| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/133633 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in L-741 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD2 | abhydrolase domain containing 2 | 2.73 |
| C14ORF93 | chromosome 14 open reading frame 93 | 2.62 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.79 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.49 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.44 |
| SQLE | squalene epoxidase | 1.41 |
| MSMO1 | methylsterol monooxygenase 1 | 1.15 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.14 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.02 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.92 |
| TSPAN3 | tetraspanin 3 | 0.9 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.85 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.81 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.81 |
| APOB | apolipoprotein B | 0.76 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.75 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.74 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | 0.74 |
| MVK | mevalonate kinase | 0.7 |
| LDLR | low density lipoprotein receptor | 0.67 |
| SC5D | sterol-C5-desaturase | 0.65 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.63 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.59 |
| CCDC9 | coiled-coil domain containing 9 | 0.54 |
| ABHD3 | abhydrolase domain containing 3 | 0.53 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.52 |
| LPIN1 | lipin 1 | 0.51 |
| MVD | mevalonate (diphospho) decarboxylase | 0.51 |
| FADS1 | fatty acid desaturase 1 | 0.5 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.5 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.5 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | 0.49 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.48 |
| S100A14 | S100 calcium binding protein A14 | 0.47 |
| CD63 | CD63 molecule | 0.45 |
| GCH1 | GTP cyclohydrolase 1 | 0.45 |
| SCARB1 | scavenger receptor class B, member 1 | 0.44 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.44 |
| DOCK11 | dedicator of cytokinesis 11 | 0.44 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.44 |
| TNXB | tenascin XB | 0.44 |
| KLHDC3 | kelch domain containing 3 | 0.42 |
| TMEM97 | transmembrane protein 97 | 0.42 |
| BOK | BCL2-related ovarian killer | 0.41 |
| ISL2 | ISL LIM homeobox 2 | 0.41 |
| GGPS1 | geranylgeranyl diphosphate synthase 1 | 0.4 |
| SMIM19 | small integral membrane protein 19 | 0.4 |
| MCOLN3 | mucolipin 3 | 0.4 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.4 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.39 |
| SPIRE2 | spire-type actin nucleation factor 2 | 0.39 |
| UBE2J2 | ubiquitin-conjugating enzyme E2, J2 | 0.39 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.39 |
| FDPS | farnesyl diphosphate synthase | 0.38 |
| NHSL1 | NHS-like 1 | 0.37 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.37 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.37 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 0.36 |
| BSDC1 | BSD domain containing 1 | 0.35 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.35 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.35 |
| NRP1 | neuropilin 1 | 0.35 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.34 |
| MCL1 | myeloid cell leukemia 1 | 0.34 |
| NPC1 | Niemann-Pick disease, type C1 | 0.34 |
| BRCA2 | breast cancer 2, early onset | 0.33 |
| ZNF526 | zinc finger protein 526 | 0.33 |
| TULP3 | tubby like protein 3 | 0.33 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.33 |
| SMOX | spermine oxidase | 0.32 |
| S100A6 | S100 calcium binding protein A6 | 0.31 |
| TIGD5 | tigger transposable element derived 5 | 0.31 |
| AREG | amphiregulin | 0.31 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.3 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.3 |
| EMC10 | ER membrane protein complex subunit 10 | 0.3 |
| TMEM39B | transmembrane protein 39B | 0.3 |
| FASN | fatty acid synthase | 0.3 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.3 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.3 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.29 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.29 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.28 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.28 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.28 |
| TMEM41B | transmembrane protein 41B | 0.28 |
| PLPP2 | phospholipid phosphatase 2 | 0.28 |
| FAR1 | fatty acyl CoA reductase 1 | 0.28 |
| ZBTB44 | zinc finger and BTB domain containing 44 | 0.28 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.28 |
| MIF4GD | MIF4G domain containing | 0.27 |
| ACACB | acetyl-CoA carboxylase beta | 0.27 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 0.27 |
| ACLY | ATP citrate lyase | 0.27 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.27 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.27 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 0.27 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 0.27 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.27 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -1.53 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | -1.47 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -1.29 |
