Keratopathy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

266 genes co-occuring with the disease Keratopathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PAX6 paired box 6 2.899
NGF nerve growth factor (beta polypeptide) 2.692
TAC1 tachykinin, precursor 1 2.578
KRT12 keratin 12, type I 2.477
LACRT lacritin 2.417
KRT3 keratin 3, type II 2.249
CTSF cathepsin F 2.161
TMSB4X thymosin beta 4, X-linked 2.106
IGF1 insulin-like growth factor 1 (somatomedin C) 2.091
CD38 CD38 molecule 2.076
KERA keratocan 2.07
EGF epidermal growth factor 2.008
FN1 fibronectin 1 1.975
GPRC5D G protein-coupled receptor, class C, group 5, member D 1.968
ELP4 elongator acetyltransferase complex subunit 4 1.965
IL1B interleukin 1, beta 1.96
IL6 interleukin 6 1.938
AIRE autoimmune regulator 1.911
HEYL hes-related family bHLH transcription factor with YRPW motif-like 1.904
CNTF ciliary neurotrophic factor 1.895
OGFR opioid growth factor receptor 1.894
DCDC1 doublecortin domain containing 1 1.881
MMP9 matrix metallopeptidase 9 1.876
INS insulin 1.867
TNF tumor necrosis factor 1.867
TGFB1 transforming growth factor, beta 1 1.865
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 1.861
PENK proenkephalin 1.853
FOLR1 folate receptor 1 (adult) 1.851
TSHR thyroid stimulating hormone receptor 1.838
SLAMF7 SLAM family member 7 1.829
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.823
FCRL5 Fc receptor-like 5 1.818
MMP10 matrix metallopeptidase 10 1.768
FOXC1 forkhead box C1 1.764
NID1 nidogen 1 1.762
CXCL8 chemokine (C-X-C motif) ligand 8 1.744
IL1A interleukin 1, alpha 1.74
PITX2 paired-like homeodomain 2 1.729
ALB albumin 1.722
LOXL1 lysyl oxidase-like 1 1.721
FGF7 fibroblast growth factor 7 1.718
LCN1 lipocalin 1 1.699
HGD homogentisate 1,2-dioxygenase 1.696
LUM lumican 1.685
LTF lactotransferrin 1.667
CTNS cystinosin, lysosomal cystine transporter 1.662
CD4 CD4 molecule 1.66
TACR1 tachykinin receptor 1 1.656
TGFBI transforming growth factor, beta-induced, 68kDa 1.653
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 1.614
PRR4 proline rich 4 (lacrimal) 1.597
IFNG interferon, gamma 1.593
HPD 4-hydroxyphenylpyruvate dioxygenase 1.591
BDNF brain-derived neurotrophic factor 1.587
IL10 interleukin 10 1.586
FGF2 fibroblast growth factor 2 (basic) 1.585
EGFR epidermal growth factor receptor 1.573
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.567
GDNF glial cell derived neurotrophic factor 1.564
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.554
VIP vasoactive intestinal peptide 1.553
MYOM2 myomesin 2 1.549
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.549
IL17A interleukin 17A 1.544
CEP70 centrosomal protein 70kDa 1.543
CEL carboxyl ester lipase 1.542
DCN decorin 1.514
IGF1R insulin-like growth factor 1 receptor 1.513
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.498
KIF21A kinesin family member 21A 1.491
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) 1.491
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 1.489
ICAM1 intercellular adhesion molecule 1 1.481
IL2 interleukin 2 1.48
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.474
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 1.47
UBIAD1 UbiA prenyltransferase domain containing 1 1.46
XPO1 exportin 1 1.451
IFNA2 interferon, alpha 2 1.447
FOXE3 forkhead box E3 1.446
TRIM44 tripartite motif containing 44 1.44
WT1 Wilms tumor 1 1.429
TJP1 tight junction protein 1 1.428
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 1.418
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.415
LYZL1 lysozyme-like 1 1.414
KRT15 keratin 15, type I 1.41
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 1.409
MET MET proto-oncogene, receptor tyrosine kinase 1.401
