L-Eflornithine (monohydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description L-Eflornithine (monohydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the L-Eflornithine (monohydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.270991
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.236364
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.195086
PLAT plasminogen activator, tissue 0.138769
CD44 CD44 molecule (Indian blood group) 0.130887
VIM vimentin 0.125952
DLG1 discs, large homolog 1 (Drosophila) 0.11838
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.114218
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0967706
MT2A metallothionein 2A 0.0842693
COL3A1 collagen, type III, alpha 1 0.0807854
B2M beta-2-microglobulin 0.0695067
FBN1 fibrillin 1 0.0637137
FNDC3B fibronectin type III domain containing 3B 0.0593788
COL1A2 collagen, type I, alpha 2 0.0592009
OGA O-GlcNAcase 0.0588283
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0573074
NAV1 neuron navigator 1 0.052674
SEPTIN9 septin 9 0.0520788
LOX lysyl oxidase 0.051783
VEGFA vascular endothelial growth factor A 0.0511104
UBC ubiquitin C 0.0506429
CALR calreticulin 0.050413
STC1 stanniocalcin 1 0.0493783
RHOBTB3 Rho-related BTB domain containing 3 0.0487898
ERRFI1 ERBB receptor feedback inhibitor 1 0.0449773
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0431633
FNIP1 folliculin interacting protein 1 0.0430044
ANKRD36 ankyrin repeat domain 36 0.0429484
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0422603
ELL2 elongation factor, RNA polymerase II, 2 0.0420597
FLNB filamin B, beta 0.0414773
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0413875
COL5A2 collagen, type V, alpha 2 0.0409363
SBF2 SET binding factor 2 0.0404306
WWTR1 WW domain containing transcription regulator 1 0.0398327
IQGAP1 IQ motif containing GTPase activating protein 1 0.0392625
HLA-B major histocompatibility complex, class I, B 0.039134
LOXL2 lysyl oxidase-like 2 0.0384599
MYOF myoferlin 0.0383413
TM4SF1 transmembrane 4 L six family member 1 0.0379705
ZNF148 zinc finger protein 148 0.0377038
TRIO trio Rho guanine nucleotide exchange factor 0.0374327
CD99 CD99 molecule 0.0372948
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0372046
YEATS2 YEATS domain containing 2 0.0359879
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0355681
ZBTB20 zinc finger and BTB domain containing 20 0.0354939
OPTN optineurin 0.035337
MYADM myeloid-associated differentiation marker 0.0353237
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0348298
APP amyloid beta (A4) precursor protein 0.0347326
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0345765
PSD3 pleckstrin and Sec7 domain containing 3 0.0341538
MB21D2 Mab-21 domain containing 2 0.0340235
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0336688
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.033535
ARRDC3 arrestin domain containing 3 0.0327465
DSCAM Down syndrome cell adhesion molecule 0.0327221
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0324993
ATP13A3 ATPase type 13A3 0.0322262
GPC6 glypican 6 0.0319163
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0306297
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0306236
PRRC2C proline-rich coiled-coil 2C 0.0305462
ZNF292 zinc finger protein 292 0.0295026
NKTR natural killer cell triggering receptor 0.0288072
SLC39A11 solute carrier family 39, member 11 0.028656
SLC22A23 solute carrier family 22, member 23 0.0284484
NF1 neurofibromin 1 0.0282474
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0281754
ANKRD36C ankyrin repeat domain 36C 0.0276963
C1D C1D nuclear receptor corepressor 0.0274759
RAI14 retinoic acid induced 14 0.0272908
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0272645
NFE2L1 nuclear factor, erythroid 2-like 1 0.0271385
ANKRD12 ankyrin repeat domain 12 0.0266473
PODXL podocalyxin-like 0.0264946
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0262199
AVL9 AVL9 homolog (S. cerevisiase) 0.0261165
DPYSL2 dihydropyrimidinase-like 2 0.0260026
AKAP9 A kinase (PRKA) anchor protein 9 0.0256604
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.025478
ANXA2 annexin A2 0.0254018
TPM3 tropomyosin 3 0.0253967
PCM1 pericentriolar material 1 0.0253755
SP3 Sp3 transcription factor 0.0253646
MT1X metallothionein 1X 0.0251924
ANO6 anoctamin 6 0.0251529
PRELID2 PRELI domain containing 2 0.0246828
DCAF6 DDB1 and CUL4 associated factor 6 0.0245453
AFDN afadin, adherens junction formation factor 0.0245202
MARCHF7 membrane associated ring-CH-type finger 7 0.0244773
SRRM2 serine/arginine repetitive matrix 2 0.0244338
ENO1 enolase 1, (alpha) 0.0243304
ARHGAP5 Rho GTPase activating protein 5 0.0242385
IFITM1 interferon induced transmembrane protein 1 0.0242298
CDK19 cyclin-dependent kinase 19 0.0239202
E2F7 E2F transcription factor 7 0.0238346
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0237243

