Keratan sulfate degradation Gene Set

Dataset Reactome Pathways 2014
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. (Gene Ontology, GO_0042340)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-2022857
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Genes

12 proteins participating in the Keratan sulfate degradation pathway from the Reactome Pathways dataset.

Symbol Name
ACAN aggrecan
FMOD fibromodulin
GLB1 galactosidase, beta 1
GLB1L galactosidase, beta 1-like
GNS glucosamine (N-acetyl)-6-sulfatase
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
KERA keratocan
LUM lumican
OGN osteoglycin
OMD osteomodulin
PRELP proline/arginine-rich end leucine-rich repeat protein