Keratoconjunctivitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

279 genes co-occuring with the disease Keratoconjunctivitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PLD3 phospholipase D family, member 3 2.423
IL4 interleukin 4 2.391
RNASE3 ribonuclease, RNase A family, 3 2.364
IL13 interleukin 13 2.359
CD4 CD4 molecule 2.281
IL5 interleukin 5 2.271
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.231
IFNG interferon, gamma 2.227
IL6 interleukin 6 2.15
CD46 CD46 molecule, complement regulatory protein 2.14
CCL11 chemokine (C-C motif) ligand 11 2.114
TNF tumor necrosis factor 2.096
NGF nerve growth factor (beta polypeptide) 2.091
IL1B interleukin 1, beta 2.08
CXCL8 chemokine (C-X-C motif) ligand 8 2.073
LTF lactotransferrin 2.061
IL17A interleukin 17A 2.051
CCL24 chemokine (C-C motif) ligand 24 2.005
LACRT lacritin 1.992
IL2 interleukin 2 1.971
CD8A CD8a molecule 1.963
AIRE autoimmune regulator 1.959
IL10 interleukin 10 1.944
TAC1 tachykinin, precursor 1 1.942
MUC16 mucin 16, cell surface associated 1.939
MMP9 matrix metallopeptidase 9 1.925
TGFB1 transforming growth factor, beta 1 1.914
TSLP thymic stromal lymphopoietin 1.905
CXADR coxsackie virus and adenovirus receptor 1.904
IL1A interleukin 1, alpha 1.898
MUC4 mucin 4, cell surface associated 1.868
CCL17 chemokine (C-C motif) ligand 17 1.867
ICAM1 intercellular adhesion molecule 1 1.849
MINK1 misshapen-like kinase 1 1.822
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 1.817
DSG2 desmoglein 2 1.797
LCN1 lipocalin 1 1.777
IFNA1 interferon, alpha 1 1.768
IL3 interleukin 3 1.757
CCL5 chemokine (C-C motif) ligand 5 1.753
IL33 interleukin 33 1.75
ALB albumin 1.75
KRT3 keratin 3, type II 1.746
IFNA2 interferon, alpha 2 1.724
ACE2 angiotensin I converting enzyme 2 1.718
FN1 fibronectin 1 1.714
VIPR1 vasoactive intestinal peptide receptor 1 1.706
EGF epidermal growth factor 1.703
MUC1 mucin 1, cell surface associated 1.703
FLG filaggrin 1.689
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 1.683
TRIM21 tripartite motif containing 21 1.682
FLG2 filaggrin family member 2 1.677
CCL2 chemokine (C-C motif) ligand 2 1.676
PSEN2 presenilin 2 1.667
IL22 interleukin 22 1.655
TLR4 toll-like receptor 4 1.652
PRR4 proline rich 4 (lacrimal) 1.631
CMA1 chymase 1, mast cell 1.63
TSHR thyroid stimulating hormone receptor 1.619
HRH1 histamine receptor H1 1.618
TLR2 toll-like receptor 2 1.618
IFNW1 interferon, omega 1 1.61
CXCL10 chemokine (C-X-C motif) ligand 10 1.605
MMP1 matrix metallopeptidase 1 1.601
KRT12 keratin 12, type I 1.576
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.55
HRH4 histamine receptor H4 1.533
PTPRC protein tyrosine phosphatase, receptor type, C 1.529
CCL20 chemokine (C-C motif) ligand 20 1.526
VSX1 visual system homeobox 1 1.524
MMP3 matrix metallopeptidase 3 1.513
CRP C-reactive protein, pentraxin-related 1.51
CCR3 chemokine (C-C motif) receptor 3 1.506
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.498
DBT dihydrolipoamide branched chain transacylase E2 1.486
SCGB2A1 secretoglobin, family 2A, member 1 1.479
TLR9 toll-like receptor 9 1.476
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 1.475
FOXP3 forkhead box P3 1.461
IL4R interleukin 4 receptor 1.461
IL9 interleukin 9 1.458
MUC7 mucin 7, secreted 1.45
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.448
CAMP cathelicidin antimicrobial peptide 1.447
IFNB1 interferon, beta 1, fibroblast 1.444
CD86 CD86 molecule 1.435
TLR3 toll-like receptor 3 1.433
POSTN periostin, osteoblast specific factor 1.43
PXDN peroxidasin 1.426
PXDNL peroxidasin-like 1.422
IL17F interleukin 17F 1.419
TMPRSS2 transmembrane protease, serine 2 1.419
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.416
VIP vasoactive intestinal peptide 1.415
IL7 interleukin 7 1.414
LYZL1 lysozyme-like 1 1.413