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0952192
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0890816
CDH13 cadherin 13 -0.0793016
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0769398
ABI3BP ABI family, member 3 (NESH) binding protein -0.0663266
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0566924
TMSB10 thymosin beta 10 -0.0524232
FN1 fibronectin 1 -0.0512433
RIGI RNA sensor RIG-I -0.0511552
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0484823
SAMD9 sterile alpha motif domain containing 9 -0.0445262
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0439309
COL5A1 collagen, type V, alpha 1 -0.0430159
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.035168
MEIS2 Meis homeobox 2 -0.0320223
SQSTM1 sequestosome 1 -0.030293
CCND1 cyclin D1 -0.0300676
JAZF1 JAZF zinc finger 1 -0.0293129
FTL ferritin, light polypeptide -0.0283402
OASL 2'-5'-oligoadenylate synthetase-like -0.0279922
JUN jun proto-oncogene -0.0261179
LMNA lamin A/C -0.0259262
PLXNA2 plexin A2 -0.0256564
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0255484
PCDH7 protocadherin 7 -0.0252531
FGFR1 fibroblast growth factor receptor 1 -0.0239308
DDIT4 DNA-damage-inducible transcript 4 -0.023814
WARS1 tryptophanyl-tRNA synthetase 1 -0.0232799
IL7R interleukin 7 receptor -0.0231962
RRBP1 ribosome binding protein 1 -0.0225144
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0223978
NDRG1 N-myc downstream regulated 1 -0.0218334
MSI2 musashi RNA-binding protein 2 -0.021636
GADD45B growth arrest and DNA-damage-inducible, beta -0.0215288
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0210762
IARS1 isoleucyl-tRNA synthetase 1 -0.0206258
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0206242
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0200168
SORBS2 sorbin and SH3 domain containing 2 -0.0197049
GARS1 glycyl-tRNA synthetase 1 -0.0194864
HSPB1 heat shock 27kDa protein 1 -0.0192868
AHNAK AHNAK nucleoprotein -0.0189771
ACTG1 actin gamma 1 -0.0189682
BHLHE40 basic helix-loop-helix family, member e40 -0.0185267
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0184811
SH3RF3 SH3 domain containing ring finger 3 -0.0181636
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0179167
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0177669
FNDC3A fibronectin type III domain containing 3A -0.0177271
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0173416
FLT1 fms-related tyrosine kinase 1 -0.0171702
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0171169
DENND1A DENN/MADD domain containing 1A -0.0167296
FSTL1 follistatin-like 1 -0.0164653
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0164487
CAVIN1 caveolae associated protein 1 -0.0163766
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0162057
ADM adrenomedullin -0.0160185
SRPK2 SRSF protein kinase 2 -0.0159166
MED13L mediator complex subunit 13-like -0.0158645
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0158624
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0157743
THBS2 thrombospondin 2 -0.0156565
IGFBP3 insulin-like growth factor binding protein 3 -0.0156404
IFIH1 interferon induced with helicase C domain 1 -0.0154422
IFRD1 interferon-related developmental regulator 1 -0.0154307
RAB7A RAB7A, member RAS oncogene family -0.015422
PARD3 par-3 family cell polarity regulator -0.0151803
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0151568
IRF1 interferon regulatory factor 1 -0.0150146
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0149436
TNS3 tensin 3 -0.0149268
WSB1 WD repeat and SOCS box containing 1 -0.0148976
SYT1 synaptotagmin I -0.0141598
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0138867
COL8A1 collagen, type VIII, alpha 1 -0.0138835
SPAG9 sperm associated antigen 9 -0.0138323
TSC22D2 TSC22 domain family, member 2 -0.0136732
RACK1 receptor for activated C kinase 1 -0.0135979
PHF21A PHD finger protein 21A -0.0133945
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0132492
RND3 Rho family GTPase 3 -0.0131517
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.0129591
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0129236
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.012708
RPS20 ribosomal protein S20 -0.0126737
TGFB1 transforming growth factor, beta 1 -0.0126642
PLCB4 phospholipase C, beta 4 -0.0123988
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0123762
NAMPT nicotinamide phosphoribosyltransferase -0.0122979
AEBP2 AE binding protein 2 -0.0121079
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0120864
NRF1 nuclear respiratory factor 1 -0.0120203
MIMS1 mitochondrial inner membrane scaffold 1 -0.0120099
CTSD cathepsin D -0.011966
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0119151
RPL11 ribosomal protein L11 -0.0118948
IER3 immediate early response 3 -0.0118721
RPL28 ribosomal protein L28 -0.0118171
FMN2 formin 2 -0.0118142