| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An optically active form of cysteine having L-configuration. (Chemical Entities of Biological Interest Ontology, CHEBI_17561) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5862 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in L-Cysteine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DENND1A | DENN/MADD domain containing 1A | 1.82 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.81 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 0.75 |
| KALRN | kalirin, RhoGEF kinase | 0.56 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.52 |
| ZNF776 | zinc finger protein 776 | 0.48 |
| TMEM14C | transmembrane protein 14C | 0.48 |
| CRYM | crystallin, mu | 0.44 |
| SH3PXD2A | SH3 and PX domains 2A | 0.42 |
| WWOX | WW domain containing oxidoreductase | 0.41 |
| MIS12 | MIS12 kinetochore complex component | 0.4 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | 0.39 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.38 |
| WDR76 | WD repeat domain 76 | 0.36 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.36 |
| RPLP1 | ribosomal protein, large, P1 | 0.36 |
| ELOC | elongin C | 0.36 |
| SPRTN | SprT-like N-terminal domain | 0.35 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.35 |
| KIF18B | kinesin family member 18B | 0.34 |
| CUL7 | cullin 7 | 0.33 |
| AP3B2 | adaptor-related protein complex 3, beta 2 subunit | 0.33 |
| PVR | poliovirus receptor | 0.33 |
| SHROOM1 | shroom family member 1 | 0.32 |
| ALG11 | ALG11, alpha-1,2-mannosyltransferase | 0.32 |
| WDR37 | WD repeat domain 37 | 0.32 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | 0.32 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.31 |
| NEMP1 | nuclear envelope integral membrane protein 1 | 0.31 |
| ZNF714 | zinc finger protein 714 | 0.31 |
| SNX11 | sorting nexin 11 | 0.31 |
| UBQLN1 | ubiquilin 1 | 0.31 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | 0.31 |
| EPHA1 | EPH receptor A1 | 0.31 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | 0.31 |
| CD99 | CD99 molecule | 0.31 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 0.3 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.3 |
| CBR1 | carbonyl reductase 1 | 0.3 |
| COP1 | COP1 E3 ubiquitin ligase | 0.3 |
| DONSON | downstream neighbor of SON | 0.3 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.29 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.29 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.29 |
| SLC9B2 | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 | 0.29 |
| NPRL3 | nitrogen permease regulator-like 3 (S. cerevisiae) | 0.29 |
| NEU3 | sialidase 3 (membrane sialidase) | 0.28 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.28 |
| FBXO42 | F-box protein 42 | 0.28 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | 0.28 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.28 |
| TYSND1 | trypsin domain containing 1 | 0.28 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.28 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.28 |
| GALNS | galactosamine (N-acetyl)-6-sulfatase | 0.27 |
| KIF26A | kinesin family member 26A | 0.27 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.27 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | 0.27 |
| AKTIP | AKT interacting protein | 0.27 |
| TMEM97 | transmembrane protein 97 | 0.27 |
| HDAC8 | histone deacetylase 8 | 0.27 |
| UBXN2A | UBX domain protein 2A | 0.26 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.26 |
| MOSPD1 | motile sperm domain containing 1 | 0.26 |
| DIXDC1 | DIX domain containing 1 | 0.26 |
| GAS2L1 | growth arrest-specific 2 like 1 | 0.26 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.26 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.26 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 0.26 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.26 |
| CHMP1B | charged multivesicular body protein 1B | 0.26 |
| DDT | D-dopachrome tautomerase | 0.26 |
| UBL3 | ubiquitin-like 3 | 0.26 |
| RPL37A | ribosomal protein L37a | 0.26 |
| RBM41 | RNA binding motif protein 41 | 0.25 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.25 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.25 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.25 |
| ZNF770 | zinc finger protein 770 | 0.25 |
| LYST | lysosomal trafficking regulator | 0.25 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.25 |
| C1D | C1D nuclear receptor corepressor | 0.25 |
| BEND3 | BEN domain containing 3 | 0.24 |
| RPA3 | replication protein A3, 14kDa | 0.24 |
| ZNF76 | zinc finger protein 76 | 0.24 |
| MINDY3 | MINDY lysine 48 deubiquitinase 3 | 0.24 |
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | 0.24 |
| RAB17 | RAB17, member RAS oncogene family | 0.24 |
| TPRN | taperin | 0.24 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.24 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 0.24 |
| MSLN | mesothelin | 0.24 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.24 |
| ATG101 | autophagy related 101 | 0.24 |
| RRAGB | Ras-related GTP binding B | 0.24 |
| FZD1 | frizzled class receptor 1 | 0.24 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | 0.24 |