| DMWD | dystrophia myotonica, WD repeat containing | -0.94 |
| ZSWIM1 | zinc finger, SWIM-type containing 1 | -0.94 |
| ACTBL2 | actin, beta-like 2 | -0.89 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.84 |
| VASN | vasorin | -0.76 |
| ADIPOR1 | adiponectin receptor 1 | -0.7 |
| FMNL3 | formin-like 3 | -0.66 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -0.65 |
| GBA | glucosidase, beta, acid | -0.62 |
| ZNF776 | zinc finger protein 776 | -0.52 |
| ABHD18 | abhydrolase domain containing 18 | -0.51 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | -0.5 |
| TPRG1L | tumor protein p63 regulated 1-like | -0.5 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.49 |
| TSPAN4 | tetraspanin 4 | -0.49 |
| ZNF276 | zinc finger protein 276 | -0.49 |
| PICK1 | protein interacting with PRKCA 1 | -0.48 |
| MT1F | metallothionein 1F | -0.47 |
| CRTC1 | CREB regulated transcription coactivator 1 | -0.46 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.46 |
| PIP | prolactin-induced protein | -0.46 |
| CA8 | carbonic anhydrase VIII | -0.46 |
| B3GLCT | beta 3-glucosyltransferase | -0.46 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -0.46 |
| NLRX1 | NLR family member X1 | -0.45 |
| ADM | adrenomedullin | -0.43 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.43 |
| RNPEPL1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | -0.42 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -0.42 |
| IRF9 | interferon regulatory factor 9 | -0.42 |
| CERK | ceramide kinase | -0.42 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.41 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.41 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.41 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.41 |
| PLSCR1 | phospholipid scramblase 1 | -0.41 |
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | -0.4 |
| CYB561 | cytochrome b561 | -0.39 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | -0.39 |
| RBM4B | RNA binding motif protein 4B | -0.39 |
| ATL1 | atlastin GTPase 1 | -0.39 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.38 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.38 |
| BRSK2 | BR serine/threonine kinase 2 | -0.38 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.37 |
| TOR4A | torsin family 4, member A | -0.37 |
| EVL | Enah/Vasp-like | -0.37 |
| FBXO17 | F-box protein 17 | -0.37 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.37 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.37 |
| CDC42SE2 | CDC42 small effector 2 | -0.37 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.36 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | -0.36 |
| TMCO4 | transmembrane and coiled-coil domains 4 | -0.36 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.35 |
| SPAG17 | sperm associated antigen 17 | -0.35 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | -0.35 |
| ZNF267 | zinc finger protein 267 | -0.34 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.33 |
| RAP1GAP | RAP1 GTPase activating protein | -0.33 |
| DUSP14 | dual specificity phosphatase 14 | -0.33 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.33 |
| FBXO45 | F-box protein 45 | -0.33 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.33 |
| NAA20 | N(alpha)-acetyltransferase 20, NatB catalytic subunit | -0.32 |
| FCHO1 | FCH domain only 1 | -0.32 |
| PIGU | phosphatidylinositol glycan anchor biosynthesis, class U | -0.32 |
| MRPL16 | mitochondrial ribosomal protein L16 | -0.32 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.32 |
| TMPO | thymopoietin | -0.32 |
| HIST2H3A | histone cluster 2, H3a | -0.32 |
| JOSD1 | Josephin domain containing 1 | -0.32 |
| ATM | ATM serine/threonine kinase | -0.31 |
| HES1 | hes family bHLH transcription factor 1 | -0.31 |
| ATG13 | autophagy related 13 | -0.31 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.31 |
| FKBPL | FK506 binding protein like | -0.31 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.31 |
| RCAN3 | RCAN family member 3 | -0.31 |
| ANO8 | anoctamin 8 | -0.3 |
| CNTNAP3 | contactin associated protein-like 3 | -0.3 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.3 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | -0.3 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.3 |
| MYL9 | myosin, light chain 9, regulatory | -0.29 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.29 |
| SVIP | small VCP/p97-interacting protein | -0.29 |
| KBTBD4 | kelch repeat and BTB (POZ) domain containing 4 | -0.29 |
| MRPL33 | mitochondrial ribosomal protein L33 | -0.29 |
| PXDN | peroxidasin | -0.29 |
| BMP8A | bone morphogenetic protein 8a | -0.28 |
| GTF3A | general transcription factor IIIA | -0.28 |
| PDE9A | phosphodiesterase 9A | -0.28 |
| ING2 | inhibitor of growth family, member 2 | -0.28 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.28 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.28 |
| MVB12B | multivesicular body subunit 12B | -0.28 |
