| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5311276 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in L-168,049 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | 1.91 |
| COL1A1 | collagen, type I, alpha 1 | 1.72 |
| MYT1 | myelin transcription factor 1 | 1.15 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.96 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.87 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.84 |
| ATE1 | arginyltransferase 1 | 0.78 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.74 |
| SLC38A7 | solute carrier family 38, member 7 | 0.55 |
| MR1 | major histocompatibility complex, class I-related | 0.53 |
| CNTRL | centriolin | 0.5 |
| DHRS4L1 | dehydrogenase/reductase (SDR family) member 4 like 1 | 0.48 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | 0.48 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.48 |
| PPT1 | palmitoyl-protein thioesterase 1 | 0.47 |
| CEP63 | centrosomal protein 63kDa | 0.46 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.45 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.45 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | 0.45 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.45 |
| DBNL | drebrin-like | 0.44 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.44 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.42 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | 0.41 |
| CDK14 | cyclin-dependent kinase 14 | 0.41 |
| TM2D3 | TM2 domain containing 3 | 0.4 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.4 |
| ISL2 | ISL LIM homeobox 2 | 0.4 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.39 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | 0.38 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | 0.37 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.36 |
| DNA2 | DNA replication helicase/nuclease 2 | 0.36 |
| ANGPTL4 | angiopoietin-like 4 | 0.36 |
| SYN2 | synapsin II | 0.35 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.34 |
| TRO | trophinin | 0.34 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.33 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.33 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.33 |
| FBXO31 | F-box protein 31 | 0.33 |
| PEF1 | penta-EF-hand domain containing 1 | 0.32 |
| PET100 | PET100 homolog (S. cerevisiae) | 0.32 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.32 |
| TSEN34 | TSEN34 tRNA splicing endonuclease subunit | 0.31 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.31 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | 0.31 |
| CPA4 | carboxypeptidase A4 | 0.31 |
| ZNF335 | zinc finger protein 335 | 0.3 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.3 |
| KLHL15 | kelch-like family member 15 | 0.3 |
| ZNF273 | zinc finger protein 273 | 0.3 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | 0.3 |
| TMEM179B | transmembrane protein 179B | 0.3 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.3 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.29 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.29 |
| ZNF189 | zinc finger protein 189 | 0.29 |
| TSPYL2 | TSPY-like 2 | 0.29 |
| DEAF1 | DEAF1 transcription factor | 0.29 |
| ACTR5 | ARP5 actin-related protein 5 homolog (yeast) | 0.29 |
| SERAC1 | serine active site containing 1 | 0.29 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | 0.28 |
| PRF1 | perforin 1 (pore forming protein) | 0.28 |
| ZNF28 | zinc finger protein 28 | 0.28 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.28 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.28 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | 0.28 |
| ADCY6 | adenylate cyclase 6 | 0.28 |
| RAB26 | RAB26, member RAS oncogene family | 0.28 |
| HFE | hemochromatosis | 0.28 |
| ZSWIM9 | zinc finger SWIM-type containing 9 | 0.27 |
| ZNF250 | zinc finger protein 250 | 0.27 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.27 |
| RNF166 | ring finger protein 166 | 0.27 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | 0.27 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.27 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | 0.27 |
| MIIP | migration and invasion inhibitory protein | 0.26 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.26 |
| FAM20C | family with sequence similarity 20, member C | 0.26 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.26 |
| PARPBP | PARP1 binding protein | 0.26 |
| ZNF600 | zinc finger protein 600 | 0.26 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.25 |
| CCNI | cyclin I | 0.25 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.25 |
| GSTO2 | glutathione S-transferase omega 2 | 0.25 |
| SLC25A30 | solute carrier family 25, member 30 | 0.25 |
| ARG2 | arginase 2 | 0.25 |
| MYLK | myosin light chain kinase | 0.25 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.25 |
| PTS | 6-pyruvoyltetrahydropterin synthase | 0.24 |
| PIP | prolactin-induced protein | 0.24 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.24 |
| CCDC77 | coiled-coil domain containing 77 | 0.24 |
| TBC1D31 | TBC1 domain family, member 31 | 0.24 |
| ALPP | alkaline phosphatase, placental | 0.24 |
