Keratoconjunctivitis Sicca Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0022575
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Genes

85 genes associated with the disease Keratoconjunctivitis Sicca in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ADSSL1 adenylosuccinate synthase like 1
AFG3L2 AFG3-like AAA ATPase 2
AIRE autoimmune regulator
ATN1 atrophin 1
B2M beta-2-microglobulin
BRD1 bromodomain containing 1
BTNL2 butyrophilin-like 2
C4A complement component 4A (Rodgers blood group)
CCR1 chemokine (C-C motif) receptor 1
CKAP4 cytoskeleton-associated protein 4
CST4 cystatin S
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
EGF epidermal growth factor
ERAP1 endoplasmic reticulum aminopeptidase 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ESR1 estrogen receptor 1
FAM111A family with sequence similarity 111, member A
FAS Fas cell surface death receptor
FOXE3 forkhead box E3
GJB2 gap junction protein, beta 2, 26kDa
GSN gelsolin
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GTF2H5 general transcription factor IIH, polypeptide 5
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL23R interleukin 23 receptor
IL4 interleukin 4
IL6 interleukin 6
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KLF4 Kruppel-like factor 4 (gut)
KLRC4 killer cell lectin-like receptor subfamily C, member 4
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LMNA lamin A/C
MAB21L1 mab-21-like 1 (C. elegans)
MEFV Mediterranean fever
MMP9 matrix metallopeptidase 9
MPLKIP M-phase specific PLK1 interacting protein
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
PAX6 paired box 6
PBK PDZ binding kinase
PPARG peroxisome proliferator-activated receptor gamma
REG4 regenerating islet-derived family, member 4
RNF113A ring finger protein 113A
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RO60 Ro60, Y RNA binding protein
RPE65 retinal pigment epithelium-specific protein 65kDa
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SMN1 survival of motor neuron 1, telomeric
SMN2 survival of motor neuron 2, centromeric
SOCS3 suppressor of cytokine signaling 3
SPHK1 sphingosine kinase 1
SSB Sjogren syndrome antigen B (autoantigen La)
STAT4 signal transducer and activator of transcription 4
SYMPK symplekin
TBCE tubulin folding cofactor E
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP63 tumor protein p63
TRIM21 tripartite motif containing 21
TUBB6 tubulin, beta 6 class V
UBAC2 UBA domain containing 2
UVRAG UV radiation resistance associated
ZMPSTE24 zinc metallopeptidase STE24