834
GPS1 G protein pathway suppressor 1 -2.24721
BAIAP3 BAI1-associated protein 3 -2.2446
EGR4 early growth response 4 -2.21361
KIF1A kinesin family member 1A -2.19176
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.1898
TRIM3 tripartite motif containing 3 -2.16345
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.14848
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.12198
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.1063
WDR33 WD repeat domain 33 -2.10303
CCDC22 coiled-coil domain containing 22 -2.10245
CBX8 chromobox homolog 8 -2.09904
RNMTL1 RNA methyltransferase like 1 -2.08927
USP47 ubiquitin specific peptidase 47 -2.08312
MAP1S microtubule-associated protein 1S -2.00786
TRAK2 trafficking protein, kinesin binding 2 -2.00657
MEIS3P1 Meis homeobox 3 pseudogene 1 -1.98775
E4F1 E4F transcription factor 1 -1.98666
RHOT2 ras homolog family member T2 -1.98252
LPL lipoprotein lipase -1.9762
FAM50B family with sequence similarity 50, member B -1.96521
TLN1 talin 1 -1.94839
MRPL52 mitochondrial ribosomal protein L52 -1.94577
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae) -1.94179
TBL1X transducin (beta)-like 1X-linked -1.93735
BTNL3 butyrophilin-like 3 -1.92267
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -1.90305
GAP43 growth associated protein 43 -1.8902
TBCD tubulin folding cofactor D -1.88263
NPTX1 neuronal pentraxin I -1.87971
PNMT phenylethanolamine N-methyltransferase -1.87054
DIAPH2 diaphanous-related formin 2 -1.8671
ARID3A AT rich interactive domain 3A (BRIGHT-like) -1.85055
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 -1.84243
RBM23 RNA binding motif protein 23 -1.84136
PTPRN protein tyrosine phosphatase, receptor type, N -1.82202
RBM10 RNA binding motif protein 10 -1.81616
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 -1.81479
TMEM110 transmembrane protein 110 -1.80877
CRAT carnitine O-acetyltransferase -1.79697
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -1.79696
FAM155B family with sequence similarity 155, member B -1.78667
FASN fatty acid synthase -1.78621
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -1.77812
IL12RB1 interleukin 12 receptor, beta 1 -1.76468
CDX1 caudal type homeobox 1 -1.755
FLJ11710 uncharacterized protein FLJ11710 -1.74913
NTHL1 nth endonuclease III-like 1 (E. coli) -1.74638
HEPH hephaestin -1.74038
AFF3 AF4/FMR2 family, member 3 -1.739
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -1.73217
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -1.72873
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -1.72487
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -1.7209
NOTCH4 notch 4 -1.71932
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -1.71026
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -1.70311
CHMP4A charged multivesicular body protein 4A -1.69051
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -1.68965
PTDSS2 phosphatidylserine synthase 2 -1.6857
CD209 CD209 molecule -1.68456
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -1.68162
PES1 pescadillo ribosomal biogenesis factor 1 -1.6788
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -1.66903
NAG18 NAG18 mRNA -1.66847
YIPF3 Yip1 domain family, member 3 -1.6535
JMJD6 jumonji domain containing 6 -1.64539
NARF nuclear prelamin A recognition factor -1.64103
INE1 inactivation escape 1 (non-protein coding) -1.64099
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -1.63845
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -1.6383
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -1.63654
RNPS1 RNA binding protein S1, serine-rich domain -1.62878
CORO7 coronin 7 -1.62433
NARFL nuclear prelamin A recognition factor-like -1.62345
METTL17 methyltransferase like 17 -1.62067
GGT5 gamma-glutamyltransferase 5 -1.6174
IRF7 interferon regulatory factor 7 -1.61377
UBIAD1 UbiA prenyltransferase domain containing 1 -1.60864
PKD1 polycystic kidney disease 1 (autosomal dominant) -1.60565
AP1B1 adaptor-related protein complex 1, beta 1 subunit -1.60494
CALCR calcitonin receptor -1.60274
TRDMT1 tRNA aspartic acid methyltransferase 1 -1.59753