NTF3 neurotrophin 3 1.399
MMP2 matrix metallopeptidase 2 1.395
MUC16 mucin 16, cell surface associated 1.392
FGF3 fibroblast growth factor 3 1.392
TUBB3 tubulin, beta 3 class III 1.39
FGF10 fibroblast growth factor 10 1.386
TACSTD2 tumor-associated calcium signal transducer 2 1.386
NPY neuropeptide Y 1.384
PITX3 paired-like homeodomain 3 1.383
CD8A CD8a molecule 1.375
FGF16 fibroblast growth factor 16 1.367
SDC1 syndecan 1 1.364
FGF4 fibroblast growth factor 4 1.363
FGF22 fibroblast growth factor 22 1.359
SIRT1 sirtuin 1 1.359
FGF6 fibroblast growth factor 6 1.357
FGF20 fibroblast growth factor 20 1.354
FGF8 fibroblast growth factor 8 (androgen-induced) 1.344
FGF17 fibroblast growth factor 17 1.342
FGF9 fibroblast growth factor 9 1.339
FGF5 fibroblast growth factor 5 1.339
FGF18 fibroblast growth factor 18 1.339
SCGB1D1 secretoglobin, family 1D, member 1 1.338
GJA1 gap junction protein, alpha 1, 43kDa 1.331
CD19 CD19 molecule 1.329
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.328
OPRPN opiorphin prepropeptide 1.32
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.316
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.314
MUC4 mucin 4, cell surface associated 1.312
FOXD3 forkhead box D3 1.31
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.309
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.307
ELN elastin 1.304
LYZ lysozyme 1.303
IFNA1 interferon, alpha 1 1.3
VEGFB vascular endothelial growth factor B 1.298
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.296
THY1 Thy-1 cell surface antigen 1.296
IL4 interleukin 4 1.296
VEGFD vascular endothelial growth factor D 1.29
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.284
KRT13 keratin 13, type I 1.284
CCL2 chemokine (C-C motif) ligand 2 1.28
VEGFC vascular endothelial growth factor C 1.276
IL5 interleukin 5 1.275
PHOX2A paired-like homeobox 2a 1.274
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.273
MMP3 matrix metallopeptidase 3 1.272
TGFB3 transforming growth factor, beta 3 1.271
TGFB2 transforming growth factor, beta 2 1.269
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.269
PXDN peroxidasin 1.268
IL18 interleukin 18 1.267
CRBN cereblon 1.266
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.263
NLRP3 NLR family, pyrin domain containing 3 1.262
CCL5 chemokine (C-C motif) ligand 5 1.262
ACTB actin, beta 1.255
STRA6 stimulated by retinoic acid 6 1.252
SLAMF1 signaling lymphocytic activation molecule family member 1 1.247
PATE2 prostate and testis expressed 2 1.247
TLR4 toll-like receptor 4 1.246
VSX1 visual system homeobox 1 1.242
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 1.229
TP53 tumor protein p53 1.229
MANF mesencephalic astrocyte-derived neurotrophic factor 1.216
KDR kinase insert domain receptor 1.214
PTPRC protein tyrosine phosphatase, receptor type, C 1.214
FLT4 fms-related tyrosine kinase 4 1.213
PXDNL peroxidasin-like 1.208
VSX2 visual system homeobox 2 1.203
G6PD glucose-6-phosphate dehydrogenase 1.202
FLT1 fms-related tyrosine kinase 1 1.194
MAB21L1 mab-21-like 1 (C. elegans) 1.194
GSDMD gasdermin D 1.192
PATE4 prostate and testis expressed 4 1.183
IL13 interleukin 13 1.182
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.179
BGN biglycan 1.174
GLA galactosidase, alpha 1.174
CD34 CD34 molecule 1.172
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.172
MSLN mesothelin 1.167
BCL2 B-cell CLL/lymphoma 2 1.166
CRP C-reactive protein, pentraxin-related 1.16
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 1.159
PRDM12 PR domain containing 12 1.156
WNT7A wingless-type MMTV integration site family, member 7A 1.156
MBTPS2 membrane-bound transcription factor peptidase, site 2 1.153
RNASE3 ribonuclease, RNase A family, 3 1.151
