Keratoacanthoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

204 genes co-occuring with the disease Keratoacanthoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.925
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.508
MSH2 mutS homolog 2 2.498
MSH6 mutS homolog 6 2.332
MLH1 mutL homolog 1 2.33
HRAS Harvey rat sarcoma viral oncogene homolog 2.318
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.293
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.212
TP53 tumor protein p53 2.189
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.162
MAP2K1 mitogen-activated protein kinase kinase 1 2.048
IVL involucrin 1.933
TGFB1 transforming growth factor, beta 1 1.897
CD274 CD274 molecule 1.88
CDKN2A cyclin-dependent kinase inhibitor 2A 1.873
EGFR epidermal growth factor receptor 1.864
TGFBR1 transforming growth factor, beta receptor 1 1.849
KRAS Kirsten rat sarcoma viral oncogene homolog 1.843
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.803
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.802
KRT5 keratin 5, type II 1.798
KRT10 keratin 10, type I 1.78
PTEN phosphatase and tensin homolog 1.769
KRT15 keratin 15, type I 1.765
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.762
PDCD1 programmed cell death 1 1.751
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.736
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.725
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.722
MAP3K8 mitogen-activated protein kinase kinase kinase 8 1.714
KRT14 keratin 14, type I 1.71
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.669
PTCH1 patched 1 1.664
PARD3 par-3 family cell polarity regulator 1.66
CD8A CD8a molecule 1.657
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.643
IFNA2 interferon, alpha 2 1.642
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.634
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.63
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.613
PMEL premelanosome protein 1.613
REEP5 receptor accessory protein 5 1.593
CD4 CD4 molecule 1.589
TGFB3 transforming growth factor, beta 3 1.585
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 1.579
KRT1 keratin 1, type II 1.578
NF1 neurofibromin 1 1.576
FLG filaggrin 1.576
EPCAM epithelial cell adhesion molecule 1.571
IFNA1 interferon, alpha 1 1.57
FLG2 filaggrin family member 2 1.557
TGFB2 transforming growth factor, beta 2 1.555
CCND1 cyclin D1 1.531
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.528
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.521
MSH3 mutS homolog 3 1.518
MUTYH mutY homolog 1.504
IL2 interleukin 2 1.499
CDK4 cyclin-dependent kinase 4 1.48
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 1.479
MITF microphthalmia-associated transcription factor 1.477
IFNA16 interferon, alpha 16 1.448
CD34 CD34 molecule 1.446
PCNA proliferating cell nuclear antigen 1.445
IFNA7 interferon, alpha 7 1.438
IFNA21 interferon, alpha 21 1.437
IFNA8 interferon, alpha 8 1.437
IFNA10 interferon, alpha 10 1.437
IFNA14 interferon, alpha 14 1.437
IFNA6 interferon, alpha 6 1.436
IFNA5 interferon, alpha 5 1.435
IFNA13 interferon, alpha 13 1.434
KRT17 keratin 17, type I 1.433
IFNA4 interferon, alpha 4 1.432
IFNA17 interferon, alpha 17 1.418
S100A7 S100 calcium binding protein A7 1.418
KRT16 keratin 16, type I 1.408
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.4
ERBB2 erb-b2 receptor tyrosine kinase 2 1.393
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.39
BCL2 B-cell CLL/lymphoma 2 1.384
CCDC17 coiled-coil domain containing 17 1.378
EGF epidermal growth factor 1.373
SMAD2 SMAD family member 2 1.367
SMAD4 SMAD family member 4 1.36
ALK anaplastic lymphoma receptor tyrosine kinase 1.356
NOTCH1 notch 1 1.347
MAPK3 mitogen-activated protein kinase 3 1.334
IGF1R insulin-like growth factor 1 receptor 1.333
KRT20 keratin 20, type I 1.319
SOS2 son of sevenless homolog 2 (Drosophila) 1.315
GLI1 GLI family zinc finger 1 1.314
CD1E CD1e molecule 1.307
MLH3 mutL homolog 3 1.306
IFNG interferon, gamma 1.304
CD1A CD1a molecule 1.296
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.292
CD1B CD1b molecule 1.289
SMAD3 SMAD family member 3 1.282
PXDNL peroxidasin-like 1.278
PXDN peroxidasin 1.277
KDR kinase insert domain receptor 1.274
KRT7 keratin 7, type II 1.269
TNF tumor necrosis factor 1.264
SOS1 son of sevenless homolog 1 (Drosophila) 1.261