VCAM1 vascular cell adhesion molecule 1 1.413
CCL26 chemokine (C-C motif) ligand 26 1.413
SSB Sjogren syndrome antigen B (autoantigen La) 1.382
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.381
CXCL9 chemokine (C-X-C motif) ligand 9 1.378
FGF7 fibroblast growth factor 7 1.377
SIGLEC8 sialic acid binding Ig-like lectin 8 1.37
ADSS2 adenylosuccinate synthase 2 1.368
NELFCD negative elongation factor complex member C/D 1.366
IL18 interleukin 18 1.366
CD80 CD80 molecule 1.364
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.357
TGFB2 transforming growth factor, beta 2 1.355
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.354
IFNA17 interferon, alpha 17 1.353
CST4 cystatin S 1.339
INS insulin 1.337
LGALS3 lectin, galactoside-binding, soluble, 3 1.334
CD40 CD40 molecule, TNF receptor superfamily member 5 1.334
CD68 CD68 molecule 1.328
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.321
IFNA8 interferon, alpha 8 1.32
MMP2 matrix metallopeptidase 2 1.319
IFNA5 interferon, alpha 5 1.318
IL31 interleukin 31 1.317
SPDEF SAM pointed domain containing ETS transcription factor 1.316
EPX eosinophil peroxidase 1.316
IFNA4 interferon, alpha 4 1.315
TIMP1 TIMP metallopeptidase inhibitor 1 1.312
KERA keratocan 1.311
IFNA7 interferon, alpha 7 1.31
IFNA16 interferon, alpha 16 1.31
IFNA14 interferon, alpha 14 1.309
IFNA21 interferon, alpha 21 1.309
IFNA10 interferon, alpha 10 1.309
IFNA6 interferon, alpha 6 1.308
CXCR3 chemokine (C-X-C motif) receptor 3 1.307
IFNA13 interferon, alpha 13 1.306
IL16 interleukin 16 1.305
PTGFR prostaglandin F receptor (FP) 1.304
NLRP5 NLR family, pyrin domain containing 5 1.302
IGF1 insulin-like growth factor 1 (somatomedin C) 1.3
MPO myeloperoxidase 1.293
KCNRG potassium channel regulator 1.288
CCL3 chemokine (C-C motif) ligand 3 1.286
RBP3 retinol binding protein 3, interstitial 1.283
MBTPS2 membrane-bound transcription factor peptidase, site 2 1.28
TMSB4X thymosin beta 4, X-linked 1.261
GYPC glycophorin C (Gerbich blood group) 1.26
MYD88 myeloid differentiation primary response 88 1.258
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 1.256
CCL22 chemokine (C-C motif) ligand 22 1.254
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.251
MMP10 matrix metallopeptidase 10 1.246
ACE angiotensin I converting enzyme 1.246
MMP8 matrix metallopeptidase 8 1.245
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.243
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.237
FGF10 fibroblast growth factor 10 1.231
PAX6 paired box 6 1.231
LYZ lysozyme 1.227
CXCL11 chemokine (C-X-C motif) ligand 11 1.224
FGF6 fibroblast growth factor 6 1.213
NECTIN1 nectin cell adhesion molecule 1 1.21
MXI1 MAX interactor 1, dimerization protein 1.208
AOC1 amine oxidase, copper containing 1 1.206
FERMT1 fermitin family member 1 1.203
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.202
BDNF brain-derived neurotrophic factor 1.202
C3 complement component 3 1.198
MUC20 mucin 20, cell surface associated 1.196
TLR7 toll-like receptor 7 1.191
DEFB4A defensin, beta 4A 1.19
CNTF ciliary neurotrophic factor 1.189
IL13RA1 interleukin 13 receptor, alpha 1 1.188
FGF3 fibroblast growth factor 3 1.188
CCR7 chemokine (C-C motif) receptor 7 1.187
NGFR nerve growth factor receptor 1.186
FGF5 fibroblast growth factor 5 1.181
MMP13 matrix metallopeptidase 13 1.18
ZNF469 zinc finger protein 469 1.18
FGF22 fibroblast growth factor 22 1.179
FGF4 fibroblast growth factor 4 1.178
FGF16 fibroblast growth factor 16 1.177
KRT10 keratin 10, type I 1.177
FGF20 fibroblast growth factor 20 1.175
FGF17 fibroblast growth factor 17 1.172
THBS1 thrombospondin 1 1.172
CCL4 chemokine (C-C motif) ligand 4 1.172
FGF18 fibroblast growth factor 18 1.169
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.167
FGF9 fibroblast growth factor 9 1.16