| DOP1A | DOP1 leucine zipper like protein A | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SRD5A3 | steroid 5 alpha-reductase 3 | -1.42 |
| OSGIN2 | oxidative stress induced growth inhibitor family member 2 | -0.74 |
| PLK4 | polo-like kinase 4 | -0.66 |
| TSPAN3 | tetraspanin 3 | -0.64 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.61 |
| TPM1 | tropomyosin 1 (alpha) | -0.6 |
| PLIN2 | perilipin 2 | -0.6 |
| REX1BD | required for excision 1-B domain containing | -0.59 |
| KLHDC3 | kelch domain containing 3 | -0.56 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -0.55 |
| CD63 | CD63 molecule | -0.54 |
| RELL1 | RELT-like 1 | -0.54 |
| ANKRD13B | ankyrin repeat domain 13B | -0.48 |
| STAB1 | stabilin 1 | -0.47 |
| DENND3 | DENN/MADD domain containing 3 | -0.47 |
| PLSCR1 | phospholipid scramblase 1 | -0.46 |
| SGSM1 | small G protein signaling modulator 1 | -0.46 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.46 |
| MYO15B | myosin XVB | -0.45 |
| METTL7A | methyltransferase like 7A | -0.44 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.43 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | -0.43 |
| PAK5 | p21 (RAC1) activated kinase 5 | -0.43 |
| CERS4 | ceramide synthase 4 | -0.42 |
| LMBR1 | limb development membrane protein 1 | -0.41 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.41 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.41 |
| TMC4 | transmembrane channel-like 4 | -0.41 |
| FGB | fibrinogen beta chain | -0.41 |
| HRH1 | histamine receptor H1 | -0.4 |
| MEGF9 | multiple EGF-like-domains 9 | -0.4 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.4 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.4 |
| TOR4A | torsin family 4, member A | -0.39 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.39 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | -0.38 |
| SIKE1 | suppressor of IKBKE 1 | -0.38 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | -0.38 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.38 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.37 |
| ZBTB45 | zinc finger and BTB domain containing 45 | -0.37 |
| GPN2 | GPN-loop GTPase 2 | -0.37 |
| ZBTB39 | zinc finger and BTB domain containing 39 | -0.36 |
| SPHK2 | sphingosine kinase 2 | -0.35 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.35 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.35 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.35 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.34 |
| TMEM128 | transmembrane protein 128 | -0.34 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.34 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | -0.34 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.33 |
| IFT22 | intraflagellar transport 22 | -0.33 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.33 |
| CHSY3 | chondroitin sulfate synthase 3 | -0.33 |
| NEMP2 | nuclear envelope integral membrane protein 2 | -0.33 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.33 |
| HAL | histidine ammonia-lyase | -0.33 |
| PRSS8 | protease, serine, 8 | -0.33 |
| SPRYD7 | SPRY domain containing 7 | -0.32 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | -0.32 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.31 |
| TMEM159 | transmembrane protein 159 | -0.31 |
| RAB40C | RAB40C, member RAS oncogene family | -0.31 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.31 |
| PRKD1 | protein kinase D1 | -0.31 |
| ZNF197 | zinc finger protein 197 | -0.31 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | -0.3 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.3 |
| MXRA7 | matrix-remodelling associated 7 | -0.3 |
| ADPRHL1 | ADP-ribosylhydrolase like 1 | -0.3 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.3 |
| TMX2 | thioredoxin-related transmembrane protein 2 | -0.3 |
| KDM8 | lysine (K)-specific demethylase 8 | -0.3 |
| TMEM87B | transmembrane protein 87B | -0.3 |
| IL6ST | interleukin 6 signal transducer | -0.3 |
| WDR90 | WD repeat domain 90 | -0.3 |
| RTN4R | reticulon 4 receptor | -0.3 |
| ITM2B | integral membrane protein 2B | -0.3 |
| TMEM200A | transmembrane protein 200A | -0.29 |
| MLXIPL | MLX interacting protein-like | -0.29 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.29 |
| NBR1 | neighbor of BRCA1 gene 1 | -0.29 |
| CDX2 | caudal type homeobox 2 | -0.29 |
| SYT17 | synaptotagmin XVII | -0.29 |
| PLPP3 | phospholipid phosphatase 3 | -0.28 |
| KCTD6 | potassium channel tetramerization domain containing 6 | -0.28 |
| CLCN5 | chloride channel, voltage-sensitive 5 | -0.28 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.28 |
| ZNF302 | zinc finger protein 302 | -0.27 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.27 |
| ARMC7 | armadillo repeat containing 7 | -0.27 |
| ZFYVE27 | zinc finger, FYVE domain containing 27 | -0.27 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.27 |
| OAF | OAF homolog (Drosophila) | -0.27 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -0.27 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | -0.27 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | -0.27 |
| NUCB2 | nucleobindin 2 | -0.27 |
