Kidney Failure Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. (Human Disease Ontology, DOID_1074)
External Link https://www.disgenet.org/browser/0/1/0/C0035078
Similar Terms
Downloads & Tools

Genes

363 genes associated with the disease Kidney Failure in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACE angiotensin I converting enzyme
ACMSD aminocarboxymuconate semialdehyde decarboxylase
ACSS2 acyl-CoA synthetase short-chain family member 2
ACTB actin, beta
ACTN4 actinin, alpha 4
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADD1 adducin 1 (alpha)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADM adrenomedullin
ADRB1 adrenoceptor beta 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALB albumin
ALPP alkaline phosphatase, placental
AMBP alpha-1-microglobulin/bikunin precursor
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANKH ANKH inorganic pyrophosphate transport regulator
ANPEP alanyl (membrane) aminopeptidase
APLN apelin
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APOL1 apolipoprotein L, 1
APRT adenine phosphoribosyltransferase
AQP2 aquaporin 2 (collecting duct)
ARSL arylsulfatase L
ASRGL1 asparaginase like 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATRNL1 attractin-like 1
AVP arginine vasopressin
B2M beta-2-microglobulin
BCL2 B-cell CLL/lymphoma 2
BEST1 bestrophin 1
BMP7 bone morphogenetic protein 7
BNC2 basonuclin 2
BSND barttin CLCNK-type chloride channel accessory beta subunit
BTBD8 BTB (POZ) domain containing 8
C3 complement component 3
CABIN1 calcineurin binding protein 1
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC51 coiled-coil domain containing 51
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL27 chemokine (C-C motif) ligand 27
CCL5 chemokine (C-C motif) ligand 5
CCN2 cellular communication network factor 2
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD2AP CD2-associated protein
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CD5L CD5 molecule-like
CD6 CD6 molecule
CD80 CD80 molecule
CFH complement factor H
CFHR5 complement factor H-related 5
CISH cytokine inducible SH2-containing protein
CLCN5 chloride channel, voltage-sensitive 5
CLCNKB chloride channel, voltage-sensitive Kb
CLDN1 claudin 1
CLDN16 claudin 16
CLDN19 claudin 19
CLDN7 claudin 7
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COQ8B coenzyme Q8B
COX1
COX2
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST3 cystatin C
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSA cathepsin A
CUBN cubilin (intrinsic factor-cobalamin receptor)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR1 chemokine (C-X-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCN decorin
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEGS1 delta(4)-desaturase, sphingolipid 1
DESI1 desumoylating isopeptidase 1
DGKE diacylglycerol kinase, epsilon 64kDa
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DLG1 discs, large homolog 1 (Drosophila)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP4 dipeptidyl-peptidase 4
DSPP dentin sialophosphoprotein
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELANE elastase, neutrophil expressed
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHB2 EPH receptor B2
EPO erythropoietin
EPOR erythropoietin receptor
EPX eosinophil peroxidase
ESRRG estrogen-related receptor gamma
ETF1 eukaryotic translation termination factor 1
EYA1 EYA transcriptional coactivator and phosphatase 1
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FBXO32 F-box protein 32
FECH ferrochelatase
FERMT2 fermitin family member 2
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FJX1 four jointed box 1 (Drosophila)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLII flightless I homolog (Drosophila)
FLNB filamin B, beta
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FRMD3 FERM domain containing 3
G6PC glucose-6-phosphatase, catalytic subunit
GATA3 GATA binding protein 3
GCG glucagon
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDF11 growth differentiation factor 11
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GGTLC3 gamma-glutamyltransferase light chain 3
GIF gastric intrinsic factor (vitamin B synthesis)
GLA galactosidase, alpha
GLIS2 GLIS family zinc finger 2
GLP1R glucagon-like peptide 1 receptor
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSN gelsolin
GUCA2A guanylate cyclase activator 2A (guanylin)
HAGH hydroxyacylglutathione hydrolase
HAMP hepcidin antimicrobial peptide