TLR5 toll-like receptor 5 1.16
ADCY10 adenylate cyclase 10 (soluble) 1.159
ERVW-1 endogenous retrovirus group W, member 1 1.159
FOLR1 folate receptor 1 (adult) 1.159
TGM4 transglutaminase 4 1.158
PIP prolactin-induced protein 1.157
FGF8 fibroblast growth factor 8 (androgen-induced) 1.154
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.152
TJP1 tight junction protein 1 1.144
PTGDR2 prostaglandin D2 receptor 2 1.142
FGF2 fibroblast growth factor 2 (basic) 1.141
ACTB actin, beta 1.141
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1.14
KRT4 keratin 4, type II 1.139
GPR35 G protein-coupled receptor 35 1.139
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.134
CLC Charcot-Leyden crystal galectin 1.131
CSF3 colony stimulating factor 3 (granulocyte) 1.13
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.129
EGFR epidermal growth factor receptor 1.128
CCR6 chemokine (C-C motif) receptor 6 1.127
CCRL2 chemokine (C-C motif) receptor-like 2 1.126
ELN elastin 1.125
PDILT protein disulfide isomerase-like, testis expressed 1.119
KITLG KIT ligand 1.118
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.118
IVL involucrin 1.116
KIF21A kinesin family member 21A 1.11
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.108
OCLN occludin 1.108
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.106
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.105
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.104
OPRPN opiorphin prepropeptide 1.099
SYK spleen tyrosine kinase 1.099
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.096
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.096
TG thyroglobulin 1.096
SELE selectin E 1.092
ANXA1 annexin A1 1.088
ASIC3 acid sensing (proton gated) ion channel 3 1.087
CD1A CD1a molecule 1.087
PLG plasminogen 1.085
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 1.084
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 1.079
CD1C CD1c molecule 1.078
TCF3 transcription factor 3 1.077
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.072
ERV3-1 endogenous retrovirus group 3, member 1 1.072
JUN jun proto-oncogene 1.072
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.068
NLRP3 NLR family, pyrin domain containing 3 1.068
KRT14 keratin 14, type I 1.063
CD40LG CD40 ligand 1.061
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.057
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 1.057
DCD dermcidin 1.051
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.049
CCL15 chemokine (C-C motif) ligand 15 1.049
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.048
CLEC7A C-type lectin domain family 7, member A 1.047
SCGB1D1 secretoglobin, family 1D, member 1 1.045
CHIA chitinase, acidic 1.044
MUC19 mucin 19, oligomeric 1.043
MUC2 mucin 2, oligomeric mucus/gel-forming 1.04
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.039
TGM1 transglutaminase 1 1.038
TLR1 toll-like receptor 1 1.038
HBEGF heparin-binding EGF-like growth factor 1.038
CXCR4 chemokine (C-X-C motif) receptor 4 1.037
CD28 CD28 molecule 1.036
TLR8 toll-like receptor 8 1.03
TGFBI transforming growth factor, beta-induced, 68kDa 1.029
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 1.025
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 1.022
LTB4R leukotriene B4 receptor 1.021
DMBT1 deleted in malignant brain tumors 1 1.019
JAK1 Janus kinase 1 1.019
CD34 CD34 molecule 1.018
DST dystonin 1.018
HPX hemopexin 1.016
H2BC21 H2B clustered histone 21 1.014
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.014
FASLG Fas ligand (TNF superfamily, member 6) 1.014
C1QL2 complement component 1, q subcomponent-like 2 1.013
CRLF2 cytokine receptor-like factor 2 1.01
KRT13 keratin 13, type I 1.009
CCL23 chemokine (C-C motif) ligand 23 1.007
CD1B CD1b molecule 1.005
SCG3 secretogranin III 1.002