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -1.5974
RGS9 regulator of G-protein signaling 9 -1.59637
ASCC2 activating signal cointegrator 1 complex subunit 2 -1.59564
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -1.59546
DCHS1 dachsous cadherin-related 1 -1.59033
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -1.58514
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -1.58182
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -1.5807
KIAA0754 KIAA0754 -1.57448
BAG6 BCL2-associated athanogene 6 -1.57423
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 -1.57121
IGF2-AS IGF2 antisense RNA -1.57107
DENND1A DENN/MADD domain containing 1A -1.56976
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -1.56963
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -1.56788
SMC5 structural maintenance of chromosomes 5 -1.56681
PLVAP plasmalemma vesicle associated protein -1.56242
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -1.56148
OSGEP O-sialoglycoprotein endopeptidase -1.5548
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -1.5495
PIAS4 protein inhibitor of activated STAT, 4 -1.54159
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -1.5411
TBCCD1 TBCC domain containing 1 -1.53797
GTPBP6 GTP binding protein 6 (putative) -1.53649
SSNA1 Sjogren syndrome nuclear autoantigen 1 -1.536
FXN frataxin -1.53495
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -1.53335
PRX periaxin -1.53016
ADAM28 ADAM metallopeptidase domain 28 -1.52948
CIAO1 cytosolic iron-sulfur assembly component 1 -1.52874
RANBP3 RAN binding protein 3 -1.52766
LOC390998 ribosomal protein L10 pseudogene -1.51241
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.51155
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -1.51147
PCDHA10 protocadherin alpha 10 -1.5097
STATH statherin -1.50835
RASAL1 RAS protein activator like 1 (GAP1 like) -1.50433
GSPT1 G1 to S phase transition 1 -1.49785
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -1.49658
MAGEA11 melanoma antigen family A11 -1.49456
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -1.49389
LY96 lymphocyte antigen 96 -1.48106
SHH sonic hedgehog -1.47744
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -1.46964
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -1.46911
MTMR8 myotubularin related protein 8 -1.46888
EPO erythropoietin -1.46781
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -1.46579
SUMO1 small ubiquitin-like modifier 1 -1.46479
GPR3 G protein-coupled receptor 3 -1.46398
DGKG diacylglycerol kinase, gamma 90kDa -1.46229
RNASE4 ribonuclease, RNase A family, 4 -1.46159
GPR4 G protein-coupled receptor 4 -1.45782
DVL1 dishevelled segment polarity protein 1 -1.45611
TRIM27 tripartite motif containing 27 -1.45334
CRELD2 cysteine-rich with EGF-like domains 2 -1.45193
CSF1 colony stimulating factor 1 (macrophage) -1.45129
PCDHB3 protocadherin beta 3 -1.451
CUTA cutA divalent cation tolerance homolog (E. coli) -1.45089
TM4SF20 transmembrane 4 L six family member 20 -1.45057
PRRX1 paired related homeobox 1 -1.45006
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -1.44814
NAP1L2 nucleosome assembly protein 1-like 2 -1.44693
CSNK2B casein kinase 2, beta polypeptide -1.44503
NONO non-POU domain containing, octamer-binding -1.44419
FBP1 fructose-1,6-bisphosphatase 1 -1.44387
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -1.44318
BCL2A1 BCL2-related protein A1 -1.44179
GADD45G growth arrest and DNA-damage-inducible, gamma -1.43554
METTL7A methyltransferase like 7A -1.43467
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -1.43178
EEA1 early endosome antigen 1 -1.4231
AKAP6 A kinase (PRKA) anchor protein 6 -1.42252
AAMP angio-associated, migratory cell protein -1.41967
RIC3 RIC3 acetylcholine receptor chaperone -1.41808
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -1.41792
S100A1 S100 calcium binding protein A1 -1.41791
PPP4R2 protein phosphatase 4, regulatory subunit 2 -1.41764
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -1.41763
HOXC5 homeobox C5 -1.41602
MDC1 mediator of DNA-damage checkpoint 1 -1.41576