HBS1L HBS1-like translational GTPase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLF hepatic leukemia factor
HNF1B HNF1 homeobox B
HP haptoglobin
HSPG2 heparan sulfate proteoglycan 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL17B interleukin 17B
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL2RA interleukin 2 receptor, alpha
IL34 interleukin 34
IL6 interleukin 6
ILK integrin-linked kinase
INF2 inverted formin, FH2 and WH2 domain containing
INS insulin
INVS inversin
IQCB1 IQ motif containing B1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA8 integrin, alpha 8
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KDM5A lysine (K)-specific demethylase 5A
KEAP1 kelch-like ECH-associated protein 1
KIF3A kinesin family member 3A
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIRREL2 kin of IRRE like 2 (Drosophila)
KL klotho
KLB klotho beta
KLF4 Kruppel-like factor 4 (gut)
KLK1 kallikrein 1
KNG1 kininogen 1
KRT18 keratin 18, type I
LAMA5 laminin, alpha 5
LAMB2 laminin, beta 2 (laminin S)
LCAT lecithin-cholesterol acyltransferase
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LMX1B LIM homeobox transcription factor 1, beta
LPA lipoprotein, Lp(a)
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
LYZ lysozyme
MAP1S microtubule-associated protein 1S
MAPK1 mitogen-activated protein kinase 1
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MBL2 mannose-binding lectin (protein C) 2, soluble
MECP2 methyl CpG binding protein 2
MEN1 multiple endocrine neoplasia I
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPV17 MpV17 mitochondrial inner membrane protein
MRPS7 mitochondrial ribosomal protein S7
MSH2 mutS homolog 2
MSX2 msh homeobox 2
MT1A metallothionein 1A
MT2A metallothionein 2A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTRF1 mitochondrial translational release factor 1
MTX1 metaxin 1
MUC1 mucin 1, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
MZB1 marginal zone B and B1 cell-specific protein
NAMPT nicotinamide phosphoribosyltransferase
NAT10 N-acetyltransferase 10 (GCN5-related)
NLGN3 neuroligin 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPHP1 nephronophthisis 1 (juvenile)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP1 neuropilin 1
NT5C1A 5'-nucleotidase, cytosolic IA
NXF1 nuclear RNA export factor 1
NXPH1 neurexophilin 1
OCRL oculocerebrorenal syndrome of Lowe
PADI4 peptidyl arginine deiminase, type IV
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PAX2 paired box 2
PAX8 paired box 8
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PGF placental growth factor
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PLG plasminogen
PODXL podocalyxin-like
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRTN3 proteinase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM45 RNA binding motif protein 45
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RENBP renin binding protein
RGN regucalcin
RHCG Rh family, C glycoprotein
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SALL1 spalt-like transcription factor 1
SCARB2 scavenger receptor class B, member 2
SCT secretin
SDC1 syndecan 1
SDC2 syndecan 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SELL selectin L
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIX6 SIX homeobox 6
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC26A5 solute carrier family 26 (anion exchanger), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35G1 solute carrier family 35, member G1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SLPI secretory leukocyte peptidase inhibitor
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOST sclerostin
SOX18 SRY (sex determining region Y)-box 18
SPP1 secreted phosphoprotein 1
SQOR sulfide quinone oxidoreductase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STAT4 signal transducer and activator of transcription 4
STX2 syntaxin 2
SUCNR1 succinate receptor 1
TBXA2R thromboxane A2 receptor
TERT telomerase reverse transcriptase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
TNF tumor necrosis factor
TP53 tumor protein p53
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTR transthyretin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UMOD uromodulin
USO1 USO1 vesicle transport factor
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VWF von Willebrand factor
WDR19 WD repeat domain 19
WNK4 WNK lysine deficient protein kinase 4
WT1 Wilms tumor 1
XDH xanthine dehydrogenase
ZGLP1 zinc finger, GATA-like protein 1
ZNF645 zinc finger protein 645