Ketosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Presence of elevated levels of ketone bodies in the body. (Human Phenotype Ontology, HP_0001946)
External Link https://www.disgenet.org/browser/0/1/0/C0022638
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Genes

117 genes associated with the disease Ketosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACAA1 acetyl-CoA acyltransferase 1
ACAA2 acetyl-CoA acyltransferase 2
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACAT1 acetyl-CoA acetyltransferase 1
ACP1 acid phosphatase 1, soluble
ACSF3 acyl-CoA synthetase family member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOBR apolipoprotein B receptor
APOE apolipoprotein E
ATG14 autophagy related 14
ATP5F1D ATP synthase F1 subunit delta
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP4 bone morphogenetic protein 4
CA5A carbonic anhydrase VA, mitochondrial
CCK cholecystokinin
CD163 CD163 molecule
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CDR2 cerebellar degeneration-related protein 2, 62kDa
CHP1 calcineurin-like EF-hand protein 1
CHPT1 choline phosphotransferase 1
CMA1 chymase 1, mast cell
CORT cortistatin
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT2 carnitine palmitoyltransferase 2
CYC1 cytochrome c-1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DMD dystrophin
DPP4 dipeptidyl-peptidase 4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FBP1 fructose-1,6-bisphosphatase 1
FGF21 fibroblast growth factor 21
G6PD glucose-6-phosphate dehydrogenase
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCG glucagon
GCK glucokinase (hexokinase 4)
GCLC glutamate-cysteine ligase, catalytic subunit
GHSR growth hormone secretagogue receptor
GK glycerol kinase
GLP1R glucagon-like peptide 1 receptor
GYS2 glycogen synthase 2 (liver)
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
IDE insulin-degrading enzyme
IFNG interferon, gamma
IL1B interleukin 1, beta
IL6 interleukin 6
INS insulin
INSR insulin receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
IVD isovaleryl-CoA dehydrogenase
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LEP leptin
LPL lipoprotein lipase
MAPK3 mitogen-activated protein kinase 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCTS1 malignant T cell amplified sequence 1
MLYCD malonyl-CoA decarboxylase
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NRSN1 neurensin 1
ORM1 orosomucoid 1
OXCT1 3-oxoacid CoA transferase 1
PAX4 paired box 4
PAX6 paired box 6
PDX1 pancreatic and duodenal homeobox 1
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POLG polymerase (DNA directed), gamma
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PTEN phosphatase and tensin homolog
PTK2B protein tyrosine kinase 2 beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RBM45 RNA binding motif protein 45
RGS6 regulator of G-protein signaling 6
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC30A10 solute carrier family 30, member 10
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOAT1 sterol O-acyltransferase 1
SOCS4 suppressor of cytokine signaling 4
SREBF1 sterol regulatory element binding transcription factor 1
TMED2 transmembrane emp24 domain trafficking protein 2
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPPP tubulin polymerization promoting protein
TWNK twinkle mtDNA helicase
UBL4A ubiquitin-like 4A
ZFP57 ZFP57 zinc finger protein
ZGLP1 zinc finger, GATA-like protein 1