CD1C CD1c molecule 1.26
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.26
TERT telomerase reverse transcriptase 1.258
POFUT1 protein O-fucosyltransferase 1 1.257
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.251
CD68 CD68 molecule 1.246
RET ret proto-oncogene 1.245
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.245
TGFBR3 transforming growth factor, beta receptor III 1.24
SMO smoothened, frizzled class receptor 1.24
SHH sonic hedgehog 1.231
MAP2K2 mitogen-activated protein kinase kinase 2 1.231
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.228
FGFR3 fibroblast growth factor receptor 3 1.225
MMP9 matrix metallopeptidase 9 1.221
IL3RA interleukin 3 receptor, alpha (low affinity) 1.221
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 1.218
GLI2 GLI family zinc finger 2 1.214
NOTCH2 notch 2 1.21
TYR tyrosinase 1.208
TCHH trichohyalin 1.203
FLT4 fms-related tyrosine kinase 4 1.198
FLT3 fms-related tyrosine kinase 3 1.184
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 1.182
CD1D CD1d molecule 1.179
DSG1 desmoglein 1 1.176
SOX10 SRY (sex determining region Y)-box 10 1.17
ZMIZ1 zinc finger, MIZ-type containing 1 1.164
FOXP3 forkhead box P3 1.159
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.159
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.157
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.154
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.154
IL6 interleukin 6 1.149
KRT13 keratin 13, type I 1.147
SCRIB scribbled planar cell polarity protein 1.146
MET MET proto-oncogene, receptor tyrosine kinase 1.146
ACVR1B activin A receptor, type IB 1.144
STK11 serine/threonine kinase 11 1.14
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.137
DUSP6 dual specificity phosphatase 6 1.132
GRB2 growth factor receptor-bound protein 2 1.129
WFDC5 WAP four-disulfide core domain 5 1.129
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1.126
STK19 serine/threonine kinase 19 1.126
PDCD1LG2 programmed cell death 1 ligand 2 1.125
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.122
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.119
ARL9 ADP-ribosylation factor-like 9 1.119
XPA xeroderma pigmentosum, complementation group A 1.112
MME membrane metallo-endopeptidase 1.109
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 1.108
TGFA transforming growth factor, alpha 1.107
KSR1 kinase suppressor of ras 1 1.106
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 1.096
FN1 fibronectin 1 1.096
TIAM1 T-cell lymphoma invasion and metastasis 1 1.091
SFN stratifin 1.091
DUSP5 dual specificity phosphatase 5 1.077
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.075
SMAD7 SMAD family member 7 1.073
IL1A interleukin 1, alpha 1.07
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 1.07
DST dystonin 1.067
FOS FBJ murine osteosarcoma viral oncogene homolog 1.067
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.067
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.062
FGFR1 fibroblast growth factor receptor 1 1.058
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.053
POGLUT1 protein O-glucosyltransferase 1 1.052
TP63 tumor protein p63 1.05
LEF1 lymphoid enhancer-binding factor 1 1.045
TMC8 transmembrane channel-like 8 1.045
PRF1 perforin 1 (pore forming protein) 1.044
LYPD3 LY6/PLAUR domain containing 3 1.043
TLR7 toll-like receptor 7 1.041
SNAI1 snail family zinc finger 1 1.038
NLRP1 NLR family, pyrin domain containing 1 1.038
ATM ATM serine/threonine kinase 1.037
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 1.035
CRABP2 cellular retinoic acid binding protein 2 1.033
ACVR1C activin A receptor, type IC 1.033
TGM1 transglutaminase 1 1.029
ERBB4 erb-b2 receptor tyrosine kinase 4 1.028
SOX9 SRY (sex determining region Y)-box 9 1.028
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.025
KRT6A keratin 6A, type II 1.025
KITLG KIT ligand 1.025
TMEM51 transmembrane protein 51 1.024
KIAA1549 KIAA1549 1.023
JUN jun proto-oncogene 1.023
BRCA2 breast cancer 2, early onset 1.023
DENND5A DENN/MADD domain containing 5A 1.02
NTHL1 nth endonuclease III-like 1 (E. coli) 1.019
CD44 CD44 molecule (Indian blood group) 1.009
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 1.003
PTPRC protein tyrosine phosphatase, receptor type, C 1.002
TCHP trichoplein, keratin filament binding 1.001
ERBB3 erb-b2 receptor tyrosine kinase 3 1.0