| TRIM29 | tripartite motif containing 29 | 0.24 |
| ATG14 | autophagy related 14 | 0.24 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCDC1 | doublecortin domain containing 1 | -4.31 |
| KLHL23 | kelch-like family member 23 | -3.07 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -2.56 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | -1.35 |
| MYT1 | myelin transcription factor 1 | -1.0 |
| SERINC1 | serine incorporator 1 | -0.95 |
| ALS2 | amyotrophic lateral sclerosis 2 (juvenile) | -0.84 |
| HLA-F | major histocompatibility complex, class I, F | -0.77 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | -0.75 |
| SYCP1 | synaptonemal complex protein 1 | -0.73 |
| NEK3 | NIMA-related kinase 3 | -0.71 |
| ETFDH | electron-transferring-flavoprotein dehydrogenase | -0.69 |
| MLXIPL | MLX interacting protein-like | -0.65 |
| ATG4A | autophagy related 4A, cysteine peptidase | -0.64 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.61 |
| SATB1 | SATB homeobox 1 | -0.61 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -0.6 |
| COMMD3 | COMM domain containing 3 | -0.57 |
| MTF1 | metal-regulatory transcription factor 1 | -0.56 |
| MBP | myelin basic protein | -0.56 |
| RNASET2 | ribonuclease T2 | -0.55 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | -0.54 |
| TATDN2 | TatD DNase domain containing 2 | -0.54 |
| CD58 | CD58 molecule | -0.53 |
| HLA-E | major histocompatibility complex, class I, E | -0.53 |
| ZNF22 | zinc finger protein 22 | -0.51 |
| FAM110C | family with sequence similarity 110, member C | -0.51 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.5 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -0.49 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.49 |
| PALB2 | partner and localizer of BRCA2 | -0.49 |
| ZNF275 | zinc finger protein 275 | -0.48 |
| TTC33 | tetratricopeptide repeat domain 33 | -0.48 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | -0.48 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.47 |
| CNTNAP1 | contactin associated protein 1 | -0.47 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.47 |
| JOSD1 | Josephin domain containing 1 | -0.46 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.46 |
| LRRC46 | leucine rich repeat containing 46 | -0.45 |
| TSPAN6 | tetraspanin 6 | -0.44 |
| TFAM | transcription factor A, mitochondrial | -0.43 |
| SFXN5 | sideroflexin 5 | -0.43 |
| TPM4 | tropomyosin 4 | -0.43 |
| PDCD7 | programmed cell death 7 | -0.42 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.42 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.42 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | -0.41 |
| TEP1 | telomerase-associated protein 1 | -0.41 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.4 |
| SMPDL3B | sphingomyelin phosphodiesterase, acid-like 3B | -0.39 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.38 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.38 |
| MARVELD3 | MARVEL domain containing 3 | -0.38 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.37 |
| LYRM2 | LYR motif containing 2 | -0.37 |
| ADIRF | adipogenesis regulatory factor | -0.37 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.37 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.36 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.36 |
| OTC | ornithine carbamoyltransferase | -0.36 |
| PCDH1 | protocadherin 1 | -0.36 |
| WDR59 | WD repeat domain 59 | -0.36 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.35 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.35 |
| WDR25 | WD repeat domain 25 | -0.35 |
| CCDC115 | coiled-coil domain containing 115 | -0.34 |
| DCP2 | decapping mRNA 2 | -0.34 |
| RPL10 | ribosomal protein L10 | -0.34 |
| ZNF689 | zinc finger protein 689 | -0.33 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | -0.33 |
| SARDH | sarcosine dehydrogenase | -0.33 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.33 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.33 |
| TPM3 | tropomyosin 3 | -0.33 |
| HGFAC | HGF activator | -0.33 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.32 |
| TSLIG1 | tRNA splicing ligase complex subunit 1 | -0.32 |
| CISD3 | CDGSH iron sulfur domain 3 | -0.32 |
| PEX6 | peroxisomal biogenesis factor 6 | -0.32 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.32 |
| ARSD | arylsulfatase D | -0.32 |
| RAB6D | RAB6D, member RAS oncogene family | -0.32 |
| TDG | thymine-DNA glycosylase | -0.31 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.31 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.31 |
| CBWD1 | COBW domain containing 1 | -0.31 |
| FAM107B | family with sequence similarity 107, member B | -0.31 |
| FOSL2 | FOS-like antigen 2 | -0.31 |
| C19ORF25 | chromosome 19 open reading frame 25 | -0.31 |
| LYRM4 | LYR motif containing 4 | -0.31 |
| SLC25A46 | solute carrier family 25, member 46 | -0.31 |
| ACP1 | acid phosphatase 1, soluble | -0.3 |
| TROAP | trophinin associated protein | -0.3 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | -0.3 |
| SASH1 | SAM and SH3 domain containing 1 | -0.3 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | -0.3 |
| RPL15 | ribosomal protein L15 | -0.3 |