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 1.149
ERBB2 erb-b2 receptor tyrosine kinase 2 1.147
SLC38A8 solute carrier family 38, member 8 1.147
PBK PDZ binding kinase 1.147
MMP8 matrix metallopeptidase 8 1.139
PECAM1 platelet/endothelial cell adhesion molecule 1 1.137
NTF4 neurotrophin 4 1.137
FGFR2 fibroblast growth factor receptor 2 1.136
JUN jun proto-oncogene 1.136
NGFR nerve growth factor receptor 1.132
NOX4 NADPH oxidase 4 1.129
THBS1 thrombospondin 1 1.129
TGM1 transglutaminase 1 1.126
COL8A2 collagen, type VIII, alpha 2 1.123
AAAS achalasia, adrenocortical insufficiency, alacrimia 1.12
TKTL2 transketolase-like 2 1.117
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1.115
CD274 CD274 molecule 1.113
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.113
MUC1 mucin 1, cell surface associated 1.109
CA6 carbonic anhydrase VI 1.106
NID2 nidogen 2 (osteonidogen) 1.106
KRT19 keratin 19, type I 1.098
POMC proopiomelanocortin 1.097
GSN gelsolin 1.097
IGFBP3 insulin-like growth factor binding protein 3 1.096
PLAU plasminogen activator, urokinase 1.09
TKT transketolase 1.089
RGN regucalcin 1.085
AQP5 aquaporin 5 1.085
CCL3 chemokine (C-C motif) ligand 3 1.083
HBEGF heparin-binding EGF-like growth factor 1.079
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.079
FGF1 fibroblast growth factor 1 (acidic) 1.077
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 1.076
DSG1 desmoglein 1 1.07
OTX2 orthodenticle homeobox 2 1.067
CLU clusterin 1.064
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.059
MAPK3 mitogen-activated protein kinase 3 1.058
TKTL1 transketolase-like 1 1.058
EDA ectodysplasin A 1.057
GJA8 gap junction protein, alpha 8, 50kDa 1.057
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 1.057
PRF1 perforin 1 (pore forming protein) 1.055
NECTIN4 nectin cell adhesion molecule 4 1.054
CXCL10 chemokine (C-X-C motif) ligand 10 1.053
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.052
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.051
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.051
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.049
RDH10 retinol dehydrogenase 10 (all-trans) 1.043
B2M beta-2-microglobulin 1.042
ACE angiotensin I converting enzyme 1.042
DNMBP dynamin binding protein 1.038
TIMP1 TIMP metallopeptidase inhibitor 1 1.037
CD40 CD40 molecule, TNF receptor superfamily member 5 1.031
CD86 CD86 molecule 1.028
TG thyroglobulin 1.027
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.024
PIP prolactin-induced protein 1.022
PPARA peroxisome proliferator-activated receptor alpha 1.022
COL18A1 collagen, type XVIII, alpha 1 1.021
FGFR3 fibroblast growth factor receptor 3 1.02
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.019
CD200 CD200 molecule 1.018
IL16 interleukin 16 1.016
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.015
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.015
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.014
CD80 CD80 molecule 1.014
PIGR polymeric immunoglobulin receptor 1.014
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.013
RPE65 retinal pigment epithelium-specific protein 65kDa 1.012
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.012
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.012
GPHA2 glycoprotein hormone alpha 2 1.012
RNASE7 ribonuclease, RNase A family, 7 1.007
SP100 SP100 nuclear antigen 1.006
TTLL5 tubulin tyrosine ligase-like family member 5 1.003
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 1.001
TAT tyrosine aminotransferase 1.001
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 1.001
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.0
FBN1 fibrillin 1 1.0